Prophylaxis of impacted teeth using MRI and focal ultra-sound ablation?… a feasible hypothesis.

Abstract:

UNLABELLED:Teeth start as bi-layered epithelial soft tissue follicles within bony jaws. Follicles grow into teeth and erupt. Early third molar follicles are detectable 8-9 years (±9 months). Intra-oral dental arches of jaws have finite space accommodating formed crowns. The last teeth to erupt are third molars. When the space needed by all the teeth exceeds the total arch space available, wisdom teeth may become impacted in bone. Lower impactions are more prevalent due to the mandible shape, and impaction associated pathologies with erupting partially or totally impacted teeth are common. Impacted third molars are universally prevalent from 17 to 23 years. Third molar impactions are sources of infection, pain, cyst formation and contribute to malocclusions and other pathologies. Surgical removal of third molars is traumatic, invasive and painful and may produce complicating morbidities. Magnetic resonance imaging (MRI) is used to locate lesions with clear definition and accurate targeting, both in soft and hard tissue organs. Focused ultrasound (FUS) is used to ablate hard and soft tissue structures and stops growth of targeted pathologies. For example, FUS is used to ablate CNS brain tumours, cell causing Parkinson's disease, prostatic growths and thrombolysis in strokes. HYPOTHESIS:Modern imaging techniques, like MRI, can accurately locate third molar follicles at age 9, before wisdom teeth form and grow. MRI in combination with FUS could be used to ablate follicles of third molars, stop tooth growth (both crown and root) and so avoid later impactions.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Touyz LZ,Dent M

doi

10.1016/j.mehy.2012.05.031

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

342-3

issue

3

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(12)00254-X

journal_volume

79

pub_type

杂志文章
  • Reduced contractile capacity of vascular smooth muscle: another mechanism of hypertension?

    abstract::Hypertension has become a large burden of global development, but the mechanisms of it have still not been well elucidated. Increased contractility of vascular smooth cells induced by the overactivity of neurohormonal system or stress is one of the main and popular explanations until now. Smoothelin-B, recognized as t...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2009.01.038

    authors: Li SH,Hui RT

    更新日期:2009-07-01 00:00:00

  • A possible explanation of the germicide effect of carbon dioxide in supercritical state based on molecular-biological evidence.

    abstract::Supercritical carbon dioxide (CO(2)) possesses germicide (bactericide and sporicide) effect. Despite of the fact, that this effect is used in industrial sterilization processes, the sterilization mechanism at molecular level is unclear. Our hypotheses can provide a molecular-biological explanation for the phenomenon. ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2009.08.043

    authors: András CD,Csajági C,Orbán CK,Albert C,Abrahám B,Miklóssy I

    更新日期:2010-02-01 00:00:00

  • A book of ideas collected from Medical Hypotheses: Death can be cured by Roger Dobson.

    abstract::A new collection of ideas from Medical Hypotheses by Roger Dobson is entitled Death can be cured and 99 other Medical Hypotheses. It consists of humorous summaries of Medical Hypotheses articles from the past 30 years. The book's humour derives mainly from the subject matter, although sometimes also from the 'unconven...

    journal_title:Medical hypotheses

    pub_type: 社论

    doi:10.1016/j.mehy.2008.01.016

    authors: Charlton BG

    更新日期:2008-01-01 00:00:00

  • The aquatic ape theory and some common diseases.

    abstract::The Aquatic Ape Theory claims that human ancestors once lived in a semi-aquatic habitat. Some human diseases might be explained by our aquatic past. Such problems include hyperventilation, periodic breathing, laryngo- and bronchospasm, vasomotor rhinopathy, seborrhea, dandruff, male pattern alopecia, rhinophyma, osteo...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(87)90076-4

    authors: Verhaegen MJ

    更新日期:1987-11-01 00:00:00

  • Therapeutic potential of lipase inhibitor orlistat in Alzheimer's disease.

    abstract::Emerging evidences indicate that elevated cholesterol and triglyceride levels precede Alzheimer's disease (AD) pathology. High caloric intake based on saturated fat raises hyperlipidaemia and also promotes AD pathology. As a result, strategy that limits the absorption of dietary fat and attenuates hyperlipidemia could...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2009.04.046

    authors: Du J,Wang Z

    更新日期:2009-11-01 00:00:00

  • Chronic infection and the origin of adaptive immune system.

    abstract::It has been speculated that the rise of the adaptive immune system in jawed vertebrates some 400 million years ago gave them a superior protection to detect and defend against pathogens that became more elusive and/or virulent to the host that had only innate immune system. First, this line of thought implies that ada...

    journal_title:Medical hypotheses

    pub_type: 杂志文章,评审

    doi:10.1016/j.mehy.2010.02.031

    authors: Usharauli D

    更新日期:2010-08-01 00:00:00

  • On the oncodevelopmental role of human imprinted genes.

    abstract::Genome imprinting has an essential role in normal embryonal mammalian development. Starting early in differentiation, the transcripts of certain human genes, e.g. the paternally-H19 and the maternally-imprinted IGF2, are expressed in specific tissues and organs during fetal life. In several malignant disorders, imprin...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(94)90062-0

    authors: Biran H,Ariel I,De Groot N,Hochberg A

    更新日期:1994-08-01 00:00:00

  • Astrocytes and their potential role in anti-NMDA receptor encephalitis.

    abstract::The N-methyl-d-aspartate receptor (NMDAR) encephalitis is the most common form of autoimmune encephalitis. Antibodies against the GluN1 subunit of the NMDAR showed in primary cultures of rat hippocampal neurons and in a mouse model pathogenic effects including cross-linking and internalization of the target receptors ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.109612

    authors: Ismail FS,Faustmann PM

    更新日期:2020-06-01 00:00:00

  • Inflammation initiates cancer by depleting stem cells.

    abstract::According to the theory presented herewith, neoplasia results solely from stem cell depletion. Besides serving as tissue progenitors, stem cells are postulated to secrete a vital substance 'A' necessary for proper tissue function. Carcinogens interfere with 'A' production mainly by destroying stem cells and since the ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(85)90026-x

    authors: Zajicek G

    更新日期:1985-11-01 00:00:00

  • Severe mood dysregulation: in the "light" of circadian functioning.

    abstract::Severe affective and behavioral dysregulation, labeled as severe mood dysregulation (SMD), is a widely spread phenomenon among adolescent psychiatric patients. This phenotype constitutes severe impairment across multiple settings, including various symptoms, such as non-episodic anger, mood instability, and hyperarous...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2011.07.019

    authors: Heiler S,Legenbauer T,Bogen T,Jensch T,Holtmann M

    更新日期:2011-10-01 00:00:00

  • Oxalates, urinary stones and risk of cardiovascular diseases.

    abstract::Increased level of oxalates in urine and plasma can be attributed to endogenous overproduction, increased ingestion or excessive intestinal absorption. When a supersaturation status is reached, oxalates combine with calcium and crystallize to form 80% of the urinary stones. Several cardiovascular diseases such as coro...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.109570

    authors: Arafa A,Eshak ES,Iso H

    更新日期:2020-04-01 00:00:00

  • "Small-for-flow" syndrome: shifting the "size" paradigm.

    abstract::The "small-for-size" syndrome and "post-hepatectomy liver failure" refers to the development of liver failure (hyperbilirubinemia, coagulopathy, encephalopathy and refractory ascites) resulting from the reduction of liver mass beyond a certain threshold. This complication is associated with a high mortality and is a m...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2013.01.028

    authors: Asencio JM,Vaquero J,Olmedilla L,García Sabrido JL

    更新日期:2013-05-01 00:00:00

  • Potential role of shear wave elastography features in medullary breast cancer differentiation.

    abstract::Shear wave sonoelastography is a valuable additional technique in differentiation between benign and malignant breast lesions. In this paper, a hypothesis of the potential role of this additional ultrasound technique as a very useful tool in differentiation of a medullary breast cancer subtype is proposed. Medullary b...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.110021

    authors: Biondić Špoljar I,Ivanac G,Radović N,Divjak E,Brkljačić B

    更新日期:2020-11-01 00:00:00

  • Depression and the causal role of specific memory system degenerations: link may be supported by reported therapeutic benefits of Omega 3 fatty acids.

    abstract::It is well documented that depressed patients, as a result of their illness, often experience some difficulties with their memory. This hypothesis suggests a vice-versa; that it is a gradual impairment and ultimate failure of specific memory systems that may underpin the onset and continuation of a depressive illness....

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2007.01.046

    authors: Frais AT

    更新日期:2007-01-01 00:00:00

  • Salt addiction: a different kind of drug addiction.

    abstract::Under the headline "drug addiction" the medical world has exclusively been interested in psychoactive drugs. For diagnosis of substance dependence (addiction), DSM-IV-TR has determined seven criteria, and fulfilling at least tree of them signifies addiction. When studied salt intake according to these criteria it is s...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2006.04.041

    authors: Tekol Y

    更新日期:2006-01-01 00:00:00

  • Plantar fasciitis: a new experimental approach to treatment.

    abstract::Plantar fasciitis has been and remains one of the most common pathologic conditions of the lower extremity. Patients diagnosed with plantar fasciitis are treated conservatively with various degrees of success. This article presents a review of the literature pertaining to treatment of plantar fasciitis as well as intr...

    journal_title:Medical hypotheses

    pub_type: 杂志文章,评审

    doi:10.1016/s0306-9877(02)00120-2

    authors: Dmitri Luke BS

    更新日期:2002-07-01 00:00:00

  • Size of quadriceps femoris may contribute to thyrotoxic periodic paralysis.

    abstract::Thyrotoxic periodic paralysis (TPP) frequently occurs on male individuals at their third and forth decades. The major site of involvement is the proximal muscles of lower limbs. Increasing evidence has shown that the occurrence of TPP is determined by multiple factors. We hypothesized that apart from hormonal fluctuat...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2015.10.014

    authors: Tang ZW,He Y,Yao Y,Qiu L,Tian HM

    更新日期:2015-12-01 00:00:00

  • Differences between somatic growth curves of males and females are a secondary sex characteristic.

    abstract::There are differences in male and female height throughout the growth period. Utilising reference standard height charts we calculated the difference in male and female height as a function of age. A triphasic relationship was observed with statistically significant peaks (males greater than females) at 8 months and 1...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(87)90122-8

    authors: Schreiber G,Baron B

    更新日期:1984-07-01 00:00:00

  • Biofilm--the other name for the regular mucosal blanket.

    abstract::Bacterial biofilms have been found in many human bacterial infectious processes including chronic rhinosinusitis. It was found also at the surface of nasal polyps, and both at the surface of the nasal part and the stalk of the antrochoanal polyp. However, our recent research clearly demonstrated the presence of the bi...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2010.04.005

    authors: Mladina R,Skitarelić N

    更新日期:2010-10-01 00:00:00

  • Balancing and imbalancing effects of astrocytic receptors in tripartite synapses. Common pathophysiological model of mental disorders and epilepsy.

    abstract::Based on a logic of balance mechanisms influencing information processing in tripartite synapses are proposed. It is hypothesized that the number of expressed astrocytic receptors determines balanced and imbalanced synaptic states. Synaptic information processing in mental disorders is underbalanced in depression, ove...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2015.01.025

    authors: Mitterauer BJ

    更新日期:2015-04-01 00:00:00

  • The relationship between plasma vascular endothelial growth factor and erythrocyte 2,3-bisphosphoglycerate: The putative role of chronic hypoxia.

    abstract::The non-invasive assessment of chronic tissue hypoxia is difficult. Pulse oximetry only allows the peripheral oxygen saturation to be measured, while the detection of hyperlactataemia needs to take into account the fact that the accumulation of lactic acid may result from several causes other than prolonged tissue hyp...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2018.01.014

    authors: Puri BK,Monro JA

    更新日期:2018-03-01 00:00:00

  • A factor in the increased risk of colorectal cancer due to ingestion of animal fat is inhibition of colon epithelial cell glutathione S-transferase, an enzyme that detoxifies mutagens.

    abstract::Dietary animal fat increases the risk of colorectal cancer. A factor in the increased risk is hypothesised to result from the inhibition of isoforms of a colonic epithelial cell enzyme that detoxifies genotoxins, glutathione S-transferase, by one of the major secondary bile acids produced in the colon by fat digestion...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(92)90168-c

    authors: Schneider H

    更新日期:1992-10-01 00:00:00

  • Monoclonal antibody therapy in the treatment of Reye's syndrome.

    abstract::A role for lipopolysaccharides (endotoxins, LPS) in 7 the pathogenesis of Reye's syndrome (RS) has previously been suggested. Impairment of hepatic LPS clearance can lead to systemic endotoxemia as previous studies by this and other laboratories have suggested for several hepatic disorders including RS. Systemic LPS m...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(92)90115-s

    authors: Treon SP,Broitman SA

    更新日期:1992-11-01 00:00:00

  • Molecular basis of the evolution of drug resistance: potential role of the transient state during infection/drug treatment.

    abstract::Transient period represents the time window between the exposure and response to the given stimuli inflicting the stress on the host. However, this time window is unlikely to engage in variety of signaling to culminate drastic impact on the host cell rather it is evolutionary in its sense implying a slow process. But ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2003.04.001

    authors: Kannan S

    更新日期:2004-01-01 00:00:00

  • Alpha lipoic acid: a novel treatment for depression.

    abstract::Insulin resistance has been associated with people diagnosed with depression. Conversely, it has also been documented that diabetics have an increased risk of depression. Evidence suggests that insulin activity plays a role in serotonergic activity by increasing the influx of tryptophan into the brain. This increased ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.2000.1103

    authors: Salazar MR

    更新日期:2000-12-01 00:00:00

  • Parkinson disease classification using one against all based data sampling with the acoustic features from the speech signals.

    abstract::Parkinson's disease (PD) is a long-term degenerative disease that primarily affects the motor system of the central nervous system. This disease is difficult to diagnose and is one of the common diseases in the public. In this paper, we have proposed a novel data sampling method for the classification of Parkinson dis...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.109678

    authors: Polat K,Nour M

    更新日期:2020-03-16 00:00:00

  • Tardive dyskinesia: a role for the endogenous opioid system.

    abstract::Neuroleptic-induced tardive dyskinesia represents a major serious side-effect of chronic therapy with neuroleptic drugs. The pathomechanisms underlying this disorder are not well understood. Although the dopaminergic supersensitivity theory has gained most attention, there is evidence to suggest involvement of other t...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(86)90138-6

    authors: Sandyk R

    更新日期:1986-01-01 00:00:00

  • Acidic pH derived from cancer cells may induce failed reprogramming of normal differentiated cells adjacent tumor cells and turn them into cancer cells.

    abstract:BACKGROUND:Eelier studies demonstrated the up-regulation of some transcriptional factors such as Oct4, Nanog, Sox2 in undifferentiated cancer cells. These transcriptional regulators are up-regulated in pluripotent cells, as well and are responsible for cell reprogramming in normal cells. It might be said that normal ce...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2014.09.014

    authors: Tavakol S

    更新日期:2014-12-01 00:00:00

  • Tumor-derived microvesicles: the metastasomes.

    abstract::Metastasis is the leading cause of cancer death, yet it is mechanistically considered a very inefficient process suggesting the presence of some sort of (e.g. systemic) routes for fuelling the process. The pre-metastatic niche formation is described as one such metastasis promoting route. Now, the emerging potentials ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2012.10.011

    authors: Ghasemi R,Grassadonia A,Tinari N,Piccolo E,Natoli C,Tomao F,Iacobelli S

    更新日期:2013-01-01 00:00:00

  • The progression of the tubulointerstitial fibrosis driven by stress-induced "proliferation-death" vicious circle.

    abstract::Several hypotheses have been developed to interpret the progression of tubulointerstitial fibrosis (TF), including senescence, epithelial-mesenchymal transition, inflammation, chronic hypoxia, and reactive oxygen species. All of these hypotheses are based on persistent cell injury and localized cell death. Proliferati...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2014.01.014

    authors: Chen BC,Bai YH,Tang LL,Wang BQ,Liu B,Cai Y,Peng X,Yang YR,Zheng SL

    更新日期:2014-06-01 00:00:00