A simple model of blood flow rate reduction in haemodynamic disorders of the spleen.

Abstract:

:The structural rearrangement of human sheathed capillaries in congestive splenomegaly has been considered. In abnormal spleens the external diameter and wall thickness were decreased, while the internal diameter was increased. Moreover, the total length and the absolute number of sheathed capillaries were increased, though not as much as the whole red pulp volume. Thus, in congestive splenomegaly, in addition to the well-known changes of the sinuses, the terminal arterial passages also appear to participate in the morphological rearrangement of the red pulp. The purpose of this paper is to formulate a simple dynamic model explaining the reduction of blood flow rate in the pathologically modified spleen. The main advantage of the present approach is that the coefficients inserted in equations describing the physical phenomena have been eliminated from the final formulae. Consequently, the model does not require the determination of parameters by means of difficult experimental measurements.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Pallotti C,Pettazzoni P,Slawomirski MR

doi

10.1016/0306-9877(95)90266-x

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

395-9

issue

5

eissn

0306-9877

issn

1532-2777

pii

0306-9877(95)90266-X

journal_volume

44

pub_type

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