Centenarian scientists: an unusual cluster newly formed in the 20th century.

Abstract:

:From biographical data sources on ranking scientists, I was able to identify 35 centenarians. Among these, only one (Michel Chevereul from France) lived before the 20th century. Since the remaining 34 individuals became centenarians only from 1965, I propose that centenarian scientists are an unusual cluster, first formed in the 20th century. Among these, all except one (Alice Hamilton) were men. Six centenarian scientists, including Hamilton, had received professional medical training. The nationality ranks of the 34 centenarian scientists identified in the 20th century show 26 Americans, 6 British, one German and one French. Four of the 26 Americans were immigrants from Europe. At least three centenarians, namely Michael Heidelberger, Nathaniel Kleitman and Victor Hamburger, belong to the 'Nobel class' category, being pioneers in the disciplines of immunochemistry, sleep physiology and neuroembryology respectively.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Sri Kantha S

doi

10.1054/mehy.2001.1480

keywords:

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

750-3

issue

6

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(01)91480-X

journal_volume

57

pub_type

历史文章,杂志文章
  • Segmental curvilinear distraction osteogenesis.

    abstract::Curvilinear distraction is currently under investigation to reconstruct curved maxillofacial bone defects. However, previous studies have revealed the discrepancy between the contour of the regenerated bone in the distraction gap and the curvilinear pathway of the transport disc. We hypothesize that the discrepancy is...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2012.06.011

    authors: Zhou L,Shang H,Feng Z,Liu C,Ye W,Ma Q,Wu W,Liu Y

    更新日期:2012-10-01 00:00:00

  • Nutraceutical strategies for ameliorating the toxic effects of alcohol.

    abstract::Rodent studies reveal that oxidative stress, much of it generated via induction/activation of NADPH oxidase, is a key mediator of a number of the pathogenic effects of chronic ethanol overconsumption. The highly reactive ethanol metabolite acetaldehyde is a key driver of this oxidative stress, and doubtless works in o...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2012.12.040

    authors: McCarty MF

    更新日期:2013-04-01 00:00:00

  • Unmasking AIDS: chemical immunosuppression and seronegative syphilis.

    abstract::In both African AIDS populations and homosexual populations outside of Africa, a high incidence of syphilis and multiple exposures to infectious diseases results in frequent, often abusive use of antibiotics. Epidemiological evidence exists for chemical immunosuppression resulting from antibiotics and other prescribed...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(86)90036-8

    authors: McKenna JJ,Miles R,Lemen D,Dunford SA,Renirie R

    更新日期:1986-12-01 00:00:00

  • First and second things, and the operations of conscience in science.

    abstract::Why is modern science less efficient than it used to be, why has revolutionary science declined, and why has science become so dishonest? One plausible explanation behind these observations comes from an essay First and second things published by CS Lewis. First Things are the goals that are given priority as the prim...

    journal_title:Medical hypotheses

    pub_type: 社论

    doi:10.1016/j.mehy.2009.08.017

    authors: Charlton BG

    更新日期:2010-01-01 00:00:00

  • Can glucose-insulin-potassium regimen suppress inflammatory bowel disease?

    abstract::Insulin seems to have the ability to suppress the production of tumor necrosis factor-alpha and superoxide anion, enhance the synthesis of nitric oxide and inhibit the expression of intercellular adhesion molecule-1 (ICAM-1) through stimulation of nitric oxide. This suggests that insulin can behave as an anti-inflamma...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.2001.1334

    authors: Das UN

    更新日期:2001-08-01 00:00:00

  • N-acetylaspartate as a reservoir for glutamate.

    abstract::N-acetylaspartate (NAA) is an intermediary metabolite that is found in relatively high concentrations in the human brain. More specifically, NAA is so concentrated in the neurons that it generates one of the most visible peaks in nuclear magnetic resonance (NMR) spectra, thus allowing NAA to serve as "a neuronal marke...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2006.02.047

    authors: Clark JF,Doepke A,Filosa JA,Wardle RL,Lu A,Meeker TJ,Pyne-Geithman GJ

    更新日期:2006-01-01 00:00:00

  • Can testosterone replacement decrease the memory problem of old age?

    abstract::The world is rapidly ageing. It is against this backdrop that there are increasing incidences of dementia reported worldwide, with Alzheimer's disease (AD) being the most common form of dementia in the elderly. It is estimated that AD affects almost 4 million people in the US, and costs the US economy more than 65 mil...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/s0306-9877(03)00072-0

    authors: Lim D,Flicker L,Dharamarajan A,Martins RN

    更新日期:2003-06-01 00:00:00

  • The phenomenon of claimed memories of previous lives: possible interpretations and importance.

    abstract::Several disorders or abnormalities observed in medicine and psychology are not explicable (or not fully explicable) by genetics and environmental influences, either alone or together. These include phobias and philias observed in early infancy, unusual play in childhood, homosexuality, gender identity disorder, a chil...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.1999.0920

    authors: Stevenson I

    更新日期:2000-04-01 00:00:00

  • An association between geomagnetic activity and dream bizarreness.

    abstract::Daily disturbances of the earth's magnetic field produce variations in geomagnetic activity (GMA) that are reportedly associated with widespread effects on human health and behaviour. Some of these effects could be mediated by an established influence of GMA on the secretion of melatonin. There is evidence from unrela...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2009.01.047

    authors: Lipnicki DM

    更新日期:2009-07-01 00:00:00

  • Hypobaric birth room may prevent intraventricular hemorrhage in extremely low birth weights infants.

    abstract::In the early postnatal period, intraventricular hemorrhage may develop in infants with extremely low birth weights due to hemodynamic instability. One of the most significant factors in intraventricular hemorrhage development is fluctuations in the cerebral blood flow due to left-to-right shunting as a result of paten...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2018.07.013

    authors: Tekgündüz KŞ,Tekgündüz SE

    更新日期:2018-10-01 00:00:00

  • Risk factors for cardiovascular disease in women: relationship to lipid peroxidation and oxidative stress.

    abstract::Many risk factors that promote cardiovascular disease (CVD) have been identified. These include hypertension, hypercholesterolemia, diabetes, decreased estrogen in post-menopausal women, increased homocysteine, and cigarette smoking. It has recently become clear that a mechanism common to these risk factors is oxidati...

    journal_title:Medical hypotheses

    pub_type: 杂志文章,评审

    doi:10.1016/j.mehy.2007.10.016

    authors: Castelao JE,Gago-Dominguez M

    更新日期:2008-01-01 00:00:00

  • Does TP53 mutation promote ovarian cancer metastasis to omentum by regulating lipid metabolism?

    abstract::TP53 (Tumor Protein 53, previously known as p53) is probably the best known of all tumor suppressor genes, and is mutated in nearly all (96%) high-grade serous ovarian cancer (HGS-OvCa), which is the most common histopathological type of epithelial ovarian cancer (EOC). Recently, TP53 is found to involve in regulating...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2013.06.009

    authors: Hu J,Liu Z,Wang X

    更新日期:2013-10-01 00:00:00

  • Subjective tinnitus, temporomandibular joint dysfunction, and serotonin modulation of neural plasticity: causal or casual triad?

    abstract::Tinnitus and temporomandibular joint dysfunction (TMJD) are among the most common complaints encountered by physicians. Though the relationship between tinnitus and TMJD has attracted great interest during the past several years, theories attempting to explain this association are still few and inconsistent. Conceivab...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/s0306-9877(03)00194-4

    authors: Salvinelli F,Casale M,Paparo F,Persico AM,Zini C

    更新日期:2003-10-01 00:00:00

  • Vitamin D status modulates the immune response to Epstein Barr virus: Synergistic effect of risk factors in multiple sclerosis.

    abstract::MS risk is associated with low vitamin D status prior to disease, and Epstein Barr virus (EBV) infection seems to be a prerequisite for MS. EBV could activate autoreactive T cells by several mechanisms, but it is not clear why this leads to MS. Only a small proportion of those infected with EBV develops MS, whereas au...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2007.04.030

    authors: Holmøy T

    更新日期:2008-01-01 00:00:00

  • The relationship between the cancer cell and the oocyte.

    abstract::What causes cancer? To date, this question is left with no answer. The scientific community keeps defining cancer as a proliferation of cells in an uncontrolled and uncontrollable manner. The hypothesis developed here through an understanding of the cancer cell's behaviour led to its re-definition, providing answers t...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.2001.1532

    authors: Majerus MA

    更新日期:2002-06-01 00:00:00

  • Renal duality, hypotheses concerning the release mechanism of a compensating hyperfunction.

    abstract::In this study, after having formed the hypothesis of the existence of a "Compensating Center" (cerebral?) that orders the increase in the function of one kidney in case of deterioration of its congener, we propose two mechanisms that may lead to the activation of this Center. The first may be the difference between th...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(88)90056-4

    authors: Collard M

    更新日期:1988-03-01 00:00:00

  • Medical knowledge integration and "systems medicine": Needs, ambitions, limitations and options.

    abstract::Medicine today is an extremely heterogeneous field of knowledge, based on clinical observations and action knowledge and on data from the biological, behavioral and social sciences. We hypothesize at first that medicine suffers from a disciplinary hyper-diversity compared to the level of conceptual interdisciplinary i...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2019.109386

    authors: Tretter F,Löffler-Stastka H

    更新日期:2019-12-01 00:00:00

  • Chronic metabolic acidosis may be the cause of cachexia: body fluid pH correction may be an effective therapy.

    abstract::Cachexia is a pathological state characterized by weight loss and protein mobilization during various diseases. Nutritional supplementation or appetite stimulants are unable to restore the loss of lean body mass. Agents interfering with TNF-alpha have not been very successful to date. Only eicosapentaenoic acid was ab...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2007.11.007

    authors: Drochioiu G

    更新日期:2008-01-01 00:00:00

  • Is cystic fibrosis-related diabetes an apoptotic consequence of ER stress in pancreatic cells?

    abstract::Cystic fibrosis-related diabetes (CFRD) has emerged in the last thirty years as a critical complication of cystic fibrosis (CF) and is present in about 15% of CF patients with increasing prevalence with age approaching 50 for over 30 year olds. The mechanism of diabetes development in this group of patients is not ver...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2008.07.058

    authors: Ali BR

    更新日期:2009-01-01 00:00:00

  • Tannins, salivary proline-rich proteins and oesophageal cancer.

    abstract::No single dietary factor or ingested substance has been implicated in the aetiology of oesophageal carcinoma especially in high-risk areas of the world. Although not well defined, there is heavy consumption of tannin-rich foods, particularly sorghum, by populations at high risk for carcinoma. The carcinogenic properti...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(88)90060-6

    authors: Warner TF,Azen EA

    更新日期:1988-06-01 00:00:00

  • Stable genes.

    abstract::Some genes such as those for histones and RNAs are conserved unchanged through much of evolution and have numerous tandem repeat copies in the genome. It is proposed that as yet undetected 'polystrand' enzymes use such multiple copies as a means of conserving their sequence by comparing the copies and eliminating erro...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(90)90099-z

    authors: Frei JV

    更新日期:1990-08-01 00:00:00

  • Psammoma bodies - friends or foes of the aging choroid plexus.

    abstract::Psammoma bodies are structures classified in the group of dystrophic calcifications, which occur in some kind of tumors and in choroid plexus during the aging process. Despite early discovery of their presence in choroid plexus stroma, mechanisms responsible for their formation remained unclear. Their presence in some...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2010.01.006

    authors: Jovanović I,Ugrenović S,Vasović L,Petrović D,Cekić S

    更新日期:2010-06-01 00:00:00

  • Is cancer stem cell a cell, or a multicellular unit capable of inducing angiogenesis?

    abstract::Cancer stem cells are presently viewed as carriers of the growth initiating potential, repopulation capability and drug resistance in tumors. However, many of these fundamental properties of cancer are host-related, modified by cell-cell interactions and/or dependent on angiogenesis. Indeed, it is well established tha...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2005.09.004

    authors: Rak J

    更新日期:2006-01-01 00:00:00

  • Coeliac disease: an analysis of aetiological possibilities and re-evaluation of the enzymopathic hypothesis.

    abstract::Although it is well established that components of wheat gluten and structurally-related cereal proteins produce intestinal damage in Coeliac disease (CD), the primary defect which confers upon the host susceptibility to these dietary substances remains a mystery. To date, three main hypotheses have been framed to exp...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(88)90093-x

    authors: Davidson AG,Bridges MA

    更新日期:1988-07-01 00:00:00

  • GNAI2 and regulators of G protein signaling as a potential Noonan syndrome mechanism.

    abstract::Noonan syndrome (NS OMIM 163950) is a relatively common autosomal dominant developmental disorder characterized by short stature, specific facial features, and congenital cardiac anomalies. Approximately 50-66% of cases have defined mutations in the K-ras/Raf/MEK/ERK pathway that lead to constitutive signaling, but a ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2009.01.040

    authors: Huang X,Fu Y,Charbeneau RA,Neubig RR

    更新日期:2009-07-01 00:00:00

  • Serum albumin-mediated strategy for the effective targeting of SARS-CoV-2.

    abstract::Novel coronavirus (NCoV-19), also known as SARS CoV-2, is a pathogen causing an emerging infection that rapidly increases in incidence and geographic range, is associated with the ever-increasing morbidity and mortality rates, and shows sever economic impact worldwide. The WHO declares the NCoV-19 infection disease (C...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.109790

    authors: Mani Mishra P,Uversky VN,Nandi CK

    更新日期:2020-04-24 00:00:00

  • Vulvodynia and fungal association: a preliminary report.

    abstract::Vulvodynia (vulvar pain syndrome) is a chronic multifactorial disease affecting almost 13 million women in the USA and can lead to morbidity and a reduced quality of life. We hypothesize that an initial microbiological insult in the vagina causes modifications in the biological vaginal milieu and/or an alteration on t...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2013.04.043

    authors: Ventolini G,Gygax SE,Adelson ME,Cool DR

    更新日期:2013-08-01 00:00:00

  • Potential human health risks associated with animal retroviruses: some hypotheses.

    abstract::Several studies have demonstrated the existence of morphological, biological, genetic and antigenic correlations between human and animal retroviruses. Furthermore, some agents of bovine and feline origin can also be considered useful comparative models for the pathogenetic study of human diseases such as leukaemia, a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(89)90194-1

    authors: Di Guardo G

    更新日期:1989-07-01 00:00:00

  • Atherosclerosis as an immune disease?

    abstract::Immunology has many effects on atherogenesis. In addition to their usual action risk factors for atherosclerosis have an immunomodulating effect and immunomodulation may be a new treatment of atherosclerosis. ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(91)90159-v

    authors: Clerc G

    更新日期:1991-09-01 00:00:00

  • Periodontal disease and targeted prevention using aMMP-8 point-of-care oral fluid analytics in the COVID-19 era.

    abstract::Periodontal disease is a chronic multifactorial infectious and inflammatory disease associated with several chronic systemic diseases, such as diabetes, cardiovascular diseases (CVD), chronic obstructive pulmonary disease, hypertension, Alzheimer's disease and so on. These same systemic diseases have been associated w...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.110276

    authors: Räisänen IT,Umeizudike KA,Pärnänen P,Heikkilä P,Tervahartiala T,Nwhator SO,Grigoriadis A,Sakellari D,Sorsa T

    更新日期:2020-11-01 00:00:00