A simple model of blood flow rate reduction in haemodynamic disorders of the spleen.


:The structural rearrangement of human sheathed capillaries in congestive splenomegaly has been considered. In abnormal spleens the external diameter and wall thickness were decreased, while the internal diameter was increased. Moreover, the total length and the absolute number of sheathed capillaries were increased, though not as much as the whole red pulp volume. Thus, in congestive splenomegaly, in addition to the well-known changes of the sinuses, the terminal arterial passages also appear to participate in the morphological rearrangement of the red pulp. The purpose of this paper is to formulate a simple dynamic model explaining the reduction of blood flow rate in the pathologically modified spleen. The main advantage of the present approach is that the coefficients inserted in equations describing the physical phenomena have been eliminated from the final formulae. Consequently, the model does not require the determination of parameters by means of difficult experimental measurements.


Med Hypotheses


Medical hypotheses


Pallotti C,Pettazzoni P,Slawomirski MR




Has Abstract


1995-05-01 00:00:00














  • Cerebellar neurocognition and Korsakoff's syndrome: an hypothesis.

    abstract::In literature, the cerebellum is given a substantial role in cognitive processes, in addition to traditional views on cerebellar function of regulating motor behaviour. The phenomenon of cerebellar damage causing impairments in memory and executive functioning was observed in various cerebellar disorders. Cerebellar c...

    journal_title:Medical hypotheses

    pub_type: 杂志文章,评审


    authors: Wijnia JW,Goossensen A

    更新日期:2010-08-01 00:00:00

  • Is cutaneous malignant melanoma associated with the use of antibacterial soaps?

    abstract::Since 1960, the incidence of melanoma has increased dramatically in Caucasians worldwide, and during the past decade has risen at a rate of 6% a year in the USA. A hypothesis regarding this increased incidence suggests that the prevalent use of antibacterial soaps that contain photosensitizing compounds may be a risk ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Arbesman H

    更新日期:1999-07-01 00:00:00

  • Predictive role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in normal-tension glaucoma.

    abstract::As a type of primary open-angle glaucoma, normal-tension glaucoma (NTG) is a health problem that manifests itself with low intraocular pressure (IOP) levels and preserves its importance for public health care. In population-based screenings, which take the IOP levels of 21mmHg as a cut-off for the diagnosis of glaucom...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Atalay K,Kaldirim Erdogan H,Kirgiz A,Asik Nacaroglu S

    更新日期:2017-06-01 00:00:00

  • IGF - Autism prevention/amelioration.

    abstract::Autism continues to be a significant cause of psychosocial pathology in affected children and adults. Until recently, the predominant research thrust to uncover the cause of this condition has been the search for a major nuclear mutation. Although a small percentage of cases do demonstrate such a DNA fault, recent eff...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Steinman G

    更新日期:2019-01-01 00:00:00

  • The 11p15.5 chromosomal region: When did the instability occur?

    abstract::The disturbances of the 11p15.5 chromosomal region are associated with Beckwith-Wiedemann syndrome, Russell-Silver syndrome, Wilms tumor, IMAGe syndrome, and idiopathic hemihyperplasia. The aim of this research was to examine the hypothesis that 11p15.5 initially became unstable in the European population about 200 ye...

    journal_title:Medical hypotheses

    pub_type: 历史文章,杂志文章


    authors: Shterenshis M,Roitblat Y,Ilani J,Lumbroso J,Padilla-Raygoza N

    更新日期:2018-12-01 00:00:00

  • Washing hands and the face may reduce COVID-19 infection.

    abstract::The contribution of various modes of transmission of SARS-CoV-2 has been the subject of recent intensive debate. The predominant route of the viral transmission is via exhaled droplets of different sizes which can be inhaled by nearby exposed individuals or deposited on peoples and surfaces. Touching contaminated surf...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Przekwas A,Chen Z

    更新日期:2020-11-01 00:00:00

  • Diagnosis of cancer multidrug resistance by bacterium-mediated imaging.

    abstract::Multidrug resistance (MDR) is a phenomenon expressed by many tumors affecting the chemotherapy efficacy, treatment decision, and the disease prognosis. Considering its great implication, non-invasive approaches are needed to identify this phenomenon in early stages of the disease. This article discusses the potential ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Elkadi OA,Abdelbasset M

    更新日期:2016-04-01 00:00:00

  • Active sleep and its role in the prevention of apoptosis in the developing brain.

    abstract::The aim of this study is to identify a possible function of Active Sleep (AS), also known as Rapid Eye Movement Sleep (REM) in humans, as a protective state during early Central Nervous System (CNS) development. Previous research suggest pharmacological agents that inhibit high levels of neuronal activity in the CNS (...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Morrissey MJ,Duntley SP,Anch AM,Nonneman R

    更新日期:2004-01-01 00:00:00

  • Nutraceutical strategies for ameliorating the toxic effects of alcohol.

    abstract::Rodent studies reveal that oxidative stress, much of it generated via induction/activation of NADPH oxidase, is a key mediator of a number of the pathogenic effects of chronic ethanol overconsumption. The highly reactive ethanol metabolite acetaldehyde is a key driver of this oxidative stress, and doubtless works in o...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: McCarty MF

    更新日期:2013-04-01 00:00:00

  • Evolutionary origin of bipolar disorder-revised: EOBD-R.

    abstract::The hypothesis of the evolutionary origin of bipolar disorder (EOBD) synthesized ideas about the biological clock and seasonal shifts in mood (Rosenthal, Wehr) with theorizing that bipolar disorder descends from a pyknic (compact, cold-adapted) group (Kretchmer). The hypothesis suggested that bipolar behaviors evolved...

    journal_title:Medical hypotheses

    pub_type: 历史文章,杂志文章


    authors: Sherman JA

    更新日期:2012-01-01 00:00:00

  • Ephedrine in the initial treatment of haemorrhagic shock.

    abstract::The initial treatment for hypotension due to blood loss is intravenous fluids. Occasionally there is need for additional medication, as well as stopping the source of the bleeding. The literature in the main discusses the use of dopamine. Ephedrine has not been reviewed as useful in such situations. This article discu...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Eldor J

    更新日期:1991-07-01 00:00:00

  • Does the impairment of the hypothalamic-pituitary-gonadal axis in anorexia nervosa depend on increased sensitivity to endogenous melatonin?

    abstract::The authors hypothesize that the impairment of hypothalamic-pituitary-gonadal axis in patients suffering from anorexia nervosa depends (at least in part) on the increased sensitivity to endogenous melatonin. The hypothesis is based mainly on the following facts: (1) melatonin is well known to exert an inhibitory effec...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Pawlikowski M,Zarzycki J

    更新日期:1999-02-01 00:00:00

  • Sir Karl Popper (1902-1994): in memoriam, 15 years later.

    abstract::September 17th, 2009 marks the 15th anniversary of Sir Karl Popper's death. Popper was an outspoken champion of critical rationalism, and a constant critic of authoritarian tendencies in science and society. He was also one of the spiritual founders of this journal and served on its first editorial advisory board. Pop...

    journal_title:Medical hypotheses

    pub_type: 传,社论,历史文章


    authors: Notturno MA

    更新日期:2009-12-01 00:00:00

  • Dietary chromium supplementation for targeted treatment of diabetes patients with comorbid depression and binge eating.

    abstract::Dietary chromium supplementation for the treatment of diabetes remains controversial. The prevailing view that chromium supplementation for glucose regulation is unjustified has been based upon prior studies showing mixed, modest-sized effects in patients with type 2 diabetes (T2DM). Based on chromium's potential to i...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Brownley KA,Boettiger CA,Young L,Cefalu WT

    更新日期:2015-07-01 00:00:00

  • Possible connection between milk and coronary heart disease: the calcium hypothesis.

    abstract::Excessive milk consumption may adversely affect the circulation on account of the high calcium content of milk and because lactose promotes the intestinal absorption of calcium. Excessive calcium intake may cause calcification and rigidification of the large elastic arteries, which could be an important factor in caus...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Seely S

    更新日期:2000-05-01 00:00:00

  • Self-injury in autism as an alternate sign of catatonia: implications for electroconvulsive therapy.

    abstract::Multiple reports show the efficacious usage of ECT for catatonia in individuals with autism. There are also a few reports showing that ECT improves self-injury in people with and without autism. In this hypothesis, self-injury in autism and other developmental disorders may be an alternate sign of catatonia, and as su...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Wachtel LE,Dhossche DM

    更新日期:2010-07-01 00:00:00

  • Gout attacks and lunar cycle.

    abstract::The aim was to search for periodical fluctuations in daily occurrence of gout attacks during the synodic lunar cycle. 126 gout attacks were recorded between 1972 and 1994 at known calendar dates. The synodic plexogram, displaying the number of attacks for each day of the cycle, was processed by cosinor regression. A p...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Mikulecký M,Rovenský J

    更新日期:2000-07-01 00:00:00

  • Cancer, a disease of defective glucose metabolism.

    abstract::The cancer cell appears to contain two non phosphorylating glycolytic pathways in addition to phosphorylating glycolysis and the aerobic citric acid and phosphogluconate cycles. It is hypothesised that these pathways are all interconnected and in the static adult cell non phosphorylating glycolysis is in a state of co...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Holt JA

    更新日期:1983-02-01 00:00:00

  • Skeletal buffer function and symptomatic magnesium deficiency.

    abstract::A major factor relating to the oversight of neurological dysfunction and seizures caused by magnesium (Mg++) depletion, involves the buffer functions of the skeletal system orchestrated primarily by the parathyroid. A Mg++ depleted subject may appear relatively asymptomatic until a short period after homeostatic respo...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Langley WF,Mann DJ

    更新日期:1991-01-01 00:00:00

  • Musculoskeletal overuse injuries and heart rate variability: Is there a link?

    abstract::Accurate detection and prevention of overuse musculoskeletal injuries is limited by the nature of somatic tissue injury. In the pathogenesis of overuse injuries, it is well recognized that an abnormal inflammatory response occurs within somatic tissue before pain is perceived which can disrupt the normal remodeling pr...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Gisselman AS,Baxter GD,Wright A,Hegedus E,Tumilty S

    更新日期:2016-02-01 00:00:00

  • Meiotic dynamics in mammalian seminal cells.

    abstract::The paper discusses certain dynamic processes leading to meiotic (haploid) partition of chromatids via the chiasmatic mode in mammalian spermatic cells. The achiasmatic case is also reviewed briefly and only in the context of homologs with centromeric braids arrayed in the Para configuration. ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Matioli GT

    更新日期:1994-12-01 00:00:00

  • Adenosine deaminase-adenosine pathway in hemolysis-associated pulmonary hypertension.

    abstract::Hemolysis-associated pulmonary hypertension (HA-PH) is a serious clinical complication of various hemolytic disorders, and pulmonary hypertension (PH) is considered the greatest risk factor for death in patients with a hemolytic disorder. It is now well established that hemolysis causes the release of soluble hemoglob...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Tofovic SP,Jackson EK,Rafikova O

    更新日期:2009-06-01 00:00:00

  • Nicotine and cigarette smoking: an alternative hypothesis.

    abstract::A new hypothesis is presented to explain some aspects of human smoking behaviour. While acknowledging the importance of the nicotine self-titration phenomenon, changes in puffing intensity during the smoking of a single cigarette are related not to the control of nicotine uptake but to the modification of cigarette sm...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Chamberlain AT,Higenbottam TW

    更新日期:1985-08-01 00:00:00

  • The etiology and possible treatment of chronic fatigue syndrome/fibromyalgia.

    abstract::It is suggested that chronic fatigue syndrome/fibromyalgia is caused by virus injury to the calcium channels leading to larger quantities than usual of calcium ions entering the striated muscle cells. Should this be true, then treatment with a calcium antagonist (CA) may possibly be of value. ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Lund-Olesen LH,Lund-Olesen K

    更新日期:1994-07-01 00:00:00

  • A possible novel technique for intraoperative imaging of the vertebral artery during arthrodesis of the upper cervical spine.

    abstract::In elderly, the fractures in C1-C2 are a common entity. Poor bone quality and wide range of motion hamper the natural bone fusion, thus making surgery often the only possible way to deal with the underlying pathology. The proximity to important neurovascular structures represents the stabilization in this segment a ch...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Pavlov O,Mirchev N,Behr R

    更新日期:2020-02-21 00:00:00

  • Multi-anticancer drugs encapsulated in the micelle: a novel chemotherapy to cancer.

    abstract::Micelle is a stable, passively targetable and solubilizing minute particle, and plays a key role to anticancer drug delivery for chemotherapy. With an increasing number of novel polymeric micelles synthesized, many anticancer drugs have been core-encapsulated in the micelles. However, only single drug was studied as t...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Liu P,Wang B,Weili Qiao JL

    更新日期:2008-09-01 00:00:00

  • The EPIIC hypothesis: intrapartum effects on the neonatal epigenome and consequent health outcomes.

    abstract::There are many published studies about the epigenetic effects of the prenatal and infant periods on health outcomes. However, there is very little knowledge regarding the effects of the intrapartum period (labor and birth) on health and epigenetic remodeling. Although the intrapartum period is relatively short compare...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Dahlen HG,Kennedy HP,Anderson CM,Bell AF,Clark A,Foureur M,Ohm JE,Shearman AM,Taylor JY,Wright ML,Downe S

    更新日期:2013-05-01 00:00:00

  • Metabolomic analysis as biomarker to study steroid hormone administration in sepsis.

    abstract::Sepsis is a life-threatening disease requiring rapid diagnosis and treatment. Steroid hormones (e.g., estradiol, dehydroepiandosterone) have been suggested to reduce the hyper-inflammatory response of the immune system and to improve outcome in sepsis. We hypothesize that the impact of steroid hormones on the metaboli...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Lehmann C,Sharawy N,Zhou J,Pavlovic D

    更新日期:2012-09-01 00:00:00

  • Human placental mast cells: a role in pre-eclampsia?

    abstract::The human placenta contains a significant amount of histamine, a potent vasoconstrictor of the placental vasculature, shown by the author to be stored within the tissues' mast cells. The proposed hypothesis suggests that placental mast cells may have an important role in normal and, or pathological processes during pr...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Purcell WM

    更新日期:1992-11-01 00:00:00

  • Role of the prostate in the regulation of pituitary secretion of follicle stimulating hormone.

    abstract::The secretion of Follicle Stimulating Hormone by the pituitary gland is not regulated entirely by the negative feedback from gonadal steroids. There is ample evidence that the secretion of FSH is regulated by a non-steroidal hormone of gonadal origin termed "inhibin". Using a radioimmunoassay procedure, immunoreactive...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Sheth AR,Vanage GR,Hurkadli KS,Sheth NA

    更新日期:1984-10-01 00:00:00