Abstract:
:Many brilliant and ambitious young women lose their drive for top careers after childbirth. New maternal impulses are at odds with their original ambitions and for many mothers stress and frustration will be the result as they have to combine child care with workweeks of 60-80h to reach or remain at the top. Pregnancy hormones modify the female's brain as has been demonstrated already for decades in animals. This brain plasticity due to adult neurogenesis in the so called maternal circuitry of the limbic system is long-lasting and perhaps lifelong. In humans hormonal and neuro-imaging studies show ample evidence for fundamental and long lasting pregnancy induced brain changes, not only in the limbic system, but also in the cortical networks like theory of mind and mirror neuron system. Recent research shows pronounced and long lasting brain changes in several of these areas. It can be concluded that there exists a maternal brain that drives mother's behaviour and priorities. Research in men shows that the more fathers are involved in raising their children, the more caring behaviour they develop. Structural anatomical changes are found in neural regions involved in parental motivation. These studies show that brain plasticity in fathers is experience dependent. In Nordic countries, a policy of paid paternal leave followed by a flexible shared parental leave, stimulates fatherly behaviour. This might reduce men's eagerness for top careers, thus creating better opportunities for women. Demolition of women's glass ceiling starts with the father.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Schulpen TWJdoi
10.1016/j.mehy.2017.07.002subject
Has Abstractpub_date
2017-09-01 00:00:00pages
41-43eissn
0306-9877issn
1532-2777pii
S0306-9877(17)30513-3journal_volume
106pub_type
杂志文章abstract::Obesity is the second largest cause of preventable death in the United States. Historically, obesity was considered a behavioral problem that could be simply addressed with behavioral modifications in diet and exercise. As scientific advancements have demonstrated in other neurological healthcare conditions such as al...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.08.041
更新日期:2007-01-01 00:00:00
abstract::Cachexia is a pathological state characterized by weight loss and protein mobilization during various diseases. Nutritional supplementation or appetite stimulants are unable to restore the loss of lean body mass. Agents interfering with TNF-alpha have not been very successful to date. Only eicosapentaenoic acid was ab...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.11.007
更新日期:2008-01-01 00:00:00
abstract::Mouth to mouth sexual kissing is seen in more than 90% of human cultures. Various theories have been put forward to account for this but none offer a full explanation within an evolutionary framework. As mouth to mouth sexual kissing exposes each participant to the diseases of the other, it must confer significant ben...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.09.033
更新日期:2010-02-01 00:00:00
abstract::Amyloid beta-protein is a major focus in efforts to understand the etiology of Alzheimer disease yet there is little known about the mechanism of its deposition in plaques. I propose deposition of amyloid in neuritic plaques depends on the remains of neurofibrillary tangles after neuronal death. The interaction of the...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90051-q
更新日期:1993-04-01 00:00:00
abstract::Medicine today is an extremely heterogeneous field of knowledge, based on clinical observations and action knowledge and on data from the biological, behavioral and social sciences. We hypothesize at first that medicine suffers from a disciplinary hyper-diversity compared to the level of conceptual interdisciplinary i...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109386
更新日期:2019-12-01 00:00:00
abstract::Osteoarthritis (OA) is a chronic, degenerative disorder of multifactorial aetiology, characterized by loss of articular cartilage and periarticular bone remodelling. Goals of managing OA include controlling pain, maintaining and improving function and health-related quality of life, and limiting functional impairment....
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.01.084
更新日期:2007-01-01 00:00:00
abstract::The etiology of most kinds of dementia is still obscure and is probably multifactorial. We query whether excessive watching of television may contribute to the development of dementive processes for the following reasons: TV spectators are exposed to a mass of successive and rapid stimuli with little or no possibility...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90128-d
更新日期:1993-11-01 00:00:00
abstract::A bi-directional association between mood disorders and migraine has been consistently reported. Nevertheless, the neurobiological substrate underlying the association between these disorders remains unknown. In the article herein we review evidence for the role of inflammatory cytokines in the neurobiology of bipolar...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2012.01.036
更新日期:2012-05-01 00:00:00
abstract::Pulseless electrical activity occurs when organised or semi-organised electrical activity of the heart persists but the product of systemic vascular resistance and the increase in systemic arterial flow generated by the ejection of the left venticular stroke volume is not sufficient to produce a clinically detectable ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.06.018
更新日期:2012-10-01 00:00:00
abstract::Cancer and other diseases may be a natural biological event, the activities of which may be dependent on the constitution of the individual. Where fetal and embryonic cells are not diseased or faulty or defective, they may be useful as therapies against cancer and other diseases. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2001.1517
更新日期:2002-05-01 00:00:00
abstract::The internal thoracic arteries (ITAs) are a source of "noncoronary collateral circulation" (NCCC), or "noncoronary collateral blood flow" (NCCBF). The hypothesis herein is that enhancement of NCCC may represent an alternative means of myocardial blood supply: (1) Ligature of the ITAs creates a local hypertensive statu...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.08.027
更新日期:2010-01-01 00:00:00
abstract::Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents the largest current health challenge for the society. At the moment, the therapeutic strategies to deal with this disease are only supportive. It is well known that zinc (Zn) possesses a variety of dir...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109848
更新日期:2020-11-01 00:00:00
abstract::Intra-peritoneal adhesions ensuing from surgery or infection may lead to chronic pelvic pain, bowel obstruction, infertility and additional invasive surgery to resolve adhesion-related complications. As a result adhesions are a major clinical, social and economic concern. The cumulative year-on-year direct costs of ad...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.11.020
更新日期:2011-03-01 00:00:00
abstract::Incidental pituitary adenoma is the common finding during brain imaging. According to multistep model of pituitary tumourigenesis genetic alterations provide the initiating event that transforms cells while hormones play a role in promoting cell proliferation. Development of pituitary adenoma in a case of excessive hy...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.11.044
更新日期:2007-01-01 00:00:00
abstract::Since 1960, the incidence of melanoma has increased dramatically in Caucasians worldwide, and during the past decade has risen at a rate of 6% a year in the USA. A hypothesis regarding this increased incidence suggests that the prevalent use of antibacterial soaps that contain photosensitizing compounds may be a risk ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1997.0718
更新日期:1999-07-01 00:00:00
abstract::The "small-for-size" syndrome and "post-hepatectomy liver failure" refers to the development of liver failure (hyperbilirubinemia, coagulopathy, encephalopathy and refractory ascites) resulting from the reduction of liver mass beyond a certain threshold. This complication is associated with a high mortality and is a m...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.01.028
更新日期:2013-05-01 00:00:00
abstract::The reluctance of physicians to get involved with child abuse can be attributed to the problem of role conflict. Physicians derive their social authority from the Aesculapian tradition. This form of social authority is fragile and easily subverted, yet of utmost importance if physicians are to retain their effectivene...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(82)90028-7
更新日期:1982-04-01 00:00:00
abstract::Cancer cells have a greater need for energy and a ready supply of the building blocks necessary for the synthesis of macromolecules (nucleotides, protein, lipids) in order to duplicate genome and biomass. The hypothesis can be postulated that those precursors for synthetic processes, which can only be furnished by gly...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.06.002
更新日期:2012-09-01 00:00:00
abstract::A five-step hypothesis on the pathogenesis of Hodgkin's disease (HD) is presented. Weak immune suppressor activity gives a predisposition for the development of the disease, after which a non-specific immune stimulation can initiate a self-perpetuating uncontrolled stimulation between interdigitating cells (IDCs), mac...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(84)90156-7
更新日期:1984-12-01 00:00:00
abstract::This evidence, then, would suggest that the olive becomes active when, with a change in the motor task, the motor performance is required to adjust to the new circumstance. From Smith's experiments on blood pressure, it is extrapolated that the olive becomes active when there is a change in the physiological state, an...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(78)90050-6
更新日期:1978-11-01 00:00:00
abstract::The cumulative incidence of uterine leiomyoma at age 50 is ≈ 70% in White women and >80% in Black women. Although risk factor research is limited, increasing age, and being premenopausal, nulliparous or Black are risk factors for leiomyomas. Black women tend to have larger leiomyomas and be younger at diagnosis. Surpr...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.04.046
更新日期:2012-08-01 00:00:00
abstract::Jet lag is a travel-induced circadian rhythm phenomenon that afflicts healthy individuals following long- distance flights through several time zones. The typical jet-lag manifestations - insomnia during local sleep time, day fatigue, reduced concentration, irritability, and exhaustion with mild depression - are attri...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1054/mehy.2000.1094
更新日期:2001-01-01 00:00:00
abstract::Infantile neuroaxonal dystrophy (INAD) and Duchenne muscular dystrophy (DMD) are two deadly neuromuscular degenerative diseases of childhood. Knowledge on their pathophysiological mechanisms may direct us towards treatment or a cure. Although these diseases are caused by two totally different gene-mutations and cause ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109589
更新日期:2020-04-01 00:00:00
abstract::For reasons that are not known, the incidence of stomach cancer is declining in most countries. In contrast, cancer of the gastric remnant after partial gastrectomy for peptic ulcer disease seems to be increasing. "Stump cancer" has been claimed to be a separate disease entity and has recently been mentioned as an iat...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(79)90112-9
更新日期:1979-04-01 00:00:00
abstract:BACKGROUND:Huachansu, a Chinese medicine that comes from dried toad venom from the skin glands of Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider, has been used in treatment of cancers. We conducted a meta-analysis to evaluate the efficacy and safety of Huachansu combined with chemotherapy for advanced gas...
journal_title:Medical hypotheses
pub_type: 杂志文章,meta分析
doi:10.1016/j.mehy.2013.04.038
更新日期:2013-08-01 00:00:00
abstract::Parkinson's disease is one of the mostly seen neurological disease. It affects to nervous system and hinders people's vital activities. The majority of Parkinson's patients lose their ability to speak, write and balance. Many machine learning methods have been proposed to automatically diagnose Parkinson's disease usi...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109483
更新日期:2020-02-01 00:00:00
abstract::A model of human language requires a theory of meaningful marks. Humans are the only species who use marks to think. A theory of marks identifies children's scribbles as significant behavior, while hypothesizing the importance of rotational systems to hominid brain evolution. By recognizing the importance of children'...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.09.002
更新日期:2005-01-01 00:00:00
abstract::Insulin seems to have the ability to suppress the production of tumor necrosis factor-alpha and superoxide anion, enhance the synthesis of nitric oxide and inhibit the expression of intercellular adhesion molecule-1 (ICAM-1) through stimulation of nitric oxide. This suggests that insulin can behave as an anti-inflamma...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2001.1334
更新日期:2001-08-01 00:00:00
abstract::The German doctor Hermann Kümmell described Kümmell's disease as the clinical scenario in which patients suffer a trivial spinal trauma, but develop a symptomatic, progressive, angular kyphosis after a symptom-free period of months to years. Since an intravertebral vacuum phenomenon, which is considered indicative of ...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2011.08.005
更新日期:2011-11-01 00:00:00
abstract::Bipedal locomotion and fine motility of hand and larynx of humans introduced musculoskeletal adaptations, new pyramidal, corticostriatal, corticobulbar, nigrostriatal, and cerebellar pathways and expansions of prefrontal, cingular, parieto-temporal and occipital cortices with derived new brain capabilities. All select...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.05.034
更新日期:2008-11-01 00:00:00