Rethinking the stalk effect: a new hypothesis explaining suprasellar tumor-induced hyperprolactinemia.

Abstract:

:The pars tuberalis is a distinct subdivision of the pituitary gland but its function remains poorly understood. Suprasellar tumors in this pars tuberalis region are frequently accompanied by hyperprolactinemia. As these tumors do not immunoreact for any of the established pituitary hormones, they are classified as nonsecretory. It has been postulated that these suprasellar tumors induce hyperprolactinemia by compressing the pituitary stalk, resulting in impaired dopamine delivery to the pituitary and, consequently, disinhibition of the lactotropes. An alternative hypothesis proposed is that suprasellar tumors secrete a specific pars tuberalis factor that stimulates prolactin secretion. Hypothesized candidates are the preprotachykinin A derived tachykinins, substance P and/or neurokinin A.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Skinner DC

doi

10.1016/j.mehy.2008.08.030

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

309-10

issue

3

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(08)00540-9

journal_volume

72

pub_type

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