Abstract：
:A five-step hypothesis on the pathogenesis of Hodgkin's disease (HD) is presented. Weak immune suppressor activity gives a predisposition for the development of the disease, after which a non-specific immune stimulation can initiate a self-perpetuating uncontrolled stimulation between interdigitating cells (IDCs), macrophages and helper T lymphocytes (TH). The disease spreads to other lymph nodes through the secretion of humoral factors and by migration of cells. The response of the suppressor branch of the immune system is delayed, and comes from areas not yet involved in the disease, primarily from the spleen and bone marrow. Treatment will result in the predominance of the suppressor activity and allow calming of the disease. In a terminal phase, a possible neoplastic transformation of the chronically stimulated immune cells may give rise to frequent extranodal localizations and a rapid progression of the disease.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Zwitter Mdoi
10.1016/0306-9877(84)90156-7subject
Has Abstractpub_date
1984-12-01 00:00:00pages
399-413issue
4eissn
0306-9877issn
1532-2777pii
0306-9877(84)90156-7journal_volume
15pub_type
杂志文章abstract：:Although frequently encountered, no available consensus about the association between skeletal abnormalities and skin pigmentation. Several syndromes are characterized by the presence of skin pigmentation in association with skeletal disorders like neurofibroamtosis 1, McCune-Albright Syndrome, Jaffe-Campanacci Syndro...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00265-2
更新日期：2003-11-01 00:00:00
abstract：:Functional, excessive-possibly temporary-deficiencies of the trace element zinc can change immune functions prematurely from predominantly cellular Th1 responses to humoral Th2 responses. T helper (Th1) cells produce cytokines such as interleukin-2 (IL-2) and interferon gamma, thereby controlling viral infections and ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(97)90244-9
更新日期：1997-07-01 00:00:00
abstract：:Parkinson's disease (PD) is a neurodegenerative disorder, characterized by loss of dopaminergic neuromelanin containing neurons in the substantia nigra. Peripheral melanin, found in skin and hair, and neuromelanin appear to have some characteristics in common and share the same precursor for their synthesis; therefore...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.04.013
更新日期：2019-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1364
更新日期：2001-10-01 00:00:00
abstract：:Reflux of biliary secretions into the pancreatic duct following gallstone obstruction of the common biliary pancreatic ampulla has been implicated as a cause of acute pancreatitis. However, the pancreatic duct pressure is higher than the biliary pressure and, therefore, the simple obstruction of the choledochoduodenal...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1998.0896
更新日期：2000-04-01 00:00:00
abstract：:Jet lag is a travel-induced circadian rhythm phenomenon that afflicts healthy individuals following long- distance flights through several time zones. The typical jet-lag manifestations - insomnia during local sleep time, day fatigue, reduced concentration, irritability, and exhaustion with mild depression - are attri...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1054/mehy.2000.1094
更新日期：2001-01-01 00:00:00
abstract：:Exercise-induced hypoalgesia is characterised by a reduction in pain sensitivity following exercise. Recently, low intensity exercise performed with blood flow restriction has been shown to induce hypoalgesia. The purpose of this manuscript is to discuss the mechanisms of exercise-induced hypoalgesia and provide ratio...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109370
更新日期：2019-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.09.029
更新日期：2005-01-01 00:00:00
abstract：:The time of re-evaluation of the role of human immunodeficiency viruses in the pathogenesis of acquired immune deficiency syndrome has now come, now that methods are available for the direct detection of human immunodeficiency viruses and for the detection of cellular anti-human immunodeficiency virus immune reactions...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(96)90192-9
更新日期：1996-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.03.054
更新日期：2006-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.01.008
更新日期：2018-03-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(81)90110-9
更新日期：1981-02-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.06.001
更新日期：2006-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(94)90160-0
更新日期：1994-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.03.031
更新日期：2012-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(91)90284-6
更新日期：1991-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(97)90196-1
更新日期：1997-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.0992
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND:Pregnancy is characterized by multiple metabolic processes to allow proper foetal development and ensure adequate stores. Little is known about the interactions between maternal and foetal metabolism during the last phase of pregnancy. Metabolomic offers potential to discover changes in maternal metabolism i...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109543
更新日期：2020-04-01 00:00:00
abstract：:Following allegations that Hepatitis B vaccination causes or triggers multiple sclerosis (MS), several epidemiological studies have been conducted to evaluate the association between MS and vaccination. In one study conducted in the US, a significant protective effect on the development of MS was observed for tetanus ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.05.009
更新日期：2005-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.11.043
更新日期：2013-03-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.04.009
更新日期：2004-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(81)90116-x
更新日期：1981-02-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.02.034
更新日期：2009-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(81)90030-x
更新日期：1981-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.06.024
更新日期：2018-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2014.10.013
更新日期：2014-12-01 00:00:00
abstract：:Following the rate of proteoglycan synthesis as the metabolic parameter of the growth of cartilage cells, indicates that hormonal and local agents are two distinct types of extracellular regulators responsible for altering the basic metabolic rates of cells. Such changes in growth rate occur regularly at physiological...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(80)90057-2
更新日期：1980-04-01 00:00:00
abstract：:At the end of 2019, a new kind of pneumonia which was proven to be supported by novel coronaviruses named SARS-CoV-2 emerges and it seems to be more complicate in its clinical course and management. Related researches have demonstrated that SARS-CoV-2 serves roles in respiratory, intestinal and neuronal diseases. Give...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110332
更新日期：2020-12-01 00:00:00
abstract：:Puberty is starting earlier than ever before and there are serious physiological and sociological implications as a result of this development. Current research has focused on the potential role of high caloric, and commensurate high adiposity, contributions to early puberty. However, girls with normal BMI also appear...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.06.029
更新日期：2015-10-01 00:00:00
