A new approach to antiviral therapy.


:A new approach to antiviral therapy is proposed, taking advantage of the recently investigated innervation of immune tissues by the sympathetic nervous system, which establishes a functional connection between the nervous and the immune system, where the sympathetic nervous system exerts a varying tonic inhibitory influence on cellular activation via secretion of norepinephrine and reception thereof by beta-receptors on leukocytes. Simultaneous beta-adrenergic blockade of leukocytes and stress-related centres of the central nervous system (paraventricular nucleus of the hypothalamus) is suggested as immunoactivating therapy in presence of foreign antigen. Immunoactivation is newly defined as facilitated activation of the immune system in presence of foreign antigen and is theoretically correlated with indirect antiviral and antitumoral activity.


Med Hypotheses


Medical hypotheses


Peuschel KE




Has Abstract


1995-10-01 00:00:00














  • Possible physiological roles of acetone metabolism in humans.

    abstract::Recently, the metabolic routes for acetone metabolism have been described. Therefore, acetone cannot further be regarded as a waste product of metabolism. However, its physiological role in biochemical machinery is not clear. Here, an integrative model for the role of acetone metabolism is presented that orders the ev...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Kalapos MP

    更新日期:1999-09-01 00:00:00

  • Fluctuation of intra-parenchymal cerebral pressure may drive the rapid spontaneous resolution of acute subdural hematoma.

    abstract::Acute subdural hematoma (ASDH) is a severe insult with a high mortality rate, and emergent surgical evacuation is recommended in the vast majority of such cases. Generally, resolution of the hemorrhage requires weeks and months in patients treated conservatively. However, numerous cases of rapid spontaneous resolution...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Liu B,Zhuang Z,Luo J

    更新日期:2013-08-01 00:00:00

  • Alpha helix capping and the conformation of threonine.

    abstract::The amino acid threonine contains two chiral carbons and thus can exist in four possible conformations. However, only a single conformation (2S, 3R) of threonine is incorporated in proteins by the cellular translation material. The conformation at the alpha carbon (carbon 2) is the same as that of the other amino acid...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Altschuler EL

    更新日期:2001-04-01 00:00:00

  • Does bitter melon contain an activator of AMP-activated kinase?

    abstract::Extracts of the unripe fruit of Momordica charantia--bitter melon, which flourishes throughout the tropics--appear to have utility in the management of type 2 diabetes. Rodent studies suggest that the thus-far-uncharacterized active components of such extracts enhance the efficiency of postprandial glucose storage in ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: McCarty MF

    更新日期:2004-01-01 00:00:00

  • The coordinated action of lecithin:retinol acyltransferase and cellular retinol-binding proteins for regulation of vitamin A esterification.

    abstract::Vitamin A is a fat-soluble vitamin required for many physiological functions. The intracellular transport of vitamin A is assisted by proteins called cellular retinol-binding proteins (CRBP I/II). The absorption, storage and usage of vitamin A are regulated by a protein called lecithin:retinol acyltransferase (LRAT), ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Mezaki Y,Fujimi TJ,Senoo H,Matsuura T

    更新日期:2016-03-01 00:00:00

  • Progression of cancer.

    abstract::Carcinoma constitution originates in the hetero-duplication mitoses (4) which divide non-maturable stem cells into two different types of daughter cells: maturable and non-maturable cancerous stem cells. Throughout the progression of such mitoses, the organoid continuity of the cancer depends only on the non-maturable...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Hirata Y

    更新日期:1999-06-01 00:00:00

  • High meniscal slope angle as a risk factor for meniscal allograft extrusion.

    abstract::A meniscal graft extrusion is still an unresolved problem that affects most patients after a meniscal transplantation. Despite the advances in surgical techniques, together with the improved methods for a meniscal allograft sizing, success is only observed in up to 75% of patients after they experience a meniscal allo...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Łuczkiewicz P,Daszkiewicz K,Chróścielewski J,Witkowski W,Kuik L

    更新日期:2017-04-01 00:00:00

  • Does smoking reduce the risk of Parkinson's disease through stimulation of the ubiquitin-proteasome system?

    abstract::Parkinson's disease is a neurodegenerative condition characterized by tremor, rigidity, bradykinesia, and postural instability. Smoking is an inverse risk factor for Parkinson's disease, although the mechanism for this apparent neuroprotection is not definitively established. Smoking consistently upregulates nicotinic...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Chapman MA

    更新日期:2009-12-01 00:00:00

  • Why it is 'better' to be reliable but dumb than smart but slapdash: are intelligence (IQ) and Conscientiousness best regarded as gifts or virtues.

    abstract::The psychological attributes of intelligence and personality are usually seen as being quite distinct in nature: higher intelligence being regarded a 'gift' (bestowed mostly by heredity); while personality or 'character' is morally evaluated by others, on the assumption that it is mostly a consequence of choice? So a ...

    journal_title:Medical hypotheses

    pub_type: 社论


    authors: Charlton BG

    更新日期:2009-10-01 00:00:00

  • A novel immunotherapy to hepatocellular carcinoma: CD40-activated B lymphocytes transfected with AFPmRNA.

    abstract::Alpha-fetoprotein (AFP) is overexpressed in the majority of hepatocellular carcinomas (HCCs), and thus may offer attractive target for immunotherapy against this neoplasm. CD40 ligand (CD40L) is the major signal that induces B cells to efficiently present antigen to T cells, and CD40-activated B (CD40-B) lymphocyte ce...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Wan Y,Ma X,Li X,Yi J

    更新日期:2009-11-01 00:00:00

  • Why can't Chinese Han drink alcohol? Hepatitis B virus infection and the evolution of acetaldehyde dehydrogenase deficiency.

    abstract::An aldehyde-dehydrogenase (ALDH2) deficiency is a biological curb on excess alcohol-drinking. This enzyme deficiency is very common amongst Oriental people while it is relatively rare for most other populations. We observe that there is good geographical correlation between the prevalence of the mutant ALDH2*2 alleles...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Lin YP,Cheng TJ

    更新日期:2002-08-01 00:00:00

  • Nicotine and cigarette smoking: an alternative hypothesis.

    abstract::A new hypothesis is presented to explain some aspects of human smoking behaviour. While acknowledging the importance of the nicotine self-titration phenomenon, changes in puffing intensity during the smoking of a single cigarette are related not to the control of nicotine uptake but to the modification of cigarette sm...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Chamberlain AT,Higenbottam TW

    更新日期:1985-08-01 00:00:00

  • New insights in atherosclerosis: endothelial shear stress as promoter rather than initiator.

    abstract::The etiology of focal distribution of atherosclerotic lesions has received much attention for many years. Current theories focus on mechanical factors such as low endothelial shear stress as an initiating factor for atherosclerosis formation. However, some evidences revealed that it could not be initiator of endotheli...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Mehdizadeh A,Norouzpour A

    更新日期:2009-12-01 00:00:00

  • Sympathetic nervous system plays an important role in the relationship between immune mediated diseases.

    abstract:UNLABELLED:T helper (Th) lymphocytes have been classified into distinct subsets, Th1 and Th2 on the basis of the cytokines they produce. According to the cross-regulatory properties of Th1 and Th2 cells, one would assume that to be affected by a Th1 type disease increases susceptibility to a Th1 type disease and inhibi...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Shahabi S,Hassan ZM,Jazani NH,Ebtekar M

    更新日期:2006-01-01 00:00:00

  • Myotonic dystrophy: a disease caused by functional zinc deficiency due to an abnormal zinc-binding ligand?

    abstract::There are large amounts of zinc in muscle and zinc ions can enhance the degree of muscle contraction in response to direct stimulation while at the same time inhibiting neuromuscular transmission. The opposites of these effects would lead to myotonia and muscle weakness. There are many parallels between the non-muscul...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Horrobin DF,Morgan RO

    更新日期:1980-04-01 00:00:00

  • Tumorigenesis and cell evolution.

    abstract::All kinds of hypotheses have been proposed to explain the mechanism of tumorigenesis. Up until now, we have not had any generally acknowledged model that helps us understand the process. In this paper, I propose a dynamic model of how tumor cells escape the supervision of the immune system; I also examine the possibil...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Cai DW

    更新日期:1995-05-01 00:00:00

  • Practical prevention of cardiac remodeling and atrial fibrillation with full-spectrum antioxidant therapy and ancillary strategies.

    abstract::A wealth of research data points to increased oxidative stress as a key driver of the cardiac remodeling triggered by chronic pressure overload, loss of functional myocardial tissue, or atrial fibrillation. Oxidative stress is a mediator of the cardiomyocyte hypertrophy and apoptosis, the cardiac fibrosis, and the def...

    journal_title:Medical hypotheses

    pub_type: 杂志文章,评审


    authors: McCarty MF

    更新日期:2010-08-01 00:00:00

  • Unexpected and unexplained increase in death due to neurological disorders in 2012 in England and Wales: is cytomegalovirus implicated?

    abstract::In early 2012 deaths (all-cause mortality) in England and Wales showed an unexpected and unexplained increase which continued for 18 months before abating. The highest percentage increase in deaths was noted to be for neurological degenerations (mainly dementia, Alzheimer's, Parkinson's). This study seeks to understan...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Jones RP,Goldeck D

    更新日期:2014-07-01 00:00:00

  • The Salted Food Addiction Hypothesis may explain overeating and the obesity epidemic.

    abstract:UNLABELLED:One plausible explanation for the controversy that surrounds the causes and clinical management of obesity is the notion that overeating and obesity may only be a couple of "symptoms" associated with a yet to be discovered medical disorder. OBJECTIVES:To introduce the Salted Food Addition Hypothesis. This t...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Cocores JA,Gold MS

    更新日期:2009-12-01 00:00:00

  • Zinc-controlled Th1/Th2 switch significantly determines development of diseases.

    abstract::Functional, excessive-possibly temporary-deficiencies of the trace element zinc can change immune functions prematurely from predominantly cellular Th1 responses to humoral Th2 responses. T helper (Th1) cells produce cytokines such as interleukin-2 (IL-2) and interferon gamma, thereby controlling viral infections and ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Sprietsma JE

    更新日期:1997-07-01 00:00:00

  • Analgesics abuse: theoretical and practical considerations.

    abstract::Three important issues must be addressed in any attempt to determine whether combination painkillers play a role in analgesic nephropathy. The first issue, namely that of a causal link between the combination itself and nephrotoxicity, has never been adequately documented. On the contrary, there is much evidence that ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Driesens F,Awouters F,Goossens T,Janssen P

    更新日期:1993-01-01 00:00:00

  • Cell therapy assisted autotransplantation of olfactory tract into the optic nerve: A potential treatment for optic neuropathy.

    abstract::Optic neuropathy is an invaliding pathology with diverse clinical manifestation and varying causes. Current understanding of etiopathological aspects of optical neuropathy does not provide an effective treatment protocol. In this article we discuss existing treatment methods, and their effectiveness, evaluated dependi...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Shkarubo AN,Nikolenko VN,Velichko AY,Sinelnikov MY

    更新日期:2020-10-01 00:00:00

  • Contribution to problems of pseudohypoaldosteronism type I in children.

    abstract::Pseudohypoaldosteronism Type I may occur due to several different causes. The authors recommend distinguishing between effector and receptor disorders with regard to the diverse mode of inheritance and prognosis. ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Bayer M,Kutílek S

    更新日期:1993-09-01 00:00:00

  • It is likely that the risk of cardiovascular events from pharmaceuticals as COX-2 inhibitors can be reduced significantly by standard pharmaceutical and lifestyle preventative measures.

    abstract::Based on the principles of the altered homeostatic theory, a case will be made that the risk of cardiovascular (CV) events from pharmaceuticals as COX-2 inhibitors (coxibs) and sympatho-mimetic drugs can be reduced significantly by using standard pharmaceutical and lifestyle preventative measures as statins, exercise,...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Hellstrom HR

    更新日期:2006-01-01 00:00:00

  • Gastric carcinoma promoted by alkaline reflux gastritis -- with special reference to bile and other surfactants as promoters of postoperative gastric cancer.

    abstract::For reasons that are not known, the incidence of stomach cancer is declining in most countries. In contrast, cancer of the gastric remnant after partial gastrectomy for peptic ulcer disease seems to be increasing. "Stump cancer" has been claimed to be a separate disease entity and has recently been mentioned as an iat...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Domellöf L

    更新日期:1979-04-01 00:00:00

  • The improvement in renal function following EDTA chelation and multi-vitamin-trace mineral therapy: a study in creatinine clearance.

    abstract::One of the most commonly alleged contraindications to the use of (ethylene diamine tetraacetic acid) chelation therapy is possible renal damage. In this experiment, 13 subjects with chronic degenerative disorders and with renal damage were treated with infusions that included EDTA, vitamins, mineral and oral supplemen...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Sehnert KW,Clague AF,Cheraskin E

    更新日期:1984-11-01 00:00:00

  • The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy.

    abstract::Recent studies confirm that dietary methionine restriction increases both mean and maximal lifespan in rats and mice, achieving "aging retardant" effects very similar to those of caloric restriction, including a suppression of mitochondrial superoxide generation. Although voluntary caloric restriction is never likely ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: McCarty MF,Barroso-Aranda J,Contreras F

    更新日期:2009-02-01 00:00:00

  • Consideration of use of phenothiazines in particular trifluorperazine for epidermal growth factor receptor associated cancers.

    abstract::Papers from a generation ago suggested that phenothiazines--in particular trifluorperazine (Stelazine) a medicinal approved by the FDA and still commonly used for schizophrenia--downregulate the epidermal growth factor receptor. As numerous cancers--e.g., colon cancer, breast cancer, pancreatic cancer and glioblastoma...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Kast RE,Altschuler EL

    更新日期:2007-01-01 00:00:00

  • An unstable nuclear matrix may contribute to genetic instability.

    abstract::Cancer cells proliferate and metastasize against the body's defense mechanisms due to their ability to change in response to challenges, both from the body's internal defenses as well as those from external sources, such as radiation and chemotherapy. This ability of tumor cell populations to change and grow in respon...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Pienta KJ,Ward WS

    更新日期:1994-01-01 00:00:00

  • Hypothesis: Role for the circadian Clock system and sleep in the pathogenesis of adhesions and chronic pelvic pain?

    abstract::Intra-peritoneal adhesions ensuing from surgery or infection may lead to chronic pelvic pain, bowel obstruction, infertility and additional invasive surgery to resolve adhesion-related complications. As a result adhesions are a major clinical, social and economic concern. The cumulative year-on-year direct costs of ad...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Sadek K,Macklon N,Bruce K,Cagampang F,Cheong Y

    更新日期:2011-03-01 00:00:00