Abstract：
:Mainstream researchers explain the etiology of SIDS with the cardiorespiratory paradigm. This has been the focus of intense study for many decades without providing consistent supporting data to link CNS findings to epidemiological risk factors or to the usual clinicopathological findings. Despite this, and the apparent oversight of the link between prone sleep position and respiratory infection, papers citing CNS, cardiac and sleep arousal findings continue to be published. Discovery of the prone sleep position risk factor provided tangential support for the cardiorespiratory control hypothesis which defines the mainstream approach. Despite many decades of research and huge expenditure, no aetiological answer has been forthcoming. In asking why?This paper exposes some of the shortcomings regarding this apparent oversight by mainstream SIDS researchers and examines the role of respiratory infection and puts the case for the "Infection Hypothesis." In addition, the paper provides encouragement to neuropathologists to examine the potential link between CNS findings and cardiac function (as opposed to respiratory function) in relation to infection and to examine possible correlates between CNS findings and established risk factors such as recent infection, contaminated sleeping surfaces, maternal/obstetric/higher birth, ethnicity, non-breast-feeding, male gender, etc. or with the usual gross pathological findings of SIDS (intrathoracic petechial hemorrhages, liquid blood, congested lungs). The shortcomings exposed through this review invite questions over current research directions and hopefully encourage research into other more plausible hypotheses, such as the infection paradigm.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Goldwater PNdoi
10.1016/j.mehy.2020.110114subject
Has Abstractpub_date
2020-11-01 00:00:00pages
110114eissn
0306-9877issn
1532-2777pii
S0306-9877(20)31919-8journal_volume
144pub_type
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pub_type： 杂志文章,评审
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pub_type： 历史文章,杂志文章
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pub_type： 杂志文章
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更新日期：1980-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1987-07-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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