Is there a local production of nitrosamines by the vaginal microflora in anaerobic vaginosis/trichomoniasis?

abstract：:I have previously assumed that stem tumour cells are 'para-embryonal cells' (PECs) poor or missing in major histocompatibility complex (MHC) antigens. PECs might induce adjoining differentiated hyperplastic cells to also express tumoral phenotype and properties, thus transforming them into 'differentiated para-embryon...

journal_title：Medical hypotheses

authors： Manzo G

更新日期：1998-05-01 00:00:00

abstract：:The prevalence of adult and childhood obesity are increasing. Most of the human newborn's body fat accumulates in the last half of intrauterine life. Fat in the fetus was thought to be mostly synthesized from glucose, but now it is commonly accepted that the bulk of it is the product of placental transfer of maternal ...

journal_title：Medical hypotheses

authors： Szabo AJ

更新日期：2019-01-01 00:00:00

abstract：:Endothelial dysfunction due to reduced bioavailability of nitric oxide (NO) is an early step in the course of atherosclerotic cardiovascular disease (CVD). NO is synthesized from L-arginine via the action of NO synthase (NOS), which is known to be blocked by endogenous L-arginine analogues such as asymmetric dimethyla...

journal_title：Medical hypotheses

authors： Yamagishi S,Ueda S,Okuda S

更新日期：2007-01-01 00:00:00

abstract：:The angiotensin-converting enzyme 2(ACE-2) receptors with approx. 0.8% congestion in conjunctival surface, leads to increase susceptibility of Covid-19 transmission through ocular surface. It has been observed that prophylactic measures such as goggle or face shield are unable to offer complete protection against ocul...

journal_title：Medical hypotheses

authors： Sahu DK,Pradhan D,Naik PK,Kar B,Ghosh G,Rath G

更新日期：2020-11-01 00:00:00

abstract：:Cancer cells proliferate and metastasize against the body's defense mechanisms due to their ability to change in response to challenges, both from the body's internal defenses as well as those from external sources, such as radiation and chemotherapy. This ability of tumor cell populations to change and grow in respon...

journal_title：Medical hypotheses

authors： Pienta KJ,Ward WS

更新日期：1994-01-01 00:00:00

abstract：:The N-methyl-d-aspartate receptor (NMDAR) encephalitis is the most common form of autoimmune encephalitis. Antibodies against the GluN1 subunit of the NMDAR showed in primary cultures of rat hippocampal neurons and in a mouse model pathogenic effects including cross-linking and internalization of the target receptors ...

journal_title：Medical hypotheses

authors： Ismail FS,Faustmann PM

更新日期：2020-06-01 00:00:00

abstract：:Incretin hormones have trophic effects on beta cell function that can aid prevention and treatment of diabetes. cAMP is the primary mediator of these effects, and has been shown to potentiate glucose-stimulated insulin secretion, promote proper beta cells differentiation by increasing expression of the crucial transcr...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2006-01-01 00:00:00

abstract：:Initial diagnosis of acute kidney injury (AKI) is usually based on measuring serum-creatinine and blood urea nitrogen levels; however such measurements are still poor in identifying renal injuries at initial stages. These standard matrices are not enough to monitor the outcome and progression of AKI. The prognosis pre...

journal_title：Medical hypotheses

authors： Singh V

更新日期：2016-10-01 00:00:00

abstract：:It has been uncovered that expansion of trinucleotide repeats in the human genome are causing a variety of genetic diseases. They are also identified in other loci that are not clearly related to particular diseases, which indicates such repeat expansion is one of the general forms of evolution occurring throughout th...

journal_title：Medical hypotheses

authors： Kubota S

更新日期：2001-03-01 00:00:00

abstract：:Acute stroke, including acute ischemic stroke (AIS) and acute hemorrhagic stroke, (AHS) is a common medical problem with particular relevance to the demographic changes in industrialized societies. In recent years, treatments for AIS have emerged, including thrombolysis with tissue plasminogen activator (t-PA). Althou...

journal_title：Medical hypotheses

authors： Kikuchi K,Kawahara K,Miyagi N,Uchikado H,Kuramoto T,Morimoto Y,Tancharoen S,Miura N,Takenouchi K,Oyama Y,Shrestha B,Matsuda F,Yoshida Y,Arimura S,Mera K,Tada K,Yoshinaga N,Maenosono R,Ohno Y,Hashiguchi T,Maruyama

更新日期：2010-12-01 00:00:00

abstract：:We suggest that polymyalgia rheumatica with giant cell arteritis (PR-GCA) is an arachidonic acid metabolites mediated disease which can be diagnosed more accurately and monitored more precisely for therapeutic benefits by the serial determinations of the major urinary prostaglandin F, serum urinary lysozymes, serum ac...

journal_title：Medical hypotheses

authors： Nalbandian RM,Henry RL,Williams GA,Fleischman JA,O'Donnell FE Jr,Reeser FH

更新日期：1981-09-01 00:00:00

abstract：:Cardiac chambers have afferent connections to the brainstem and to the spinal cord. Vagal afferents mediate depressor responses and become activated by volume expansion, increased myocardial contractility and atrial natriuretic factor. Sympathetic afferents, on the contrary, are activated by metabolic mediators, myoca...

journal_title：Medical hypotheses

authors： Davila DF,Donis JH,Bellabarba G,Torres A,Casado J,Mazzei de Davila C

更新日期：2000-02-01 00:00:00

abstract：:Left ventricular thrombus (LVT) after acute myocardial infarction (AMI) remains to be a common complication bearing adverse prognostic implication. Majority of LVT occurs within the first week after AMI. Over decades, the regional stasis of blood flow is regarded as the main reason for LVT formation. Here we hypothesi...

journal_title：Medical hypotheses

authors： Ma S,Lu Q,Hu H,Du XJ

更新日期：2020-11-01 00:00:00

abstract：:Cancer is caused by a combination of factors, genetic, epigenetics and environmental. Among the latter, environmental pollutants absorbed by contact, inhalation, or ingestion are major proven or suspected culprits. Depleted uranium (DU) is one of them directly pertinent to the military and civilians working in militar...

journal_title：Medical hypotheses

authors： Cappello F,Macario AJL

更新日期：2019-03-01 00:00:00

abstract：:Hypertension has become a large burden of global development, but the mechanisms of it have still not been well elucidated. Increased contractility of vascular smooth cells induced by the overactivity of neurohormonal system or stress is one of the main and popular explanations until now. Smoothelin-B, recognized as t...

journal_title：Medical hypotheses

authors： Li SH,Hui RT

更新日期：2009-07-01 00:00:00

abstract：:A possible mechanism for maintaining immune memory, based on idiotypic-anti-idiotypic interactions, is described. It is proposed that pendular dynamic swings in the levels of idiotypic antibodies (Ab1) and anti-idiotypic Ab2 may underlay immune memory. In the terms of the advanced concept, Ab dynamics in the maternal ...

journal_title：Medical hypotheses

authors： Seledtsov VI,Seledtsova GV

更新日期：2001-02-01 00:00:00

abstract：:The U.S. Environmental Protection Agency's (EPA) proposed drinking water standard for radium-226 (226Ra) of 5 pCi/l is evaluated according to its health basis and carcinogenic implications. Proposed health risks of 226Ra in drinking water by other leading theoreticians (Evans, Gofman-Tamplin and Peterson) are also con...

journal_title：Medical hypotheses

authors： Riddiough CR,Musselman R,Calabrese EJ

更新日期：1977-09-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative condition characterized by tremor, rigidity, bradykinesia, and postural instability. Smoking is an inverse risk factor for Parkinson's disease, although the mechanism for this apparent neuroprotection is not definitively established. Smoking consistently upregulates nicotinic...

journal_title：Medical hypotheses

authors： Chapman MA

更新日期：2009-12-01 00:00:00

abstract：:The inverse association between maternal folate status and incidence of infants born with neural tube defects (NTD's) was recognized over twenty years ago and led the US health agencies in the early 1990s to recommend that women of childbearing age consume 400 microg of folic acid each day. The FDA followed by mandati...

journal_title：Medical hypotheses

authors： Rogers EJ

更新日期：2008-09-01 00:00:00

abstract：:Bacterial biofilms have been found in many human bacterial infectious processes including chronic rhinosinusitis. It was found also at the surface of nasal polyps, and both at the surface of the nasal part and the stalk of the antrochoanal polyp. However, our recent research clearly demonstrated the presence of the bi...

journal_title：Medical hypotheses

authors： Mladina R,Skitarelić N

更新日期：2010-10-01 00:00:00

abstract：:Trigeminal neuralgia (TN) is a rare form of neuropathic pain that results in sudden, unilateral and recurrent pains in the distribution of one or more branches of the trigeminal nerve. The aetiology of TN remains unclear and several theories have been proposed. Many medical and surgical methods have been applied with ...

journal_title：Medical hypotheses

authors： Collet C,Haen P,Laversanne S,Brignol L,Thiéry G

更新日期：2013-12-01 00:00:00

abstract：:Superficial fraying, splitting and fibrillation of articular cartilage as a consequence of ageing or mechanical injury is not always associated with joint pain. However, similar cartilage lesions accompanied by synovitis and engorgement of the subchondral vasculature generally is; the disorder being known as osteoarth...

journal_title：Medical hypotheses

authors： Ghosh P,Smith M

更新日期：1993-08-01 00:00:00

abstract：:The etiology of intra-abdominal adhesions is explained by hydrolysis of the peritoneal phospholipid layer caused by phospholipase A2 activity. This view could unify the pre-existing hypotheses that intra-abdominal adhesions are due to ischemia or increased plasminogen activator activity. New therapeutic approaches are...

journal_title：Medical hypotheses

authors： Snoj M

更新日期：1993-12-01 00:00:00

abstract：:Some drugs blocking glutamate release produce reduced brain injury in some animal models of cerebral ischemia whereas others lack a clear effect. Meta-analysis is a widely used technique in clinical and epidemiological studies. However, it has never been used in the analysis of preclinical studies. In order to estimat...

journal_title：Medical hypotheses

authors： Nava-Ocampo AA,Reyes-Pérez H,Bello-Ramírez AM,Mansilla-Olivares A,Ponce-Monter H

更新日期：2000-01-01 00:00:00

abstract：:The most important obstacle for preventing hypertension is the belief that systemic hypertension has no identifiable cause. This belief, hiding the main offender, sodium chloride, causes too much time wasting for combating against hypertension. Accepting that sodium chloride is a drug and re-evaluating the situation a...

journal_title：Medical hypotheses

authors： Tekol Y

更新日期：2006-01-01 00:00:00

abstract：:It is postulated that the metabolically variable fine structure of pericellular heparan glycosaminoglycans affects the ability of these molecules to influence cell proliferation-associated proteinase-catalysed reactions occurring at cell surfaces. Evidence suggesting the possibility of a wide repertoire of glycosamino...

journal_title：Medical hypotheses

authors： Long WF,Williamson FB

更新日期：1983-07-01 00:00:00

abstract：:Intra-peritoneal adhesions ensuing from surgery or infection may lead to chronic pelvic pain, bowel obstruction, infertility and additional invasive surgery to resolve adhesion-related complications. As a result adhesions are a major clinical, social and economic concern. The cumulative year-on-year direct costs of ad...

journal_title：Medical hypotheses

authors： Sadek K,Macklon N,Bruce K,Cagampang F,Cheong Y

更新日期：2011-03-01 00:00:00

abstract：:Oesophageal carcinoma is a devastating disease with a poor prognosis. This hypothesis shows how prostaglandin E2 exerts carcinogenic effects in the oesophagus. The contribution of prostaglandin E2 is related to other factors that predispose to oesophageal carcinoma. The implication of the hypothesis is that nonsteroid...

journal_title：Medical hypotheses

authors： Morgan G

更新日期：1997-02-01 00:00:00

abstract：:Space adaptation syndrome (SAS) incapacitates about 50% of the astronauts with symptoms of headache, malaise, vomiting, vertigo, etc. A hypothesis that SAS is caused by elevated intracranial pressure secondary to the cephalad fluid shift in zero G is proposed. A mechanism of how the cephalad fluid shift could cause el...

journal_title：Medical hypotheses

authors： Jennings T

更新日期：1990-08-01 00:00:00

abstract：:The current epidemic of obesity has developed at a rate that cannot be attributed to genetic drift. Attempts to treat obesity using diet and activity have been largely disappointing. Genes are fixed at conception, but genetic expression is known to be influenced by nutriture during the stages of growth and development...

journal_title：Medical hypotheses

authors： Blonz ER

更新日期：2006-01-01 00:00:00