High meniscal slope angle as a risk factor for meniscal allograft extrusion.

Abstract:

:A meniscal graft extrusion is still an unresolved problem that affects most patients after a meniscal transplantation. Despite the advances in surgical techniques, together with the improved methods for a meniscal allograft sizing, success is only observed in up to 75% of patients after they experience a meniscal allograft transplantation. Because a meniscal extrusion is associated with a cartilage deterioration and the progression of osteoarthritis there is a great interest in how to prevent this phenomenon. The crucial factor for the minimisation of a meniscal allograft extrusion is by perfectly matching the implant. Most methods for a meniscal allograft sizing only focus on assessing the length and the width of the meniscus. Even though there is some evidence that there is a relationship between the shape of the meniscus in a cross-sectional plane and the meniscal extrusion, any of the planning methods do not take this factor into consideration. Although there is a large variability of meniscus shapes in cross-section, we hypothesise that by taking the meniscal slope into account during surgical planning, as well as performing the correct adjustments of this particular parameter, we can diminish the risk of a meniscal allograft extrusion.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Łuczkiewicz P,Daszkiewicz K,Chróścielewski J,Witkowski W,Kuik L

doi

10.1016/j.mehy.2017.02.003

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

48-51

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(16)30880-5

journal_volume

101

pub_type

杂志文章
  • Cortisol abnormality as a cause of elevated estrogen and immune destabilization: insights for human medicine from a veterinary perspective.

    abstract::For more than 35 years the author has treated multiple serious diseases in cats and dogs by correcting an unrecognized endocrine-immune imbalance originating with a deficiency or defect of cortisol. The cortisol abnormality creates a domino effect on feedback loops involving the hypothalamus-pituitary-adrenal axis. In...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2003.12.005

    authors: Plechner AJ

    更新日期:2004-01-01 00:00:00

  • Parkinson disease classification using one against all based data sampling with the acoustic features from the speech signals.

    abstract::Parkinson's disease (PD) is a long-term degenerative disease that primarily affects the motor system of the central nervous system. This disease is difficult to diagnose and is one of the common diseases in the public. In this paper, we have proposed a novel data sampling method for the classification of Parkinson dis...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.109678

    authors: Polat K,Nour M

    更新日期:2020-03-16 00:00:00

  • Mechanisms of tissue damage resulting from the use of oral water irrigation devices.

    abstract::Oral water irrigation devices (WIDs) are widely used for oral physiotherapy in homes and dental clinics throughout the world. A major area of concern in the use of WIDs has been the possibility of injury to the sulcular epithelium and underlying tissue. There are several documented clinical cases of tissue injury with...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(85)90110-0

    authors: Reddy NP,Kesavan SK

    更新日期:1985-12-01 00:00:00

  • Does the impairment of the hypothalamic-pituitary-gonadal axis in anorexia nervosa depend on increased sensitivity to endogenous melatonin?

    abstract::The authors hypothesize that the impairment of hypothalamic-pituitary-gonadal axis in patients suffering from anorexia nervosa depends (at least in part) on the increased sensitivity to endogenous melatonin. The hypothesis is based mainly on the following facts: (1) melatonin is well known to exert an inhibitory effec...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.1997.0631

    authors: Pawlikowski M,Zarzycki J

    更新日期:1999-02-01 00:00:00

  • Induction of a local pseudo-pregnancy for the treatment of endometriosis.

    abstract::As a common cause of chronic pelvic pain, endometriosis affects 10% of women of reproductive age. The most popular strategy for treating endometriosis is pseudo-pregnancy therapy. However, the efficacy of common systemic pseudo-pregnancy therapy is significantly attenuated by poor compliance because of so many side ef...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2009.08.001

    authors: Yuan P,Huang Y,Cheng B,Zhang J,Xin X

    更新日期:2010-01-01 00:00:00

  • On the general theory of neural circuitry.

    abstract::A general theory of neural circuitry is proposed wherein neural impulses travel in a continuous circuit from the brain to the extremities and back to the brain. At the extremities the impulse may be modified by the environment there. At the spinal column the return signal is compared with the outgoing signal and the a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(94)90002-7

    authors: Kingham DJ

    更新日期:1994-05-01 00:00:00

  • The tumoricidal effect of Trypanosoma cruzi: its intracellular cycle and the immune response of the host.

    abstract::Many experimental evidences indicate that infection with Trypanosoma cruzi delays or inhibits the growth of malignant tumors in different strains of mice and in rats. These facts were verified by different workers. Although earlier workers proposed that this effect would be due to a toxin of T. cruzi, most of the accu...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.1998.0808

    authors: Cabral HR

    更新日期:2000-01-01 00:00:00

  • Rapid reduction in uric acid by a urate-lowering agent is associated with recurrent cardiovascular events.

    abstract:OBJECTIVES:Results from a recent study showed that the risk of cardiovascular and all-cause mortality was higher in patients who received febuxostat, a potent urate-lowering agent, than that in patients who received allopurinol. Therefore, we hypothesized that an abrupt change in serum urate levels caused by urate-lowe...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.109740

    authors: Lee JS,Oh JS,Kim YG,Lee CK,Yoo B,Hong S

    更新日期:2020-08-01 00:00:00

  • The role of aromatic hydrocarbons in the genesis of breast cancer.

    abstract::The incidence of breast cancer in women has increased dramatically over the last decade. Epidemiological markers of this increased incidence include: endocrine related phenomena (early menarche, age of first parity and age of menopause); exposure of the breast to X-radiation; and a group of seemingly disparate factors...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(92)90090-y

    authors: Morris JJ,Seifter E

    更新日期:1992-07-01 00:00:00

  • Functionalized nanoliposomes loaded with anti survivin and anti angiogenic agents to enhance the activity of chemotherapy against melanoma by 4-pronged action.

    abstract::Melanoma is one of the most aggressive cancers which has very low response rate and survival rate. Melanoma cells are known to be inherently resistant to the chemotherapy which results in poor outcomes and even failure of the therapy. For this reason, a better understanding of underlying mechanism of melanoma pathogen...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2018.05.002

    authors: Mishra H,Mishra PK,Ekielski A,Iqbal Z,Jaggi M,Talegaonkar S

    更新日期:2018-07-01 00:00:00

  • The good oncogene: When bad genes identify good outcome in cancer.

    abstract::Some cancer patients live many decades after diagnosis while others are not so fortunate. Understanding why this occurs is a fundamental issue in cancer research. We hypothesize that among the factors controlling favorable outcome are a class of genes that we describe as "good oncogenes". These genes have a paradoxica...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2010.10.015

    authors: Lee JM

    更新日期:2011-02-01 00:00:00

  • The integrated model of glutamate and dopamine hypothesis for schizophrenia: Prediction and personalized medicine for prevent potential treatment-resistant patients.

    abstract::Treatment-resistant schizophrenia (TRS) is one of the subgroups of schizophrenia of which little is known with regard to its optimal mechanism. Treatment response, either as full remission of symptoms or prediction by biomarker, is important in psychiatry. We have proposed a model that integrates dopaminergic and glut...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.110159

    authors: Huang LC,Lin SH,Tseng HH,Chen KC,Yang YK

    更新日期:2020-10-01 00:00:00

  • Aetiology of spinal deformities in neurofibromatosis 1: new hypotheses.

    abstract::Neurofibromatosis 1 is a common heritable disorder. The gene causing neurofibromatosis 1 had been recognized and the protein encoded by this gene, neurofibromin, was supposed to play a role in development of various tissues. Neurofibromin was found to have GTP-ase (GAP) domain against small p21 ras. IQGAP1 is another ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.2000.1232

    authors: Abdel-Wanis ME,Kawahara N

    更新日期:2001-03-01 00:00:00

  • A new model for regulation of sodium transport in high resistance epithelia.

    abstract::A new three barrier, four compartment model for sodium transport in high resistance urinary epithelia is presented. This model provides a unified and simplified mechanistic explanation for sodium transport and its quantitative regulation. Sodium enters the epithelial cell by passive diffusion. Active extrusion occurs ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(76)90050-5

    authors: Ziegler TW

    更新日期:1976-05-01 00:00:00

  • Is sleep apnea a predisposing factor for tobacco use?

    abstract::We present a plausible and powerful explanation for nicotine addiction that is consistent with recent findings. Sleep apnea, the periodic cessation of breathing during sleep, may be responsible for the addictive nature of nicotine. The main symptoms of sleep apnea are somnolence and obesity. Nicotine has been shown to...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/s0306-9877(96)90155-3

    authors: Schrand JR

    更新日期:1996-12-01 00:00:00

  • Maternal plasma homocysteine levels in women with preterm premature rupture of membranes.

    abstract::Homocysteine is a sulfur-containing amino acid produced by the breakdown of methionine. Plasma homocysteine levels can be elevated due to a variety of genetic and nutritional factors. Poor nutrition from diets low in folate and vitamin B12 can lead to hyperhomocysteinemia. Mildly elevated levels of homocysteine have b...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.2000.1116

    authors: Ferguson SE,Smith GN,Walker MC

    更新日期:2001-01-01 00:00:00

  • What is the genetic factor in migraine?

    abstract::Migraine is frequently assumed to have an hereditary origin, but what this hereditary factor is, no one really knows. Researchers are currently trying to find defects in genes which could either cause, or tend towards, the development of migraine. This approach is deemed mistaken for two reasons: firstly, pain, being ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/s0306-9877(02)00176-7

    authors: Eidelman D

    更新日期:2002-09-01 00:00:00

  • Metabolic syndrome is a real disease and premalignant state induced by oncogenic stresses to block malignant transformation.

    abstract::Damaged DNA can lead to aneuploidy and/or chromosomal instability, which is believed to be major contributor to tumor progression. Genotoxic and oncogenic stresses-induced DNA damage activate the tumor suppressor pathways initiate DNA damage response (DDR). One of the cellular fates in response to DDR is permanent gro...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2010.01.001

    authors: Erol A

    更新日期:2010-06-01 00:00:00

  • In atherogenesis, the apoptosis of endothelial cell itself could directly induce over-proliferation of smooth muscle cells.

    abstract::Over-proliferation of SMC (smooth muscle cell) is one characteristics of atherosclerosis. One well accepted mechanism is that the decrease of ECs (endothelial cells) induced by over apoptosis leads to endothelial dysfunction, which in turn results in over-proliferation of SMC. Obviously, the mechanism works after endo...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2006.07.037

    authors: Qin C,Liu Z

    更新日期:2007-01-01 00:00:00

  • Could the high consumption of high glycaemic index carbohydrates and sugars, associated with the nutritional transition to the Western type of diet, be the common cause of the obesity epidemic and the worldwide increasing incidences of Type 1 and Type 2 d

    abstract::The globally increasing incidences of Type 1 diabetes (T1DM) and Type 2 diabetes (T2DM) can have a common background. If challenged by the contemporary high level of nutritional glucose stimulation, the β-cells in genetically predisposed individuals are at risk for damage which can lead to the diseases. The fat to car...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2019.02.027

    authors: Sjöblad S

    更新日期:2019-04-01 00:00:00

  • Postencephalitic Parkinson's disease, amyotrophic lateral sclerosis on Guam and influenza revisited: focusing on neurofibrillary tangles and the trail of tau.

    abstract::Circumstantial evidence links neuropathological changes in postencephalitic Parkinson's disease and amyotrophic lateral sclerosis on Guam to the 1918 influenza pandemic. Postencephalitic Parkinson's disease and amyotrophic lateral sclerosis have neuronal neurofibrillary tangles that anatomically correlate with clinica...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.2000.1224

    authors: Maurizi CP

    更新日期:2002-03-01 00:00:00

  • Water pipe smoking and human oral cancers.

    abstract::While cigarette smoking is recognized as an important risk factor in human oral cancers, the effect of water pipe smoking (WPS) on these cancers is not known. WPS is very common in the young adult population, especially in the Middle East, and has been associated with several respiratory problems. However, to date, th...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2009.10.013

    authors: Rastam S,Li FM,Fouad FM,Al Kamal HM,Akil N,Al Moustafa AE

    更新日期:2010-03-01 00:00:00

  • Personality traits of aggression-submissiveness and perfectionism associate with ABO blood groups through catecholamine activities.

    abstract::Personality trait research has shown associations with many genes, prominently those of the catecholamine metabolism such as dopamine beta hydroxylase (DBH), catechol-O-methyltransferase (COMT), and monoamine oxidase A (MAOA). Because DBH gene is in linkage disequilibrium with ABO gene, there is reason to think that o...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2011.04.039

    authors: Hobgood DK

    更新日期:2011-08-01 00:00:00

  • Hormonal and local agents as extracellular regulators of cartilage growth measured by the rate of proteoglycan synthesis. A hypothesis.

    abstract::Following the rate of proteoglycan synthesis as the metabolic parameter of the growth of cartilage cells, indicates that hormonal and local agents are two distinct types of extracellular regulators responsible for altering the basic metabolic rates of cells. Such changes in growth rate occur regularly at physiological...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(80)90057-2

    authors: Nevo Z,Laron Z

    更新日期:1980-04-01 00:00:00

  • Multiple sclerosis: a geographical hypothesis.

    abstract::Multiple sclerosis remains a rare neurological disease of unknown aetiology, with a unique distribution, both geographically and historically. Rare in equatorial regions, it becomes increasingly common in higher latitudes; historically, it was first clinically recognized in the early nineteenth century. A hypothesis, ...

    journal_title:Medical hypotheses

    pub_type: 历史文章,杂志文章

    doi:10.1016/s0306-9877(97)90065-7

    authors: Carlyle IP

    更新日期:1997-12-01 00:00:00

  • The glutathionyl radical formation in the reaction between manganese and glutathione and its neurotoxic implications.

    abstract::Electron spin resonance (ESR) spin trapping methodology has been used to study the reactions of manganese dusts with glutathione, employing alpha-(4-pyridyl-1-oxide)-N-tert-butyl-nitrone (PBN) and 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as spin traps. The results show evidence for the glutathionyl radical formation in...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(90)90184-g

    authors: Shi XL,Dalal NS

    更新日期:1990-10-01 00:00:00

  • Pathophysiology of brain injuries in acute carbon monoxide poisoning: a novel hypothesis.

    abstract::Acute carbon monoxide (CO) poisoning causes the neurologic symptoms and brain lesions during both acute and delayed phase. We propose that catecholamine crises in globus pallidus and deep white matter are the key pathophysiological factors causing acute and delayed brain injuries respectively. Increased sympathetic ac...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2014.04.032

    authors: Park EJ,Min YG,Kim GW,Cho JP,Maeng WJ,Choi SC

    更新日期:2014-08-01 00:00:00

  • How to write up a hypothesis: the good, the bad and the ugly.

    abstract::Medical Hypotheses exists to give ideas and speculations in medicine a fair hearing. Doing this is not easy. Most conventional journals would regard some of what is published here as questionable, most referees would reject it as 'unproven'. We have more liberal standards, for reasons we have presented before. But we ...

    journal_title:Medical hypotheses

    pub_type: 社论

    doi:10.1016/j.mehy.2004.10.003

    authors: Bains W

    更新日期:2005-01-01 00:00:00

  • Autism and Clostridium tetani.

    abstract::Autism is a severe developmental disability believed to have multiple etiologies. This paper outlines the possibility of a subacute, chronic tetanus infection of the intestinal tract as the underlying cause for symptoms of autism observed in some individuals. A significant percentage of individuals with autism have a ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章,评审

    doi:10.1016/s0306-9877(98)90107-4

    authors: Bolte ER

    更新日期:1998-08-01 00:00:00

  • The chlorophyll metabolite phytanic acid is a natural rexinoid--potential for treatment and prevention of diabetes.

    abstract::Synthetic ligands of the retinoid X receptor (RXR) have shown antidiabetic activity in mice, apparently owing to the fact that they stimulate the transcriptional activity of PPAR-gamma/RXR heterodimers, much like thiazolidinedione drugs. The chlorophyll metabolite phytanic acid has been shown to be a natural ligand fo...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.2000.1153

    authors: McCarty MF

    更新日期:2001-02-01 00:00:00