Are pulmonary factors responsible for the direction of the spinal curvature in idiopathic scoliosis?

abstract：:The polyol pathway consists of two enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH); the former is the first enzyme in the polyol pathway, that catalyzes the reduction of glucose to sorbitol, the latter is the second one, that converts sorbitol to fructose using by NAD(+) as a cofactor. We along with oth...

journal_title：Medical hypotheses

authors： Amano S,Yamagishi S,Koda Y,Tsuneoka M,Soejima M,Okamoto T,Inagaki Y,Yamada K,Kimura H

更新日期：2003-04-01 00:00:00

abstract：:Yawning continues to pose as a scientist's conundrum. Evidence is presented of yawning and contagious yawning in a number of different neurological disorders. Explanations are discussed in the context of disparate neurological disorders together with proposals for how theses findings may be linked. Thus, greater under...

journal_title：Medical hypotheses

authors： Thompson SB

更新日期：2010-12-01 00:00:00

abstract：:Recent articles about the roles and relationships of tissue inhibitor of metalloproteinase-1 and transforming growth factor-beta 1 in various types of normal tissues and malignancies give rise to the question: 'Is there a relationship between them with regard to malignant melanoma progression?' In the light of many re...

journal_title：Medical hypotheses

authors： Kurdoglu M,Güllü IH,Akalin I

更新日期：2001-08-01 00:00:00

abstract：:Anemia of chronic disease (ACD) is a condition of decreased red cell mass secondary to some other chronic inflammatory condition. In ACD total body iron stores are normal, though serum iron is typically low secondary to iron sequestration by macrophages, and often iron supplementation is not an effective treatment for...

journal_title：Medical hypotheses

authors： Altschuler EL,Kast RE

更新日期：2005-01-01 00:00:00

abstract：:The activity of the lithium ion against DNA type viruses is explained by its competition with magnesium ions. Magnesium acts as the cofactor of the enzymes responsible for the replicative building of viral proteins and nucleosides. When lithium replaces magnesium, it appears to render the polymerase enzymes impotent. ...

journal_title：Medical hypotheses

authors： Bach RO

更新日期：1987-06-01 00:00:00

abstract：:A new approach to antiviral therapy is proposed, taking advantage of the recently investigated innervation of immune tissues by the sympathetic nervous system, which establishes a functional connection between the nervous and the immune system, where the sympathetic nervous system exerts a varying tonic inhibitory inf...

journal_title：Medical hypotheses

authors： Peuschel KE

更新日期：1995-10-01 00:00:00

abstract：:Many risk factors that promote cardiovascular disease (CVD) have been identified. These include hypertension, hypercholesterolemia, diabetes, decreased estrogen in post-menopausal women, increased homocysteine, and cigarette smoking. It has recently become clear that a mechanism common to these risk factors is oxidati...

journal_title：Medical hypotheses

authors： Castelao JE,Gago-Dominguez M

更新日期：2008-01-01 00:00:00

abstract：:Almost all solid tumors consist of aneuploid cells with highly abnormal chromosome numbers. Such cancer cells could very well originate from chromosome missegregation which is a disturbingly common phenomenon, happening in 0.01 to 4 percent of cell divisions. Missegregated cells are aneuploid, typically lacking a chro...

journal_title：Medical hypotheses

authors： Engvild KC

更新日期：2018-11-01 00:00:00

abstract：:Since 1960, the incidence of melanoma has increased dramatically in Caucasians worldwide, and during the past decade has risen at a rate of 6% a year in the USA. A hypothesis regarding this increased incidence suggests that the prevalent use of antibacterial soaps that contain photosensitizing compounds may be a risk ...

journal_title：Medical hypotheses

authors： Arbesman H

更新日期：1999-07-01 00:00:00

abstract：:An aldehyde-dehydrogenase (ALDH2) deficiency is a biological curb on excess alcohol-drinking. This enzyme deficiency is very common amongst Oriental people while it is relatively rare for most other populations. We observe that there is good geographical correlation between the prevalence of the mutant ALDH2*2 alleles...

journal_title：Medical hypotheses

authors： Lin YP,Cheng TJ

更新日期：2002-08-01 00:00:00

abstract：:This article reviews the biochemical and physiological observations underpinning the synergism between ghrelin and ghrelin agonists with exercise, especially progressive resistance training that has been shown to increase muscle mass. The synergy of ghrelin agonists and physical exercise could be beneficial in conditi...

journal_title：Medical hypotheses

authors： Fuoco D,Kilgour RD,Vigano A

更新日期：2015-12-01 00:00:00

abstract：:Functional, excessive-possibly temporary-deficiencies of the trace element zinc can change immune functions prematurely from predominantly cellular Th1 responses to humoral Th2 responses. T helper (Th1) cells produce cytokines such as interleukin-2 (IL-2) and interferon gamma, thereby controlling viral infections and ...

journal_title：Medical hypotheses

authors： Sprietsma JE

更新日期：1997-07-01 00:00:00

abstract：:We were interested whether fluorine, at the concentrations regarded as normal, can play a role in PCOS pathogenesis. The effect was not described in PCOS. Women with PCOS were diagnosed according to Rotterdam's criteria. The average age of 40 examined women with PCOS was 26.3 ± 5.5 years, BMI-29.16 ± 0.8, WHR-0.91 ± 0...

journal_title：Medical hypotheses

authors： Szczuko M,Splinter J,Zapałowska-Chwyć M,Ziętek M,Maciejewska D

更新日期：2019-07-01 00:00:00

abstract：:Based on the principles of the altered homeostatic theory, a case will be made that the risk of cardiovascular (CV) events from pharmaceuticals as COX-2 inhibitors (coxibs) and sympatho-mimetic drugs can be reduced significantly by using standard pharmaceutical and lifestyle preventative measures as statins, exercise,...

journal_title：Medical hypotheses

authors： Hellstrom HR

更新日期：2006-01-01 00:00:00

abstract：:Antisense oligonucleotides (oligos) have demonstrated efficacy for the treatment of various cancers, infectious diseases and metabolic disorders. While most studies have utilized single oligos either administered alone, or more recently in combination therapy with other drugs, some investigators have administered more...

journal_title：Medical hypotheses

authors： Rubenstein M,Tsui P,Guinan P

更新日期：2005-01-01 00:00:00

abstract：:Host cholesterol is widely getting recognized as an important factor in the pathogenesis of tuberculosis in multiple ways. Therefore it is logically expected that cholesterol reduction by statins is going to have a positive outcome in the context of tuberculosis management. But at the present moment statin therapy in ...

journal_title：Medical hypotheses

authors： Banerjee D,Bhattacharyya R

更新日期：2014-07-01 00:00:00

abstract：:Oxygen therapy, usually administered by a facemask or nasal cannulae, is the current default treatment of respiratory failure. Since respiration entails intake of oxygen and release of carbon dioxide from tissues as waste product, the notion of administering carbon dioxide in respiratory failure appears counter-intuit...

journal_title：Medical hypotheses

authors： Julu POO,Shah M,Monro JA,Puri BK

更新日期：2018-01-01 00:00:00

abstract：:Some drugs blocking glutamate release produce reduced brain injury in some animal models of cerebral ischemia whereas others lack a clear effect. Meta-analysis is a widely used technique in clinical and epidemiological studies. However, it has never been used in the analysis of preclinical studies. In order to estimat...

journal_title：Medical hypotheses

authors： Nava-Ocampo AA,Reyes-Pérez H,Bello-Ramírez AM,Mansilla-Olivares A,Ponce-Monter H

更新日期：2000-01-01 00:00:00

abstract：:Scrub typhus is a mite borne infectious disease which has re-emerged in India in the 3rd millennium after years of quiescence. In this review, the authors hypothesize the various factors responsible for resurgence of this disease. The main drivers that could have contributed to the upsurge in scrub typhus cases in pas...

journal_title：Medical hypotheses

authors： Ranjan J,Prakash JAJ

更新日期：2018-06-01 00:00:00

abstract：:Data on lymphocyte biology indicate that the humoral system of B-cells is specifically active with precise analogies at all mucosal levels. Might there be a corresponding function for T-lymphocytes at the cutaneous structure level? Certain physiological findings appear to suggest that the two main lymphocyte populatio...

journal_title：Medical hypotheses

authors： Franchi F,Seminara P,Montella F

更新日期：1981-09-01 00:00:00

abstract：:This paper discusses a mechanism for converting heterochromatin into the more relaxed state of euchromatin. Actuation of such state conversion stems from disassembly of internal vesicles that are incapable of surviving when trapped within the inner chamber of mammalian nuclei. ...

journal_title：Medical hypotheses

authors： Matioli GT

更新日期：2002-11-01 00:00:00

abstract：:The inverse association between maternal folate status and incidence of infants born with neural tube defects (NTD's) was recognized over twenty years ago and led the US health agencies in the early 1990s to recommend that women of childbearing age consume 400 microg of folic acid each day. The FDA followed by mandati...

journal_title：Medical hypotheses

authors： Rogers EJ

更新日期：2008-09-01 00:00:00

abstract：:Developmental alcohol exposure adversely influences the developing brain. Alcohol exposure during rapid brain growth causes cell loss, alters connections between brain regions, and lowers the production of biological substances responsible for the communication among neurons. It is reasonable to suggest that alcohol m...

journal_title：Medical hypotheses

authors： Sher L

更新日期：2004-01-01 00:00:00

abstract：:The right timing of surgical intervention in patients with aortic insufficiency is the crucial precondition for optimal postoperative course. To meet this demand, it is essential to have precise knowledge of the pathogenesis of this disease. Within the rabbit model of aortic insufficiency, four periods of adaptational...

journal_title：Medical hypotheses

authors： Simko F

更新日期：1995-12-01 00:00:00

abstract：:The review briefly describes the evolution of hypotheses about cronic thyroiditis, the escape of colloid hypothesis, basement membrane destruction, the auto-immune theory and the role of disregulatory genes. ...

journal_title：Medical hypotheses

authors： Stuart A

更新日期：2011-09-01 00:00:00

abstract：:Ampligen, a mismatched double stranded RNA, is hypothesized to be an ideal base therapy for HIV disease to which other agents, such as the nucleoside analogue, AZT, can be advantageously added. The unique properties of Ampligen which support this hypothesis include activation of immune cells, inhibition of virus repli...

journal_title：Medical hypotheses

authors： Gillespie D,Carter WA

更新日期：1992-01-01 00:00:00

abstract：:The science of osteoimmunology, a relatively new field of research, reveals the important interactions between the immune system and skeletal system. Interactions occur between prostaglandin metabolism, inflammatory proteins and bone metabolism. Systemic as well as local sources of inflammation appear to be actively i...

journal_title：Medical hypotheses

authors： van Esch RW,Kool MM,van As S

更新日期：2013-08-01 00:00:00

abstract：:Cancer cells proliferate and metastasize against the body's defense mechanisms due to their ability to change in response to challenges, both from the body's internal defenses as well as those from external sources, such as radiation and chemotherapy. This ability of tumor cell populations to change and grow in respon...

journal_title：Medical hypotheses

authors： Pienta KJ,Ward WS

更新日期：1994-01-01 00:00:00

abstract：:Along with oxygen, glucose is an essential macronutrient for most cells, a source of carbons for biosynthesis and energy. However, alongside this indispensable role for cell survival and growth, glucose is intrinsically toxic by reacting with primary amines such as lysine in proteins in a non-enzymatic glycation proce...

journal_title：Medical hypotheses

authors： Szwergold BS

更新日期：2005-01-01 00:00:00

abstract：:Lymphocytes of the CD8 phenotype play an important role in controlling viral burden in HIV-1 infection. Cytotoxic CD8+ T lymphocytes (CTL) can kill HIV-infected cells and in addition, are able to secrete a soluble factor that inhibits HIV replication. In most cases, HIV-infected individuals experience an unexplained C...

journal_title：Medical hypotheses

authors： Mercure L,Wainberg MA

更新日期：1994-03-01 00:00:00