Abstract：
:Chloroquine is one of the antimalaria drugs, also used to treat rheumatoid arthritis and systemic lupus erythematosus (SLE). Although well tolerated in most individuals, it was suggested that chloroquine can exert a profound influence on renal function, especially in individuals with compromised body fluid status. However, epidemiological studies are still lacking. The renal actions of chloroquine are further exacerbated by co-administration of other commonly used drugs such as paracetamol. The following discussion will focus on the evidence that chloroquine is a stimulator of nitric oxide (NO), which mediates many of its renal actions (diuresis, natriuresis and an increase in both glomerular filtration rate (GFR) and plasma vasopressin). Chloroquine appears to modulate the renal tubular response to vasopressin either by directly inhibiting cAMP generation or indirectly via NO.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Ahmed MH,Osman MMdoi
10.1016/j.mehy.2006.06.012subject
Has Abstractpub_date
2007-01-01 00:00:00pages
140-3issue
1eissn
0306-9877issn
1532-2777pii
S0306-9877(06)00449-Xjournal_volume
68pub_type
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