Abstract：
:A large number of epileptic patients suffer from refractory epilepsy, despite optimal treatment; thus these patients require new therapeutic approaches. Focal seizure activity is typically initiated in a fixed and localized region, which subsequently spreads to neighboring regions or more distant areas. At the initial onset of a seizure, the epileptic discharge will generate a relatively high voltage in seizure focus, and the discharge subsequently spreads to other relatively low-voltage regions. However, it is unknown whether seizure can be controlled through current shunt using a conduction microelectrode to conduct the epileptic discharge with a relatively high voltage in the seizure focus outside the brain. The current therapies for epilepsy, including drugs, resective surgery and neuromodulation, focus on inhibiting abnormal excessive or synchronous neuronal activity to control seizures; thus, the basic mechanism underlying these therapies is "inhibition". In contrast, we proposed a "conduction" mechanism, whereby a current shunt with conduction electrode is used to control seizures. To our knowledge, this therapeutic strategy has not been previously reported, and we propose that this approach might be an alternative choice for the treatment of refractory partial epilepsy in the future.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Zhang L,Liang S,Zhang G,Kang Xdoi
10.1016/j.mehy.2013.07.046subject
Has Abstractpub_date
2013-11-01 00:00:00pages
763-5issue
5eissn
0306-9877issn
1532-2777pii
S0306-9877(13)00370-8journal_volume
81pub_type
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journal_title：Medical hypotheses
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更新日期：2012-09-01 00:00:00
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更新日期：2019-08-01 00:00:00
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更新日期：2020-11-01 00:00:00
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更新日期：2003-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-05-01 00:00:00
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更新日期：2009-07-01 00:00:00
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更新日期：2006-01-01 00:00:00
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更新日期：2011-05-01 00:00:00
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journal_title：Medical hypotheses
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更新日期：2005-01-01 00:00:00
