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Gap junctions enhancer combined with Vaughan Williams class III antiarrhythmic drugs, a promising antiarrhythmic method?

Abstract：

:Arrhythmias is one of the leading causes of death in the world. Current antiarrhythmic drugs are limited by unsatisfactory efficacy and adverse effects such as proarrhythmias. Reentry mechanism plays an important role in persistence of arrhythmias. Reentry can only continue when reentry path-length is longer than cardiac wavelength which is equal to the product of conduction velocity (CV) and effective refractory period (ERP). Gap junctions uncoupling is associated with proarrhythmic CV slowing and transmural dispersion of repolarization (TDR) increasing in many cardiac diseases. Vaughan Williams class III antiarrhythmic drugs prolong ERP with an augmented TDR which is the main mechanism of the proarrhythmic effects. Gap junctions enhancer can augment CV and diminish TDR. As a result, gap junctions enhancer combined with class III drugs may be a promising antiarrhythmic method.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Li LD,Zhang CT,Ruan L,Ni MK,Quan XQ

doi

10.1016/j.mehy.2010.08.047

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

119-21

issue

1

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(10)00351-8

journal_volume

76

pub_type

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