Abstract：
:Organogenesis is the result of cell allocation followed by cell differentiation, and the processes involved are still to be elucidated. Present-day teaching suggests that the cytoplasmic membrane, the extracellular matrix and the cytoskeleton, in combination, are responsible, but the literature also suggests that other factors must be working as well. Because organogenesis is under strict genetic control, the controlling mechanism must reside in the nucleus and when the biology of the embryonic stem cell's nucleus was looked into, some interesting features emerged. One noteworthy feature was that the cytoplasm formed an incomplete ring around the nucleus so that part of the nuclear envelope was bare of cytoplasm, and in the aggregates of stem cells which made up an organ rudiment, the bare margins were in intimate contact. Another noteworthy feature was that the cytoplasm of the embryonic cells then underwent dissolution prior to differentiation, and the specialized cytoplasm arose progressively from the bare nuclei. The argument is put that, when embryonic stem cells join to form an organ rudiment, the bare margins of the nuclei of adjoining cells make intimate contact, allowing the correct spatial orientation of the cells to be achieved by means of positional cues in the nuclei. The cytoplasm of the embryonic cells then undergoes dissolution and the specialized cytoplasm of the differentiated cells is constructed by the denuded nuclei.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Drummond Rdoi
10.1016/s0306-9877(96)90249-2subject
Has Abstractpub_date
1996-03-01 00:00:00pages
245-8issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(96)90249-2journal_volume
46pub_type
杂志文章abstract：:A method for fast nucleotide sequencing is described. It is based in the selection of well-known small oligomers able to be hybridized with the unknown target. The selected oligomers are afterwards ordered following a simple statistical approach. The use of capillary electrophoresis for the analysis is emphasized. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.1026
更新日期：2000-07-01 00:00:00
abstract：:High-molecular-weight hyaluronic acid (HA) produced by the synovium may function physiologically to aid preservation of cartilage structure and prevent arthritic pain; both the size and concentration of HA in synovial fluid are diminished in osteoarthritis (OA). Glucosamine therapy for OA can be expected to increase s...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.0954
更新日期：2000-05-01 00:00:00
abstract：:Geographic patterns with diminishing rates from north to south toward the equator have been described for a number of diseases, putatively related largely to "western" lifestyle. Among these the inflammatory bowel diseases; Crohn's (CD) and Ulcerative colitis (UC) have been prominent in sharing distributions with a nu...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.10.001
更新日期：2016-11-01 00:00:00
abstract：:Left ventricular thrombus (LVT) after acute myocardial infarction (AMI) remains to be a common complication bearing adverse prognostic implication. Majority of LVT occurs within the first week after AMI. Over decades, the regional stasis of blood flow is regarded as the main reason for LVT formation. Here we hypothesi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109938
更新日期：2020-11-01 00:00:00
abstract：:Too small size at birth (due to poor fetal growth and/or preterm delivery) has been associated with substantially elevated risks of the metabolic syndrome (dislipidemia, insulin resistance, hypertension), type 2 diabetes and cardiovascular disease in adulthood. The mechanisms of such "fetal origins" or "programming" o...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.08.020
更新日期：2006-01-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs) therapy has emerged as a potent therapeutic strategy to improve myocardial infarction. However MSCs therapy encounters a few obstacles regarding the poor viability of the transplanted cells. Therefore, it is important to explore a strategy to enhance post-transplanted MSC viability. To ov...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.12.021
更新日期：2012-04-01 00:00:00
abstract：:Low carbohydrate high fat (LCHF) diets are emerging in popularity. Several athletics have adopted LCHF diets in an attempt to improve exercise performance and body composition by enhancing fat utilization. However, these diets impair maximal and supramaximal exercise performance due to limited glycogen stores as well ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110369
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Huachansu, a Chinese medicine that comes from dried toad venom from the skin glands of Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider, has been used in treatment of cancers. We conducted a meta-analysis to evaluate the efficacy and safety of Huachansu combined with chemotherapy for advanced gas...
journal_title：Medical hypotheses
pub_type： 杂志文章,meta分析
doi：10.1016/j.mehy.2013.04.038
更新日期：2013-08-01 00:00:00
abstract：:Maintaining a body temperature within a narrow range is vital for the survival of all mammals, including humans. With the help of optogenetics, a better understanding of the thermoregulatory organs and pathways is achieved. Optogenetic activation of the GABAergic neurons in the ventral part of the lateral preoptic nuc...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109704
更新日期：2020-06-01 00:00:00
abstract：:A hypothesis is presented concerning the origin of the action of muscles in the human and animal bodies It is advanced that muscle action originates with very rapid chemical reactions known as percussion reactions. These give rise to the temporary precipitation of solids in muscle cells. The accompanying volume change...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00149-4
更新日期：2002-08-01 00:00:00
abstract：:Since 1960, the incidence of melanoma has increased dramatically in Caucasians worldwide, and during the past decade has risen at a rate of 6% a year in the USA. A hypothesis regarding this increased incidence suggests that the prevalent use of antibacterial soaps that contain photosensitizing compounds may be a risk ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1997.0718
更新日期：1999-07-01 00:00:00
abstract：:While cigarette smoking is recognized as an important risk factor in human oral cancers, the effect of water pipe smoking (WPS) on these cancers is not known. WPS is very common in the young adult population, especially in the Middle East, and has been associated with several respiratory problems. However, to date, th...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.10.013
更新日期：2010-03-01 00:00:00
abstract：:The aim of the present paper is to give a schematic illustration of the basic humoral mechanisms of sodium, calcium and glucose homeostasis regulation. These can be compared to a lever system that maintains a dynamic equilibrium. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1998.0740
更新日期：1999-09-01 00:00:00
abstract：:The recent global pandemic created by the Coronavirus SARS-CoV-2, started in Wuhan, China in December 2019, has generated panic, both in term of human death (4-5% of infected patients identified through testing) and the global economy. Human sufferings seem to be continuing, and it is not clear how long this will cont...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109754
更新日期：2020-09-01 00:00:00
abstract：:To discuss the possible pathogenesis of outlet obstructive constipation (OOC) and identify the theoretical basis of the Procedure for Prolapse and Hemorrhoids (PPH) used to treat outlet obstructive constipation (OOC). 19 patients diagnosed with outlet obstructive constipation (OOC) form the case group, and 9 healthy v...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.03.022
更新日期：2015-07-01 00:00:00
abstract：:We developed a new hypothesis claiming that natriuresis of fasting is not only caused by diminished insulin resistance and hyperinsulinaemia with the subsequent reduction of renal sodium retention but it can also be attributed to the function of the leptin-NPY system. Each element of this concept has been substantiate...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2000.1176
更新日期：2001-05-01 00:00:00
abstract：:The aim was to search for periodical fluctuations in daily occurrence of gout attacks during the synodic lunar cycle. 126 gout attacks were recorded between 1972 and 1994 at known calendar dates. The synodic plexogram, displaying the number of attacks for each day of the cycle, was processed by cosinor regression. A p...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.0973
更新日期：2000-07-01 00:00:00
abstract：:Ergothioneine is believed not to be synthesized by man but it accumulates to high concentrations in some mammalian cells as a result of dietary intake. Ergothioneine is known to chelate divalent metal ions with high affinity. Other substances which are potent chelators of divalent metal ions such as diphenylthiocarbaz...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(82)90137-2
更新日期：1982-08-01 00:00:00
abstract：:One of the most commonly alleged contraindications to the use of (ethylene diamine tetraacetic acid) chelation therapy is possible renal damage. In this experiment, 13 subjects with chronic degenerative disorders and with renal damage were treated with infusions that included EDTA, vitamins, mineral and oral supplemen...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(84)90020-3
更新日期：1984-11-01 00:00:00
abstract：:Many of the movement disorders seen in psychiatric patients are determined, in large part, by the dynamic balance of dopamine and acetylcholine in the basal ganglia. Gamma aminobutyric acid has effects on various neurotransmitters in the brain including dopamine and acetylcholine and is therefore relevant to a discuss...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(88)90008-4
更新日期：1988-12-01 00:00:00
abstract：:The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 virus is now considered a global public health threat. The primary focus has been on reducing the viral spread and treating respiratory symptoms; as time goes on, the impact of COVID-19 on neurological and haemostatic systems becomes mor...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110480
更新日期：2021-01-04 00:00:00
abstract：BACKGROUND:Short-term acute care public county hospitals in the US were a mainstay of much "safety net" medical care in the early twentieth century. The private sector currently provides much of what was in the past public medical care. Does this transition affect health care indices? METHODS:The presence of public ho...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109265
更新日期：2019-11-01 00:00:00
abstract：:Obesity is a major risk factor for type 2 diabetes mellitus and insulin resistance (IR). In the state of obesity, excess fat accumulates in the liver, a key organ in systemic metabolism, altering the inflammatory and metabolic signals contributing substantially to the development of hepatic IR. Current therapies for t...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109671
更新日期：2020-03-14 00:00:00
abstract：:There are different theories and hypotheses related to the aetiology of depression. The interaction between brain 5-HT level and the activity of its autoreceptors plays a role in mood changes and depression. In major depression, activation of the inflammatory response system (IRS) and, increased concentrations of proi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00207-x
更新日期：2003-11-01 00:00:00
abstract：:Both, hamstring and ACL injuries are among the most typical injuries, particularly in change of direction and high speed running sports. They're also difficult to treat. Therefore, in the past few years, sports medicine practitioners and exercise scientists have mainly been focusing on the development and implementati...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.10.002
更新日期：2017-11-01 00:00:00
abstract：:Recent evidence suggests that covalent modifications to the genomic platform in the brain, that is DNA and its surrounding histones, provide a stable potentially lifelong mechanism for remembrance. Consequently, the making and unmaking of memories is accessible through pharmacological manipulations of these modificati...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.03.042
更新日期：2011-07-01 00:00:00
abstract：:Avascular necrosis of the femoral head (ANFH) is a common ailment characterized by necrosis of bone trabecular and bone marrow. It's mainly caused by the destruction of the blood supply in the femoral head and high rate of morbidity and disability is involved. Many methods have been tried including conservative treatm...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.09.028
更新日期：2011-02-01 00:00:00
abstract：:It was hypothesized decades ago that reduced levels of brain monoamines such as serotonin or norepinephrine form, at least in part, a pathophysiological basis for major depression. Consistent with this hypothesis, a conventional strategy used, with varying success, to treat major depression involves administering anti...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.03.023
更新日期：2013-06-01 00:00:00
abstract：:A hypothetical pathogenesis for a typical case of amyotrophic lateral sclerosis (ALS) follows from opinions of Rowland and results of neuroscientists at Baylor. ALS might typically result from an autoimmune disorder that causes IgG to enhance release of acetylcholine (ACh) from axon terminals. Motor neuron overactivit...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(94)90160-0
更新日期：1994-06-01 00:00:00
abstract：:Malignant hyperthermia (MH) is a rare myopathy inducing severe accident when carriers are exposed to triggering agents. MH susceptibility (MHS) is assessed by pharmacological tests performed on muscle strips. Exertional heat stroke (EHS) is a severe accident occurring during long and strenuous exercise. It has been ob...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(95)90116-7
更新日期：1995-09-01 00:00:00
