Abstract:
:The structural rearrangement of human sheathed capillaries in congestive splenomegaly has been considered. In abnormal spleens the external diameter and wall thickness were decreased, while the internal diameter was increased. Moreover, the total length and the absolute number of sheathed capillaries were increased, though not as much as the whole red pulp volume. Thus, in congestive splenomegaly, in addition to the well-known changes of the sinuses, the terminal arterial passages also appear to participate in the morphological rearrangement of the red pulp. The purpose of this paper is to formulate a simple dynamic model explaining the reduction of blood flow rate in the pathologically modified spleen. The main advantage of the present approach is that the coefficients inserted in equations describing the physical phenomena have been eliminated from the final formulae. Consequently, the model does not require the determination of parameters by means of difficult experimental measurements.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Pallotti C,Pettazzoni P,Slawomirski MRdoi
10.1016/0306-9877(95)90266-xsubject
Has Abstractpub_date
1995-05-01 00:00:00pages
395-9issue
5eissn
0306-9877issn
1532-2777pii
0306-9877(95)90266-Xjournal_volume
44pub_type
杂志文章abstract::We were interested whether fluorine, at the concentrations regarded as normal, can play a role in PCOS pathogenesis. The effect was not described in PCOS. Women with PCOS were diagnosed according to Rotterdam's criteria. The average age of 40 examined women with PCOS was 26.3 ± 5.5 years, BMI-29.16 ± 0.8, WHR-0.91 ± 0...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.05.007
更新日期:2019-07-01 00:00:00
abstract::All kinds of hypotheses have been proposed to explain the mechanism of tumorigenesis. Up until now, we have not had any generally acknowledged model that helps us understand the process. In this paper, I propose a dynamic model of how tumor cells escape the supervision of the immune system; I also examine the possibil...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(95)90256-2
更新日期:1995-05-01 00:00:00
abstract::A hypothetical pathogenesis for a typical case of amyotrophic lateral sclerosis (ALS) follows from opinions of Rowland and results of neuroscientists at Baylor. ALS might typically result from an autoimmune disorder that causes IgG to enhance release of acetylcholine (ACh) from axon terminals. Motor neuron overactivit...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(94)90160-0
更新日期:1994-06-01 00:00:00
abstract::The cause and therapy of neurodegenerative diseases remain unsolved puzzles. These diseases are correlated with presence of beta sheet-rich amyloid assemblies. Here, I derive and assemble puzzle pieces to obtain a loose end-tying hypothesis for cause with direct implications for therapy. I use the following extrapolat...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.11.001
更新日期:2018-01-01 00:00:00
abstract::The dominant role of the physical and chemical environment in the development of cancer is challenged. Analyses of the etiology of skin, bladder, respiratory and gastric cancers are presented which demonstrate the considerable extent to which one's health status may modify the initiation and promotion of environmental...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(79)90058-6
更新日期:1979-01-01 00:00:00
abstract::Trigeminal neuralgia (TN) is a rare form of neuropathic pain that results in sudden, unilateral and recurrent pains in the distribution of one or more branches of the trigeminal nerve. The aetiology of TN remains unclear and several theories have been proposed. Many medical and surgical methods have been applied with ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.10.010
更新日期:2013-12-01 00:00:00
abstract::In UK educational circles it has long been regarded as a platitude that a good scientific education at school and undergraduate level should aim to teach critical thinking and encourage students to challenge mainstream science, debate scientific issues and express their personal opinions. However, I believe that this ...
journal_title:Medical hypotheses
pub_type: 社论
doi:10.1016/j.mehy.2009.07.050
更新日期:2010-02-01 00:00:00
abstract::Metastasis is the leading cause of cancer death, yet it is mechanistically considered a very inefficient process suggesting the presence of some sort of (e.g. systemic) routes for fuelling the process. The pre-metastatic niche formation is described as one such metastasis promoting route. Now, the emerging potentials ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.10.011
更新日期:2013-01-01 00:00:00
abstract::Alcoholism is a major and world-wide health problem. A characteristic pattern of congenital defects, known as the fetal alcohol syndrome, has been detected in the offspring of mothers who are chronic alcoholics. The mechanism underlying the teratogenic effects of ethanol is not known. An important hypothesis is that e...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(91)90185-2
更新日期:1991-02-01 00:00:00
abstract::Cancer and other diseases may be a natural biological event, the activities of which may be dependent on the constitution of the individual. Where fetal and embryonic cells are not diseased or faulty or defective, they may be useful as therapies against cancer and other diseases. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2001.1517
更新日期:2002-05-01 00:00:00
abstract::The etiology of most kinds of dementia is still obscure and is probably multifactorial. We query whether excessive watching of television may contribute to the development of dementive processes for the following reasons: TV spectators are exposed to a mass of successive and rapid stimuli with little or no possibility...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90128-d
更新日期:1993-11-01 00:00:00
abstract::The molecular similarity between certain human antigenic determinants with those of HIV has been already described. In this matter, we have previously demonstrated, by a chromatographic method, the cross reactivity of human serum albumin with HIV gp 120. The hypothesis that this similarity could be one of the reasons ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2001.1520
更新日期:2002-05-01 00:00:00
abstract::The recent global pandemic created by the Coronavirus SARS-CoV-2, started in Wuhan, China in December 2019, has generated panic, both in term of human death (4-5% of infected patients identified through testing) and the global economy. Human sufferings seem to be continuing, and it is not clear how long this will cont...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109754
更新日期:2020-09-01 00:00:00
abstract::Multidrug resistance (MDR) is a phenomenon expressed by many tumors affecting the chemotherapy efficacy, treatment decision, and the disease prognosis. Considering its great implication, non-invasive approaches are needed to identify this phenomenon in early stages of the disease. This article discusses the potential ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.01.016
更新日期:2016-04-01 00:00:00
abstract::A study of the strikingly low incidence of sudden infant death syndrome in Eastern countries revealed significant differences in infant handling thought to have an etiological bearing; therefore this writer suggested that adoption of certain Eastern methods of nursing may reduce the incidence of sudden infant death sy...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(97)90254-1
更新日期:1997-07-01 00:00:00
abstract::Genetic diseases of the skeletal system are difficult to accurately diagnose. Changes in the chemical structure of collagen significantly modify the structure of collagen in bone. The ratio of collagen hydration to hydroxylation reflects specific features of the collagen structure. The hypothesis proposes to use this ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(88)90148-x
更新日期:1988-11-01 00:00:00
abstract::It has been shown by Elmets et al. (1) that ultraviolet irradiation of the skin followed by the application of a normally sensitizing antigen results in tolerance induction to the antigen. This tolerance is due to the induction of suppressor T-cells specific for the antigen. Multiple sclerosis is more common in certai...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(86)90104-0
更新日期:1986-04-01 00:00:00
abstract::There are many published studies about the epigenetic effects of the prenatal and infant periods on health outcomes. However, there is very little knowledge regarding the effects of the intrapartum period (labor and birth) on health and epigenetic remodeling. Although the intrapartum period is relatively short compare...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.01.017
更新日期:2013-05-01 00:00:00
abstract::Neuroleptic-induced tardive dyskinesia represents a major serious side-effect of chronic therapy with neuroleptic drugs. The pathomechanisms underlying this disorder are not well understood. Although the dopaminergic supersensitivity theory has gained most attention, there is evidence to suggest involvement of other t...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(86)90138-6
更新日期:1986-01-01 00:00:00
abstract::Although the classical ideal is that scientific theories are evaluated by a careful teasing-out of their internal logic and external implications, and checking whether these deductions and predictions are in-line-with old and new observations; the fact that so many vague, dumb or incoherent scientific theories are app...
journal_title:Medical hypotheses
pub_type: 社论
doi:10.1016/j.mehy.2008.05.018
更新日期:2008-09-01 00:00:00
abstract::It is universally accepted that the use of antibiotics will lead to antimicrobial resistance. Traditionally, the explanation to this phenomenon was random mutation and horizontal gene transfer and amplification by selective pressure. Subsequently, a second mechanism of antibiotic-induced antimicrobial resistance acqui...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(03)00205-6
更新日期:2003-10-01 00:00:00
abstract::The possibility that Hematopoiesis is under CNS control has been discussed in the literature; but never been conclusively proved at the molecular level. Evidence in the form of antigenic similarity between murine brain and the Stem Cell, and the decline in the number of Stem Cells following the lesioning of the Locus ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(88)90010-2
更新日期:1988-12-01 00:00:00
abstract::Cancer is the second cause of death worldwide, but current therapies are often insufficient or linked with toxicity. Initial evidence in scientific literature seems to support the role of non-pharmacological strategies, including hypoglycemia, in cancer treatment. The biological rationale for hypoglycemia-based treatm...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109276
更新日期:2019-09-01 00:00:00
abstract::A new approach to antiviral therapy is proposed, taking advantage of the recently investigated innervation of immune tissues by the sympathetic nervous system, which establishes a functional connection between the nervous and the immune system, where the sympathetic nervous system exerts a varying tonic inhibitory inf...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(95)90097-7
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Eelier studies demonstrated the up-regulation of some transcriptional factors such as Oct4, Nanog, Sox2 in undifferentiated cancer cells. These transcriptional regulators are up-regulated in pluripotent cells, as well and are responsible for cell reprogramming in normal cells. It might be said that normal ce...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.09.014
更新日期:2014-12-01 00:00:00
abstract::The time of re-evaluation of the role of human immunodeficiency viruses in the pathogenesis of acquired immune deficiency syndrome has now come, now that methods are available for the direct detection of human immunodeficiency viruses and for the detection of cellular anti-human immunodeficiency virus immune reactions...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(96)90192-9
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:Ovarian cancer has a different prognosis between early (I and II) and advanced stage (III and IV). The mechanism of disease progression is unknown, but patients with advanced disease may have a higher propensity for seeding of the abdominal cavity early in the disease process than those with early stage. The...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.01.027
更新日期:2013-05-01 00:00:00
abstract::Chronic stresses can induce physiological and psychological changes and result in stress-related neuropsychiatry, sometimes they may also contribute to hypersensitivity to pain known as stress-induced hyperalgesia (SIH). Recently it was found that GABAergic disinhibition is closely related to morphine and chronic infl...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.10.008
更新日期:2014-12-01 00:00:00
abstract::The role of ozone on earth is controversial, as in the stratosphere it is protective against excessive ultra violet irradiation, and in the troposphere it is toxic for animals and plants. The effectiveness of ozone against pathogens is well recognized and ozone appears to be the best agent for sterilization of water. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(96)90016-x
更新日期:1996-02-01 00:00:00
abstract::"Consciousness" "mood," "identity" and "personality" are all emergent properties from whole-brain organizations; these are typically disturbed in psychiatric disorders. This work proposes that the underlying etiopathology of mental disorders originates from disturbances to global brain dynamics, or "Globalopathies" th...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2013.09.032
更新日期:2013-12-01 00:00:00