Efficacy and safety of Huachansu combined with chemotherapy in advanced gastric cancer: a meta-analysis.

abstract：:Insulin resistance (IR) is a common denominator of metabolic and hemodynamic disorders simultaneously present in one person and responsible for elevated risk of developing type 2 diabetes (T2DM) and cardiovascular incidents. According to the latest research, IR is present in 25-45% of the general population. Therefore...

journal_title：Medical hypotheses

authors： Blaslov K,Kruljac I,Mirošević G,Kirigin Biloš LS,Vrkljan M

更新日期：2018-05-01 00:00:00

abstract：:In light of the progressive, pubertal increases in serum gonadotropin (FSH, LH) levels coinciding with the peak incidence of simple goiters; the common alpha subunits associated with the gonadotropins, TSH and hCG; the ability of LH and hCG to bind to thyroid TSH receptors and affect thyroid function; and, the probabl...

journal_title：Medical hypotheses

authors： DiNicola AF

更新日期：1983-04-01 00:00:00

abstract：:Almost all solid tumors consist of aneuploid cells with highly abnormal chromosome numbers. Such cancer cells could very well originate from chromosome missegregation which is a disturbingly common phenomenon, happening in 0.01 to 4 percent of cell divisions. Missegregated cells are aneuploid, typically lacking a chro...

journal_title：Medical hypotheses

authors： Engvild KC

更新日期：2018-11-01 00:00:00

abstract：:Evidence exists for the presence of a neuro-anatomy that can produce cardiac vasospasm. Recent experimental and clinical data suggest that this neuro-anatomic mechanism can be activated by behavioral events in the psycho-social surround of the patient with coronary artery disease. I hypothesize that this mechanism can...

journal_title：Medical hypotheses

authors： Natelson BH

更新日期：1987-12-01 00:00:00

abstract：:The number of patients with diabetes has been expected around 300 million by 2025 and 366 million by 2030 by WHO. On the other hand, diabetic wounds as one of the common complications of diabetes represent major health challenges. Recently, wound care biological products have been proposed for treatment of chronic wou...

journal_title：Medical hypotheses

authors： Larijani B,Ghahari A,Warnock GL,Aghayan HR,Goodarzi P,Falahzadeh K,Arjmand B

更新日期：2015-06-01 00:00:00

abstract：:Burnout is a state of physical or mental collapse caused by overwork or stress. Burnout during residency training has gained significant attention secondary to concerns regarding job performance and patient care. The new COVID-19 pandemic has raised public health problems around the world and required a reorganization...

journal_title：Medical hypotheses

authors： Dimitriu MCT,Pantea-Stoian A,Smaranda AC,Nica AA,Carap AC,Constantin VD,Davitoiu AM,Cirstoveanu C,Bacalbasa N,Bratu OG,Jacota-Alexe F,Badiu CD,Smarandache CG,Socea B

更新日期：2020-11-01 00:00:00

abstract：:It is proposed that there is biological regulation of the low molecular weight antioxidant (LMWA) status of the body, and that these different antioxidants work in concert and in homeostasis as a system analogous to the regulation of acid-base status (pH). The theoretical design characteristics for such a system inclu...

journal_title：Medical hypotheses

authors： Berry EM,Kohen R

更新日期：1999-11-01 00:00:00

abstract：:Hypoxic-ischemic brain injury is an important cause of neonatal mortality and subsequent serious neurological sequel. In neonatal brain the severity of hypoxic injury varies most probably due to the effects of multiple protective or deleterious factors. But the mechanisms under this difference are still not full under...

journal_title：Medical hypotheses

authors： Kumral A,Tuzun F,Yesilirmak D,Duman N,Ozkan H

更新日期：2009-06-01 00:00:00

abstract：:Emerging evidences indicate that elevated cholesterol and triglyceride levels precede Alzheimer's disease (AD) pathology. High caloric intake based on saturated fat raises hyperlipidaemia and also promotes AD pathology. As a result, strategy that limits the absorption of dietary fat and attenuates hyperlipidemia could...

journal_title：Medical hypotheses

authors： Du J,Wang Z

更新日期：2009-11-01 00:00:00

abstract：:Fulminant hepatitis is associated with an 80% mortality rate. Surviving patients do not develop chronic liver disease. Failure to produce adequate amounts of interferon and to achieve an antiviral state seem to be the basic defects in this condition. Tumor necrosis factor (TNF) has been shown to be induced by viruses....

journal_title：Medical hypotheses

authors： Aderka D,Levo Y

更新日期：1988-11-01 00:00:00

abstract：:It has been previously proposed that conscious process involves the collapse of quantum, dynamical brain states through conscious observation. It has been further proposed that the brain process has an active role in selecting the status of uncertain stimuli. On the basis of these proposals it was predicted that event...

journal_title：Medical hypotheses

authors： Germine M

更新日期：2004-01-01 00:00:00

abstract：:This paper presents the hypothesis, that pain and functional disturbances of organs which lie on the midline of the body might be caused by a venous congestion of these organs. Cause of their congestion is the participation of these organs (vertebral column, skull, brain, spinal medullary, uterus, prostate, left ovary...

journal_title：Medical hypotheses

authors： Scholbach T

更新日期：2007-01-01 00:00:00

abstract：:The limb remote ischaemia postconditioning (RIPOC), a newly conceived idea of applying brief limb ischaemic stimulus after onset of the myocardial ischaemia but prior to the reperfusion, can offer the possibility of applying this cardioprotective strategy to the patients with acute myocardial infraction. Although incr...

journal_title：Medical hypotheses

authors： Xu YC,Xue FS,Liao X,Xiong J,Yang QY,Wang WL,Zhang YM

更新日期：2009-09-01 00:00:00

abstract：:The authors present an extended version of Clark's and Ariëns's classical theory that enables the interpretation and quantitative characterization of dose-response curves which are not in accordance with classical theory. Being supported by the chemical receptor theory, the new model expands its applicability to two o...

journal_title：Medical hypotheses

authors： Várkonyi P,Gabányi Z,Körmöczy P

更新日期：1985-04-01 00:00:00

abstract：:The new prion diseases that have emerged in the last 15 years are bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (variant CJD). Although initially confined to the UK, these diseases have recently emerged in other European countries. The accepted cause of the human disease is that BSE spre...

journal_title：Medical hypotheses

authors： Brown DR

更新日期：2001-11-01 00:00:00

abstract：:The two-stage initiation-progression model of cancer is widely accepted. Initiation appears to result most often from accumulation of damage to the DNA expressed as multiple mutations in the phenotype. Unsymmetrical chromosome segregation during mitosis of normal or mutated cells produces aneuploid cells and also cont...

journal_title：Medical hypotheses

authors： Parris G

更新日期：2006-01-01 00:00:00

abstract：:The hypothesis proposed in this article is that a haemodynamic mechanism may cause amyotrophic lateral sclerosis (ALS). The hypothesis is synthesized from three separate streams of medical research: (1) multiple sclerosis (MS) research; (2) ALS research; (3) atherosclerosis research. Each research stream was reviewed ...

journal_title：Medical hypotheses

authors： Arhart RW

更新日期：2010-10-01 00:00:00

abstract：:Intestinal dysbiosis refers to an imbalance in the intestinal flora. The concept of small intestinal bacterial overgrowth (SIBO), a condition of abnormal proliferation of the small intestine microbiota, has been proposed as a form of small intestine dysbiosis. In Parkinson's disease patients, weight loss and metabolic...

journal_title：Medical hypotheses

authors： Hasuike Y,Endo T,Koroyasu M,Matsui M,Mori C,Yamadera M,Fujimura H,Sakoda S

更新日期：2020-01-01 00:00:00

abstract：:Cancer cells proliferate and metastasize against the body's defense mechanisms due to their ability to change in response to challenges, both from the body's internal defenses as well as those from external sources, such as radiation and chemotherapy. This ability of tumor cell populations to change and grow in respon...

journal_title：Medical hypotheses

authors： Pienta KJ,Ward WS

更新日期：1994-01-01 00:00:00

abstract：:Ontogenesis might be considered as the development of phylogenetically consequent genic systems that mainly imply: homoeotic genes and ras protooncogene in segmentation; ras and myc protooncogenes in gastrulation; ras, myc and other nuclear protooncogenes in organogenesis; ras myc, other nuclear and cytomembrane proto...

journal_title：Medical hypotheses

authors： Manzo G

更新日期：1989-12-01 00:00:00

abstract：:Articles dealing with the epidemiological aspects of asthma were carefully reviewed in order to support or reject our clinical impression of increased rate of asthma among immigrants. Particular emphasis was put on data on very high or very low rates of asthma. The proposed theories to explain these differences were c...

journal_title：Medical hypotheses

authors： Ballin A,Somekh E,Geva D,Meytes D

更新日期：1998-10-01 00:00:00

abstract：:Selective serotonin re-uptake inhibitors (SSRIs), has been increasingly used for the treatment of premature ejaculation over the past 5 years. It was reported that folic acid plays important roles in synthesis of 5-HT. Therefore, we hypothesize that folic acid supplementation may cures premature ejaculation by the sam...

journal_title：Medical hypotheses

authors： Yin TL,Yang J,Zhang B,Yan WJ,Xu WM,Li W,Yu L,Li SJ,Wu GX

更新日期：2011-03-01 00:00:00

abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN), which is also called BASIGIN/CD147, is a cell surface glycoprotein that belongs to the immunoglobulin superfamily and plays a significant role in intercellular recognition in immunology, cellular differentiation and development. Apart from ACE-2, recently EMMPR...

journal_title：Medical hypotheses

authors： Varadarajan S,Balaji TM,Sarode SC,Sarode GS,Sharma NK,Gondivkar S,Gadbail A,Patil S

更新日期：2020-10-01 00:00:00

abstract：:Random connection weight disturbances within an assembly of artificial neural networks (ANN) drive a progression of activation patterns that are tantamount to the memories and ideas nucleating within the brain's cortex. The numerical evaluation of these pattern-based notions by another, more placid system of ANNs gove...

journal_title：Medical hypotheses

authors： Thaler SL

更新日期：2016-09-01 00:00:00

abstract：:In this work we propose a simple mathematical model for the analysis of the impact of control measures against an emerging infection, namely, the severe acute respiratory syndrome (SARS). The model provides a testable hypothesis by considering a dynamical equation for the contact parameter, which drops exponentially w...

journal_title：Medical hypotheses

authors： Massad E,Burattini MN,Lopez LF,Coutinho FA

更新日期：2005-01-01 00:00:00

abstract：:Proteins are assumed to contain all the information necessary for unambiguous folding and specific interaction with each other. However, ab initio structure prediction is often not successful because the amino acid sequence itself is simply not sufficient to guide between endless folding possibilities. It seems to be ...

journal_title：Medical hypotheses

authors： Biro JC

更新日期：2006-01-01 00:00:00

abstract：:Data on lymphocyte biology indicate that the humoral system of B-cells is specifically active with precise analogies at all mucosal levels. Might there be a corresponding function for T-lymphocytes at the cutaneous structure level? Certain physiological findings appear to suggest that the two main lymphocyte populatio...

journal_title：Medical hypotheses

authors： Franchi F,Seminara P,Montella F

更新日期：1981-09-01 00:00:00

abstract：:Roux-en-Y gastric bypass (RYGB) surgery is one of the most effective treatments for obesity and type II diabetes. RYGB was originally believed to work by mechanically restricting caloric intake or causing macronutrient malabsorption. However, such mechanical effects play no role in the remarkable efficacy of gastric b...

journal_title：Medical hypotheses

authors： Celiker H

更新日期：2017-09-01 00:00:00

abstract：:For many years there was a general belief that the enzyme renin, having been secreted into the circulation by the kidney in response to appropriate stimuli, initially generates the inactive decapeptide angiotensin I in the bloodstream. This is then converted to the biologically active octapeptide angiotensin II by ang...

journal_title：Medical hypotheses

authors： Duckworth AJ,Goodship AE,Kendall HJ,Osborn EC

更新日期：2001-04-01 00:00:00

abstract：:Recent investigations on protease inhibitors in articular cartilage have provided new insights into the possible initial lesions of osteoarthrosis. A hypothesis has been formulated based upon an impaired ability of chondrocytes to synthesize protease inhibitors, which leads to loss of matrix integrity and vascular inv...

journal_title：Medical hypotheses

authors： Stephens RW,Ghosh P,Taylor TK

更新日期：1979-07-01 00:00:00