Sulfite oxidase deficiency: a high risk factor in SO2, sulfite, and bisulfite toxicity?

abstract：:Despite the widespread use of antidepressant medication, there are no signs that the burden of depression and suicide is decreasing in the industrialised world. This is generating mounting scepticism on the effectiveness of this class of drugs as an approach for the treatment of mood disorders. These doubts are also f...

journal_title：Medical hypotheses

authors： Procopio M

更新日期：2005-01-01 00:00:00

abstract：:Antidepressants, including tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors and serotonin-noradrenalin reuptake inhibitors, are the main biological treatment for major depression. However, not all depressed patients improve clinically despite appropriate treatment. Thus,...

journal_title：Medical hypotheses

authors： Tsai SJ

更新日期：2006-01-01 00:00:00

abstract：:COVID-19 exacts a disproportionate toll on both the elderly and those with diabetes; these patients are more likely to require costly intensive care, longer hospitalisation, and die from complications. Nations would thus find it extremely difficult to either lift or sustain socially, economically, and politically dama...

journal_title：Medical hypotheses

authors： Wee AKH

更新日期：2021-01-01 00:00:00

abstract：:Arthritis is inflammation in a joint often with joint damage, usually accompanied by pain, swelling and stiffness, resulting from infection, trauma, degenerative changes, metabolic disturbances, autoimmune or other causes. It occurs in various forms, including rheumatoid arthritis, osteoarthritis, bacterial arthritis ...

journal_title：Medical hypotheses

authors： Eby G

更新日期：2005-01-01 00:00:00

abstract：:Endothelial dysfunction due to reduced bioavailability of nitric oxide (NO) is an early step in the course of atherosclerotic cardiovascular disease (CVD). NO is synthesized from L-arginine via the action of NO synthase (NOS), which is known to be blocked by endogenous L-arginine analogues such as asymmetric dimethyla...

journal_title：Medical hypotheses

authors： Yamagishi S,Ueda S,Okuda S

更新日期：2007-01-01 00:00:00

abstract：:Current paper aims to hypothesize that, oral surgical interventions such as tooth extractions, endosseous implant placement, subgingival curettage, etc. might result in widespread of fungal species via blood stream and can cause fungal contaminations of the cardiac valves. We hereby suggest that, an additional fungal ...

journal_title：Medical hypotheses

authors： Gülses A,Açil Y,Wiltfang J

更新日期：2020-02-01 00:00:00

abstract：:Dizziness is one of the most common hemodialysis-associated symptoms, and has been thought to be caused by cerebral edema or intravascular hypovolemia. However, the possibility of a peripheral vestibular disturbance due to hemodialysis has not been addressed as a cause of hemodialysis-associated dizziness. In the pres...

journal_title：Medical hypotheses

authors： Kim CH,Shin JE,Park JH

更新日期：2019-08-01 00:00:00

abstract：:Dental caries, a bacterial process that results in the acidic destruction of tooth structure, has historically been managed by the mechanical excavation of diseased tooth structure and then restoration with a synthetic material. The mechanical excavation of the infected site is most commonly achieved by a dental handp...

journal_title：Medical hypotheses

authors： Quock RL,Patel SA,Falcao FA,Barros JA

更新日期：2011-09-01 00:00:00

abstract：:Metabolic targeting of liver 5-aminolevulinate synthase (5-ALAS) by inhibition of heme utilisation by tryptophan (Trp) 2,3-dioxygenase (TDO) or the use of tryptophan is proposed as a therapy of acute hepatic porphyrias. 5-ALAS, the rate-limiting enzyme of heme biosynthesis, is under negative feedback control by a smal...

journal_title：Medical hypotheses

authors： Badawy AA

更新日期：2019-10-01 00:00:00

abstract：:The resonator theory claims that light scattering by the melanin granules of the retinal pigment epithelium causes light to be reflected back through the outer segment of the cones, in a direction opposite that of the incident light. These two opposite directed wave motions may produce standing waves inside the cone o...

journal_title：Medical hypotheses

authors： Bülow N

更新日期：1992-02-01 00:00:00

abstract：:Although all multicellular organisms undergo structural and functional deterioration with age, senescence is not a uniform process. Rather, each organism experiences a constellation of changes that reflect the heterogeneous effects of age on molecules, cells, organs and systems, an idiosyncratic pattern that we refer ...

journal_title：Medical hypotheses

authors： Walker LC,Herndon JG

更新日期：2010-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disease and oligodendrocyte degeneration and white matter damage play a critical role in the pathogenesis of AD. FGF/FGF receptor signaling have been implicated in diverse cellular processes including cell apoptosis, survival, adhesion, migration, different...

journal_title：Medical hypotheses

authors： Li JS,Yao ZX

更新日期：2013-04-01 00:00:00

abstract：:It has long been recognized that the symptom complex of fibromyalgia can be seen with hypothyroidism. Hypothyroidism may been categorized, like diabetes, into type I (hormone deficient) and type II (hormone resistant). Most cases of fibromyalgia fall into the latter category. The syndrome is reversible with treatment,...

journal_title：Medical hypotheses

authors： Garrison RL,Breeding PC

更新日期：2003-08-01 00:00:00

abstract：:The mitogenic action of the estrogen-receptor complex is supposedly similar in both normal and malignant target tissues. As receptors are present in several types of non-target tissues, in the case of lesions at the nuclear acceptor sites, the complex in those might be able to cause successive mitoses. Estrogen-depend...

journal_title：Medical hypotheses

authors： Litvay M

更新日期：1979-09-01 00:00:00

abstract：:Melatonin is well recognized for its role as a potent antioxidant and is directly implicated in the free radical theory of aging [1] [Reiter RJ, Pablos MI, Agapito TT, Guerrero JM. Melatonin in the context of the free radical theory of aging. Ann N Y Acad Sci 1996;786:362-78]. Moreover, melatonin has been shown to ret...

journal_title：Medical hypotheses

authors： Yeager RL,Oleske DA,Sanders RA,Watkins JB 3rd,Eells JT,Henshel DS

更新日期：2007-01-01 00:00:00

abstract：:Intrauterine Contraceptive Devices with multifaceted application potential is a need of an hour. Although, copper-based IUDs exert an effective contraceptive as well as anticancer effects in a long-term basis, but also results in multiple complications. In this regard, RISUG® a polymer based contraceptive device has b...

journal_title：Medical hypotheses

authors： Subramanian B,Agarwal T,Basak P,Maiti TK,Guha SK

更新日期：2019-03-01 00:00:00

abstract：:Vagus nerve stimulation (VNS) and electroacupuncture (EA) at specific acupoints have both shown promising anticonvulsant effects in intractable epilepsy patients. The differences between these therapies are target selection and stimulation parameter modulation. It has been demonstrated that EA of the extremities resul...

journal_title：Medical hypotheses

authors： Chen N,Zhang H,Gao XD,Yan N,Ma Y,Yu CJ

更新日期：2013-12-01 00:00:00

abstract：:Chronic Interstitial Nephritis in Agricultural Communities (CINAC) continues to attract controversy in the scientific community. It was previously known as Chronic Kidney Disease of Unknown Etiology (CKDu) and is not associated with the common aetiological factors such as diabetes. There is general acceptance that it ...

journal_title：Medical hypotheses

authors： Rodrigo C,Nawarathne P,Jayasinghe S

更新日期：2021-01-01 00:00:00

abstract：:The various neurotransmitter systems postulated to be involved in the pathogenesis of Gilles de la Tourette syndrome(GTS) are described with special reference to the endogenous opioid system(EOS). Malfunction of the opioid system is proposed as the underlying disturbance in this disease causing secondary dysfunction o...

journal_title：Medical hypotheses

authors： Gillman MA,Sandyk R

更新日期：1986-04-01 00:00:00

abstract：:In literature, the cerebellum is given a substantial role in cognitive processes, in addition to traditional views on cerebellar function of regulating motor behaviour. The phenomenon of cerebellar damage causing impairments in memory and executive functioning was observed in various cerebellar disorders. Cerebellar c...

journal_title：Medical hypotheses

authors： Wijnia JW,Goossensen A

更新日期：2010-08-01 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a lethal muscle wasting disease caused by a lack of dystrophin, which eventually leads to apoptosis of muscle cells and impaired muscle contractility. Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated protein 9 (CRISPR/Cas9) gene editing of induced pluripo...

journal_title：Medical hypotheses

authors： Hagan M,Ashraf M,Kim IM,Weintraub NL,Tang Y

更新日期：2018-01-01 00:00:00

abstract：:It is proposed that there is biological regulation of the low molecular weight antioxidant (LMWA) status of the body, and that these different antioxidants work in concert and in homeostasis as a system analogous to the regulation of acid-base status (pH). The theoretical design characteristics for such a system inclu...

journal_title：Medical hypotheses

authors： Berry EM,Kohen R

更新日期：1999-11-01 00:00:00

abstract：:Jet lag is a travel-induced circadian rhythm phenomenon that afflicts healthy individuals following long- distance flights through several time zones. The typical jet-lag manifestations - insomnia during local sleep time, day fatigue, reduced concentration, irritability, and exhaustion with mild depression - are attri...

journal_title：Medical hypotheses

authors： Katz G,Durst R,Zislin Y,Barel Y,Knobler HY

更新日期：2001-01-01 00:00:00

abstract：:This hypothesis clearly proposes the true and previously undiscovered cause of male homosexuality or bisexuality and in most cases the predictability in infancy of the development of this sexuality in adulthood. It is based on compelling new evidence which has accumulated over many years. The fetal and neonatal period...

journal_title：Medical hypotheses

authors： Roper WG

更新日期：2016-09-01 00:00:00

abstract：:The objective of this work is to propose a biomechanical model of sacro-iliac joint dysfunction as a cause of low back pain. Sacro-iliac joint is known to be a source of low back pain. We also know that it is a very stable joint with little mobility. Surrounding lower limb and back muscles contribute a major part of t...

journal_title：Medical hypotheses

authors： Hossain M,Nokes LD

更新日期：2005-01-01 00:00:00

abstract：:Rheumatic heart disease (RHD) remains a major cause of cardiac related mortality and morbidity in the developing countries due to poor diagnosis and lack of proper therapeutics. The definite reason of heart valve injury during RHD is poorly understood. Valvular endothelial cells play an important role in pathogenesis ...

journal_title：Medical hypotheses

authors： Sarkar S,Chopra S,Rohit MK,Banerjee D,Chakraborti A

更新日期：2016-10-01 00:00:00

abstract：:Einstein is often quoted to have said that without the bee, mankind would have but 4years to live. It is highly unlikely that he made this comment, which was even mentioned in a Lancet article on honey bees. However, the current vanishing of the bees can have serious consequences for human health, because 35% of the h...

journal_title：Medical hypotheses

authors： Stindl R,Stindl W Jr

更新日期：2010-10-01 00:00:00

abstract：:The favourable effects of eicosapentaenoic acid (EPA)- and doco-sahexaenoic acid (DHA)-rich diets (marine fish, fish oil) on several risk factors for cardiovascular disease are well established. The present survey describes possible new indications for diets supplemented with long-chain n-3 fatty acids. During a stand...

journal_title：Medical hypotheses

authors： Singer P,Richter-Heinrich E

更新日期：1991-09-01 00:00:00

abstract：:The new prion diseases that have emerged in the last 15 years are bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (variant CJD). Although initially confined to the UK, these diseases have recently emerged in other European countries. The accepted cause of the human disease is that BSE spre...

journal_title：Medical hypotheses

authors： Brown DR

更新日期：2001-11-01 00:00:00

abstract：:In this paper it is proposed to extend the classical models of sleepiness in two ways. Firstly, the role of a wake drive, besides a sleep drive, in determining sleepiness is emphasised. Although this has already been suggested in literature and convincing arguments can be found, it is not generally accepted. Secondly,...

journal_title：Medical hypotheses

authors： De Valck E,Cluydts R

更新日期：2003-04-01 00:00:00