Could angiotensin-(1-7) be connected with improvement of microvascular function in diabetic patients? Angiotensin-(1-7) iontophoresis may provide the answer.

abstract：:Synthetic and semisynthetic fabrics generate electrostatic potentials on the surface of the skin. The author suggests that the effects of electrostatic potentials on physical and psychological condition are mediated by acupuncture points. The author further suggests that electrostatic charges on the surface of the ski...

journal_title：Medical hypotheses

authors： Sher L

更新日期：2000-03-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is a common neuropsychiatric complication of liver disease affecting about 20-30% patients with cirrhosis. HE may only affect quality of life (e.g. impairments in attention; coordination; driving ability), but in some patients this progresses to coma and death; defining mortality in those w...

journal_title：Medical hypotheses

authors： Jalan R,Wright G,Davies NA,Hodges SJ

更新日期：2007-01-01 00:00:00

abstract：:Administration of certain drugs such as antidepressants have been shown to produce a phenomenon known as time-dependent sensitization, a process in which the acute effects of the drugs sensitize and grow over time. While both preclinical and clinical studies have demonstrated time-dependent sensitization, it is still ...

journal_title：Medical hypotheses

authors： Nathan P

更新日期：2000-06-01 00:00:00

abstract：:Sperm production is regulated by inhibin. Inhibin secretion may be controlled by the number of ejaculations. The more the number of ejaculations, the less the inhibin in blood and the more the production of spermatozoa. ...

journal_title：Medical hypotheses

authors： Skandhan KP

更新日期：1989-10-01 00:00:00

abstract：:Multiple reports show the efficacious usage of ECT for catatonia in individuals with autism. There are also a few reports showing that ECT improves self-injury in people with and without autism. In this hypothesis, self-injury in autism and other developmental disorders may be an alternate sign of catatonia, and as su...

journal_title：Medical hypotheses

authors： Wachtel LE,Dhossche DM

更新日期：2010-07-01 00:00:00

abstract：:Diabetes is a metabolic condition associated with hyperglycemia manifested by the elevation of blood glucose levels occurring when the pancreas decreases or stops the production of insulin, in case of insulin resistance or both. The current literature supports that insulin resistance may be responsible for the memory ...

journal_title：Medical hypotheses

authors： Leão LL,Tangen G,Barca ML,Engedal K,Santos SHS,Machado FSM,de Paula AMB,Monteiro-Junior RS

更新日期：2020-06-01 00:00:00

abstract：:Insulin resistance (IR) is a common denominator of metabolic and hemodynamic disorders simultaneously present in one person and responsible for elevated risk of developing type 2 diabetes (T2DM) and cardiovascular incidents. According to the latest research, IR is present in 25-45% of the general population. Therefore...

journal_title：Medical hypotheses

authors： Blaslov K,Kruljac I,Mirošević G,Kirigin Biloš LS,Vrkljan M

更新日期：2018-05-01 00:00:00

abstract：:The authors support the hypothesis that a causative agent in Parkinson's disease (PD) might be either fungus or bacteria with fungus-like properties - Actinobacteria, and that their spores may serve as 'infectious agents'. Updated research and the epidemiology of PD suggest that the disease might be induced by environ...

journal_title：Medical hypotheses

authors： Berstad K,Berstad JER

更新日期：2017-07-01 00:00:00

abstract：:Cancer cells proliferate and metastasize against the body's defense mechanisms due to their ability to change in response to challenges, both from the body's internal defenses as well as those from external sources, such as radiation and chemotherapy. This ability of tumor cell populations to change and grow in respon...

journal_title：Medical hypotheses

authors： Pienta KJ,Ward WS

更新日期：1994-01-01 00:00:00

abstract：:Inadequately responsive glycaemic control is an important factor in the causation of diabetic end-organ damage. Artificial or hybrid bioartificial pancreases can provide responsive glycaemic control that can reduce the enormous personal suffering and socio-economic costs of diabetes. However, they share the shortcomin...

journal_title：Medical hypotheses

authors： Lim MW,Fan TP

更新日期：2007-01-01 00:00:00

abstract：:Acute stroke, including acute ischemic stroke (AIS) and acute hemorrhagic stroke, (AHS) is a common medical problem with particular relevance to the demographic changes in industrialized societies. In recent years, treatments for AIS have emerged, including thrombolysis with tissue plasminogen activator (t-PA). Althou...

journal_title：Medical hypotheses

authors： Kikuchi K,Kawahara K,Miyagi N,Uchikado H,Kuramoto T,Morimoto Y,Tancharoen S,Miura N,Takenouchi K,Oyama Y,Shrestha B,Matsuda F,Yoshida Y,Arimura S,Mera K,Tada K,Yoshinaga N,Maenosono R,Ohno Y,Hashiguchi T,Maruyama

更新日期：2010-12-01 00:00:00

abstract：:At the end of 2019, an emerging outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first reported from Wuhan, China. The first manifestations of patients infected with SARS-CoV-2 was flu-like symptoms, while other type of manifestations, especially gastrointestinal manifestations were...

journal_title：Medical hypotheses

authors： Nejadghaderi SA,Nazemalhosseini-Mojarad E,Asadzadeh Aghdaei H

更新日期：2020-12-31 00:00:00

abstract：:Although it is well established that components of wheat gluten and structurally-related cereal proteins produce intestinal damage in Coeliac disease (CD), the primary defect which confers upon the host susceptibility to these dietary substances remains a mystery. To date, three main hypotheses have been framed to exp...

journal_title：Medical hypotheses

authors： Davidson AG,Bridges MA

更新日期：1988-07-01 00:00:00

abstract：:Schizophrenia has a polygenic mode of inheritance and an estimated heritability of over 80%, but success in understanding its genetic underpinnings to date has been modest. Unlike in trinucleotide neurodegenerative disorders, the phenomenon of genetic anticipation observed in schizophrenia or bipolar disorder has not ...

journal_title：Medical hypotheses

authors： Hegde MV,Saraph AA

更新日期：2011-08-01 00:00:00

abstract：:The universal 24-hour circadian clock has a profound impact on many daily biological processes. Disturbance of circadian rhythms has been implicated in the etiologies of many chronic illnesses, including cancer; with correlations most profoundly found among hormone-related breast and prostate cancers. Given the fact t...

journal_title：Medical hypotheses

authors： Zhu Y,Zheng T

更新日期：2008-01-01 00:00:00

abstract：:Curvilinear distraction is currently under investigation to reconstruct curved maxillofacial bone defects. However, previous studies have revealed the discrepancy between the contour of the regenerated bone in the distraction gap and the curvilinear pathway of the transport disc. We hypothesize that the discrepancy is...

journal_title：Medical hypotheses

authors： Zhou L,Shang H,Feng Z,Liu C,Ye W,Ma Q,Wu W,Liu Y

更新日期：2012-10-01 00:00:00

abstract：:Cachexia is a pathological state characterized by weight loss and protein mobilization during various diseases. Nutritional supplementation or appetite stimulants are unable to restore the loss of lean body mass. Agents interfering with TNF-alpha have not been very successful to date. Only eicosapentaenoic acid was ab...

journal_title：Medical hypotheses

authors： Drochioiu G

更新日期：2008-01-01 00:00:00

abstract：:It has been shown by Elmets et al. (1) that ultraviolet irradiation of the skin followed by the application of a normally sensitizing antigen results in tolerance induction to the antigen. This tolerance is due to the induction of suppressor T-cells specific for the antigen. Multiple sclerosis is more common in certai...

journal_title：Medical hypotheses

authors： Sharpe RJ

更新日期：1986-04-01 00:00:00

abstract：:Hepatopulmonary syndrome (HPS) is a severe pulmonary sequela which can affect up to 15% of patients with cirrhotic liver disease. There is no treatment for HPS other than liver transplantation. The cause of HPS is incompletely understood, but the pulmonary vasodilation in HPS is thought to be related to increased leve...

journal_title：Medical hypotheses

authors： Altschuler EL,Kast RE

更新日期：2004-01-01 00:00:00

abstract：:Our hypothesis was that testosterone therapy (TT) interacts with previously undiagnosed thrombophilia-hypofibrinolysis, leading to hospitalization for deep venous thrombosis (DVT)-pulmonary emboli (PE). We determined the prevalence of DVT-PE associated with TT 147 men hospitalized in the last 12 months for DVT-PE. Of ...

journal_title：Medical hypotheses

authors： Glueck CJ,Friedman J,Hafeez A,Hassan A,Wang P

更新日期：2015-04-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) is a novel technique of non-invasive brain stimulation which has been used to treat several neuropsychiatric disorders such as major depressive disorder, chronic pain and epilepsy. Recent studies have shown that the therapeutic effects of rTMS are associated with pla...

journal_title：Medical hypotheses

authors： Brunoni AR,Boggio PS,Fregni F

更新日期：2008-08-01 00:00:00

abstract：:Chronic adult periodontitis (CAP) is a common disease of the supporting tissues of teeth, and is a major cause of tooth loss. This disease is distinguished from more rare rapidly progressing forms of periodontitis, in which a variety of neutrophilic polymorphonuclear leukocyte (PMN) defects have been identified. PMN d...

journal_title：Medical hypotheses

authors： Zoellner H,Hunter N

更新日期：1991-12-01 00:00:00

abstract：:Cancer's random, reversible, unstable transitions to "normal" structures imply their functional relation. Similar random, continuous, reversible oncogene "mutational transformation" also lacks a consistent hybrid. Positing cancer's "mutationally altered genotype" leads to medically foreign causes, qualities, inducers,...

journal_title：Medical hypotheses

authors： Kharasch JA

更新日期：1987-06-01 00:00:00

abstract：:Bovine serum albumin and human serum transferrin modified by the water soluble carbodiimides N-ethyl-N'-(3-dimethyl propylamino) carbodiimide (CDI) or N-ethyl-N'-(3-trimethyl propylammonium) carbodiimide (Me+CDI) to yield N-acylurea proteins bind pBR322 DNA reversibly showing electrostatic and non-electrostatic compon...

journal_title：Medical hypotheses

authors： Ariatti M,Hawtrey AO

更新日期：1987-09-01 00:00:00

abstract：:I have previously assumed that stem tumour cells are 'para-embryonal cells' (PECs) poor or missing in major histocompatibility complex (MHC) antigens. PECs might induce adjoining differentiated hyperplastic cells to also express tumoral phenotype and properties, thus transforming them into 'differentiated para-embryon...

journal_title：Medical hypotheses

authors： Manzo G

更新日期：1998-05-01 00:00:00

abstract：:It is proposed that there is biological regulation of the low molecular weight antioxidant (LMWA) status of the body, and that these different antioxidants work in concert and in homeostasis as a system analogous to the regulation of acid-base status (pH). The theoretical design characteristics for such a system inclu...

journal_title：Medical hypotheses

authors： Berry EM,Kohen R

更新日期：1999-11-01 00:00:00

abstract：:A steady fall in mortality rates from cardiovascular diseases (CVD) has been reported recently in the United States. This study tests the hypothesis that fruits and vegetables had a protective effect against cardiovascular mortality among the American population from 1964-78. Special attention was focused on more spec...

journal_title：Medical hypotheses

authors： Verlangieri AJ,Kapeghian JC,el-Dean S,Bush M

更新日期：1985-01-01 00:00:00

abstract：:Pre-implantation genetic diagnosis (PGD) is a powerful clinical tool to identify embryos with or at risk of specific genetic diseases before implantation in utero after in vitro fertilization (IVF). PGD is performed on embryo biopsies that are obtained by aspiration of one or two cells from pre-implantation embryos at...

journal_title：Medical hypotheses

authors： Assou S,Aït-Ahmed O,El Messaoudi S,Thierry AR,Hamamah S

更新日期：2014-10-01 00:00:00

abstract：:Previous reports of specific patterns of increased fragility at common chromosomal fragile sites (CFS) found in association with certain neurobehavioural disorders did not attract attention at the time due to a shift towards molecular approaches to delineate neuropsychiatric disorder candidate genes. Links with miRNA,...

journal_title：Medical hypotheses

authors： Gericke GS

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is the most common cardiac arrhythmia. Many studies have investigated the cause for the development of AF, however, the question remains unanswered. METHODS:A comparison of hydrodynamics between AF and sinus rhythm was performed. RESULTS:I proposed the hypothesis that atrial fibril...

journal_title：Medical hypotheses

authors： Tilman V

更新日期：2016-01-01 00:00:00