Abstract：
:The new prion diseases that have emerged in the last 15 years are bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (variant CJD). Although initially confined to the UK, these diseases have recently emerged in other European countries. The accepted cause of the human disease is that BSE spread from cattle to humans by the consumption of infected beef. However, the evidence that supports this is very thin. This article describes this evidence and lists a series of hypotheses concerning the cause of both BSE and variant CJD. The final hypothesis is based on recent evidence linking prion diseases to environmental factors including manganese. High environmental availability of manganese is associated with the prevalence of those prion diseases not linked to BSE. Therefore it is quite possible that BSE and variant CJD have emerged as a result of manganese-rich industrial pollution that has only occurred in the last century.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Brown DRdoi
10.1054/mehy.2001.1388keywords:
subject
Has Abstractpub_date
2001-11-01 00:00:00pages
555-60issue
5eissn
0306-9877issn
1532-2777pii
S0306-9877(01)91388-Xjournal_volume
57pub_type
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2012-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2013-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-06-01 00:00:00
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