Abstract:
:Tinnitus and temporomandibular joint dysfunction (TMJD) are among the most common complaints encountered by physicians. Though the relationship between tinnitus and TMJD has attracted great interest during the past several years, theories attempting to explain this association are still few and inconsistent. Conceivably, TMJD could irritate auricolo-temporal nerve (ATN), triggering a somatosensory pathway-induced disinhibition of dorsal cochlear nucleus (DCN) activity in the auditory pathway. In genetically-predisposed TMJD patients, signals from cronically stimulated DCNs activating specific cortical neuronal networks, could yield plastic neural changes resulting in tinnitus. Based on current evidence of serotoninergic modulation of neural activity and plasticity in sensory pathways, reduced serotoninergic tone could promote plastic changes underlying tinnitus through diminished filtering of incoming signals. Therefore, the early establishment of specific treatments aimed at improving TMJD and/or boosting serotoninergic activity may be required to prevent the creation of 'tinnitus memory circuits'.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Salvinelli F,Casale M,Paparo F,Persico AM,Zini Cdoi
10.1016/s0306-9877(03)00194-4keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
446-8issue
4eissn
0306-9877issn
1532-2777pii
S0306987703001944journal_volume
61pub_type
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