Abstract:
:Kawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology that occurs predominantly in children <5 years of age. For the etiopathogenesis of KD, there is no agreement even as to whether KD is an infectious disease or an immune-mediated disease. The epidemiologic characteristics of KD, including the strict predilection of age in all ethnic groups and the gradually increased incidence after the KD emergence, suggest that KD is affected by the immune maturation in early childhood that may be determined by genetic factors, and KD is also affected by the changed environmental circumstances such as improved public hygiene. We postulated that the pathogenesis of KD is a hyperimmune reaction in genetically susceptible children to the variants of normal flora, which are induced by the environmental factors. Using this hypothesis, we might partly explain the clinical and epidemiological characteristics of KD. We expect that this hypothesis may help to determine the causative agents for KD in the near future.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Lee KY,Han JW,Lee JSdoi
10.1016/j.mehy.2006.12.051subject
Has Abstractpub_date
2007-01-01 00:00:00pages
642-51issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(07)00054-0journal_volume
69pub_type
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
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