Abstract:
:Although frequently disseminated to other anatomical sites, neuroblastoma (NB) is rarely reported as involving the central nervous system (CNS), which may reflect insufficient research in poorly controlled systemic disease. Here we demonstrate the involvement of the CNS in patients with NB over 18 months of age at diagnosis of extensive systemic disease. Meningeal metastases were observed even in the presence of complete systemic control. Although no improvement in patient's survival was observed, radiotherapy was effective in preventing CNS recurrence after observation of actual or previous dural disease. In conclusion, this study uncovered the uncommon pathologic involvement of the CNS in children with advanced NB and underscores the meningeal surface as a potential pathway for this to occur.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Odone-Filho V,Cristofani LM,Maluf PT,Almeida MTA,Halley N,Vince CSC,de Azambuja AMP,Brumatti M,Lubraico P,da Camara Lopes LHA,Leite KRM,Silva JLF,Plese JPP,Weltman Edoi
10.1016/j.mehy.2019.109479subject
Has Abstractpub_date
2020-03-01 00:00:00pages
109479eissn
0306-9877issn
1532-2777pii
S0306-9877(19)30903-Xjournal_volume
136pub_type
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journal_title:Medical hypotheses
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