Forecasting versus projection models in epidemiology: the case of the SARS epidemics.

abstract：:The adaptive value of sleep remains unknown in spite of the intense research performed throughout the last decades. However, few sleep researchers are aware of the difficulties posed by the blind acceptance of an extreme adaptationist viewpoint. Under this philosophy, every anatomical and functional detail present in ...

journal_title：Medical hypotheses

authors： Gamundí A,Akaârir M,Coenen AM,Esteban S,Rial RV,Nicolau MC

更新日期：2005-01-01 00:00:00

abstract：:Although it is well established that components of wheat gluten and structurally-related cereal proteins produce intestinal damage in Coeliac disease (CD), the primary defect which confers upon the host susceptibility to these dietary substances remains a mystery. To date, three main hypotheses have been framed to exp...

journal_title：Medical hypotheses

authors： Davidson AG,Bridges MA

更新日期：1988-07-01 00:00:00

abstract：:Oral administration of L-arginine in pharmacological doses induces growth hormone and insulin-like growth factor-I responses and stimulates nitric oxide synthesis. Growth hormone and insulin-like growth factor-I are important mediators of bone turnover and osteoblastic bone formation, while nitric oxide is a potent in...

journal_title：Medical hypotheses

authors： Visser JJ,Hoekman K

更新日期：1994-11-01 00:00:00

abstract：:Based on the principles of the altered homeostatic theory, a case will be made that the risk of cardiovascular (CV) events from pharmaceuticals as COX-2 inhibitors (coxibs) and sympatho-mimetic drugs can be reduced significantly by using standard pharmaceutical and lifestyle preventative measures as statins, exercise,...

journal_title：Medical hypotheses

authors： Hellstrom HR

更新日期：2006-01-01 00:00:00

abstract：:In an effort to develop a method to ascertain whether ancient physicians used certain drugs because of their efficacy or for other reasons (random process, tradition, etc.), the authors have devised a statistical test (Efficacy Quotient-EQ) to evaluate ancient therapeutic data quantitatively. They have applied the Eff...

journal_title：Medical hypotheses

authors： Prioreschi P,Heaney RP,Brehm E

更新日期：1998-10-01 00:00:00

abstract：:A mechanism is proposed for the formation of Ebg-evolved beta galactosidase-of E. coli based on the following assumptions: 1. In the presence of lactose, certain proteins being translated bind to their m-RNA-ribosome complexes; 2. This binding interferes with the release of m-RNA from the bacterial chromosome, marking...

journal_title：Medical hypotheses

authors： Erhan S

更新日期：1979-11-01 00:00:00

abstract：:About 19-26% of patients with chronic lymphocytic leukemia (CLL) have intractable disease resistant to chemotherapy, have a relatively short median survival time and are responsive to splenectomy. Lymphocytes from patients with intractable CLL are resistant in vitro to X-irradiation and to colchicine. Responsive CLL i...

journal_title：Medical hypotheses

authors： Schrek R

更新日期：1990-02-01 00:00:00

abstract：:It is postulated that the induction of immunological tolerance to chemical carcinogens is due to the penetration of carcinogens and its albumin and DNA adducts from the maternal organism into the embryo. Maternal serum lgG-antibodies to carcinogens promote the transportation of carcinogens and adducts into the embryo ...

journal_title：Medical hypotheses

authors： Glushkov AN

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Huachansu, a Chinese medicine that comes from dried toad venom from the skin glands of Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider, has been used in treatment of cancers. We conducted a meta-analysis to evaluate the efficacy and safety of Huachansu combined with chemotherapy for advanced gas...

journal_title：Medical hypotheses

authors： Xie X,Huang X,Li J,Lv X,Huang J,Tang S,Sun Y

更新日期：2013-08-01 00:00:00

abstract：:Atherosclerosis develops gradually as a subclinical condition and eventually becomes clinically apparent as heart disease or stroke. The degree of decreased arterial compliance affects both pulse pressure (PP) and diastolic blood pressure (DBP). These relations would be clear in the distal periphery. We propose that t...

journal_title：Medical hypotheses

authors： Nesnawy S,Tolba K,Roshdy I,Abdel Kader M

更新日期：2020-02-01 00:00:00

abstract：:Current paper aims to hypothesize that, oral surgical interventions such as tooth extractions, endosseous implant placement, subgingival curettage, etc. might result in widespread of fungal species via blood stream and can cause fungal contaminations of the cardiac valves. We hereby suggest that, an additional fungal ...

journal_title：Medical hypotheses

authors： Gülses A,Açil Y,Wiltfang J

更新日期：2020-02-01 00:00:00

abstract：:Bone grafting uses a wide range of materials derived mainly from exogenous sources. Autogenous teeth are often used fresh or fixed with alcohol for later use. Proposed here is a method of using cryogenically preserved autogenous extracted teeth, which could be macerated after thawing. This method avoids the possibilit...

journal_title：Medical hypotheses

authors： Touyz LZ,Afrashtehfar KI

更新日期：2016-07-01 00:00:00

abstract：:We would like to put forward the hypothesis that cancer patients may produce autoantibodies that promote uncontrolled cell growth and thereby function as oncogenes. Dying cells release proteins that stimulate the production of autoantibodies, an event also known to occur during the earliest stages of tumor growth. If ...

journal_title：Medical hypotheses

authors： Admon A,Shoshan SH

更新日期：2006-01-01 00:00:00

abstract：:Over the past decade evidence from multiple research trajectories have converged to provide evidence that impaired glucose metabolism and mitochondrial dysfunction in the brain are the critical issues laying at the root of Bipolar Disorder (BD). These developments have been paralleled by increasing recognition of the ...

journal_title：Medical hypotheses

authors： Campbell I,Campbell H

更新日期：2020-12-01 00:00:00

abstract：:The results of numerous investigations on the impact of obesity on renal insufficiency conducted in recent years introduce certain dilemmas about their mutual agreement. Some studies suggest that obesity is negatively correlated with the terminal phase of renal failure. On the other hand, other research has shown that...

journal_title：Medical hypotheses

authors： Stolic R

更新日期：2010-12-01 00:00:00

abstract：:At present no good method of assisting the right ventricle of the heart exists. This paper presents a new and effective approach to assisting the right ventricle of the heart which can be utilized independently or during cardiac surgery. Through implementation of this method, and timed inflation and deflation of sever...

journal_title：Medical hypotheses

authors： Gordon RT,Gordon D

更新日期：1979-11-01 00:00:00

abstract：:Current tuberculosis control measures are focused on the prompt detection and treatment of active tuberculosis. Despite the measured success of this strategy, tuberculosis continues to be a public health issue of major significance around the world. This unwanted situation suggests the need to expand our control effor...

journal_title：Medical hypotheses

authors： Mao F,Chen T,Zhao Y,Zhang C,Bai B,Zhao S,Xu Z,Shi C

更新日期：2011-07-01 00:00:00

abstract：:Primary angle closure glaucoma has been called the most common form of glaucoma in the world, and the leading cause of bilateral blindness. Pupillary block is felt to be the main mechanism of outflow obstruction in this condition. Recent advances in morphologic assessment of angle closure, specifically by means of ult...

journal_title：Medical hypotheses

authors： Razeghinejad MR,Kamali-Sarvestani E

更新日期：2007-01-01 00:00:00

abstract：:Cell-mediated immunity is generally regarded as the essential factor in recovery from measles infection. In other viral infections humoral immunity has been considered a critical factor when antibody titres were correlated with outcome or when serum therapy proved protective. A review of available studies of severe-to...

journal_title：Medical hypotheses

authors： Aaby P,Bukh J,Hoff G,Lisse IM,Smits AJ

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:Operative risk prediction systems (logistic EuroSCORE I, EuroSCORE II and STS Score) are employed together with multidisciplinary discussion to contraindicate conventional surgery in patients with valvular heart disease and propose the employment of alternative transcatheter procedures. The EuroSCORE I has b...

journal_title：Medical hypotheses

authors： Anselmi A,Ruggieri VG,Harmouche M,Mascle S,Auffret V,Le Breton H,Beneux X,Verhoye JP

更新日期：2015-05-01 00:00:00

abstract：:Developmental alcohol exposure adversely influences the developing brain. Alcohol exposure during rapid brain growth causes cell loss, alters connections between brain regions, and lowers the production of biological substances responsible for the communication among neurons. It is reasonable to suggest that alcohol m...

journal_title：Medical hypotheses

authors： Sher L

更新日期：2004-01-01 00:00:00

abstract：:The treatment and prevention of migraine within the last decade has become largely pharmacological. While there is little doubt that the advent of drugs (e.g. triptans) has helped many migraine sufferers to lead a normal life, there is still little knowledge with respect to the factors responsible for precipitating a ...

journal_title：Medical hypotheses

authors： Kokavec A

更新日期：2016-12-01 00:00:00

abstract：:Reconciling the early promising results of radiation therapy in the treatment of epilepsy with the recent theory concerning the role of nonsynaptic mechanisms in focal epileptogenesis, it is suggested that the potential of irradiation as an alternative to temporal lobe resection in intractable epilepsy should be re-ev...

journal_title：Medical hypotheses

authors： Elomaa E

更新日期：1980-05-01 00:00:00

abstract：:Alpha-fetoprotein (AFP) serum levels in man have long been utilized as a tumor marker and as a birth defect screening agent in the clinical laboratory. Although the physiological role of AFP has remained obscure, the stereotypic carrier/transport function of a fetal counterpart to albumin has been attributed to this o...

journal_title：Medical hypotheses

authors： Dauphinée MJ,Mizejewski GJ

更新日期：2002-06-01 00:00:00

abstract：:Chronic active Epstein-Barr virus (EBV) infection has been recognized as clonal non-neoplastic lymphoproliferative diseases. However, some reports of cases with a multiphenotypic expansion of EBV-infected lymphocytes give rise to questions of how EBV infects multiphenotypic lymphocytes and whether chronic active EBV i...

journal_title：Medical hypotheses

authors： Endo R,Yoshioka M,Ebihara T,Ishiguro N,Kikuta H,Kobayashi K

更新日期：2004-01-01 00:00:00

abstract：:Inflammation and the genes, molecules, and biological pathways that lead to inflammatory processes influence many important and disparate biological processes and disease states that are quite often not generally considered classical inflammatory or autoimmune disorders. These include development, reproduction, aging,...

journal_title：Medical hypotheses

authors： Becker KG

更新日期：2007-01-01 00:00:00

abstract：:Obesity is the second largest cause of preventable death in the United States. Historically, obesity was considered a behavioral problem that could be simply addressed with behavioral modifications in diet and exercise. As scientific advancements have demonstrated in other neurological healthcare conditions such as al...

journal_title：Medical hypotheses

authors： Blum K,Chen TJ,Meshkin B,Downs BW,Gordon CA,Blum S,Mangucci JF,Braverman ER,Arcuri V,Deutsch R,Pons MM

更新日期：2007-01-01 00:00:00

abstract：:A five-step hypothesis on the pathogenesis of Hodgkin's disease (HD) is presented. Weak immune suppressor activity gives a predisposition for the development of the disease, after which a non-specific immune stimulation can initiate a self-perpetuating uncontrolled stimulation between interdigitating cells (IDCs), mac...

journal_title：Medical hypotheses

authors： Zwitter M

更新日期：1984-12-01 00:00:00

abstract：:Emerging evidences indicate that elevated cholesterol and triglyceride levels precede Alzheimer's disease (AD) pathology. High caloric intake based on saturated fat raises hyperlipidaemia and also promotes AD pathology. As a result, strategy that limits the absorption of dietary fat and attenuates hyperlipidemia could...

journal_title：Medical hypotheses

authors： Du J,Wang Z

更新日期：2009-11-01 00:00:00

abstract：:Neuroleptic-induced tardive dyskinesia represents a major serious side-effect of chronic therapy with neuroleptic drugs. The pathomechanisms underlying this disorder are not well understood. Although the dopaminergic supersensitivity theory has gained most attention, there is evidence to suggest involvement of other t...

journal_title：Medical hypotheses

authors： Sandyk R

更新日期：1986-01-01 00:00:00