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AIDS possibly caused by HIV and latent malaria coinfection.

Abstract：

:The presented hypothesis suggests that chronic latent malaria infection prepares the niche where the otherwise feeble HIV coinfection can thrive and cause AIDS. It is suggested that the roots of the HIV outbreak and AIDS pandemic lay in the urbanization processes in Africa that resulted in the eradication of the Anopheles vector from previously endemic areas, which changed the immunological status of the inhabitants there as they lost their natural immunity to malaria. Since malarial parasites may persist in the lymphatic network for a lifetime and reduce T cell proliferation while adhering to immature dendritic cells, the loss of this natural immunity made the African population, which was chronically affected with scanty parasitemia, vulnerable to opportunistic infections, HIV among them. The specific transmission modes of latent malaria infection elucidate why AIDS flares up in Africa and spreads there evenly in the population, while in the West it expands rather slowly and is restricted mainly to homosexuals and blood recipients.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Yaffe I

doi

10.1054/mehy.2001.1299

keywords:

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

419-22

issue

4

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(01)91299-X

journal_volume

57

pub_type

杂志文章

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