A new approach to antiviral therapy.

abstract：:Recently, the metabolic routes for acetone metabolism have been described. Therefore, acetone cannot further be regarded as a waste product of metabolism. However, its physiological role in biochemical machinery is not clear. Here, an integrative model for the role of acetone metabolism is presented that orders the ev...

journal_title：Medical hypotheses

authors： Kalapos MP

更新日期：1999-09-01 00:00:00

abstract：:Acute subdural hematoma (ASDH) is a severe insult with a high mortality rate, and emergent surgical evacuation is recommended in the vast majority of such cases. Generally, resolution of the hemorrhage requires weeks and months in patients treated conservatively. However, numerous cases of rapid spontaneous resolution...

journal_title：Medical hypotheses

authors： Liu B,Zhuang Z,Luo J

更新日期：2013-08-01 00:00:00

abstract：:The amino acid threonine contains two chiral carbons and thus can exist in four possible conformations. However, only a single conformation (2S, 3R) of threonine is incorporated in proteins by the cellular translation material. The conformation at the alpha carbon (carbon 2) is the same as that of the other amino acid...

journal_title：Medical hypotheses

authors： Altschuler EL

更新日期：2001-04-01 00:00:00

abstract：:Extracts of the unripe fruit of Momordica charantia--bitter melon, which flourishes throughout the tropics--appear to have utility in the management of type 2 diabetes. Rodent studies suggest that the thus-far-uncharacterized active components of such extracts enhance the efficiency of postprandial glucose storage in ...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2004-01-01 00:00:00

abstract：:Vitamin A is a fat-soluble vitamin required for many physiological functions. The intracellular transport of vitamin A is assisted by proteins called cellular retinol-binding proteins (CRBP I/II). The absorption, storage and usage of vitamin A are regulated by a protein called lecithin:retinol acyltransferase (LRAT), ...

journal_title：Medical hypotheses

authors： Mezaki Y,Fujimi TJ,Senoo H,Matsuura T

更新日期：2016-03-01 00:00:00

abstract：:Carcinoma constitution originates in the hetero-duplication mitoses (4) which divide non-maturable stem cells into two different types of daughter cells: maturable and non-maturable cancerous stem cells. Throughout the progression of such mitoses, the organoid continuity of the cancer depends only on the non-maturable...

journal_title：Medical hypotheses

authors： Hirata Y

更新日期：1999-06-01 00:00:00

abstract：:A meniscal graft extrusion is still an unresolved problem that affects most patients after a meniscal transplantation. Despite the advances in surgical techniques, together with the improved methods for a meniscal allograft sizing, success is only observed in up to 75% of patients after they experience a meniscal allo...

journal_title：Medical hypotheses

authors： Łuczkiewicz P,Daszkiewicz K,Chróścielewski J,Witkowski W,Kuik L

更新日期：2017-04-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative condition characterized by tremor, rigidity, bradykinesia, and postural instability. Smoking is an inverse risk factor for Parkinson's disease, although the mechanism for this apparent neuroprotection is not definitively established. Smoking consistently upregulates nicotinic...

journal_title：Medical hypotheses

authors： Chapman MA

更新日期：2009-12-01 00:00:00

abstract：:The psychological attributes of intelligence and personality are usually seen as being quite distinct in nature: higher intelligence being regarded a 'gift' (bestowed mostly by heredity); while personality or 'character' is morally evaluated by others, on the assumption that it is mostly a consequence of choice? So a ...

journal_title：Medical hypotheses

authors： Charlton BG

更新日期：2009-10-01 00:00:00

abstract：:Alpha-fetoprotein (AFP) is overexpressed in the majority of hepatocellular carcinomas (HCCs), and thus may offer attractive target for immunotherapy against this neoplasm. CD40 ligand (CD40L) is the major signal that induces B cells to efficiently present antigen to T cells, and CD40-activated B (CD40-B) lymphocyte ce...

journal_title：Medical hypotheses

authors： Wan Y,Ma X,Li X,Yi J

更新日期：2009-11-01 00:00:00

abstract：:An aldehyde-dehydrogenase (ALDH2) deficiency is a biological curb on excess alcohol-drinking. This enzyme deficiency is very common amongst Oriental people while it is relatively rare for most other populations. We observe that there is good geographical correlation between the prevalence of the mutant ALDH2*2 alleles...

journal_title：Medical hypotheses

authors： Lin YP,Cheng TJ

更新日期：2002-08-01 00:00:00

abstract：:A new hypothesis is presented to explain some aspects of human smoking behaviour. While acknowledging the importance of the nicotine self-titration phenomenon, changes in puffing intensity during the smoking of a single cigarette are related not to the control of nicotine uptake but to the modification of cigarette sm...

journal_title：Medical hypotheses

authors： Chamberlain AT,Higenbottam TW

更新日期：1985-08-01 00:00:00

abstract：:The etiology of focal distribution of atherosclerotic lesions has received much attention for many years. Current theories focus on mechanical factors such as low endothelial shear stress as an initiating factor for atherosclerosis formation. However, some evidences revealed that it could not be initiator of endotheli...

journal_title：Medical hypotheses

authors： Mehdizadeh A,Norouzpour A

更新日期：2009-12-01 00:00:00

abstract：UNLABELLED:T helper (Th) lymphocytes have been classified into distinct subsets, Th1 and Th2 on the basis of the cytokines they produce. According to the cross-regulatory properties of Th1 and Th2 cells, one would assume that to be affected by a Th1 type disease increases susceptibility to a Th1 type disease and inhibi...

journal_title：Medical hypotheses

authors： Shahabi S,Hassan ZM,Jazani NH,Ebtekar M

更新日期：2006-01-01 00:00:00

abstract：:There are large amounts of zinc in muscle and zinc ions can enhance the degree of muscle contraction in response to direct stimulation while at the same time inhibiting neuromuscular transmission. The opposites of these effects would lead to myotonia and muscle weakness. There are many parallels between the non-muscul...

journal_title：Medical hypotheses

authors： Horrobin DF,Morgan RO

更新日期：1980-04-01 00:00:00

abstract：:All kinds of hypotheses have been proposed to explain the mechanism of tumorigenesis. Up until now, we have not had any generally acknowledged model that helps us understand the process. In this paper, I propose a dynamic model of how tumor cells escape the supervision of the immune system; I also examine the possibil...

journal_title：Medical hypotheses

authors： Cai DW

更新日期：1995-05-01 00:00:00

abstract：:A wealth of research data points to increased oxidative stress as a key driver of the cardiac remodeling triggered by chronic pressure overload, loss of functional myocardial tissue, or atrial fibrillation. Oxidative stress is a mediator of the cardiomyocyte hypertrophy and apoptosis, the cardiac fibrosis, and the def...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2010-08-01 00:00:00

abstract：:In early 2012 deaths (all-cause mortality) in England and Wales showed an unexpected and unexplained increase which continued for 18 months before abating. The highest percentage increase in deaths was noted to be for neurological degenerations (mainly dementia, Alzheimer's, Parkinson's). This study seeks to understan...

journal_title：Medical hypotheses

authors： Jones RP,Goldeck D

更新日期：2014-07-01 00:00:00

abstract：UNLABELLED:One plausible explanation for the controversy that surrounds the causes and clinical management of obesity is the notion that overeating and obesity may only be a couple of "symptoms" associated with a yet to be discovered medical disorder. OBJECTIVES:To introduce the Salted Food Addition Hypothesis. This t...

journal_title：Medical hypotheses

authors： Cocores JA,Gold MS

更新日期：2009-12-01 00:00:00

abstract：:Functional, excessive-possibly temporary-deficiencies of the trace element zinc can change immune functions prematurely from predominantly cellular Th1 responses to humoral Th2 responses. T helper (Th1) cells produce cytokines such as interleukin-2 (IL-2) and interferon gamma, thereby controlling viral infections and ...

journal_title：Medical hypotheses

authors： Sprietsma JE

更新日期：1997-07-01 00:00:00

abstract：:Three important issues must be addressed in any attempt to determine whether combination painkillers play a role in analgesic nephropathy. The first issue, namely that of a causal link between the combination itself and nephrotoxicity, has never been adequately documented. On the contrary, there is much evidence that ...

journal_title：Medical hypotheses

authors： Driesens F,Awouters F,Goossens T,Janssen P

更新日期：1993-01-01 00:00:00

abstract：:Optic neuropathy is an invaliding pathology with diverse clinical manifestation and varying causes. Current understanding of etiopathological aspects of optical neuropathy does not provide an effective treatment protocol. In this article we discuss existing treatment methods, and their effectiveness, evaluated dependi...

journal_title：Medical hypotheses

authors： Shkarubo AN,Nikolenko VN,Velichko AY,Sinelnikov MY

更新日期：2020-10-01 00:00:00

abstract：:Pseudohypoaldosteronism Type I may occur due to several different causes. The authors recommend distinguishing between effector and receptor disorders with regard to the diverse mode of inheritance and prognosis. ...

journal_title：Medical hypotheses

authors： Bayer M,Kutílek S

更新日期：1993-09-01 00:00:00

abstract：:Based on the principles of the altered homeostatic theory, a case will be made that the risk of cardiovascular (CV) events from pharmaceuticals as COX-2 inhibitors (coxibs) and sympatho-mimetic drugs can be reduced significantly by using standard pharmaceutical and lifestyle preventative measures as statins, exercise,...

journal_title：Medical hypotheses

authors： Hellstrom HR

更新日期：2006-01-01 00:00:00

abstract：:For reasons that are not known, the incidence of stomach cancer is declining in most countries. In contrast, cancer of the gastric remnant after partial gastrectomy for peptic ulcer disease seems to be increasing. "Stump cancer" has been claimed to be a separate disease entity and has recently been mentioned as an iat...

journal_title：Medical hypotheses

authors： Domellöf L

更新日期：1979-04-01 00:00:00

abstract：:One of the most commonly alleged contraindications to the use of (ethylene diamine tetraacetic acid) chelation therapy is possible renal damage. In this experiment, 13 subjects with chronic degenerative disorders and with renal damage were treated with infusions that included EDTA, vitamins, mineral and oral supplemen...

journal_title：Medical hypotheses

authors： Sehnert KW,Clague AF,Cheraskin E

更新日期：1984-11-01 00:00:00

abstract：:Recent studies confirm that dietary methionine restriction increases both mean and maximal lifespan in rats and mice, achieving "aging retardant" effects very similar to those of caloric restriction, including a suppression of mitochondrial superoxide generation. Although voluntary caloric restriction is never likely ...

journal_title：Medical hypotheses

authors： McCarty MF,Barroso-Aranda J,Contreras F

更新日期：2009-02-01 00:00:00

abstract：:Papers from a generation ago suggested that phenothiazines--in particular trifluorperazine (Stelazine) a medicinal approved by the FDA and still commonly used for schizophrenia--downregulate the epidermal growth factor receptor. As numerous cancers--e.g., colon cancer, breast cancer, pancreatic cancer and glioblastoma...

journal_title：Medical hypotheses

authors： Kast RE,Altschuler EL

更新日期：2007-01-01 00:00:00

abstract：:Cancer cells proliferate and metastasize against the body's defense mechanisms due to their ability to change in response to challenges, both from the body's internal defenses as well as those from external sources, such as radiation and chemotherapy. This ability of tumor cell populations to change and grow in respon...

journal_title：Medical hypotheses

authors： Pienta KJ,Ward WS

更新日期：1994-01-01 00:00:00

abstract：:Intra-peritoneal adhesions ensuing from surgery or infection may lead to chronic pelvic pain, bowel obstruction, infertility and additional invasive surgery to resolve adhesion-related complications. As a result adhesions are a major clinical, social and economic concern. The cumulative year-on-year direct costs of ad...

journal_title：Medical hypotheses

authors： Sadek K,Macklon N,Bruce K,Cagampang F,Cheong Y

更新日期：2011-03-01 00:00:00