The low incidence of multiple sclerosis in areas near the equator may be due to ultraviolet light induced suppressor cells to melanocyte antigens.

abstract：:Initial diagnosis of acute kidney injury (AKI) is usually based on measuring serum-creatinine and blood urea nitrogen levels; however such measurements are still poor in identifying renal injuries at initial stages. These standard matrices are not enough to monitor the outcome and progression of AKI. The prognosis pre...

journal_title：Medical hypotheses

authors： Singh V

更新日期：2016-10-01 00:00:00

abstract：:In contrast to Geschwind, Behan and Galaburda (GBG) theory, there is strong evidence that inheritance through maternal line is responsible for the coexistence of asthma and left-handedness early in childhood. A new model that incorporates GBG's theory and maternal inheritance is proposed. This hypothesis suggests that...

journal_title：Medical hypotheses

authors： Krommydas G,Gourgoulianis KI,Andreou G,Kotrotsiou E,Raftopulos V,Paralikas T,Molyvdas PA

更新日期：2004-01-01 00:00:00

abstract：:The etiology of Autism Spectrum Disorders (ASDs) continues to be elusive. While ASDs have been shown to be heritable, several environmental co-factors, such as, e.g. pre- or perinatal adverse events, could play a role in the pathogenesis of the disorder as well. Prevalence of ASDs appears to have increased in the last...

journal_title：Medical hypotheses

authors： Gialloreti LE,Benvenuto A,Benassi F,Curatolo P

更新日期：2014-06-01 00:00:00

abstract：:Stressful events occur in the lives of millions of individuals each year. Such events, or "stressors", are experiences that threaten personal well-being, and include traumatic events such as motor vehicle collision, infectious illness, and situations such as military deployment. While most individuals recover from suc...

journal_title：Medical hypotheses

authors： McLean SA,Clauw DJ

更新日期：2004-01-01 00:00:00

abstract：:The incidence of breast cancer in women has increased dramatically over the last decade. Epidemiological markers of this increased incidence include: endocrine related phenomena (early menarche, age of first parity and age of menopause); exposure of the breast to X-radiation; and a group of seemingly disparate factors...

journal_title：Medical hypotheses

authors： Morris JJ,Seifter E

更新日期：1992-07-01 00:00:00

abstract：:The Aquatic Ape Theory claims that human ancestors once lived in a semi-aquatic habitat. Some human diseases might be explained by our aquatic past. Such problems include hyperventilation, periodic breathing, laryngo- and bronchospasm, vasomotor rhinopathy, seborrhea, dandruff, male pattern alopecia, rhinophyma, osteo...

journal_title：Medical hypotheses

authors： Verhaegen MJ

更新日期：1987-11-01 00:00:00

abstract：:Prostate cancer incidence increases with age; along with many other cancers, it could be considered a disease of aging. Prostate cancer screening has led to a significant proportion of men diagnosed with low-grade, low-stage prostate cancer who are now more likely to choose an active surveillance strategy rather than ...

journal_title：Medical hypotheses

authors： Liss MA,Rickborn L,DiGiovanni J,Bacich D,DeGraffenried LA,Parihar M,Thompson IM,Sharp ZD

更新日期：2018-08-01 00:00:00

abstract：:At present no good method of assisting the right ventricle of the heart exists. This paper presents a new and effective approach to assisting the right ventricle of the heart which can be utilized independently or during cardiac surgery. Through implementation of this method, and timed inflation and deflation of sever...

journal_title：Medical hypotheses

authors： Gordon RT,Gordon D

更新日期：1979-11-01 00:00:00

abstract：:Hyperbaric oxygen exposure is a recent hazzard for higher animals that originated as humans began underwater construction, exploration, and sports. Exposure can lead to abnormal brain EEG, convulsions, and death, the time to onset of each stage of pathology decreasing with increase in oxygen pressure. We provide evide...

journal_title：Medical hypotheses

authors： Wilson DF,Matschinsky FM

更新日期：2019-11-01 00:00:00

abstract：:Goldberger discovered human pellagra was a non-infectious disease, affecting mostly the small and the timid in overcrowded institutions. Symptoms were diarrhoea, dermatitis and dementia. The staff and older children escaped the disease. They ate the meat and left the small and timid with the gravy. The 'Goldberger syn...

journal_title：Medical hypotheses

authors： Reid G

更新日期：1993-05-01 00:00:00

abstract：:N-acetylaspartate (NAA) is an intermediary metabolite that is found in relatively high concentrations in the human brain. More specifically, NAA is so concentrated in the neurons that it generates one of the most visible peaks in nuclear magnetic resonance (NMR) spectra, thus allowing NAA to serve as "a neuronal marke...

journal_title：Medical hypotheses

authors： Clark JF,Doepke A,Filosa JA,Wardle RL,Lu A,Meeker TJ,Pyne-Geithman GJ

更新日期：2006-01-01 00:00:00

abstract：:We propose that in any acid-base disturbance there is a predictable mathematical relationship between the changes in the individual serum anionic concentrations of chloride, bicarbonate and the unmeasured anion gap. Two indices were developed, from the ratios of the changes in these anionic concentrations, that are us...

journal_title：Medical hypotheses

authors： Lee SM

更新日期：1989-11-01 00:00:00

abstract：:Melatonin is well recognized for its role as a potent antioxidant and is directly implicated in the free radical theory of aging [1] [Reiter RJ, Pablos MI, Agapito TT, Guerrero JM. Melatonin in the context of the free radical theory of aging. Ann N Y Acad Sci 1996;786:362-78]. Moreover, melatonin has been shown to ret...

journal_title：Medical hypotheses

authors： Yeager RL,Oleske DA,Sanders RA,Watkins JB 3rd,Eells JT,Henshel DS

更新日期：2007-01-01 00:00:00

abstract：:The ability of tumor cells to differentiate in combination with their ability to express genes that are not expressed in normal tissues, may result in the emergence of new cell types in evolution. Tumors may play an evolutionary role by providing conditions (space and resources) for the expression of newly evolving ge...

journal_title：Medical hypotheses

authors： Kozlov AP

更新日期：2010-01-01 00:00:00

abstract：:Stress, in its many forms, is long associated with the etiology and course of schizophrenia. The mechanisms mediating the impacts of stress are not fully elucidated. Here it is proposed that stress induced cortisol alters kynurenic acid (KA) and quinolinic acid (QA) in the cortex and amygdala/striatum, respectively. T...

journal_title：Medical hypotheses

authors： Anderson G

更新日期：2011-01-01 00:00:00

abstract：:Colic is generally defined as excessive crying in early infancy and can have negative consequences on the infant as well as on the infant's family life. Excessive crying can result in escalating parental stress levels, abusive caregiver response, increased risk of shaken baby syndrome and parental postpartum depressio...

journal_title：Medical hypotheses

authors： Jordan GJ

更新日期：2014-09-01 00:00:00

abstract：:Obstructive sleep apnea (OSA) is a common and underdiagnosed medical disorder. OSA is associated with the symptoms of excessive daytime sleepiness (EDS). These patients typically follow a sedentary lifestyle, and sedentary behavior is related to impaired fluid dynamics in the lower body, particularly the legs. In a su...

journal_title：Medical hypotheses

authors： Mirrakhimov AE

更新日期：2013-02-01 00:00:00

abstract：:The review briefly describes the evolution of hypotheses about cronic thyroiditis, the escape of colloid hypothesis, basement membrane destruction, the auto-immune theory and the role of disregulatory genes. ...

journal_title：Medical hypotheses

authors： Stuart A

更新日期：2011-09-01 00:00:00

abstract：:A large number of epileptic patients suffer from refractory epilepsy, despite optimal treatment; thus these patients require new therapeutic approaches. Focal seizure activity is typically initiated in a fixed and localized region, which subsequently spreads to neighboring regions or more distant areas. At the initial...

journal_title：Medical hypotheses

authors： Zhang L,Liang S,Zhang G,Kang X

更新日期：2013-11-01 00:00:00

abstract：:Daily disturbances of the earth's magnetic field produce variations in geomagnetic activity (GMA) that are reportedly associated with widespread effects on human health and behaviour. Some of these effects could be mediated by an established influence of GMA on the secretion of melatonin. There is evidence from unrela...

journal_title：Medical hypotheses

authors： Lipnicki DM

更新日期：2009-07-01 00:00:00

abstract：:Chronic fatigue syndrome (CFS) has gained prominence since 1988 and a substantial amount of research has been done in this domain. However, it is still regarded as a controversial condition. Moreover, most of the symptoms of CFS itself are non-specific, occurring in many illnesses; some of the symptoms are also common...

journal_title：Medical hypotheses

authors： Van Hoof E,Cluydts R,De Meirleir K

更新日期：2003-07-01 00:00:00

abstract：:Recent advances into the neuroscience research related to pathophysiology of schizophrenia have been impressive. While some are based on pre-existing theories and models, others have explored on a molecular level attempting to integrate the concepts of the past and present. However, given the complex multifactorial et...

journal_title：Medical hypotheses

authors： Yarlagadda A

更新日期：2002-02-01 00:00:00

abstract：:The mitogenic action of the estrogen-receptor complex is supposedly similar in both normal and malignant target tissues. As receptors are present in several types of non-target tissues, in the case of lesions at the nuclear acceptor sites, the complex in those might be able to cause successive mitoses. Estrogen-depend...

journal_title：Medical hypotheses

authors： Litvay M

更新日期：1979-09-01 00:00:00

abstract：:It is suggested here that a Hemoglobin S (HbS)-mediated membrane oxidant injury is responsible for both the protection from malaria infection in the heterozygous sickle cell state, and for a critical pathologic process in homozygous sickle cell disease. This suggestion is arrived at by applying to the HbS condition th...

journal_title：Medical hypotheses

authors： Anastasi J

更新日期：1984-07-01 00:00:00

abstract：:Chronic stresses can induce physiological and psychological changes and result in stress-related neuropsychiatry, sometimes they may also contribute to hypersensitivity to pain known as stress-induced hyperalgesia (SIH). Recently it was found that GABAergic disinhibition is closely related to morphine and chronic infl...

journal_title：Medical hypotheses

authors： Dai S,Ma Z

更新日期：2014-12-01 00:00:00

abstract：:Recently, the concept of drug delivery requires that the release of encapsulated drug be produced only at the diseased site with controllable rates. Given that thermosensitive hydrogels have been widely investigated for controlled delivery based on their phase transition, we speculate that nanoparticles with the novel...

journal_title：Medical hypotheses

authors： Li J,Wang B,Liu P

更新日期：2008-08-01 00:00:00

abstract：:Despite aggressive intervention, patients who survive an out-of-hospital cardiac arrest (OHCA) generally have very poor prognoses, with nationwide survival rates of approximately 10-20%. Approximately 90% of survivors will have moderate to severe neurological injury ranging from moderate cognitive impairment to brain ...

journal_title：Medical hypotheses

authors： Gul SS,Huesgen KW,Wang KK,Mark K,Tyndall JA

更新日期：2017-08-01 00:00:00

abstract：:Trigeminal neuralgia (TN) is a rare form of neuropathic pain that results in sudden, unilateral and recurrent pains in the distribution of one or more branches of the trigeminal nerve. The aetiology of TN remains unclear and several theories have been proposed. Many medical and surgical methods have been applied with ...

journal_title：Medical hypotheses

authors： Collet C,Haen P,Laversanne S,Brignol L,Thiéry G

更新日期：2013-12-01 00:00:00

abstract：:Despite the fact that antidepressants represent the gold standard for the treatment of depression, not all patients treated with an antidepressant monotherapy achieve complete remission of depressive symptoms and functional recovery. Therefore, further examination of the components that may be involved in the action m...

journal_title：Medical hypotheses

authors： Pae CU,Lee C,Paik IH

更新日期：2007-01-01 00:00:00

abstract：:The repair and reconstruction of tissue defects and organ loss are severe problems, and many patients are eager to find avenues to these matters. Up until now, the number of methods used to repair tissue defects has increased, but all of these have their own advantages and inconveniences, and do not seem to have been ...

journal_title：Medical hypotheses

authors： Yang M,Liu L

更新日期：2008-01-01 00:00:00