Abstract:
:We describe a new term: glutamate-based depression (GBD). GBD is defined as a chronic depressive illness associated with environmental stress and diseases associated with altered glutamate neurotransmission. We hypothesize that glutamate-induced over-activation of extrasynaptic NMDA receptors in the subgenual cingulate area called Brodmann's 25 plays an important role in the etiology of depression and may be responsible for the high incidence of co-morbid depression associated in diseases with glutamate etiology. While depression is a syndrome with multiple possible etiologies, we propose that a disruption in glutamatergic neurotransmission may underline a substantial proportion of clinically observed depression. The high rates of depressive symptoms associated with various disorders in which altered glutamatergic functions have been identified, may suggest a common pathophysiological mechanism is underlying the diverse clinical presentations.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
McCarthy DJ,Alexander R,Smith MA,Pathak S,Kanes S,Lee CM,Sanacora Gdoi
10.1016/j.mehy.2012.02.009subject
Has Abstractpub_date
2012-05-01 00:00:00pages
675-81issue
5eissn
0306-9877issn
1532-2777pii
S0306-9877(12)00075-8journal_volume
78pub_type
杂志文章abstract::The aim was to search for periodical fluctuations in daily occurrence of gout attacks during the synodic lunar cycle. 126 gout attacks were recorded between 1972 and 1994 at known calendar dates. The synodic plexogram, displaying the number of attacks for each day of the cycle, was processed by cosinor regression. A p...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1999.0973
更新日期:2000-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(87)90195-2
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2000.1089
更新日期:2000-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2018.06.021
更新日期:2018-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 社论
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更新日期:2010-02-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.02.001
更新日期:2010-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.09.011
更新日期:2013-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(76)80005-9
更新日期:1976-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.110178
更新日期:2020-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(03)00072-0
更新日期:2003-06-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.06.040
更新日期:2011-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.01.015
更新日期:2013-05-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(83)90003-8
更新日期:1983-04-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
doi:10.1016/s0306-9877(97)90065-7
更新日期:1997-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.01.033
更新日期:2014-06-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(92)90161-5
更新日期:1992-05-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.01.016
更新日期:2016-04-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(02)00410-3
更新日期:2003-02-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
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更新日期:2001-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(97)90081-5
更新日期:1997-11-01 00:00:00
abstract::(1) Background: RNA viruses and especially coronaviruses could act inside host cells not only by building their own proteins, but also by perturbing the cell metabolism. We show the possibility of miRNA-like inhibitions by the SARS-CoV-2 concerning for example the hemoglobin and type I interferons syntheses, hence hig...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.110245
更新日期:2020-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.10.011
更新日期:2006-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2001.1298
更新日期:2001-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.07.030
更新日期:2011-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.03.030
更新日期:2009-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2001.1364
更新日期:2001-10-01 00:00:00
abstract::High doses of oestrogens in the dog and ferret cause myeloid hyperplasia in the bone marrow superseded by hypoplasia affecting all cell lines. In the peripheral blood after an initial leucocytosis, there is thrombocytopenia, anaemia and leucopenia. These effects, which are ultimately lethal, do not occur in cats, rats...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(85)90070-2
更新日期:1985-02-01 00:00:00