Abstract：
:Growing evidences suggest a link between normal tension glaucoma (NTG) and Alzheimer's disease (AD). Both of them are progressive neurodegenerative disorders. Recently researches provide a clue that optineurin may be a new common underlying risk factor involved in NTG and AD. OPTINEURIN (OPTN) gene coding for "optineurin" protein is identified as the causative gene in NTG. Interestingly, optineurin was also found in neurofibrillary tangles and dystrophic neurites in AD, as well as other neurodegenerative diseases. This suggested a new hypothesis for neurodegeneration in AD involving chronic optineurin neurotoxicity, mimicking NTG at the molecular level. A theoretical relationship between optineurin, NTG and AD seems to exist. Indicating that optineurin may play a role in both NTG and AD will shed new light on the link between these two diseases and lead to a better understanding of the common mechanisms underlying NTG and AD.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Liu YH,Tian Tdoi
10.1016/j.mehy.2011.06.040subject
Has Abstractpub_date
2011-10-01 00:00:00pages
591-2issue
4eissn
0306-9877issn
1532-2777pii
S0306-9877(11)00298-2journal_volume
77pub_type
杂志文章abstract：:Over the last century and a half there has been a secular decline in the age of menarche in Western, industrialized cultures. This trend has been largely ascribed to improved nutrition and health, and we offer an alternative hypothesis that changes in socio-economic conditions have resulted in changes in the pheromona...
journal_title：Medical hypotheses
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更新日期：2016-02-01 00:00:00
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journal_title：Medical hypotheses
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