Abstract：
:It is suggested here that a Hemoglobin S (HbS)-mediated membrane oxidant injury is responsible for both the protection from malaria infection in the heterozygous sickle cell state, and for a critical pathologic process in homozygous sickle cell disease. This suggestion is arrived at by applying to the HbS condition the oxidant stress model for malaria resistance. Such a model had been developed to explain the protection from malaria in thalassemia and in glucose-6-phosphate dehydrogenase (G6PD) deficiency (9).
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Anastasi Jdoi
10.1016/0306-9877(87)90135-6subject
Has Abstractpub_date
1984-07-01 00:00:00pages
311-20issue
3eissn
0306-9877issn
1532-2777pii
0306-9877(87)90135-6journal_volume
14pub_type
杂志文章abstract：:The paper discusses the unifying concept that cell hydration is the primary factor in the mechanism of carcinogenesis. The concept includes the following hypotheses: (1) Increased cell hydration causes cancer not only by promoting cell division and oncogene expression, but also by inactivating genes inducing cell diff...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.09.022
更新日期：2006-01-01 00:00:00
abstract：:As known, gamma-interferon-induced cell death in HeLa cells can be mediated via the recently identified protein kinase, death associated protein (DAP) kinase which is localized to the microfilament system of the cytoskeleton. However, the downstream or upstream effectors of DAP kinase remain uncertain. In the present ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.0967
更新日期：2000-05-01 00:00:00
abstract：:Memory is a complex cognition that plays a critical role in daily functioning. This review discusses the dynamic effects of acute exercise on memory function, via a hypothesized exercise-memory interaction model, taking into consideration multiple memory systems and exercise parameters. ...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2019.03.010
更新日期：2019-05-01 00:00:00
abstract：:It is proposed here that the initial events in gastric carcinogenesis occur at the junction of the oxyntic and antral mucosae. Intestinal metaplasia represents an adaptive counter-response to early neoplastic change at this site. Chronic gastric ulceration may arise due to the elimination of overtly dedifferentiated c...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(91)90229-r
更新日期：1991-07-01 00:00:00
abstract：:Human papillomavirus (HPV) type 16 is causally associated with a subset of oral cancers, predominantly those cancers arising in the oropharynx (OP). Increased HPV16 E6 and E7 oncogene expressions are responsible for the malignant transmission in these cancers. ErbB-2 is the family member most closely implicated in hum...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.03.013
更新日期：2004-01-01 00:00:00
abstract：:Interleukin (IL)-17 is a pro-inflammatory cytokine originally described in T lymphocytes. Increased production of IL-17 has been linked to the induction of cytokines, chemokines and adhesion molecules in various cell types, effects that likely contribute to a number of inflammatory diseases including rheumatoid arthri...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.03.009
更新日期：2004-01-01 00:00:00
abstract：:We recently demonstrated that amyloid beta peptide (Abeta) is catabolized primarily by a neutral endopeptidase, neprilysin, in the brain and that a neuropeptide, somatostatin (SST), regulates brain Abeta level via modulation of neprilysin activity. Because SST expression in the brain declines upon aging in various mam...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.02.045
更新日期：2005-01-01 00:00:00
abstract：:Preliminary but increasing evidence suggests that attention-deficit/hyperactivity disorder (ADHD), Tourette's syndrome (TS), and restless legs syndrome (RLS) may be comorbid. In the present article, we hypothesize that ADHD, TS, and RLS may be part of a spectrum, and that iron deficiency contributes to the pathophysio...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.10.013
更新日期：2008-01-01 00:00:00
abstract：:Diabetes mellitus, a metabolic disorder with significant global health care burden, causes chronic microvascular and macrovascular complications that still comprise a therapeutic challenge. Angiotensin-(1-7), a heptapeptide with vasodilatory properties, has been found to restore vascular reactivity and endothelial cel...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.05.010
更新日期：2016-08-01 00:00:00
abstract：:Both epidemiological and experimental studies have shown that impaired growth in utero due to maternal malnutrition, resulting in low birth weight, is associated with a high incidence of glucose intolerance, insulin resistance, and type 2 diabetes in adult life. Maternal malnutrition is a worldwide problem and unavoid...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.12.024
更新日期：2006-01-01 00:00:00
abstract：:Advances in human genome analyses have not yet allowed identification of specific genetic mechanisms underlying the expression of human neurobehavioural disorders. There is an increasing awareness that several genes may contribute to behavioural phenotypes and these genes appear to interact in as yet undetermined ways...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.06.032
更新日期：2006-01-01 00:00:00
abstract：:In idiopathic scoliosis the convexity of the thoracic curve of the vertebral column is most commonly directed toward the right side. The right lung is normally larger than the left lung. This asymmetry acting through chest wall movement is hypothesized to exert rotatory forces on the vertebral column. The result, in p...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(89)90074-1
更新日期：1989-04-01 00:00:00
abstract：:It has been shown by Elmets et al. (1) that ultraviolet irradiation of the skin followed by the application of a normally sensitizing antigen results in tolerance induction to the antigen. This tolerance is due to the induction of suppressor T-cells specific for the antigen. Multiple sclerosis is more common in certai...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(86)90104-0
更新日期：1986-04-01 00:00:00
abstract：:The small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis are associated with autoantibodies to neutrophil cytoplasm antigens (ANCA), principally proteinase-3 (PR3) and myeloperoxidase (MPO). There is an association between GPA and nasal carriage of Staphylococcus aureus. The re...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.01.008
更新日期：2018-03-01 00:00:00
abstract：:To discuss the possible pathogenesis of outlet obstructive constipation (OOC) and identify the theoretical basis of the Procedure for Prolapse and Hemorrhoids (PPH) used to treat outlet obstructive constipation (OOC). 19 patients diagnosed with outlet obstructive constipation (OOC) form the case group, and 9 healthy v...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.03.022
更新日期：2015-07-01 00:00:00
abstract：:Recent findings indicate a principal role for Hepcidin in iron homeostasis. Hepcidin is also thought to play a vital role in the pathogenic mechanism of anaemia in patients with inflammation or chronic disease. Under normal conditions influx and efflux of iron from duodenal enterocytes is regulated by Ferroportin. Fer...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.10.007
更新日期：2008-01-01 00:00:00
abstract：:The aim of this study is to identify a possible function of Active Sleep (AS), also known as Rapid Eye Movement Sleep (REM) in humans, as a protective state during early Central Nervous System (CNS) development. Previous research suggest pharmacological agents that inhibit high levels of neuronal activity in the CNS (...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.01.014
更新日期：2004-01-01 00:00:00
abstract：:Triggering receptor expressed on myeloid cells-1 (TREM-1) is a recently identified cell surface receptor that is expressed mainly on monocytes and neutrophils, and plays an important role as an amplifier of inflammatory response in acute and chronic inflammatory conditions. Recent studies suggested that TREM-1 contrib...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.10.042
更新日期：2012-02-01 00:00:00
abstract：:Plasticity of adult cells has been identified in several post-natal tissues in the past few years and has attracted special attention in regenerative medicine. Skin is the biggest organ in the body. Adult skin consists of epidermis, dermis and appendages such as hairs and glands which are linked to the epidermis but p...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.12.022
更新日期：2004-01-01 00:00:00
abstract：:A recent published model described the phenomenon of a global panic reaction (GPR) on the stock markets based on two remarkable stock market crashes in the months of January and March [Sperling W, Bleich S, Reulbach U, Black Monday on stock markets throughout the world - a new phenomenon of collective panic disorder? ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.05.011
更新日期：2009-11-01 00:00:00
abstract：:Numerous studies have shown that opioids and cannabinoids share some pharmacological properties. Accordingly, similarly to opioids, tolerance and dependence develops after chronic use of cannabinoids. Nitric oxide (NO) has been shown to play important roles both in opioid- and cannabinoid-induced tolerance and depende...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.02.013
更新日期：2009-08-01 00:00:00
abstract：:Contralateral central nervous control may be an evolutionary consequence of dependence on the image-forming eye, especially in large organisms. As a result of the topological transformation of the visual stimulus in the pupillary eye, the external environmental hemispace impinges directly upon the contralateral intern...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(95)90225-2
更新日期：1995-11-01 00:00:00
abstract：:Increased level of oxalates in urine and plasma can be attributed to endogenous overproduction, increased ingestion or excessive intestinal absorption. When a supersaturation status is reached, oxalates combine with calcium and crystallize to form 80% of the urinary stones. Several cardiovascular diseases such as coro...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109570
更新日期：2020-04-01 00:00:00
abstract：:The world is rapidly ageing. It is against this backdrop that there are increasing incidences of dementia reported worldwide, with Alzheimer's disease (AD) being the most common form of dementia in the elderly. It is estimated that AD affects almost 4 million people in the US, and costs the US economy more than 65 mil...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00072-0
更新日期：2003-06-01 00:00:00
abstract：:Crossed cerebellar diaschisis (CCD) refers to transneuronal degeneration of the corticopontocerebellar pathway, resulting in atrophy of cerebellum contralateral to supratentorial pathology. CCD is traditionally diagnosed on nuclear medicine studies. Our aim is to apply a biexponential diffusion model, composed of intr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.08.025
更新日期：2018-11-01 00:00:00
abstract：:Pro PSA, the precursor of PSA, is an inactive 244-amino acid protein secreted by prostatic cells. Pro PSA, a distinct molecular form of free PSA in serum, includes native as well as several truncated forms. Clinical studies have recently provided evidence that pro PSA is associated with prostate cancer (PCa). The trun...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.06.006
更新日期：2005-01-01 00:00:00
abstract：:Cancer cells proliferate and metastasize against the body's defense mechanisms due to their ability to change in response to challenges, both from the body's internal defenses as well as those from external sources, such as radiation and chemotherapy. This ability of tumor cell populations to change and grow in respon...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(94)90035-3
更新日期：1994-01-01 00:00:00
abstract：:Ergothioneine is believed not to be synthesized by man but it accumulates to high concentrations in some mammalian cells as a result of dietary intake. Ergothioneine is known to chelate divalent metal ions with high affinity. Other substances which are potent chelators of divalent metal ions such as diphenylthiocarbaz...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(82)90137-2
更新日期：1982-08-01 00:00:00
abstract：:Clinical studies have shown that ionic zinc (Zn2+) dissolved in the mouth shortened manifestations of the common cold significantly, by an unknown mechanism. The observed immediate effect on symptoms is consonant with osmotic transport of Zn2+, placing a temporary chemical clamp on critical nerves. It is proposed that...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(96)90259-5
更新日期：1996-03-01 00:00:00
abstract：:The ability of tumor cells to differentiate in combination with their ability to express genes that are not expressed in normal tissues, may result in the emergence of new cell types in evolution. Tumors may play an evolutionary role by providing conditions (space and resources) for the expression of newly evolving ge...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.07.027
更新日期：2010-01-01 00:00:00
