Lipoproteins versus structural glycoproteins: atherosclerosis as an analogue and competitor of normal connective tissue interactions.

abstract：:Lithium is a naturally occurring alkali metal, which living organisms ingest from dietary sources and which is also present in trace amounts in the human body. In much higher concentrations, lithium is effective as a medication for mania and mood swings including manic depressive disorders. Many studies have shown tha...

journal_title：Medical hypotheses

authors： Demling JH,Eglau MC,Autenrieth T

更新日期：2001-10-01 00:00:00

abstract：:Insufficient attention has been given to reports in the literature describing patients with symptomatic migraine who, in addition to, or instead of, the well-recognized zones of hypofusion, have zones of hyperperfusion, which can be interpreted as hypermetabolism due to neuronal activation. A new neural theory of migr...

journal_title：Medical hypotheses

authors： Eggers AE

更新日期：2001-03-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder, characterized by loss of dopaminergic neuromelanin containing neurons in the substantia nigra. Peripheral melanin, found in skin and hair, and neuromelanin appear to have some characteristics in common and share the same precursor for their synthesis; therefore...

journal_title：Medical hypotheses

authors： Jucevičiūtė N,Banaitytė I,Vaitkus A,Balnytė R

更新日期：2019-06-01 00:00:00

abstract：:No single dietary factor or ingested substance has been implicated in the aetiology of oesophageal carcinoma especially in high-risk areas of the world. Although not well defined, there is heavy consumption of tannin-rich foods, particularly sorghum, by populations at high risk for carcinoma. The carcinogenic properti...

journal_title：Medical hypotheses

authors： Warner TF,Azen EA

更新日期：1988-06-01 00:00:00

abstract：:The largely empirical dopamine theory has limited value in clarifying the pathogenesis of schizophrenia, due to its inability to explain consistent imaging findings, such as cortical grey matter loss, reduced frontal and thalamic activity, and, reduced D1 receptor load. Furthermore, the most effective drug for treatin...

journal_title：Medical hypotheses

authors： McDermott E,de Silva P

更新日期：2005-01-01 00:00:00

abstract：:Encouraging results have been obtained with stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC). However, local control rates decrease in larger volume disease. Several studies have found a correlation between T stage or tumor volume and local progression-free survival. In man...

journal_title：Medical hypotheses

authors： Nieder C,Andratschke N

更新日期：2012-04-01 00:00:00

abstract：:The authors sought to establish whether maternal dietary methanol during pregnancy was a factor in the etiology of autism spectrum disorders. A seven item questionnaire was given to women who had given birth to at least one child after 1984. The subjects were solicited from a large primary care practice and several in...

journal_title：Medical hypotheses

authors： Walton RG,Monte WC

更新日期：2015-10-01 00:00:00

abstract：:Acute viral infection is characterised by high-level replication before prompt decline of viraemia and, commonly, viral clearance. This kinetic pattern is generally held to be due to immune control. However, infection with some viruses, notably hepatitis C (HCV), hepatitis B (HBV) and the human immunodeficiency virus ...

journal_title：Medical hypotheses

authors： Sallie R

更新日期：2004-01-01 00:00:00

abstract：:By influencing fetal brain development pregnancy may be prolonged beyond term for an unknown time period. In late gestation the mother animal (host) is nephrectomized. The urine of the fetus (transplant) is guided to the outside so that the fetal kidneys excrete the host's urinary secretory substances and eventually h...

journal_title：Medical hypotheses

authors： Metka W

更新日期：1982-10-01 00:00:00

abstract：:Most cancer cells would not result in devastating tumours if it were not for their ability to metastasize. The process of cancer metastasis involves significant cell shape, motility, and adhesive changes of pre-cancerous cells, and the remodelling of the extracellular matrix, as well as cognate properties of neighbour...

journal_title：Medical hypotheses

authors： Haile S

更新日期：2008-01-01 00:00:00

abstract：:Oral administration of L-arginine in pharmacological doses induces growth hormone and insulin-like growth factor-I responses and stimulates nitric oxide synthesis. Growth hormone and insulin-like growth factor-I are important mediators of bone turnover and osteoblastic bone formation, while nitric oxide is a potent in...

journal_title：Medical hypotheses

authors： Visser JJ,Hoekman K

更新日期：1994-11-01 00:00:00

abstract：:Obesity is a major risk factor for type 2 diabetes mellitus and insulin resistance (IR). In the state of obesity, excess fat accumulates in the liver, a key organ in systemic metabolism, altering the inflammatory and metabolic signals contributing substantially to the development of hepatic IR. Current therapies for t...

journal_title：Medical hypotheses

authors： Deng J,Wang M,Guo Y,Fischer H,Yu X,Kem D,Li H

更新日期：2020-03-14 00:00:00

abstract：:In recent years a male-specific but species non-specific mammalian cell surface antigen, the H-Y antigen, has been demonstrated on somatic cells as well as on sperm. This raises some questions regarding unforeseen risks of certain medical procedures, notably blood transfusion. It is stressed that especially the possib...

journal_title：Medical hypotheses

authors： Nørby S

更新日期：1980-11-01 00:00:00

abstract：:Can consciousness be understood as the ongoing active creation of information (of meaning)? 'Emergence', the central concept in this hypothesis, plays an essentially different role in it than in theories previously proposed. ...

journal_title：Medical hypotheses

authors： Atkin A

更新日期：1992-08-01 00:00:00

abstract：:The prevalence of adult and childhood obesity are increasing. Most of the human newborn's body fat accumulates in the last half of intrauterine life. Fat in the fetus was thought to be mostly synthesized from glucose, but now it is commonly accepted that the bulk of it is the product of placental transfer of maternal ...

journal_title：Medical hypotheses

authors： Szabo AJ

更新日期：2019-01-01 00:00:00

abstract：:Incidental pituitary adenoma is the common finding during brain imaging. According to multistep model of pituitary tumourigenesis genetic alterations provide the initiating event that transforms cells while hormones play a role in promoting cell proliferation. Development of pituitary adenoma in a case of excessive hy...

journal_title：Medical hypotheses

authors： Kastelan D,Korsic M

更新日期：2007-01-01 00:00:00

abstract：:Arrhythmias is one of the leading causes of death in the world. Current antiarrhythmic drugs are limited by unsatisfactory efficacy and adverse effects such as proarrhythmias. Reentry mechanism plays an important role in persistence of arrhythmias. Reentry can only continue when reentry path-length is longer than card...

journal_title：Medical hypotheses

authors： Li LD,Zhang CT,Ruan L,Ni MK,Quan XQ

更新日期：2011-01-01 00:00:00

abstract：:Left ventricular thrombus (LVT) after acute myocardial infarction (AMI) remains to be a common complication bearing adverse prognostic implication. Majority of LVT occurs within the first week after AMI. Over decades, the regional stasis of blood flow is regarded as the main reason for LVT formation. Here we hypothesi...

journal_title：Medical hypotheses

authors： Ma S,Lu Q,Hu H,Du XJ

更新日期：2020-11-01 00:00:00

abstract：:In the present report we have developed a mathematical model to describe the processes involved during high steroid therapy. We have shown that the model can predict clinical observations as well as determine the optimum steroid regimen without relying on trial and error methods. The model incorporates rate processes ...

journal_title：Medical hypotheses

authors： Golding EM,Golding RM

更新日期：2001-07-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. The hallmark pathologic feature of PD is dopamine deficiency, caused by the degeneration of nigrostriatal dopaminergic neurons. Current treatments for PD mainly address the dopaminergic features of the disease; howe...

journal_title：Medical hypotheses

authors： Tsai SJ

更新日期：2007-01-01 00:00:00

abstract：:A meniscal graft extrusion is still an unresolved problem that affects most patients after a meniscal transplantation. Despite the advances in surgical techniques, together with the improved methods for a meniscal allograft sizing, success is only observed in up to 75% of patients after they experience a meniscal allo...

journal_title：Medical hypotheses

authors： Łuczkiewicz P,Daszkiewicz K,Chróścielewski J,Witkowski W,Kuik L

更新日期：2017-04-01 00:00:00

abstract：:Styrene is one of the most important plastic monomers worldwide. Styrene-7,8-oxide (SO), the major in-vivo metabolite of styrene, is classified as probably carcinogenic to humans and carcinogenic in rodents. Biological monitoring of exposure to styrene is usually carried out by determination of mandelic acid and pheny...

journal_title：Medical hypotheses

authors： Marczynski B,Peel M,Baur X

更新日期：2000-04-01 00:00:00

abstract：:The various neurotransmitter systems postulated to be involved in the pathogenesis of Gilles de la Tourette syndrome(GTS) are described with special reference to the endogenous opioid system(EOS). Malfunction of the opioid system is proposed as the underlying disturbance in this disease causing secondary dysfunction o...

journal_title：Medical hypotheses

authors： Gillman MA,Sandyk R

更新日期：1986-04-01 00:00:00

abstract：:Several studies have described unusually high incidence of vascular thrombosis in coronavirus disease-2019 (COVID-19) patients. Pathogenesis of the vascular thrombosis in COVID-19 is least understood for now and presents a challenge to the treating physicians. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-...

journal_title：Medical hypotheses

authors： Kumar A,Narayan RK,Kumari C,Faiq MA,Kulandhasamy M,Kant K,Pareek V

更新日期：2020-12-01 00:00:00

abstract：:Exosomes are small vesicles that are released by almost every cell type and play a crucial role in many physiological and pathological processes associated with different diseases. Specifically, they promote angiogenesis in the pathogenesis of some diseases. According to previous research, the proteins of exosomes tak...

journal_title：Medical hypotheses

authors： Tong Y,Zhou YL,Wang YX,Zhao PQ,Wang ZY

更新日期：2016-12-01 00:00:00

abstract：:Severe affective and behavioral dysregulation, labeled as severe mood dysregulation (SMD), is a widely spread phenomenon among adolescent psychiatric patients. This phenotype constitutes severe impairment across multiple settings, including various symptoms, such as non-episodic anger, mood instability, and hyperarous...

journal_title：Medical hypotheses

authors： Heiler S,Legenbauer T,Bogen T,Jensch T,Holtmann M

更新日期：2011-10-01 00:00:00

abstract：:For American medical historiography, to borrow from Dickens, these are the best of times and the worst of times. These are the times when rigorous scholarship has been brought to bear on the field (with great improvement in the quality of research) and when medicine is disappearing from its own history. These are the ...

journal_title：Medical hypotheses

authors： Prioreschi P

更新日期：1992-06-01 00:00:00

abstract：:Although frequently disseminated to other anatomical sites, neuroblastoma (NB) is rarely reported as involving the central nervous system (CNS), which may reflect insufficient research in poorly controlled systemic disease. Here we demonstrate the involvement of the CNS in patients with NB over 18 months of age at dia...

journal_title：Medical hypotheses

authors： Odone-Filho V,Cristofani LM,Maluf PT,Almeida MTA,Halley N,Vince CSC,de Azambuja AMP,Brumatti M,Lubraico P,da Camara Lopes LHA,Leite KRM,Silva JLF,Plese JPP,Weltman E

更新日期：2020-03-01 00:00:00

abstract：:Dependence on benzodiazepines (BZDs) or Z-drugs (zolpidem, zopicline and zaleplon) is a common clinical phenomenon. Traditional detoxification of BZDs dependence includes tapering used dose gradually and using equivalent doses of long-acting BZDs as substitutes. This kind of regimen tends to take a long time (up to 4w...

journal_title：Medical hypotheses

authors： Lin SK

更新日期：2014-07-01 00:00:00

abstract：:Information about the etiology of pressure sores has been contradictory and is inconsistent with the idea that pressure sore formation is due extensively to depriving a tissue region of blood. Based on these observations and on studies done in the cooperating laboratories, an hypothesis has been formulated that integr...

journal_title：Medical hypotheses

authors： Krouskop TA

更新日期：1983-06-01 00:00:00