Abstract:
:The universal 24-hour circadian clock has a profound impact on many daily biological processes. Disturbance of circadian rhythms has been implicated in the etiologies of many chronic illnesses, including cancer; with correlations most profoundly found among hormone-related breast and prostate cancers. Given the fact that circadian disruption can cause immune deregulation, which is so far the only established risk factor for non-Hodgkin's lymphoma (NHL), we hypothesize that altered circadian rhythms due to environmental factors and/or genetic variations in genes responsible for maintaining circadian rhythms may result in the deregulation of clock-associated biological processes such as immune responses and activities, and consequently influence an individual's risk of developing NHL. Our recent findings provided the first molecular epidemiological evidence linking a major circadian gene to NHL and warrant further investigation. Confirmation of this hypothesis will further add to our understanding of the role of the circadian clock in lymphomagenesis and facilitate the development of novel risk and prognostic biomarkers for NHL.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Zhu Y,Zheng Tdoi
10.1016/j.mehy.2007.07.040subject
Has Abstractpub_date
2008-01-01 00:00:00pages
788-92issue
4eissn
0306-9877issn
1532-2777pii
S0306-9877(07)00530-0journal_volume
70pub_type
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journal_title:Medical hypotheses
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.12.050
更新日期:2009-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2003-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:1993-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.04.029
更新日期:2004-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章,评审
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更新日期:2002-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
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更新日期:2018-02-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(86)90036-8
更新日期:1986-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.06.030
更新日期:2013-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109282
更新日期:2019-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.01.038
更新日期:2009-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.07.007
更新日期:2017-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.01.047
更新日期:2009-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2011.05.035
更新日期:2011-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(91)90077-c
更新日期:1991-05-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(88)90010-2
更新日期:1988-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109437
更新日期:2020-01-01 00:00:00
abstract::Kawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology that occurs predominantly in children <5 years of age. For the etiopathogenesis of KD, there is no agreement even as to whether KD is an infectious disease or an immune-mediated disease. The epidemiologic characteristics of KD, including...
journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.07.022
更新日期:2013-10-01 00:00:00
abstract::Cocaine is one of the principal drugs of abuse. Although impressive advances have been made, unanswered questions remain concerning mechanism of toxicity and addiction. Discussion of action mode usually centers on receptor binding and enzyme inhibition, with limited attention to events at the molecular level. This rev...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.06.028
更新日期:2005-01-01 00:00:00