Chronic adult periodontitis and burst progression may reflect local neutrophil defects due to perivascular hyaline deposits.

abstract：:Schizophrenia, if not the most difficult, is one of the most difficult mysterious puzzles for psychiatrists, psychologists, and neuroscientists to solve. In this paper, based on the previously known pathologies of schizophrenia, a new model is proposed for explanation of the formation of positive psychotic symptoms of...

journal_title：Medical hypotheses

authors： Javanbakht A

更新日期：2006-01-01 00:00:00

abstract：:Dietary animal fat increases the risk of colorectal cancer. A factor in the increased risk is hypothesised to result from the inhibition of isoforms of a colonic epithelial cell enzyme that detoxifies genotoxins, glutathione S-transferase, by one of the major secondary bile acids produced in the colon by fat digestion...

journal_title：Medical hypotheses

authors： Schneider H

更新日期：1992-10-01 00:00:00

abstract：:Osteosarcoma is the most common primary malignant tumor of bone. Except for the improvement in five-year survival achieved by the adoption of neoadjuvant chemotherapy strategy, there are nearly no improvement for the treatment of osteosarcoma in the past 30 years, especially for the patients with metastatic disease. I...

journal_title：Medical hypotheses

authors： Weibo P,Zhaoming Y

更新日期：2012-05-01 00:00:00

abstract：:Left ventricular thrombus (LVT) after acute myocardial infarction (AMI) remains to be a common complication bearing adverse prognostic implication. Majority of LVT occurs within the first week after AMI. Over decades, the regional stasis of blood flow is regarded as the main reason for LVT formation. Here we hypothesi...

journal_title：Medical hypotheses

authors： Ma S,Lu Q,Hu H,Du XJ

更新日期：2020-11-01 00:00:00

abstract：:Angiogenesis and the acquisition of an angiogenic phenotype is important for cancer cell proliferation. Copper in an essential trace element that participates in many enzymatic complexes like the cytochrome c, superoxide dismutase and lysyl oxidase and it is involved in processes, like embryogenesis, growth, angiogene...

journal_title：Medical hypotheses

authors： Antoniades V,Sioga A,Dietrich EM,Meditskou S,Ekonomou L,Antoniades K

更新日期：2013-12-01 00:00:00

abstract：:The recent global pandemic created by the Coronavirus SARS-CoV-2, started in Wuhan, China in December 2019, has generated panic, both in term of human death (4-5% of infected patients identified through testing) and the global economy. Human sufferings seem to be continuing, and it is not clear how long this will cont...

journal_title：Medical hypotheses

authors： Ahmad SI

更新日期：2020-09-01 00:00:00

abstract：:For more than 35 years the author has treated multiple serious diseases in cats and dogs by correcting an unrecognized endocrine-immune imbalance originating with a deficiency or defect of cortisol. The cortisol abnormality creates a domino effect on feedback loops involving the hypothalamus-pituitary-adrenal axis. In...

journal_title：Medical hypotheses

authors： Plechner AJ

更新日期：2004-01-01 00:00:00

abstract：:The structural rearrangement of human sheathed capillaries in congestive splenomegaly has been considered. In abnormal spleens the external diameter and wall thickness were decreased, while the internal diameter was increased. Moreover, the total length and the absolute number of sheathed capillaries were increased, t...

journal_title：Medical hypotheses

authors： Pallotti C,Pettazzoni P,Slawomirski MR

更新日期：1995-05-01 00:00:00

abstract：:Epidemiological studies reveal that chronic alcoholics exhibiting liver disease are generally malnourished. Experimental studies unequivocally demonstrate that incidence of malnutrition cannot be avoided in animals fed liquid diets containing high concentrations of alcohol. Furthermore, ingestion of additional amounts...

journal_title：Medical hypotheses

authors： Sankaran H,Larkin EC,Rao GA

更新日期：1994-02-01 00:00:00

abstract：:Although all multicellular organisms undergo structural and functional deterioration with age, senescence is not a uniform process. Rather, each organism experiences a constellation of changes that reflect the heterogeneous effects of age on molecules, cells, organs and systems, an idiosyncratic pattern that we refer ...

journal_title：Medical hypotheses

authors： Walker LC,Herndon JG

更新日期：2010-06-01 00:00:00

abstract：:Epidural haematoma in newborn infants is rare, and few specific obstetrical data related to its formation are available in the literature. The aim of this study is to discuss the pathophysiology of this condition. EDH is always a post traumatic lesion and it is only possible if the insult has produced a cleavage of th...

journal_title：Medical hypotheses

authors： Hamlat A,Heckly A,Adn M,Poulain P

更新日期：2006-01-01 00:00:00

abstract：:Acute stroke, including acute ischemic stroke (AIS) and acute hemorrhagic stroke, (AHS) is a common medical problem with particular relevance to the demographic changes in industrialized societies. In recent years, treatments for AIS have emerged, including thrombolysis with tissue plasminogen activator (t-PA). Althou...

journal_title：Medical hypotheses

authors： Kikuchi K,Kawahara K,Miyagi N,Uchikado H,Kuramoto T,Morimoto Y,Tancharoen S,Miura N,Takenouchi K,Oyama Y,Shrestha B,Matsuda F,Yoshida Y,Arimura S,Mera K,Tada K,Yoshinaga N,Maenosono R,Ohno Y,Hashiguchi T,Maruyama

更新日期：2010-12-01 00:00:00

abstract：:The presented hypothesis suggests that chronic latent malaria infection prepares the niche where the otherwise feeble HIV coinfection can thrive and cause AIDS. It is suggested that the roots of the HIV outbreak and AIDS pandemic lay in the urbanization processes in Africa that resulted in the eradication of the Anoph...

journal_title：Medical hypotheses

authors： Yaffe I

更新日期：2001-10-01 00:00:00

abstract：:This evidence, then, would suggest that the olive becomes active when, with a change in the motor task, the motor performance is required to adjust to the new circumstance. From Smith's experiments on blood pressure, it is extrapolated that the olive becomes active when there is a change in the physiological state, an...

journal_title：Medical hypotheses

authors： Kennedy PR

更新日期：1978-11-01 00:00:00

abstract：:Intestinal dysbiosis refers to an imbalance in the intestinal flora. The concept of small intestinal bacterial overgrowth (SIBO), a condition of abnormal proliferation of the small intestine microbiota, has been proposed as a form of small intestine dysbiosis. In Parkinson's disease patients, weight loss and metabolic...

journal_title：Medical hypotheses

authors： Hasuike Y,Endo T,Koroyasu M,Matsui M,Mori C,Yamadera M,Fujimura H,Sakoda S

更新日期：2020-01-01 00:00:00

abstract：:Intractable epilepsy has always posed a challenge to management; conventional, surgical and alternative techniques available so far (e.g., vagal nerve stimulation, i.e. VNS). The author has attempted to search for a novel alternative (drug-regime) approach to its management to minimise any invasive technique or surger...

journal_title：Medical hypotheses

authors： Jaseja H

更新日期：2003-08-01 00:00:00

abstract：:In idiopathic scoliosis the convexity of the thoracic curve of the vertebral column is most commonly directed toward the right side. The right lung is normally larger than the left lung. This asymmetry acting through chest wall movement is hypothesized to exert rotatory forces on the vertebral column. The result, in p...

journal_title：Medical hypotheses

authors： Del Bigio MR

更新日期：1989-04-01 00:00:00

abstract：:Cancer is a tissue that requires a genetic program, possibly involving hundreds of genes, as indicated by studies of differential gene expression performed with microarrays in various types of cancer. Cancer is thus a biological process of considerable precision as described by Schrödinger's equation, and it is not si...

journal_title：Medical hypotheses

authors： Garcia-Garcia A

更新日期：2009-04-01 00:00:00

abstract：:The rigid gas permeable contact lens (RGPCL) is an ideal choice to improve the corrective vision of patients with a high degree of refractive error, keratoconus and corneal transplantation. However, RGPCL fitting is not an easy work for those patients with extremely irregular corneal surface. Technicians or doctors of...

journal_title：Medical hypotheses

authors： Zhao F,Zhao G,Weijie F,Chen L

更新日期：2018-04-01 00:00:00

abstract：:Autism continues to be a significant cause of psychosocial pathology in affected children and adults. Until recently, the predominant research thrust to uncover the cause of this condition has been the search for a major nuclear mutation. Although a small percentage of cases do demonstrate such a DNA fault, recent eff...

journal_title：Medical hypotheses

authors： Steinman G

更新日期：2019-01-01 00:00:00

abstract：:Many parasites induce characteristic changes in their host. The effect of Toxoplasma gondii infection on the cerebrum and neuropsychiatric patients has been increasingly emphasized in recent years. T. gondii has a high affinity for brain tissue where tachyzoites may form tissue cysts and persist for a life long time. ...

journal_title：Medical hypotheses

authors： Zhu S

更新日期：2009-11-01 00:00:00

abstract：:In this work some aspects of carcinogenesis are given. The importance of the emergence of Z or H DNA structure in the gene, or in the flanking gene sequences for the gene deletion and unusual gene recombination, is discussed. Some considerations on the role of selective pressure (of polyamines, of Mg2+, of the various...

journal_title：Medical hypotheses

authors： Juranic Z,Kidric M,Tomin R,Juranić I,Spuzić I,Petrović J

更新日期：1991-08-01 00:00:00

abstract：:Diabetes is a metabolic condition associated with hyperglycemia manifested by the elevation of blood glucose levels occurring when the pancreas decreases or stops the production of insulin, in case of insulin resistance or both. The current literature supports that insulin resistance may be responsible for the memory ...

journal_title：Medical hypotheses

authors： Leão LL,Tangen G,Barca ML,Engedal K,Santos SHS,Machado FSM,de Paula AMB,Monteiro-Junior RS

更新日期：2020-06-01 00:00:00

abstract：:Many clinical trials have clearly demonstrated the benefit of statins in the prevention of coronary heart disease. Although other effects have subsequently been described, the so-called pleiotropic effects of statins, there is a tendency to relate all those effects, more or less directly, to inhibition of 3-hydroxy-3-...

journal_title：Medical hypotheses

authors： Negrão MR,Mota A,Azevedo I,Martins MJ

更新日期：2006-01-01 00:00:00

abstract：:Cognitive plasticity, a developmental trait that promotes acquisition of complex skills such as language or playing musical instruments, diminishes substantially during puberty. The loss of plasticity has been attributed to surge of sex steroids during adolescence, but the phenomenon remains poorly understood. We hypo...

journal_title：Medical hypotheses

authors： Yun AJ,Bazar KA,Lee PY

更新日期：2004-01-01 00:00:00

abstract：:It has been uncovered that expansion of trinucleotide repeats in the human genome are causing a variety of genetic diseases. They are also identified in other loci that are not clearly related to particular diseases, which indicates such repeat expansion is one of the general forms of evolution occurring throughout th...

journal_title：Medical hypotheses

authors： Kubota S

更新日期：2001-03-01 00:00:00

abstract：:Clinical trials designed to answer treatment-related questions typically compare an intervention group that receives a drug or other intervention to a control group that serves as a standard against which results of the intervention are evaluated. An observed divergence from this trend in research papers on breastfeed...

journal_title：Medical hypotheses

authors： Dimnjakovic J,Poljicanin T,Svajda M

更新日期：2020-08-01 00:00:00

abstract：:A mechanism is proposed for the formation of Ebg-evolved beta galactosidase-of E. coli based on the following assumptions: 1. In the presence of lactose, certain proteins being translated bind to their m-RNA-ribosome complexes; 2. This binding interferes with the release of m-RNA from the bacterial chromosome, marking...

journal_title：Medical hypotheses

authors： Erhan S

更新日期：1979-11-01 00:00:00

abstract：:Ischaemic stroke ranks among the most important causes of death and disability in developed countries. Abnormal lipid metabolism is among the several factors that have a role in the pathogenesis of atherosclerosis. We hypothesize that the decreased resistance of low-density lipoproteins against oxidative stress is an ...

journal_title：Medical hypotheses

authors： Bereczki D,Balla G,Csiba L,Jeney V,Valikovics A,Magyar T,Balla J

更新日期：2001-06-01 00:00:00

abstract：:For diagnosis of Human Immunodeficiency Virus (HIV) infection by the recently developed Polymerase Chain Reaction (PCR), the two commonly used clinical samples are either the peripheral blood monocytes (PBMC) or the plasma of the infected individuals. In the former instance, DNA is extracted from PBMC. The integrated ...

journal_title：Medical hypotheses

authors： Nandi J,Banerjee K

更新日期：1993-01-01 00:00:00