Views on the sustenance of resistant Mycobacterium tuberculosis in the environment.

abstract：:Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, with increasing incidence and prevalence in the last one-half century. IBD patients suffer from autonomic vagal neuropathy and nerve dysfunction, with deficiency of acetylcholine in inflamed mucosa. Recent studies showed that death of enteric neuron ...

journal_title：Medical hypotheses

authors： Guo Y,Lu N,Bai A

更新日期：2012-11-01 00:00:00

abstract：:A mechanism is proposed for the formation of Ebg-evolved beta galactosidase-of E. coli based on the following assumptions: 1. In the presence of lactose, certain proteins being translated bind to their m-RNA-ribosome complexes; 2. This binding interferes with the release of m-RNA from the bacterial chromosome, marking...

journal_title：Medical hypotheses

authors： Erhan S

更新日期：1979-11-01 00:00:00

abstract：:Structures which morphologically resemble treponemes have been found in material from patients suffering from latent or late latent syphilis, many of whom have received treatment in the past. These structures were also found in the blood or spinal fluid (SF) of asymptomatic patients with both positive and negative ser...

journal_title：Medical hypotheses

authors： Ghinsberg RC,Nitzan Y

更新日期：1992-09-01 00:00:00

abstract：:The malignant cell, in vivo, metabolizes and respires anaerobically. For a good many years scientists have been aware of anaerobia being present in malignant growths. The prevailing opinion is that the malignant cell is able to remain viable in an anaerobic medium. This assumption is incorrect and is actually misleadi...

journal_title：Medical hypotheses

authors： White MW

更新日期：1992-12-01 00:00:00

abstract：:An unconventional interaction between a patient and parasites was recently reported, in which parasitic cells invaded host's tissues, establishing several tumors. This finding raises various intriguing hypotheses on unpredicted forms of interplay between a patient and infecting parasites. Here we present four unusual ...

journal_title：Medical hypotheses

authors： de Souza TA,de Carli GJ,Pereira TC

更新日期：2016-09-01 00:00:00

abstract：:The structural rearrangement of human sheathed capillaries in congestive splenomegaly has been considered. In abnormal spleens the external diameter and wall thickness were decreased, while the internal diameter was increased. Moreover, the total length and the absolute number of sheathed capillaries were increased, t...

journal_title：Medical hypotheses

authors： Pallotti C,Pettazzoni P,Slawomirski MR

更新日期：1995-05-01 00:00:00

abstract：:Hypertensive left ventricular hypertrophy (LVH) is a maladaptive response to chronic pressure overload and a strong independent risk factor for cardiovascular disease. Regression of LVH is associated with improved prognosis. Regression of LVH with antihypertensive therapy (angiotensin-converting enzyme inhibitors, ang...

journal_title：Medical hypotheses

authors： Quintana-Villamandos B,Delgado-Baeza E

更新日期：2016-02-01 00:00:00

abstract：:Epidural haematoma in newborn infants is rare, and few specific obstetrical data related to its formation are available in the literature. The aim of this study is to discuss the pathophysiology of this condition. EDH is always a post traumatic lesion and it is only possible if the insult has produced a cleavage of th...

journal_title：Medical hypotheses

authors： Hamlat A,Heckly A,Adn M,Poulain P

更新日期：2006-01-01 00:00:00

abstract：:Mandibular asymmetry (MA) is one of the most common craniofacial malformations. However, there is no optimal technique for this malformation nowadays. A novel technique for both children and adults with less disadvantages is a must. Parathyroid hormone (PTH) is a straight-chain polypeptide secreted by the parathyroid ...

journal_title：Medical hypotheses

authors： Wan Q,Li ZB

更新日期：2010-04-01 00:00:00

abstract：:Micelle is a stable, passively targetable and solubilizing minute particle, and plays a key role to anticancer drug delivery for chemotherapy. With an increasing number of novel polymeric micelles synthesized, many anticancer drugs have been core-encapsulated in the micelles. However, only single drug was studied as t...

journal_title：Medical hypotheses

authors： Liu P,Wang B,Weili Qiao JL

更新日期：2008-09-01 00:00:00

abstract：:A wealth of research data points to increased oxidative stress as a key driver of the cardiac remodeling triggered by chronic pressure overload, loss of functional myocardial tissue, or atrial fibrillation. Oxidative stress is a mediator of the cardiomyocyte hypertrophy and apoptosis, the cardiac fibrosis, and the def...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2010-08-01 00:00:00

abstract：:Treatment with non-selective beta-blockers has been proposed to have an indirect antiviral activity acting via an enhanced performance of the immune system, and the mechanism of this activity has been laid out earlier. Experimental and clinical findings are presented that corroborate the hypothesis that inhibiting the...

journal_title：Medical hypotheses

authors： Peuschel KE

更新日期：2005-01-01 00:00:00

abstract：:Condylar cartilage is absolutely necessary for the normal function of temporomandibular joint (TMJ). Unfortunately, condylar cartilage defect or missing is also one of the common clinical problems. Repair or reconstruction of cartilage is always a hot topic. Cell based cartilage regeneration is suggested as novel ther...

journal_title：Medical hypotheses

authors： Dai J,Wang X,Shen G

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Geldanamycin, which is one of the most potent and effective hsp90 alpha inhibitor until date, is normally used to target breast cancer. Inhibition of hsp90 alpha leads to the degradation of client proteins involved in the initiation and progress of breast cancer pathogenesis. Hence, Geldanamycin has been wid...

journal_title：Medical hypotheses

authors： Mahanta S,Pilla S,Paul S

更新日期：2013-09-01 00:00:00

abstract：:The incidence of insulin-dependent diabetes mellitus (IDDM), a chronic disease with a well-known genetic basis, is highest in Scandinavian and Sardinian populations. The high incidence of IDDM in Scandinavia and Sardinia, which were genetically isolated from the spread of agriculturists in Europe about 8000 years ago,...

journal_title：Medical hypotheses

authors： Wendorf MA

更新日期：1999-05-01 00:00:00

abstract：:The polyol pathway consists of two enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH); the former is the first enzyme in the polyol pathway, that catalyzes the reduction of glucose to sorbitol, the latter is the second one, that converts sorbitol to fructose using by NAD(+) as a cofactor. We along with oth...

journal_title：Medical hypotheses

authors： Amano S,Yamagishi S,Koda Y,Tsuneoka M,Soejima M,Okamoto T,Inagaki Y,Yamada K,Kimura H

更新日期：2003-04-01 00:00:00

abstract：:Many experimental evidences indicate that infection with Trypanosoma cruzi delays or inhibits the growth of malignant tumors in different strains of mice and in rats. These facts were verified by different workers. Although earlier workers proposed that this effect would be due to a toxin of T. cruzi, most of the accu...

journal_title：Medical hypotheses

authors： Cabral HR

更新日期：2000-01-01 00:00:00

abstract：:Toll-like receptor 7 is critical in recognition of single strand RNA viruses, including SARS CoV-2, and generation of anti-viral immunity. Coronaviruses evolved strategies to dampen the host immunity. Herein, we discuss the potential use of TLR7 agonists in the early stages of COVID-19 treatment. ...

journal_title：Medical hypotheses

authors： Avcilar H,Eken A

更新日期：2020-11-01 00:00:00

abstract：:Music is ubiquitous. Yet, its biological relevance is still an ongoing debate. Supporting the view that music had an ancestral role in courtship displays, a pilot study presented here provides preliminary evidence on the link between music and sexual selection. The underlying hypothesis is based on the fact that the s...

journal_title：Medical hypotheses

authors： Miani A

更新日期：2016-08-01 00:00:00

abstract：:Lymphocytes of the CD8 phenotype play an important role in controlling viral burden in HIV-1 infection. Cytotoxic CD8+ T lymphocytes (CTL) can kill HIV-infected cells and in addition, are able to secrete a soluble factor that inhibits HIV replication. In most cases, HIV-infected individuals experience an unexplained C...

journal_title：Medical hypotheses

authors： Mercure L,Wainberg MA

更新日期：1994-03-01 00:00:00

abstract：:Intestinal dysbiosis refers to an imbalance in the intestinal flora. The concept of small intestinal bacterial overgrowth (SIBO), a condition of abnormal proliferation of the small intestine microbiota, has been proposed as a form of small intestine dysbiosis. In Parkinson's disease patients, weight loss and metabolic...

journal_title：Medical hypotheses

authors： Hasuike Y,Endo T,Koroyasu M,Matsui M,Mori C,Yamadera M,Fujimura H,Sakoda S

更新日期：2020-01-01 00:00:00

abstract：:A wide range of hyperimmune-associated diseases plague post-industrial society, with a prevalence and impact that is staggering. Strong evidence points towards a loss of helminths from the ecosystem of the human body (the human biome) as the most important factor in this epidemic. Helminths, intestinal worms which are...

journal_title：Medical hypotheses

authors： Bilbo SD,Wray GA,Perkins SE,Parker W

更新日期：2011-10-01 00:00:00

abstract：:Melatonin is well recognized for its role as a potent antioxidant and is directly implicated in the free radical theory of aging [1] [Reiter RJ, Pablos MI, Agapito TT, Guerrero JM. Melatonin in the context of the free radical theory of aging. Ann N Y Acad Sci 1996;786:362-78]. Moreover, melatonin has been shown to ret...

journal_title：Medical hypotheses

authors： Yeager RL,Oleske DA,Sanders RA,Watkins JB 3rd,Eells JT,Henshel DS

更新日期：2007-01-01 00:00:00

abstract：:Jet lag is a travel-induced circadian rhythm phenomenon that afflicts healthy individuals following long- distance flights through several time zones. The typical jet-lag manifestations - insomnia during local sleep time, day fatigue, reduced concentration, irritability, and exhaustion with mild depression - are attri...

journal_title：Medical hypotheses

authors： Katz G,Durst R,Zislin Y,Barel Y,Knobler HY

更新日期：2001-01-01 00:00:00

abstract：:Despite all improvements in transplant medicine, renal transplant recipients have a high risk for cardiovascular mortality. A high prevalence of cardiovascular complications in renal transplant recipients (RTR) is explained by cardiovascular risk factors present before transplantation, in addition to the development o...

journal_title：Medical hypotheses

authors： Mikolasevic I,Racki S,Lukenda V,Pavletic-Persic M,Milic S,Orlic L

更新日期：2014-01-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. The hallmark pathologic feature of PD is dopamine deficiency, caused by the degeneration of nigrostriatal dopaminergic neurons. Current treatments for PD mainly address the dopaminergic features of the disease; howe...

journal_title：Medical hypotheses

authors： Tsai SJ

更新日期：2007-01-01 00:00:00

abstract：:Intractable epilepsy has always posed a challenge to management; conventional, surgical and alternative techniques available so far (e.g., vagal nerve stimulation, i.e. VNS). The author has attempted to search for a novel alternative (drug-regime) approach to its management to minimise any invasive technique or surger...

journal_title：Medical hypotheses

authors： Jaseja H

更新日期：2003-08-01 00:00:00

abstract：:In this review, tumor necrosis factor-alpha (TNF-alpha) is identified as the uniting principle linking the pathogenesis of insulin-dependent diabetes mellitus (IDDM), non-insulin dependent diabetes mellitus (NIDDM) and carcinoma. Elevated TNF-alpha initially increases, and then inhibits, the activity of a number of ke...

journal_title：Medical hypotheses

authors： Holden RJ,Pakula IS,Mooney PA

更新日期：1999-04-01 00:00:00

abstract：:Novel coronavirus (NCoV-19), also known as SARS CoV-2, is a pathogen causing an emerging infection that rapidly increases in incidence and geographic range, is associated with the ever-increasing morbidity and mortality rates, and shows sever economic impact worldwide. The WHO declares the NCoV-19 infection disease (C...

journal_title：Medical hypotheses

authors： Mani Mishra P,Uversky VN,Nandi CK

更新日期：2020-04-24 00:00:00

abstract：:It is well known, that most of the psychiatric diseases affect various neurotransmitter systems. It is the aim of this profile to define a set of cheap analyses, indicative for a specific psychiatric disease, to facilitate differential diagnosis and to offer an additional tool to the already existing clinical-descript...

journal_title：Medical hypotheses

authors： Niederhofer H

更新日期：2011-10-01 00:00:00