Abstract:
:The incidence of insulin-dependent diabetes mellitus (IDDM), a chronic disease with a well-known genetic basis, is highest in Scandinavian and Sardinian populations. The high incidence of IDDM in Scandinavia and Sardinia, which were genetically isolated from the spread of agriculturists in Europe about 8000 years ago, suggests that an IDDM-susceptible genotype(s) may have been beneficial in Europe more than 8000 years ago. In glacial times, Europe had an extremely cold climate that was frequently interrupted by episodes of warming. When enteroviruses were locked in the ice and permafrost, glacial Europeans would have had little immunity to these viruses. Each time the climate warmed, enteroviruses would have spread through increased amounts of melt water. With a genetic ability to mount an autoimmune defense, the IDDM genotype(s) would have been beneficial in glacial Europe as a defense against all enteroviruses, including those that had co-evolved to mimic host tissue.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Wendorf MAdoi
10.1054/mehy.1997.0663keywords:
subject
Has Abstractpub_date
1999-05-01 00:00:00pages
423-9issue
5eissn
0306-9877issn
1532-2777pii
S0306987797906630journal_volume
52pub_type
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pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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pub_type: 历史文章,杂志文章
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