Abstract:
:Although all multicellular organisms undergo structural and functional deterioration with age, senescence is not a uniform process. Rather, each organism experiences a constellation of changes that reflect the heterogeneous effects of age on molecules, cells, organs and systems, an idiosyncratic pattern that we refer to as mosaic aging. Varying genetic, epigenetic and environmental factors (local and extrinsic) contribute to the aging phenotype in a given individual, and these agents influence the type and rate of functional decline, as well as the likelihood of developing age-associated afflictions such as cardiovascular disease, arthritis, cancer, and neurodegenerative disorders. Identifying key factors that drive aging, clarifying their activities in different systems, and in particular understanding how they interact will enhance our comprehension of the aging process, and could yield insights into the permissive role that senescence plays in the emergence of acute and chronic diseases of the elderly.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Walker LC,Herndon JGdoi
10.1016/j.mehy.2009.12.031subject
Has Abstractpub_date
2010-06-01 00:00:00pages
1048-51issue
6eissn
0306-9877issn
1532-2777pii
S0306-9877(10)00002-2journal_volume
74pub_type
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