Abstract:
:The pars tuberalis is a distinct subdivision of the pituitary gland but its function remains poorly understood. Suprasellar tumors in this pars tuberalis region are frequently accompanied by hyperprolactinemia. As these tumors do not immunoreact for any of the established pituitary hormones, they are classified as nonsecretory. It has been postulated that these suprasellar tumors induce hyperprolactinemia by compressing the pituitary stalk, resulting in impaired dopamine delivery to the pituitary and, consequently, disinhibition of the lactotropes. An alternative hypothesis proposed is that suprasellar tumors secrete a specific pars tuberalis factor that stimulates prolactin secretion. Hypothesized candidates are the preprotachykinin A derived tachykinins, substance P and/or neurokinin A.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Skinner DCdoi
10.1016/j.mehy.2008.08.030subject
Has Abstractpub_date
2009-03-01 00:00:00pages
309-10issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(08)00540-9journal_volume
72pub_type
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