The effect of valsartan and nebivolol treatment on ADMA and pentraxin-3 levels in hypertensive patients.

abstract：:Dependence on benzodiazepines (BZDs) or Z-drugs (zolpidem, zopicline and zaleplon) is a common clinical phenomenon. Traditional detoxification of BZDs dependence includes tapering used dose gradually and using equivalent doses of long-acting BZDs as substitutes. This kind of regimen tends to take a long time (up to 4w...

journal_title：Medical hypotheses

authors： Lin SK

更新日期：2014-07-01 00:00:00

abstract：:The thickness of the choroid is measured on the optical coherence tomography (OCT) as the distance between the hyperreflective retinal pigment epithelium and the hyperreflective chorio-scleral junction, contributed by the choroidal vessels and choroidal melanocytes. Our hypothesis is that the amount of absorption and ...

journal_title：Medical hypotheses

authors： Venkatesh R,Reddy NG,Chhablani J

更新日期：2021-01-01 00:00:00

abstract：:The classical form of Barlow's disease or infantile scurvy, with bruises, broken bones and sores that will not heal, is rarely seen today, but it seems to be reappearing under a different guise, when infants with borderline vitamin C depletion are assaulted with too many inoculations at one time.Moreover, it is now so...

journal_title：Medical hypotheses

authors： Clemetson CA

更新日期：2002-07-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, with increasing incidence and prevalence in the last one-half century. IBD patients suffer from autonomic vagal neuropathy and nerve dysfunction, with deficiency of acetylcholine in inflamed mucosa. Recent studies showed that death of enteric neuron ...

journal_title：Medical hypotheses

authors： Guo Y,Lu N,Bai A

更新日期：2012-11-01 00:00:00

abstract：:Many brilliant and ambitious young women lose their drive for top careers after childbirth. New maternal impulses are at odds with their original ambitions and for many mothers stress and frustration will be the result as they have to combine child care with workweeks of 60-80h to reach or remain at the top. Pregnancy...

journal_title：Medical hypotheses

authors： Schulpen TWJ

更新日期：2017-09-01 00:00:00

abstract：:MS risk is associated with low vitamin D status prior to disease, and Epstein Barr virus (EBV) infection seems to be a prerequisite for MS. EBV could activate autoreactive T cells by several mechanisms, but it is not clear why this leads to MS. Only a small proportion of those infected with EBV develops MS, whereas au...

journal_title：Medical hypotheses

authors： Holmøy T

更新日期：2008-01-01 00:00:00

abstract：:The purpose of this paper is to present a model for removing antidromically activated afferent input from cervically elicited neurogenic motor evoked potentials (nMEPs). nMEPs have recently been used clinically, purportedly for monitoring spinal cord motor function, during spine surgery. However, the nMEP response may...

journal_title：Medical hypotheses

authors： Rose RD

更新日期：1998-02-01 00:00:00

abstract：:Over the past decade evidence from multiple research trajectories have converged to provide evidence that impaired glucose metabolism and mitochondrial dysfunction in the brain are the critical issues laying at the root of Bipolar Disorder (BD). These developments have been paralleled by increasing recognition of the ...

journal_title：Medical hypotheses

authors： Campbell I,Campbell H

更新日期：2020-12-01 00:00:00

abstract：:Neurodegenerative diseases are associated with neuronal inclusions, comprised of protein aggregates. In Alzheimer's Disease (AD) and Lewy Body Disease (LBD) such lesions are distributed in a hierarchical retrograde transynaptic spatial pattern. This implies a retrograde transynaptic temporal propagation as well. There...

journal_title：Medical hypotheses

authors： Royall DR

更新日期：2013-02-01 00:00:00

abstract：:Crossed cerebellar diaschisis (CCD) refers to transneuronal degeneration of the corticopontocerebellar pathway, resulting in atrophy of cerebellum contralateral to supratentorial pathology. CCD is traditionally diagnosed on nuclear medicine studies. Our aim is to apply a biexponential diffusion model, composed of intr...

journal_title：Medical hypotheses

authors： Kohannim O,Huang JC,Hathout GM

更新日期：2018-11-01 00:00:00

abstract：:Severe affective and behavioral dysregulation, labeled as severe mood dysregulation (SMD), is a widely spread phenomenon among adolescent psychiatric patients. This phenotype constitutes severe impairment across multiple settings, including various symptoms, such as non-episodic anger, mood instability, and hyperarous...

journal_title：Medical hypotheses

authors： Heiler S,Legenbauer T,Bogen T,Jensch T,Holtmann M

更新日期：2011-10-01 00:00:00

abstract：:An increase in pro-inflammatory cytokines, decrease in endothelial nitric oxide (eNO) and adiponectin levels and an alteration in hypothalamic peptides and gastrointestinal hormones such as incretins and cholecystokinin that regulate satiety, hunger, and food intake occur in metabolic syndrome. Thus, metabolic syndrom...

journal_title：Medical hypotheses

authors： Das UN

更新日期：2011-03-01 00:00:00

abstract：:It is increasingly admitted that Crohn's disease and ulcerative colitis, the two entities of inflammatory bowel disease, are initiated and reactivated by environmental factors in genetically susceptible hosts, and result from aberrant immune response to specific intestinal microbes, in the context of altered compositi...

journal_title：Medical hypotheses

authors： Beaugerie L,Langholz E,Nyboe-Andersen N,Pigneur B,Sokol H,ECCO Epicom.

更新日期：2018-06-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Medical hypotheses

authors： Dillon SP,Kurien BT,Maier-Moore JS,Wiley GB,Gaffney PM,Scofield RH

更新日期：2012-08-20 00:00:00

abstract：:Obesity is a major risk-factor for the development of insulin resistance, type 2 diabetes, and cardiovascular disease. Circulating molecules associated with obesity, such as saturated fatty acids and cholesterol crystals, stimulate the innate immune system to incite a chronic inflammatory state. Studies in mouse model...

journal_title：Medical hypotheses

authors： Demidowich AP,Davis AI,Dedhia N,Yanovski JA

更新日期：2016-07-01 00:00:00

abstract：UNLABELLED:CRPS is an acute pain disease expressed as chronic pain with a severe loss of tissue and function. CRPS usually occurs after minor injuries and then progresses in a way that is scarcely controllable, or completely uncontrollable. This article addresses the functional control mechanism of a biological organis...

journal_title：Medical hypotheses

authors： van der Veen P

更新日期：2015-11-01 00:00:00

abstract：:The exact aetiology of mitral valve prolapse (MVP) is unknown, although this is the most common cardiac valvular abnormality currently detected. MVP has high incidence in young individuals, particularly during the second and third decades. These individuals are usually of a slender body habitus indicating higher rates...

journal_title：Medical hypotheses

authors： Kumar PD

更新日期：2000-02-01 00:00:00

abstract：:The three events, viz. schizophrenia, dissociative anaesthesia and Near-Death Experience, despite their seemingly unrelated manifestation to each other, have nevertheless similar functional basis. All three events are linked to the glutamate sensitive N-methyl-D-aspartate (NMDA) receptor complex, which serves as their...

journal_title：Medical hypotheses

authors： Bonta IL

更新日期：2004-01-01 00:00:00

abstract：:Reconciling the early promising results of radiation therapy in the treatment of epilepsy with the recent theory concerning the role of nonsynaptic mechanisms in focal epileptogenesis, it is suggested that the potential of irradiation as an alternative to temporal lobe resection in intractable epilepsy should be re-ev...

journal_title：Medical hypotheses

authors： Elomaa E

更新日期：1980-05-01 00:00:00

abstract：:A model of human language requires a theory of meaningful marks. Humans are the only species who use marks to think. A theory of marks identifies children's scribbles as significant behavior, while hypothesizing the importance of rotational systems to hominid brain evolution. By recognizing the importance of children'...

journal_title：Medical hypotheses

authors： Sheridan SR

更新日期：2005-01-01 00:00:00

abstract：:Metastasis is the leading cause of cancer death, yet it is mechanistically considered a very inefficient process suggesting the presence of some sort of (e.g. systemic) routes for fuelling the process. The pre-metastatic niche formation is described as one such metastasis promoting route. Now, the emerging potentials ...

journal_title：Medical hypotheses

authors： Ghasemi R,Grassadonia A,Tinari N,Piccolo E,Natoli C,Tomao F,Iacobelli S

更新日期：2013-01-01 00:00:00

abstract：UNLABELLED:T helper (Th) lymphocytes have been classified into distinct subsets, Th1 and Th2 on the basis of the cytokines they produce. According to the cross-regulatory properties of Th1 and Th2 cells, one would assume that to be affected by a Th1 type disease increases susceptibility to a Th1 type disease and inhibi...

journal_title：Medical hypotheses

authors： Shahabi S,Hassan ZM,Jazani NH,Ebtekar M

更新日期：2006-01-01 00:00:00

abstract：:Several hypotheses have been developed to interpret the progression of tubulointerstitial fibrosis (TF), including senescence, epithelial-mesenchymal transition, inflammation, chronic hypoxia, and reactive oxygen species. All of these hypotheses are based on persistent cell injury and localized cell death. Proliferati...

journal_title：Medical hypotheses

authors： Chen BC,Bai YH,Tang LL,Wang BQ,Liu B,Cai Y,Peng X,Yang YR,Zheng SL

更新日期：2014-06-01 00:00:00

abstract：:Tinnitus and temporomandibular joint dysfunction (TMJD) are among the most common complaints encountered by physicians. Though the relationship between tinnitus and TMJD has attracted great interest during the past several years, theories attempting to explain this association are still few and inconsistent. Conceivab...

journal_title：Medical hypotheses

authors： Salvinelli F,Casale M,Paparo F,Persico AM,Zini C

更新日期：2003-10-01 00:00:00

abstract：:Except for a few diseases of molecular mimicry such as rheumatic fever, post-streptococcal glomerulonephritis in children, and gluten-sensitive enteropathy, the cause of autoimmune diseases is unknown. Most autoimmune diseases are remitting-relapsing and the pathophysiology of either the initial attack or subsequent r...

journal_title：Medical hypotheses

authors： Eggers AE

更新日期：2013-05-01 00:00:00

abstract：:Helical bundles are found in all the known structures of peanut allergens. The peptide fragments, which survive gastrointestinal digestion of the allergens and are absorbed intact, are hypothesized to reassociate and form stable helical bundles in the circulation, which could elicit a specific IgE response resulting i...

journal_title：Medical hypotheses

authors： Mikita CP,Padlan EA

更新日期：2012-11-01 00:00:00

abstract：:The presence of the tumour induces important metabolic changes in the cancer patient which are not merely due to the fact that the tumour acts as a parasite, thus depleting the host of nutrients, but that are mainly the result of both tumoral and humoral mediators. The new metabolic status of the cancer patient may le...

journal_title：Medical hypotheses

authors： Argilés JM,López-Soriano FJ

更新日期：1998-11-01 00:00:00

abstract：:Benign intracranial hypertension and communicating hydrocephalus are uncommon but important disorders that affect cerebrospinal fluid dynamics. They have clinical similarities but their management is usually different. The factors determining which of the two disorders will develop include brain compliance, the state ...

journal_title：Medical hypotheses

authors： Salman MS

更新日期：1997-11-01 00:00:00

abstract：:Relapse to cocaine, heroin, and alcohol is a common occurrence in ex-abusers of these substances. Although there are many potential causes for relapse, we postulate that one cause in some people may be re-exposure in an anesthesia setting to a drug similar to the formerly abused drug. We hypothesize, for example, that...

journal_title：Medical hypotheses

authors： Sadeghi P,Zacny JP

更新日期：1999-12-01 00:00:00

abstract：:Chronic fatigue syndrome (CFS) has gained prominence since 1988 and a substantial amount of research has been done in this domain. However, it is still regarded as a controversial condition. Moreover, most of the symptoms of CFS itself are non-specific, occurring in many illnesses; some of the symptoms are also common...

journal_title：Medical hypotheses

authors： Van Hoof E,Cluydts R,De Meirleir K

更新日期：2003-07-01 00:00:00