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Lithium and viruses.

Abstract：

:The activity of the lithium ion against DNA type viruses is explained by its competition with magnesium ions. Magnesium acts as the cofactor of the enzymes responsible for the replicative building of viral proteins and nucleosides. When lithium replaces magnesium, it appears to render the polymerase enzymes impotent. Association constants for lithium and magnesium with ATP, a pertinent model substance, are of the same order of magnitude, which shows that interference must occur. Some chelating agents such as PAA have antiviral properties, and their action can be explained also if the delta G of their binding of magnesium is more negative than that of magnesium with ATP. This again displaces the magnesium as the enzymatic cofactor, thereby halting viral replication.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Bach RO

doi

10.1016/0306-9877(87)90152-6

subject

Has Abstract

pub_date

1987-06-01 00:00:00

pages

157-70

issue

2

eissn

0306-9877

issn

1532-2777

pii

0306-9877(87)90152-6

journal_volume

23

pub_type

杂志文章

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