Proposition of treatment to improve the immune response: possible application to AIDS.


:The molecular similarity between certain human antigenic determinants with those of HIV has been already described. In this matter, we have previously demonstrated, by a chromatographic method, the cross reactivity of human serum albumin with HIV gp 120. The hypothesis that this similarity could be one of the reasons why the virus escapes to the immune system is presented in this paper and a treatment is proposed to enhance the efficiency of the immune response: it is based on the blocking of the determinants of the self, expressed in the thymus, which are in common with the virus. Repeated injections within the thymus of neutralizing antibodies against the pathogen, obtained from a sufficiently distant animal species and purified by affinity chromatography, would prevent the T cells of the host recognizing these epitopes, common to the host and to the virus, from clonal deletion and would improve the immune response.


Med Hypotheses


Medical hypotheses


Berger G





Has Abstract


2002-05-01 00:00:00














  • Simplifying the complexity of cell signaling in medicine and the life sciences: radicals and electrochemistry.

    abstract::There have been various comments on the complexity of cell signaling and the need for simplification. Recently, new mechanics was proposed by Hlavacek and Faeder as a means of achieving this goal. Some of the important tenets include: (1) phosphorylation of nearby phosphorylation sites is likely to be cooperative and ...

    journal_title:Medical hypotheses

    pub_type: 社论


    authors: Kovacic P

    更新日期:2010-05-01 00:00:00

  • It is likely that the risk of cardiovascular events from pharmaceuticals as COX-2 inhibitors can be reduced significantly by standard pharmaceutical and lifestyle preventative measures.

    abstract::Based on the principles of the altered homeostatic theory, a case will be made that the risk of cardiovascular (CV) events from pharmaceuticals as COX-2 inhibitors (coxibs) and sympatho-mimetic drugs can be reduced significantly by using standard pharmaceutical and lifestyle preventative measures as statins, exercise,...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Hellstrom HR

    更新日期:2006-01-01 00:00:00

  • Possibility of active targeting to tumor by local hyperthermia with temperature-sensitive nanoparticles.

    abstract::Recently, the concept of drug delivery requires that the release of encapsulated drug be produced only at the diseased site with controllable rates. Given that thermosensitive hydrogels have been widely investigated for controlled delivery based on their phase transition, we speculate that nanoparticles with the novel...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Li J,Wang B,Liu P

    更新日期:2008-08-01 00:00:00

  • Retino-hypothalamic-pineal hypothesis in the pathophysiology of primary headaches.

    abstract::Primary headaches include migraine, tension, cluster headaches, paroxysmal hemicrania and miscellaneous headaches unassociated with structural lesions. A putative role of the retino-hypothalamic-pineal (RHP) axis in the pathophysiology of primary headaches is reviewed in terms of (1) retinal dysfunction, (2) hypothala...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Deshmukh VD

    更新日期:2006-01-01 00:00:00

  • A two-piece dental implant comprising a replaceable thin titanium sleeve may be a new approach to re-osseointegration following peri-implant disease.

    abstract::Bacteria initiated peri-implantitis can lead to bone destruction around a dental implant, modifying its surface and preventing re-osseointegration. Consequently, all available methods for treating periimplantitis have disappointing long-term results. Implant failure will lead to loss of the prosthetic reconstruction a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Chaushu L,Shabat R,Gadyukov A,Chaushu G

    更新日期:2018-12-01 00:00:00

  • Repression of the enzyme lactate dehydrogenase and the spontaneous remission or regression of cancer.

    abstract::Lactic acid produced by the malignant tumor is what keeps the malignancy going. Suppression or the removal of lactic acid is the prerequisite for any cancer treatment. ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Niakan B

    更新日期:2001-05-01 00:00:00

  • Pellagra: A clue as to why energy failure causes diseases?

    abstract::Pellagra is a curable dietary illness that unchecked leads to dementia, diarrhoea, dermatitis and death due to lack of the precursors for NAD(H). In addition it caused a wide range of monosyndromic degenerative and functional neurological disorders as well as profound developmental, premature aging and metabolic syndr...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Williams AC,Ramsden DB

    更新日期:2007-01-01 00:00:00

  • Coupling inflammation with evo-devo.

    abstract::Inflammation integrates diverse mechanisms that are associated not only with pathological conditions, such as cardiovascular diseases, type 2 diabetes, obesity, neurodegenerative diseases and cancer, but also with physiological processes like reproduction i.e. oogenesis and embryogenesis as well as aging. In the curre...

    journal_title:Medical hypotheses

    pub_type: 杂志文章,评审


    authors: Aller MA,Arias N,Fuentes-Julian S,Blazquez-Martinez A,Argudo S,Miguel MP,Arias JL,Arias J

    更新日期:2012-06-01 00:00:00

  • Impaired fatty acid oxidation as a cause of liver disease associated with hyperemesis gravidarum.

    abstract::Hyperemesis gravidarum (HG) is the most severe form of illness within the spectrum of nausea and vomiting of pregnancy. Liver disease, usually consisting of mild serum transaminase elevation, occurs in almost 50% of patients with HG. While multiple risk factors have been proposed, the etiology and underlying mechanism...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Outlaw WM,Ibdah JA

    更新日期:2005-01-01 00:00:00

  • NSAIDs can have adverse effects on bone healing.

    abstract::The science of osteoimmunology, a relatively new field of research, reveals the important interactions between the immune system and skeletal system. Interactions occur between prostaglandin metabolism, inflammatory proteins and bone metabolism. Systemic as well as local sources of inflammation appear to be actively i...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: van Esch RW,Kool MM,van As S

    更新日期:2013-08-01 00:00:00

  • Phylogenesis--ontogenesis--oncogenesis.

    abstract::Ontogenesis might be considered as the development of phylogenetically consequent genic systems that mainly imply: homoeotic genes and ras protooncogene in segmentation; ras and myc protooncogenes in gastrulation; ras, myc and other nuclear protooncogenes in organogenesis; ras myc, other nuclear and cytomembrane proto...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Manzo G

    更新日期:1989-12-01 00:00:00

  • On consciousness: what is the role of emergence?

    abstract::Can consciousness be understood as the ongoing active creation of information (of meaning)? 'Emergence', the central concept in this hypothesis, plays an essentially different role in it than in theories previously proposed. ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Atkin A

    更新日期:1992-08-01 00:00:00

  • Are some melanomas caused by artificial light?

    abstract::The incidence rate of cutaneous melanoma has been increasing faster than that of any other cancer in white-skinned populations over the past decades. The main risk factors for melanoma (i.e. exposure to sunlight, naevus count, phototype, and family history of melanoma) may not wholly explain the epidemiological trends...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Kvaskoff M,Weinstein P

    更新日期:2010-09-01 00:00:00

  • The role of reactive oxygen species, antioxidants and phytopharmaceuticals in human immunodeficiency virus activity.

    abstract::Currently, several prominent researchers are investigating the role of reactive oxygen and free radicals in the activation of latent HIV in infected individuals. Early clinical applications of free radical scavengers and plant-based antioxidant systems have shown promise of efficacy in altering this process. This manu...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Greenspan HC

    更新日期:1993-02-01 00:00:00

  • Pathomechanism of iris sphincter tear.

    abstract::Traumatic iris sphincter tear has been thought to occur secondary to anteroposterior compression of the globe with defined forces lead to equatorial expansion and active pull along the corneoscleral junction and sphincter tear. However, here in this report, we elaborate the additional forces involved in the traumatic ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Pujari A,Agarwal D,Kumar Behera A,Bhaskaran K,Sharma N

    更新日期:2019-01-01 00:00:00

  • A new hypothesis of neurodegenerative diseases: the deleterious network hypothesis.

    abstract::Growing evidence has indicated the existence of deleterious networks in the brains of neurodegenerative disorders, including Alzheimer's disease. Parkinson's disease, amyotrophic lateral sclerosis and Huntington's disease. The deleterious networks are formed on the basis of the intimate interactions among the key path...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Ying W

    更新日期:1996-10-01 00:00:00

  • Percussion chemistry and muscle function.

    abstract::A hypothesis is presented concerning the origin of the action of muscles in the human and animal bodies It is advanced that muscle action originates with very rapid chemical reactions known as percussion reactions. These give rise to the temporary precipitation of solids in muscle cells. The accompanying volume change...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Robertson DS

    更新日期:2002-08-01 00:00:00

  • Copper as the most likely pathogenic divergence factor between lung fibrosis and emphysema.

    abstract::Although fibrosis and emphysema are in many ways on opposite ends of the pulmonary parenchymal disease spectrum, they seem to share common pathomechanistic steps. This is illustrated by the coexistence of both entities in lungs of individuals with combined pulmonary fibrosis and emphysema. Macroproteins elastin and co...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Janssen R,de Brouwer B,von der Thüsen JH,Wouters EFM

    更新日期:2018-11-01 00:00:00

  • The role of the nucleus in organogenesis: Part 1.

    abstract::Organogenesis is the result of cell allocation followed by cell differentiation, and the processes involved are still to be elucidated. Present-day teaching suggests that the cytoplasmic membrane, the extracellular matrix and the cytoskeleton, in combination, are responsible, but the literature also suggests that othe...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Drummond R

    更新日期:1996-03-01 00:00:00

  • A new perspective to assess relaxation time of tumor.

    abstract::The dissimilarities in spin-lattice relaxation time (T1) of water proton from one tumor to the other is due to the yield of hypoxic fraction in the tumor. The yield of higher relaxation time (T1) in the KHT tumor compared to the RIF-1 tumor as a function of growth is due to the hypoxic fraction of the tumor. The hypox...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Akber SF

    更新日期:1992-01-01 00:00:00

  • A proposed role for nerve growth factor in the etiology of multiple sclerosis.

    abstract::It is proposed that, in addition to genetic factors involved in immune attack on myelin, higher concentrations of nerve growth factor in certain tissues during development determine susceptibility to multiple sclerosis. High early nerve growth factor in some vasculature of spontaneously hypertensive rats increases sym...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Olson RC

    更新日期:1998-12-01 00:00:00

  • X-ray induced thyroid adenocarcinoma.

    abstract::A comparison is made of the x-ray induced thyroid adenocarcinoma in the rat by the in-vitro, in-vivo method of Clifton et al. with previous data of Doniach on in-vivo irradiation in whole animals. The Clifton data consists of only one point at 500 rad. I have assumed that the probability of transformation per viable c...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Rosen P

    更新日期:1984-04-01 00:00:00

  • Is the antiepileptic effect of the ketogenic diet due to ketones?

    abstract::For many years, the ketogenic diet, including recent variants such the medium-chain triglyceride (MCT) diet, has been used with good clinical results in the management of refractory epilepsies, particularly in children. The antiepileptic effects of the diet, like the antiepileptic effects of starvation, have been attr...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Mainardi P,Albano C

    更新日期:2008-01-01 00:00:00

  • Tumor-derived microvesicles: the metastasomes.

    abstract::Metastasis is the leading cause of cancer death, yet it is mechanistically considered a very inefficient process suggesting the presence of some sort of (e.g. systemic) routes for fuelling the process. The pre-metastatic niche formation is described as one such metastasis promoting route. Now, the emerging potentials ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Ghasemi R,Grassadonia A,Tinari N,Piccolo E,Natoli C,Tomao F,Iacobelli S

    更新日期:2013-01-01 00:00:00

  • Depressed exocytosis and endocytosis of type II alveolar epithelial cells are responsible for the surfactant deficiency in the lung of newborn with congenital diaphragmatic hernia.

    abstract::Exocytosis and endocytosis are the way of macromolecules transmembrane transport. Pulmonary surfactant (PS), one of such macromolecules, is secreted via exocytosis of lamellar bodies and recycled via endocytosis by type II alveolar epithelial cells (AEC II). It maintains low alveolar surface tension and is therefore e...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Xu C,Liu W,Wang Y,Chen Z,Ji Y

    更新日期:2009-02-01 00:00:00

  • Mosaic aging.

    abstract::Although all multicellular organisms undergo structural and functional deterioration with age, senescence is not a uniform process. Rather, each organism experiences a constellation of changes that reflect the heterogeneous effects of age on molecules, cells, organs and systems, an idiosyncratic pattern that we refer ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Walker LC,Herndon JG

    更新日期:2010-06-01 00:00:00

  • A potential treatment of low intensity pulsed ultrasound on cavernous nerve injury for erectile dysfunction.

    abstract::Erectile dysfunction after nerve injury is a common disease after radical prostatectomy. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family, which plays an important role in the survival of existing neurons, the differentiation of new neurons, and synaptic plasticity. It has been demonstra...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Chiang PK,Yang FY

    更新日期:2019-01-01 00:00:00

  • SARS-CoV-2 and miRNA-like inhibition power.

    abstract::(1) Background: RNA viruses and especially coronaviruses could act inside host cells not only by building their own proteins, but also by perturbing the cell metabolism. We show the possibility of miRNA-like inhibitions by the SARS-CoV-2 concerning for example the hemoglobin and type I interferons syntheses, hence hig...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Demongeot J,Seligmann H

    更新日期:2020-11-01 00:00:00

  • Piezoelectric material - A promising approach for bone and cartilage regeneration.

    abstract::Bone and cartilage are major weight-bearing connective tissues in human and possesses utmost vulnerability for degeneration. The potential causes are mechanical trauma, cancer and disease condition like osteoarthritis and osteoporosis, etc. The regeneration/repair is a challenging, since their complex structures and a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: More N,Kapusetti G

    更新日期:2017-10-01 00:00:00

  • Metabolomic analysis as biomarker to study steroid hormone administration in sepsis.

    abstract::Sepsis is a life-threatening disease requiring rapid diagnosis and treatment. Steroid hormones (e.g., estradiol, dehydroepiandosterone) have been suggested to reduce the hyper-inflammatory response of the immune system and to improve outcome in sepsis. We hypothesize that the impact of steroid hormones on the metaboli...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Lehmann C,Sharawy N,Zhou J,Pavlovic D

    更新日期:2012-09-01 00:00:00