Abstract:
:In plastic and reconstructive surgery, there is a tremendous clinical need for adequate implants are needed to restore soft-tissue defects resulting from tumor resection, traumatic injury, or congenital anomalies. Restoring the aesthetic function of the soft tissue is as important as restoring the natural tissue function. To address aesthetic issues, injection of hyaluronic acid and collagen and use of artificially synthesized biomaterials and autologous fat tissue grafts is extensive in the clinic, still faces limitations. Achieving minimal morbidity while compensating contour irregularities remains a major challenge because the available reconstruction methods and unsatisfactory biomaterials. Adipose tissue engineering holds great promise for reconstruction, but so far, there was no reports of large-volume engineered adipose tissue. Construction of a large volume of vascularized engineered fat tissue may overcome clinical challenges because vascularization is essential for the survival of engineered fat tissue and its integration with the host tissue. An arteriovenous bundle model for soft tissue has been used in prefabricating a large volume fat tissue with axial vascularization in vivo. Therefore, we hypothesized that combining adipose tissue-derived stem cells (ASCs), and prefabricated vascularized collagen scaffolds, with perforated chamber and arteriovenous bundle, could generate a large volume of engineered fat tissue with an axial vascular pedicle in vivo. Like vascularized autologous tissue, the new constructs could be transferred to the defective site by local transference or microsurgical techniques. The novel strategy could provide a large volume of engineered fat tissue suitable for clinical application and new therapeutic strategies for reconstructing defects if the hypothesis proved to be practical.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Chang Q,Lu Fdoi
10.1016/j.mehy.2012.05.007subject
Has Abstractpub_date
2012-08-01 00:00:00pages
267-70issue
2eissn
0306-9877issn
1532-2777pii
S0306-9877(12)00221-6journal_volume
79pub_type
杂志文章abstract::The terminology of cerebellar ataxias encompasses a variety of sporadic and inherited debilitating diseases. Patients exhibit disabling deficits such as dysmetria, kinetic tremor and ataxia of stance/gait. We are currently lacking effective treatments in degenerative cerebellar ataxias. Animal models of cerebellar dis...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.01.009
更新日期:2008-01-01 00:00:00
abstract::Tourette syndrome is a chronic, idiopathic, childhood onset neuropsychiatric disorder with both motor and vocal tics. Tourette syndrome occurs worldwide and the clinical features are similar irrespective of the country of origin, with genetic causes suspected, but to date not proven. A link between red hair colour and...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.03.052
更新日期:2009-11-01 00:00:00
abstract::Preliminary but increasing evidence suggests that attention-deficit/hyperactivity disorder (ADHD), Tourette's syndrome (TS), and restless legs syndrome (RLS) may be comorbid. In the present article, we hypothesize that ADHD, TS, and RLS may be part of a spectrum, and that iron deficiency contributes to the pathophysio...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.10.013
更新日期:2008-01-01 00:00:00
abstract::In orthognathic surgery, many serious medical disputes and postsurgical dissatisfactions are not caused by the doctors' reasons, but due to the patients' psychological problems. These adverse events obsess not only surgeons, but also patients to a great extent. An effective method is expected to screen patients for or...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.04.022
更新日期:2013-08-01 00:00:00
abstract::The prevalence of adult and childhood obesity are increasing. Most of the human newborn's body fat accumulates in the last half of intrauterine life. Fat in the fetus was thought to be mostly synthesized from glucose, but now it is commonly accepted that the bulk of it is the product of placental transfer of maternal ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2018.10.022
更新日期:2019-01-01 00:00:00
abstract::Bacterial biofilms have been found in many human bacterial infectious processes including chronic rhinosinusitis. It was found also at the surface of nasal polyps, and both at the surface of the nasal part and the stalk of the antrochoanal polyp. However, our recent research clearly demonstrated the presence of the bi...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.04.005
更新日期:2010-10-01 00:00:00
abstract::The ability of tumor cells to differentiate in combination with their ability to express genes that are not expressed in normal tissues, may result in the emergence of new cell types in evolution. Tumors may play an evolutionary role by providing conditions (space and resources) for the expression of newly evolving ge...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.07.027
更新日期:2010-01-01 00:00:00
abstract::Primary headaches include migraine, tension, cluster headaches, paroxysmal hemicrania and miscellaneous headaches unassociated with structural lesions. A putative role of the retino-hypothalamic-pineal (RHP) axis in the pathophysiology of primary headaches is reviewed in terms of (1) retinal dysfunction, (2) hypothala...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.12.026
更新日期:2006-01-01 00:00:00
abstract::It is hypothesized that a topical application of a sulfonylurea drug, which can inhibit the ATP-sensitive potassium-gated channels (Kir6.X/SUR) present in human hair bulb tissues, will inhibit hair growth in a targeted manner. Diazoxide is used to treat severe hypoglycemia due to hyperinsulinism of infancy. However, t...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2015.08.025
更新日期:2015-12-01 00:00:00
abstract::Random connection weight disturbances within an assembly of artificial neural networks (ANN) drive a progression of activation patterns that are tantamount to the memories and ideas nucleating within the brain's cortex. The numerical evaluation of these pattern-based notions by another, more placid system of ANNs gove...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.07.010
更新日期:2016-09-01 00:00:00
abstract::It is suggested that apart from aflatoxins, plant medicinal preparations containing active compounds imperatorin, dictamine, marmesin and heraclenin may be responsible for some human cancers in Nigeria and perhaps other parts of Africa. Therefore, in this paper, a hypothesis is put forward that these compounds or thei...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(83)90096-8
更新日期:1983-07-01 00:00:00
abstract::Many risk factors that promote cardiovascular disease (CVD) have been identified. These include hypertension, hypercholesterolemia, diabetes, decreased estrogen in post-menopausal women, increased homocysteine, and cigarette smoking. It has recently become clear that a mechanism common to these risk factors is oxidati...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2007.10.016
更新日期:2008-01-01 00:00:00
abstract::The problem how tumor cells get the metastatic ability is still a hot debate. Based on the premise that the default state of normal cells is quiescent rather than mobile, the classic progression and early metastasis model suggested that tumor metastasis should be an acquired trait contributed by the late or early gene...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.11.023
更新日期:2010-05-01 00:00:00
abstract::The persistent use of different forms of nicotine replacement therapy (NRT) is an under-investigated issue in medical research. While the data concerning the proportion of long-term users in the population of total NRT users seems reassuring at first glance, we must recognize that the small relative numbers (proportio...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.08.045
更新日期:2011-12-01 00:00:00
abstract::For diagnosis of Human Immunodeficiency Virus (HIV) infection by the recently developed Polymerase Chain Reaction (PCR), the two commonly used clinical samples are either the peripheral blood monocytes (PBMC) or the plasma of the infected individuals. In the former instance, DNA is extracted from PBMC. The integrated ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90188-v
更新日期:1993-01-01 00:00:00
abstract::Chronic adult periodontitis (CAP) is a common disease of the supporting tissues of teeth, and is a major cause of tooth loss. This disease is distinguished from more rare rapidly progressing forms of periodontitis, in which a variety of neutrophilic polymorphonuclear leukocyte (PMN) defects have been identified. PMN d...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(91)90008-m
更新日期:1991-12-01 00:00:00
abstract::A general theory of neural circuitry is proposed wherein neural impulses travel in a continuous circuit from the brain to the extremities and back to the brain. At the extremities the impulse may be modified by the environment there. At the spinal column the return signal is compared with the outgoing signal and the a...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(94)90002-7
更新日期:1994-05-01 00:00:00
abstract::Alpha-fetoprotein (AFP) serum levels in man have long been utilized as a tumor marker and as a birth defect screening agent in the clinical laboratory. Although the physiological role of AFP has remained obscure, the stereotypic carrier/transport function of a fetal counterpart to albumin has been attributed to this o...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2001.1445
更新日期:2002-06-01 00:00:00
abstract::Skin cells produce endogenous opioids in response to light. This results in increased skin and plasma levels of endogenous opioids. Increased plasma levels of endogenous opioids may improve mood and affect behavior. The author suggests that improvement in mood after exposure to light may be related to the light-induce...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2001.1423
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Somatization is a multisomatoform disorder characterized by medically unexplained, functional or psychosomatic symptoms. Similar somatic symptoms are key components of depression and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). METHODS:This paper reviews the evidence that such symptoms are o...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2012.02.023
更新日期:2012-06-01 00:00:00
abstract::Why is modern science less efficient than it used to be, why has revolutionary science declined, and why has science become so dishonest? One plausible explanation behind these observations comes from an essay First and second things published by CS Lewis. First Things are the goals that are given priority as the prim...
journal_title:Medical hypotheses
pub_type: 社论
doi:10.1016/j.mehy.2009.08.017
更新日期:2010-01-01 00:00:00
abstract::In endemic pemphigus foliaceus (EPF) or "fogo selvagem" the epidemiological evidence shows that all the described outbreaks occur on the banks of rivers where there is mercury contamination from alluvium gold mining and deforestation. Pathophysiological evidence shows a similarity to pemphigus induced by sulphydryl (S...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.09.041
更新日期:2012-01-01 00:00:00
abstract::Interventions focusing on the prevention and treatment of chronic non-communicable diseases are on rise. In the current article, we propose that dysfunction of the mesocortico-limbic reward system contributes to the emergence of the WHO-identified risk behaviors (tobacco use, unhealthy diet, physical inactivity and ha...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.02.020
更新日期:2016-05-01 00:00:00
abstract::Chronic idiopathic axonal polyneuropathy (CIAP) is referred to as axonal neuropathy after an adequate workup fails to determine a cause. A subgroup of patients with CIAP has impaired glucose tolerance (IGT). These patients have been considered by some investigators to have a neuropathy as a result of IGT and/or metabo...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.12.012
更新日期:2011-04-01 00:00:00
abstract::About 1900, modern food selection and processing caused widespread epidemics of the B vitamin deficiency diseases of beriberi and pellagra which, for genetic reasons, often expressed as different diseases ranging from bowel and heart disease to dermatoses and psychoses. But the B vitamins merely help convert essential...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(82)90088-3
更新日期:1982-01-01 00:00:00
abstract::Circulating tumor cells (CTCs) have the potential to provide a surrogate for "real-time biopsy" of tumor biological activity. Enumeration and molecular characterization of CTCs in pancreatic cancer could play an important role in diagnosis, predicting the risk for tumor recurrence, and providing novel target therapy b...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.03.027
更新日期:2013-06-01 00:00:00
abstract::The number of patients with diabetes has been expected around 300 million by 2025 and 366 million by 2030 by WHO. On the other hand, diabetic wounds as one of the common complications of diabetes represent major health challenges. Recently, wound care biological products have been proposed for treatment of chronic wou...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2015.03.004
更新日期:2015-06-01 00:00:00
abstract::Vagus nerve stimulation (VNS) and electroacupuncture (EA) at specific acupoints have both shown promising anticonvulsant effects in intractable epilepsy patients. The differences between these therapies are target selection and stimulation parameter modulation. It has been demonstrated that EA of the extremities resul...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.10.005
更新日期:2013-12-01 00:00:00
abstract::Mainstream researchers explain the etiology of SIDS with the cardiorespiratory paradigm. This has been the focus of intense study for many decades without providing consistent supporting data to link CNS findings to epidemiological risk factors or to the usual clinicopathological findings. Despite this, and the appare...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.110114
更新日期:2020-11-01 00:00:00
abstract::ATP sensitive (K(+)(ATP)) potassium cardiac channels are recruited when ATP levels are low as in ischemic injury and acute trauma. Such activation results in ECG-ST elevation and cardiac arrhythmias. K(+)(ATP) channel recruitment may be blocked by the sulfonylurea glibenclamide, permitting a wide variety of animal exp...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(03)00055-0
更新日期:2003-04-01 00:00:00