Abstract：
:The concept of disease is central to modern medicine and society's concept of health and illness. Its recognition and nomenclature are based on correlating clinical syndromes, underlying morbid pathologies and pathophysiologies. This conceptualization is being challenged by the advances in the field of "-omics" (e.g. proteomics) where arrays of compounds are assayed. Complex mathematical algorithms of their results reveal clusters that are prognostically important, yet not recognized as disease states (Prognostic -Omic Clusters, -POCs). At a given point in time, they are termed Static-POCs. However, the dynamism of the body's physiology should be incorporated to this concept. This requires using the patterns of the rates of change of these '-omics' (Dynamic-POCs), a method used in ICU settings. The latter has yielded prognostically important patterns of the rates of change of several physiological parameters. These Static and Dynamic POCs will become apparent in 'healthy' individuals, and their progress ought to reveal unique paths of progress towards disease states. This will enable interventions for prevention at a very early stage. The margins between health and diseases will blur, and diseases as a concept will become increasingly redundant with major implications to clinical practice and preventive health.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Jayasinghe Sdoi
10.1016/j.mehy.2014.03.008subject
Has Abstractpub_date
2014-06-01 00:00:00pages
703-5issue
6eissn
0306-9877issn
1532-2777pii
S0306-9877(14)00110-8journal_volume
82pub_type
杂志文章abstract：:Supercritical carbon dioxide (CO(2)) possesses germicide (bactericide and sporicide) effect. Despite of the fact, that this effect is used in industrial sterilization processes, the sterilization mechanism at molecular level is unclear. Our hypotheses can provide a molecular-biological explanation for the phenomenon. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.08.043
更新日期：2010-02-01 00:00:00
abstract：:Following allegations that Hepatitis B vaccination causes or triggers multiple sclerosis (MS), several epidemiological studies have been conducted to evaluate the association between MS and vaccination. In one study conducted in the US, a significant protective effect on the development of MS was observed for tetanus ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.05.009
更新日期：2005-01-01 00:00:00
abstract：:Using order parameters from field theory, the paper rationalizes the statistics of myeloid and erythroid leukemias more satisfactorily than the random mutation hypothesis. Adapted to B- and plasma cell lineages, the same arguments conceptualize the statistics of related malignancies congruently to clinical findings. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1364
更新日期：2001-10-01 00:00:00
abstract：:Arrhythmias is one of the leading causes of death in the world. Current antiarrhythmic drugs are limited by unsatisfactory efficacy and adverse effects such as proarrhythmias. Reentry mechanism plays an important role in persistence of arrhythmias. Reentry can only continue when reentry path-length is longer than card...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.08.047
更新日期：2011-01-01 00:00:00
abstract：:Parkinson's disease (PD) is a neurodegenerative disorder, characterized by loss of dopaminergic neuromelanin containing neurons in the substantia nigra. Peripheral melanin, found in skin and hair, and neuromelanin appear to have some characteristics in common and share the same precursor for their synthesis; therefore...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.04.013
更新日期：2019-06-01 00:00:00
abstract：:Whether retroviral integration is a phenomenon specific to properties of the surrounding genomic region is a widely debated question. In this paper we attempt to enlight the involvement of genomic regions prone to DNA double strand breaks in such process, as well as the more general concept of genome plasticity concer...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00410-3
更新日期：2003-02-01 00:00:00
abstract：:Late follicular progesterone (P) elevation continues to complicate a significant part of assisted reproductive technologies (ART) cycles, despite the ardent employment of gonadotropin releasing hormone (GnRH) analogues. In women with good ovarian reserve, late follicular P elevation is believed to be the result of the...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.02.047
更新日期：2019-04-01 00:00:00
abstract：:Many brilliant and ambitious young women lose their drive for top careers after childbirth. New maternal impulses are at odds with their original ambitions and for many mothers stress and frustration will be the result as they have to combine child care with workweeks of 60-80h to reach or remain at the top. Pregnancy...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.07.002
更新日期：2017-09-01 00:00:00
abstract：:Damaged DNA can lead to aneuploidy and/or chromosomal instability, which is believed to be major contributor to tumor progression. Genotoxic and oncogenic stresses-induced DNA damage activate the tumor suppressor pathways initiate DNA damage response (DDR). One of the cellular fates in response to DDR is permanent gro...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.01.001
更新日期：2010-06-01 00:00:00
abstract：:One of the most commonly alleged contraindications to the use of (ethylene diamine tetraacetic acid) chelation therapy is possible renal damage. In this experiment, 13 subjects with chronic degenerative disorders and with renal damage were treated with infusions that included EDTA, vitamins, mineral and oral supplemen...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(84)90020-3
更新日期：1984-11-01 00:00:00
abstract：:The accepted paradigms of mainstream neuropsychiatry appear to be incompletely adequate and in various cases offer equivocal analyses. However, a growing number of new approaches are being proposed that suggest the emergence of paradigm shifts in this area. In particular, quantum theories of mind, brain and consciousn...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.02.013
更新日期：2017-04-01 00:00:00
abstract：:This thesis explores the activation of chemicals in metabolic systems from the viewpoint that this activation is under the control of elements of the space-sea in which the chemicals are immersed. Themselves inert, the chemicals are theorised to exploit a force or action issuing from space (fluctuation) and characteri...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1298
更新日期：2001-07-01 00:00:00
abstract：:MS risk is associated with low vitamin D status prior to disease, and Epstein Barr virus (EBV) infection seems to be a prerequisite for MS. EBV could activate autoreactive T cells by several mechanisms, but it is not clear why this leads to MS. Only a small proportion of those infected with EBV develops MS, whereas au...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.04.030
更新日期：2008-01-01 00:00:00
abstract：:In plastic and reconstructive surgery, there is a tremendous clinical need for adequate implants are needed to restore soft-tissue defects resulting from tumor resection, traumatic injury, or congenital anomalies. Restoring the aesthetic function of the soft tissue is as important as restoring the natural tissue funct...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.05.007
更新日期：2012-08-01 00:00:00
abstract：:Recent articles about the roles and relationships of tissue inhibitor of metalloproteinase-1 and transforming growth factor-beta 1 in various types of normal tissues and malignancies give rise to the question: 'Is there a relationship between them with regard to malignant melanoma progression?' In the light of many re...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1270
更新日期：2001-08-01 00:00:00
abstract：:Recent studies using a combination of isotope and balance techniques have shown that, in the postabsorptive state, the human kidney contributes substantially to overall glucose production and consumption. The kidney may contribute as much as the liver to gluconeogenesis and play an important role in the counterregulat...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1997.0655
更新日期：1999-05-01 00:00:00
abstract：:Pinealectomy leads to increased formation of fibrous tissue in the abdominal cavity, increased skin pigmentation and elevated cholesterol and alkaline phosphatase levels. It also leads to reduced formation and/or action of prostaglandin (PG) E1 and thromboxane (TX) A2. PGE1 plays an important role in enhancing functio...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(79)90107-5
更新日期：1979-04-01 00:00:00
abstract：:Dementia and other causes of functional disability can create considerable burdens for families and society as a whole, but it may be possible to partially alleviate this strain through technical innovations that replace some functions of human caregivers. This article proposes the hypothesis that cell phones, interne...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.11.045
更新日期：2006-01-01 00:00:00
abstract：:Hemolysis-associated pulmonary hypertension (HA-PH) is a serious clinical complication of various hemolytic disorders, and pulmonary hypertension (PH) is considered the greatest risk factor for death in patients with a hemolytic disorder. It is now well established that hemolysis causes the release of soluble hemoglob...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.12.043
更新日期：2009-06-01 00:00:00
abstract：:Tinnitus and temporomandibular joint dysfunction (TMJD) are among the most common complaints encountered by physicians. Though the relationship between tinnitus and TMJD has attracted great interest during the past several years, theories attempting to explain this association are still few and inconsistent. Conceivab...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00194-4
更新日期：2003-10-01 00:00:00
abstract：:Parkinson's disease is one of the mostly seen neurological disease. It affects to nervous system and hinders people's vital activities. The majority of Parkinson's patients lose their ability to speak, write and balance. Many machine learning methods have been proposed to automatically diagnose Parkinson's disease usi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109483
更新日期：2020-02-01 00:00:00
abstract：:Hypertension has become a large burden of global development, but the mechanisms of it have still not been well elucidated. Increased contractility of vascular smooth cells induced by the overactivity of neurohormonal system or stress is one of the main and popular explanations until now. Smoothelin-B, recognized as t...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.01.038
更新日期：2009-07-01 00:00:00
abstract：:A wealth of research data points to increased oxidative stress as a key driver of the cardiac remodeling triggered by chronic pressure overload, loss of functional myocardial tissue, or atrial fibrillation. Oxidative stress is a mediator of the cardiomyocyte hypertrophy and apoptosis, the cardiac fibrosis, and the def...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2009.12.025
更新日期：2010-08-01 00:00:00
abstract：:The results of numerous investigations on the impact of obesity on renal insufficiency conducted in recent years introduce certain dilemmas about their mutual agreement. Some studies suggest that obesity is negatively correlated with the terminal phase of renal failure. On the other hand, other research has shown that...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.07.004
更新日期：2010-12-01 00:00:00
abstract：:Cancer stem cells are presently viewed as carriers of the growth initiating potential, repopulation capability and drug resistance in tumors. However, many of these fundamental properties of cancer are host-related, modified by cell-cell interactions and/or dependent on angiogenesis. Indeed, it is well established tha...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.09.004
更新日期：2006-01-01 00:00:00
abstract：:The apparent association of laryngeal cancer with asbestos and possibly other occupational exposures can be accounted for by the hypothesis that chronic vocal abuse peculiar to certain working conditions will act as a promoting factor for active carcinogens found mainly in tobacco smoke. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(81)90050-5
更新日期：1981-07-01 00:00:00
abstract：:In contrast to Geschwind, Behan and Galaburda (GBG) theory, there is strong evidence that inheritance through maternal line is responsible for the coexistence of asthma and left-handedness early in childhood. A new model that incorporates GBG's theory and maternal inheritance is proposed. This hypothesis suggests that...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00325-6
更新日期：2004-01-01 00:00:00
abstract：:Autism is a neurodevelopmental disorder that according to the Centers for Disease Control and Prevention (CDC) affects 1 in 150 children in the United States. Autism is characterized by impairments in social relatedness and communication, repetitive behaviors, abnormal movements, and sensory dysfunction. Recently emer...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.11.018
更新日期：2005-01-01 00:00:00
abstract：:Reflux of biliary secretions into the pancreatic duct following gallstone obstruction of the common biliary pancreatic ampulla has been implicated as a cause of acute pancreatitis. However, the pancreatic duct pressure is higher than the biliary pressure and, therefore, the simple obstruction of the choledochoduodenal...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1998.0896
更新日期：2000-04-01 00:00:00
abstract：:The "small-for-size" syndrome and "post-hepatectomy liver failure" refers to the development of liver failure (hyperbilirubinemia, coagulopathy, encephalopathy and refractory ascites) resulting from the reduction of liver mass beyond a certain threshold. This complication is associated with a high mortality and is a m...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.01.028
更新日期：2013-05-01 00:00:00
