Abstract:
:Space adaptation syndrome (SAS) incapacitates about 50% of the astronauts with symptoms of headache, malaise, vomiting, vertigo, etc. A hypothesis that SAS is caused by elevated intracranial pressure secondary to the cephalad fluid shift in zero G is proposed. A mechanism of how the cephalad fluid shift could cause elevated intracranial pressure is discussed. Factors known to alleviate and exacerbate SAS are interpreted in light of the elevated intracranial pressure mechanism.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Jennings Tdoi
10.1016/0306-9877(90)90108-qsubject
Has Abstractpub_date
1990-08-01 00:00:00pages
289-91issue
4eissn
0306-9877issn
1532-2777pii
0306-9877(90)90108-Qjournal_volume
32pub_type
杂志文章abstract::The symptom spectra of several 'popular press' diagnoses are examined and compared to Diagnostic and Statistical Manual of Mental Disorders-IIIR criteria for somatization disorder, depression, and generalized anxiety disorder. While there is much overlap, there are clear distinctions, and these psychiatric terms do no...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(96)90182-6
更新日期:1996-04-01 00:00:00
abstract::A hypothesis which explains disease prevalence among different socio-economic groups following early infantile modulation of cell-mediated immunity by infection and nutrition related stress is presented. Wealthy populations living under highly hygienic circumstances can develop their cell-mediated immunity to genetic ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(75)90002-x
更新日期:1975-11-01 00:00:00
abstract::In the present report we have developed a mathematical model to describe the processes involved during high steroid therapy. We have shown that the model can predict clinical observations as well as determine the optimum steroid regimen without relying on trial and error methods. The model incorporates rate processes ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2001.1308
更新日期:2001-07-01 00:00:00
abstract::A new approach to antiviral therapy is proposed, taking advantage of the recently investigated innervation of immune tissues by the sympathetic nervous system, which establishes a functional connection between the nervous and the immune system, where the sympathetic nervous system exerts a varying tonic inhibitory inf...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(95)90097-7
更新日期:1995-10-01 00:00:00
abstract::In early synovitides the tissue inflammatory cell reaction is often weak and sometimes absent, many alterations being consistent with nonvasculitic exudation (I). Increased permeability to protein may require little, if any, endothelial damage. In rheumatoid arthritis (RA) increased transfer of fluid and protein from ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(82)90063-9
更新日期:1982-07-01 00:00:00
abstract::Purpura fulminans is a life threatening complication of many septic states, most notably meningococcaemia. It can also occur due to congenital deficiency of anticoagulant proteins. The pathophysiology of purpura fulminans is complex and not fully understood, but involves abnormalities of coagulation pathways, damage t...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.11.011
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Migraine is a highly prevalent, disabling, and costly disorder worldwide. From a long time ago, headaches have been known to be associated with gastrointestinal (GI) disorders. Headaches originating from gastric complaints were appreciated by Persian Medicine (PM) scholars. Today, functional GI disorders are...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.02.041
更新日期:2019-04-01 00:00:00
abstract::It is well known, that most of the psychiatric diseases affect various neurotransmitter systems. It is the aim of this profile to define a set of cheap analyses, indicative for a specific psychiatric disease, to facilitate differential diagnosis and to offer an additional tool to the already existing clinical-descript...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.06.023
更新日期:2011-10-01 00:00:00
abstract::Foster found areas with the highest incidence of SIDS in USA in 1983-1984 coincided with the highest areas recorded with the highest incidence of goitre in First World War troops (1). Reid compared the two populations described as having the highest incidence of SIDS worldwide. Both were selenium deficient areas (King...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(94)90124-4
更新日期:1994-04-01 00:00:00
abstract::A new hypothesis concerning the association of low levels of steroid hormones and hypercholesterolemia is proposed. This study presents data that concurrent restoration to youthful levels of multiple normally found steroid hormones is able to normalize or improve serum total cholesterol (TC). We evaluated 20 patients ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(02)00324-9
更新日期:2002-12-01 00:00:00
abstract::Articles dealing with the epidemiological aspects of asthma were carefully reviewed in order to support or reject our clinical impression of increased rate of asthma among immigrants. Particular emphasis was put on data on very high or very low rates of asthma. The proposed theories to explain these differences were c...
journal_title:Medical hypotheses
pub_type: 杂志文章,meta分析
doi:10.1016/s0306-9877(98)90047-0
更新日期:1998-10-01 00:00:00
abstract::Currently, drug repurposing is an alternative to novel drug development for the treatment of COVID-19 patients. The antimalarial drug chloroquine (CQ) and its metabolite hydroxychloroquine (HCQ) are currently being tested in several clinical studies as potential candidates to limit SARS-CoV-2-mediated morbidity and mo...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109815
更新日期:2020-09-01 00:00:00
abstract::The German doctor Hermann Kümmell described Kümmell's disease as the clinical scenario in which patients suffer a trivial spinal trauma, but develop a symptomatic, progressive, angular kyphosis after a symptom-free period of months to years. Since an intravertebral vacuum phenomenon, which is considered indicative of ...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2011.08.005
更新日期:2011-11-01 00:00:00
abstract::Pulmonary congestion is a hallmark feature of heart failure and is a major reason for hospital admissions in this patient population. Heart failure patients often demonstrate restrictive and obstructive pulmonary function abnormalities; however, the mechanisms of these changes remain controversial. It has been suggest...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.03.033
更新日期:2009-09-01 00:00:00
abstract::This paper treats evidence for an increasing recognition of a force with intangible properties in biosystems with special reference to its ability to transport electrons at near 0 degree Kelvin. It is implied that such force, whose demonstration at these temperatures is an experimental contrivance to emphasise its str...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(95)90517-0
更新日期:1995-06-01 00:00:00
abstract::Along with oxygen, glucose is an essential macronutrient for most cells, a source of carbons for biosynthesis and energy. However, alongside this indispensable role for cell survival and growth, glucose is intrinsically toxic by reacting with primary amines such as lysine in proteins in a non-enzymatic glycation proce...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.02.017
更新日期:2005-01-01 00:00:00
abstract::Analysis of the age distribution of cancers of the uterus reveals three clearly distinctive types: early- and late-onset cancers of the cervix and one form of cancer of the corpus. England and Wales mortality data are available for the three types combined from 1911; cancers of the cervix and corpus have been listed s...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(86)90086-1
更新日期:1986-05-01 00:00:00
abstract:AIMS:To investigate the role of urinary BK polyoma virus (BKPyV) in the pathophysiology and prognosis of patients with painful bladder syndrome/interstitial cystitis (PBS/IC). METHODS:Urine samples were collected from 15 patients with PBS/IC and 8 control patients (with urolithiasis, overactive bladder and benign pros...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.06.004
更新日期:2014-09-01 00:00:00
abstract::A hypothesis is presented describing the operation of mammalian brains on the basis of rapid percussion chemical reactions and shock waves generated by such reactions. It is shown that the products of these are various chemical compounds identified as present in the brain. The manner in which the brain deals with vari...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(02)00296-7
更新日期:2002-12-01 00:00:00
abstract::Several hypotheses have been developed to interpret the progression of tubulointerstitial fibrosis (TF), including senescence, epithelial-mesenchymal transition, inflammation, chronic hypoxia, and reactive oxygen species. All of these hypotheses are based on persistent cell injury and localized cell death. Proliferati...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.01.014
更新日期:2014-06-01 00:00:00
abstract::Duchenne muscular dystrophy (DMD) is a lethal muscle wasting disease caused by a lack of dystrophin, which eventually leads to apoptosis of muscle cells and impaired muscle contractility. Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated protein 9 (CRISPR/Cas9) gene editing of induced pluripo...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.11.009
更新日期:2018-01-01 00:00:00
abstract::The lymphatic system is an important component of human health and is critical in maintaining microcirculatory flow and immune system homeostasis. During septic shock, increased capillary permeability results in excess filtration of intravascular fluid and solutes producing interstitial edema with subsequent hydrostat...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109748
更新日期:2020-09-01 00:00:00
abstract::Non-union after bone fracture is rather common with an increasing frequency of incidence rate due to poorly treated early operations, among which the mechanism of atrophic non-union remains unclear. Previous opinions showed that impaired blood supply of affected limbs might mostly contribute to the atrophic non-union,...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.03.027
更新日期:2011-07-01 00:00:00
abstract::Narcolepsy is a disorder characterized by the sudden urge to sleep. The biochemical etiology of this disorder is believed to be due to dopamine abnormalities. Since the precursor of dopamine is L-tyrosine, the administration of this amino acid may prove beneficial in the treatment of narcolepsy. Preliminary research a...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(90)90141-z
更新日期:1990-12-01 00:00:00
abstract::Stressful events occur in the lives of millions of individuals each year. Such events, or "stressors", are experiences that threaten personal well-being, and include traumatic events such as motor vehicle collision, infectious illness, and situations such as military deployment. While most individuals recover from suc...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.03.022
更新日期:2004-01-01 00:00:00
abstract::Parkinson's disease (PD) is a long-term degenerative disease that primarily affects the motor system of the central nervous system. This disease is difficult to diagnose and is one of the common diseases in the public. In this paper, we have proposed a novel data sampling method for the classification of Parkinson dis...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109678
更新日期:2020-03-16 00:00:00
abstract::It is proposed that there is biological regulation of the low molecular weight antioxidant (LMWA) status of the body, and that these different antioxidants work in concert and in homeostasis as a system analogous to the regulation of acid-base status (pH). The theoretical design characteristics for such a system inclu...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1998.0786
更新日期:1999-11-01 00:00:00
abstract::The precise role of erythrophagocytosis in sickle cell disease is not known. Using hematological data from three studies and 791 subjects comprising of eight epidemiological groups, we found a strong statistical support for the hypothesis that erythrophagocytosis is increased in sickle cell trait, that neutrophils and...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.09.044
更新日期:2007-01-01 00:00:00
abstract::It has been shown previously that the precipitator hypothesis of causation is able to account for certain key features of the epidemiological evidence that conflict with initiator and promoter hypotheses. The precipitator hypothesis states that the carcinogenic risk depends linearly in the average rate of smoking at a...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(81)90145-6
更新日期:1981-12-01 00:00:00
abstract::So far, the pathogenesis of Alzheimer's disease (AD) has not been clarified, nor has patient therapy been satisfactory. Although inheritance dominates the less frequent early-onset AD in young and middle-aged individuals, environmental and immunogenetic factors have been identified in the most frequently occurring lat...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.12.001
更新日期:2017-02-01 00:00:00