Alpha lipoic acid: a novel treatment for depression.

abstract：:The concept of local pathology has long served neurology admirably. Relevant models include self-organizing nonlinear brain dynamics, global workspace and dynamic core theories. However such models are inconsistent with certain clinical phenomena found in Charles Bonnet syndrome, disjunctive agnosia and schizophrenia,...

journal_title：Medical hypotheses

authors： Globus GG,O'Carroll CP

更新日期：2010-11-01 00:00:00

abstract：:Numerous studies implicate cellular immunological effector systems in the partial containment of virus replication during the early stages of HIV infection. Immunostimulatory therapeutic regimes designed to enhance virus clearance are therefore theoretically attractive, but are accompanied by the risk of concomitant a...

journal_title：Medical hypotheses

authors： Wrightham MN,Cann AJ,Sewell HF

更新日期：1992-07-01 00:00:00

abstract：:Elevated levels of aluminium (Al), strontium (Sr), barium (Ba), iron (Fe), manganese (Mn) cations - combined with deficiencies of magnesium (Mg)/calcium (Ca) - have been observed in the foodchains that traditionally support the Chamorro populations affected by high incidence clusters of Alzheimer (AD), Parkinson-like ...

journal_title：Medical hypotheses

authors： Purdey M

更新日期：2004-01-01 00:00:00

abstract：:Randomized clinical trials comparing neoadjuvant chemotherapy (NAC) followed by surgery with initial surgery in cervical cancer reported conflicting results. We provided a hypothesis explaining the different outcomes between trials. NAC was reported to make a lymph node metastasis smaller. Smaller tumors are hard to d...

journal_title：Medical hypotheses

authors： Kim K,Kim MJ,Chung HH,Choi SC,Ryu SY,Kim JW,Park NH,Song YS,Kang SB

更新日期：2009-12-01 00:00:00

abstract：:In early 2012 deaths (all-cause mortality) in England and Wales showed an unexpected and unexplained increase which continued for 18 months before abating. The highest percentage increase in deaths was noted to be for neurological degenerations (mainly dementia, Alzheimer's, Parkinson's). This study seeks to understan...

journal_title：Medical hypotheses

authors： Jones RP,Goldeck D

更新日期：2014-07-01 00:00:00

abstract：:Micelle is a stable, passively targetable and solubilizing minute particle, and plays a key role to anticancer drug delivery for chemotherapy. With an increasing number of novel polymeric micelles synthesized, many anticancer drugs have been core-encapsulated in the micelles. However, only single drug was studied as t...

journal_title：Medical hypotheses

authors： Liu P,Wang B,Weili Qiao JL

更新日期：2008-09-01 00:00:00

abstract：:The mechanisms by which blast pressure waves cause mild-to-moderate traumatic brain injury (mTBI) are an open question. Possibilities include acceleration of the head, direct passage of the blast wave via the cranium, and propagation of the blast wave to the brain via a thoracic mechanism. The hypothesis that the blas...

journal_title：Medical hypotheses

authors： Courtney AC,Courtney MW

更新日期：2009-01-01 00:00:00

abstract：:Mainstream researchers explain the etiology of SIDS with the cardiorespiratory paradigm. This has been the focus of intense study for many decades without providing consistent supporting data to link CNS findings to epidemiological risk factors or to the usual clinicopathological findings. Despite this, and the appare...

journal_title：Medical hypotheses

authors： Goldwater PN

更新日期：2020-11-01 00:00:00

abstract：:It is estimated that about 1 million patients are hospitalized for acute coronary events each years in the United States. An acceptable theory is that the acute coronary syndrome is caused by rupture of the atherosclerotic plaque with superimposed thrombus, which is a complex process and involving a number of differen...

journal_title：Medical hypotheses

authors： Fang CH,Li JJ,Hui RT

更新日期：2005-01-01 00:00:00

abstract：:An unacceptably high incidence of preterm labour is seen in the black and coloured communities of South Africa. This hypothesis proposes that sodium-potassium adenosine triphosphatase activity plays an important role in preterm labour. The impaired activity of the sodium pump leads to increased cytosolic calcium level...

journal_title：Medical hypotheses

authors： Du Toit PJ,Theron JJ,Grobler AS,Steinmann CM,Van Papendorp DH

更新日期：1996-09-01 00:00:00

abstract：:This article presents a novel view on the diabetes aetiology from the standpoint of a single epidemiological factor. It has been observed that, irrespective of the type of diabetes, sufferers have a stable, persistent behavioural habit: to take a rest or to have a nap within two hours of a meal. Such habitual behaviou...

journal_title：Medical hypotheses

authors： Dynyak AK,Dynyak AA,Popova FV

更新日期：2010-06-01 00:00:00

abstract：:It was hypothesized decades ago that reduced levels of brain monoamines such as serotonin or norepinephrine form, at least in part, a pathophysiological basis for major depression. Consistent with this hypothesis, a conventional strategy used, with varying success, to treat major depression involves administering anti...

journal_title：Medical hypotheses

authors： Fitzgerald PJ

更新日期：2013-06-01 00:00:00

abstract：:Previous papers of our group have reported that, in the first stages of nutritional recovery, the needs of undernourished infants, in terms of Protein Calories percentage (P%) were higher than normal, and similar to those of other mammals which double their birth weight faster than man. During this period, a high diet...

journal_title：Medical hypotheses

authors： Portela ML,Zeni S,Río ME

更新日期：1985-10-01 00:00:00

abstract：:The molecular similarity between certain human antigenic determinants with those of HIV has been already described. In this matter, we have previously demonstrated, by a chromatographic method, the cross reactivity of human serum albumin with HIV gp 120. The hypothesis that this similarity could be one of the reasons ...

journal_title：Medical hypotheses

authors： Berger G

更新日期：2002-05-01 00:00:00

abstract：:Submagnetic domain magnetic fluid particles of approximately 10 nm average diameter complexed with CD4 or monoclonal antibody and then injected into the patient, will localize to the cell membrane of the target cell. These ferrofluid particles will interact with an externally applied rotating magnetic field of rapidly...

journal_title：Medical hypotheses

authors： Peasley KW

更新日期：1996-01-01 00:00:00

abstract：:It has been proposed that combination of indole-3-acetic acid (IAA) and horseradish peroxidase (HRP) could be useful as the basis for targeted cancer therapy involving antibody-, polymer-, or gene-directed approaches. By circulating IAA in human body, the cells labeled with HRP could be selectively killed since cytoto...

journal_title：Medical hypotheses

authors： Kawano T

更新日期：2003-05-01 00:00:00

abstract：:Historically, cluster reports have been considered to be only marginally productive and generally discouraged as statistical artifacts. This report presents the results of a three year study involving in excess of 100 cancer cluster reports. The majority of these investigations represented statistical events; there we...

journal_title：Medical hypotheses

authors： Aldrich TE,Garcia N,Ziechner S,Berger S

更新日期：1983-09-01 00:00:00

abstract：:Characteristics of malignant tumors, including anaerobic metabolism and metastases to lung, liver, bone and brain, may permit the enhanced survival of edited parts of the genome during periods of rapid environmental change. Carcinogenesis may be partially analogous to fossilization. ...

journal_title：Medical hypotheses

authors： Fischer K

更新日期：1989-01-01 00:00:00

abstract：:Chronic, tertiary Lyme disease, a vector-borne infection most accurately designated neuroborreliosis, is often misdiagnosed. Infectors of the human brain, Lyme borrelial spirochetes are neurotropic, similar to the spirochetes of syphilis. Symptoms of either disease may be stable and persistent, transient and inconsist...

journal_title：Medical hypotheses

authors： Sherr VT

更新日期：2005-01-01 00:00:00

abstract：:Complex Regional Pain Syndrome (CRPS) has defied a clear unified pathological explanation to date. Not surprisingly, treatments for the condition are limited in number, efficacy and their ability to enact a cure. Whilst many observations have been made of physiological abnormalities, how these explain the condition an...

journal_title：Medical hypotheses

authors： Russo M,Georgius P,Santarelli DM

更新日期：2018-10-01 00:00:00

abstract：:Epoxides as reactive intermediates of estrogen metabolism have been considered to be potential precursors of the 2- and 4-hydroxy, catechol estrogens and even to be mutagenic/carcinogenic agents themselves. The labile nature of the intermediates has made proof of their existence difficult in natural biological conditi...

journal_title：Medical hypotheses

authors： Raeside JI

更新日期：2016-06-01 00:00:00

abstract：:It has long been recognized that the symptom complex of fibromyalgia can be seen with hypothyroidism. Hypothyroidism may been categorized, like diabetes, into type I (hormone deficient) and type II (hormone resistant). Most cases of fibromyalgia fall into the latter category. The syndrome is reversible with treatment,...

journal_title：Medical hypotheses

authors： Garrison RL,Breeding PC

更新日期：2003-08-01 00:00:00

abstract：:The favourable effects of eicosapentaenoic acid (EPA)- and doco-sahexaenoic acid (DHA)-rich diets (marine fish, fish oil) on several risk factors for cardiovascular disease are well established. The present survey describes possible new indications for diets supplemented with long-chain n-3 fatty acids. During a stand...

journal_title：Medical hypotheses

authors： Singer P,Richter-Heinrich E

更新日期：1991-09-01 00:00:00

abstract：:Bacteria initiated peri-implantitis can lead to bone destruction around a dental implant, modifying its surface and preventing re-osseointegration. Consequently, all available methods for treating periimplantitis have disappointing long-term results. Implant failure will lead to loss of the prosthetic reconstruction a...

journal_title：Medical hypotheses

authors： Chaushu L,Shabat R,Gadyukov A,Chaushu G

更新日期：2018-12-01 00:00:00

abstract：:The aim of the present paper is to give a schematic illustration of the basic humoral mechanisms of sodium, calcium and glucose homeostasis regulation. These can be compared to a lever system that maintains a dynamic equilibrium. ...

journal_title：Medical hypotheses

authors： Tolekova A,Popov B

更新日期：1999-09-01 00:00:00

abstract：:All kinds of hypotheses have been proposed to explain the mechanism of tumorigenesis. Up until now, we have not had any generally acknowledged model that helps us understand the process. In this paper, I propose a dynamic model of how tumor cells escape the supervision of the immune system; I also examine the possibil...

journal_title：Medical hypotheses

authors： Cai DW

更新日期：1995-05-01 00:00:00

abstract：:Many embryonic genes may be sets of repeated genes. Processes of differentiation where the quantity of gene activity changes during embryogenesis may not reflect the transcription rate per se but instead be a result of the state of expression of constitutive repeated genes. Such repeated genes (in fact or theory) is d...

journal_title：Medical hypotheses

authors： Hancock RL

更新日期：1991-03-01 00:00:00

abstract：:The concept of disease is central to modern medicine and society's concept of health and illness. Its recognition and nomenclature are based on correlating clinical syndromes, underlying morbid pathologies and pathophysiologies. This conceptualization is being challenged by the advances in the field of "-omics" (e.g. ...

journal_title：Medical hypotheses

authors： Jayasinghe S

更新日期：2014-06-01 00:00:00

abstract：:Women with polycystic ovary syndrome (PCOS) have been shown to have a higher incidence of cancer. It is suggested that several factors, including hyperinsulinemia, dyslipidemia, raised estrogen levels, chronic inflammation, and reduced apoptosis are responsible for this association. However, in this paper we propose t...

journal_title：Medical hypotheses

authors： Mravec B,Tibensky M

更新日期：2020-01-01 00:00:00

abstract：:Most cancer cells would not result in devastating tumours if it were not for their ability to metastasize. The process of cancer metastasis involves significant cell shape, motility, and adhesive changes of pre-cancerous cells, and the remodelling of the extracellular matrix, as well as cognate properties of neighbour...

journal_title：Medical hypotheses

authors： Haile S

更新日期：2008-01-01 00:00:00