Abstract：
:An aldehyde-dehydrogenase (ALDH2) deficiency is a biological curb on excess alcohol-drinking. This enzyme deficiency is very common amongst Oriental people while it is relatively rare for most other populations. We observe that there is good geographical correlation between the prevalence of the mutant ALDH2*2 alleles and hepatitis B virus (HBV) infections. Populations that demonstrate a high ALDH2*2 prevalence are all located in HBV-endemic areas. Further, studies have shown that HBV and alcohol drinking exhibit a synergistic effect upon liver cirrhosis and cancer. A shorter life span for those with HBV infection and heavy alcohol consumption may result in a selection of the ALDH2*2 gene. We postulate that there may be patterns of evolutionary adaptation for ALDH2 deficiency in certain HBV-endemic areas and that these adaptations can produce differences in human alcohol-drinking capability.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Lin YP,Cheng TJdoi
10.1016/s0306-9877(02)00253-0keywords:
subject
Has Abstractpub_date
2002-08-01 00:00:00pages
204-7issue
2eissn
0306-9877issn
1532-2777pii
S0306987702002530journal_volume
59pub_type
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