Mesenchymal stem cells cultured on tantalum used in early-stage avascular necrosis of the femoral head.

abstract：:Natural whole foods contain fats as structural components, and have a balance of polyunsaturated fat, monounsaturated fat, and saturated fat. Since we are still a Paleolithic species, adapted to eating only wild foods, it is difficult to justify the consumption of anything other than an overall balance of triglyceride...

journal_title：Medical hypotheses

authors： Broadhurst CL

更新日期：1997-09-01 00:00:00

abstract：:The incidence rate of cutaneous melanoma has been increasing faster than that of any other cancer in white-skinned populations over the past decades. The main risk factors for melanoma (i.e. exposure to sunlight, naevus count, phototype, and family history of melanoma) may not wholly explain the epidemiological trends...

journal_title：Medical hypotheses

authors： Kvaskoff M,Weinstein P

更新日期：2010-09-01 00:00:00

abstract：:Acute renal failure (ARF) is a rapid loss of kidney function. The reasons and mechanism by which this occurs has not been clarified so far thus creating obstacles to management of this disease. Presently, the experimental research using the accepted renal ischemia reperfusion injury (I/R injury) model represented for ...

journal_title：Medical hypotheses

authors： Hao JL,Li YF,Li RS

更新日期：2013-04-01 00:00:00

abstract：:This hypothesis agrees with Le Vay's suggestion that the two phenomena of childhood behavior and adult sexuality are induced by separate events rather than being two events in a single chain. However, it differs from Le Vay in that it includes the postnatal period, as being of crucial importance in the development of ...

journal_title：Medical hypotheses

authors： Roper WG

更新日期：1996-02-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) is a novel technique of non-invasive brain stimulation which has been used to treat several neuropsychiatric disorders such as major depressive disorder, chronic pain and epilepsy. Recent studies have shown that the therapeutic effects of rTMS are associated with pla...

journal_title：Medical hypotheses

authors： Brunoni AR,Boggio PS,Fregni F

更新日期：2008-08-01 00:00:00

abstract：:In 1937, Drs. Moritz and Oldt described arteriolar injuries in the kidneys (and other viscera) in hypertension, across the age range, in both sexes, and, in different races. This hypothesis proposes that injuries to vasomotor nerves cause the arteriolar injury in the kidney in hypertension, (as well as that in the ute...

journal_title：Medical hypotheses

authors： Gu QR,Li YY,Chen GR,Quinn MJ

更新日期：2018-02-01 00:00:00

abstract：:The German doctor Hermann Kümmell described Kümmell's disease as the clinical scenario in which patients suffer a trivial spinal trauma, but develop a symptomatic, progressive, angular kyphosis after a symptom-free period of months to years. Since an intravertebral vacuum phenomenon, which is considered indicative of ...

journal_title：Medical hypotheses

authors： Li H,Liang CZ,Shen CC,Chen QX

更新日期：2011-11-01 00:00:00

abstract：:Supercritical carbon dioxide (CO(2)) possesses germicide (bactericide and sporicide) effect. Despite of the fact, that this effect is used in industrial sterilization processes, the sterilization mechanism at molecular level is unclear. Our hypotheses can provide a molecular-biological explanation for the phenomenon. ...

journal_title：Medical hypotheses

authors： András CD,Csajági C,Orbán CK,Albert C,Abrahám B,Miklóssy I

更新日期：2010-02-01 00:00:00

abstract：:So-called 'limited life span' of diploid cells does not depend on their unresponsiveness to growth factors from the data obtained by complete protein-free culture of tumor cells. Limited proliferation (called limited life span) of diploid cells is one of the 'ad-hoc' negative regulatory mechanisms in animals, and can ...

journal_title：Medical hypotheses

authors： Chigira M,Watanabe H

更新日期：1993-10-01 00:00:00

abstract：:Acid hydrolysis of components from the diet in the stomach require the presence of an acid and a hydrolysing agent. The acid involved is hydrochloric acid. The present mechanism of hydrochloric acid production in the stomach is demonstrated to be incompatible with measured intracellular or intercellular concentrations...

journal_title：Medical hypotheses

authors： Robertson DS

更新日期：2005-01-01 00:00:00

abstract：:Hyperuricemia has been labeled both a risk factor and marker for cardiovascular pathology in addition to being associated with gout and kidney disease. Uric acid in vitro acts as a potent antioxidant capable of scavenging hydroxy radicals and peroxynitrite and reacting with nitric oxide. Some clinical studies have pro...

journal_title：Medical hypotheses

authors： Kirschbaum B

更新日期：2001-06-01 00:00:00

abstract：:Prostate cancer incidence increases with age; along with many other cancers, it could be considered a disease of aging. Prostate cancer screening has led to a significant proportion of men diagnosed with low-grade, low-stage prostate cancer who are now more likely to choose an active surveillance strategy rather than ...

journal_title：Medical hypotheses

authors： Liss MA,Rickborn L,DiGiovanni J,Bacich D,DeGraffenried LA,Parihar M,Thompson IM,Sharp ZD

更新日期：2018-08-01 00:00:00

abstract：:Fibromyalgia (FM) is a debilitating, widespread pain disorder that is assumed to originate from inappropriate pain processing in the central nervous system. Psychological and behavioral factors are both believed to underlie the pathogenesis and complicate the treatment. This hypothesis, however, has not yet been suffi...

journal_title：Medical hypotheses

authors： Hulens M,Dankaerts W,Stalmans I,Somers A,Vansant G,Rasschaert R,Bruyninckx F

更新日期：2018-01-01 00:00:00

abstract：:A comparison of more important physical, chemical and biological properties of the nitric oxide (NO) and free stable nitroxyl radicals (nitroxides) on the base of their structural similarity is made in the article. The active moiety in the nitroxide molecule represents a sterically hindered nitric oxide. The mechanism...

journal_title：Medical hypotheses

authors： Raikov ZD,Raikova ET,Atanasov AT

更新日期：2001-09-01 00:00:00

abstract：:Over the past decade evidence from multiple research trajectories have converged to provide evidence that impaired glucose metabolism and mitochondrial dysfunction in the brain are the critical issues laying at the root of Bipolar Disorder (BD). These developments have been paralleled by increasing recognition of the ...

journal_title：Medical hypotheses

authors： Campbell I,Campbell H

更新日期：2020-12-01 00:00:00

abstract：AIMS:To investigate the role of urinary BK polyoma virus (BKPyV) in the pathophysiology and prognosis of patients with painful bladder syndrome/interstitial cystitis (PBS/IC). METHODS:Urine samples were collected from 15 patients with PBS/IC and 8 control patients (with urolithiasis, overactive bladder and benign pros...

journal_title：Medical hypotheses

authors： Van der Aa F,Beckley I,de Ridder D

更新日期：2014-09-01 00:00:00

abstract：:Cancer cells proliferate and metastasize against the body's defense mechanisms due to their ability to change in response to challenges, both from the body's internal defenses as well as those from external sources, such as radiation and chemotherapy. This ability of tumor cell populations to change and grow in respon...

journal_title：Medical hypotheses

authors： Pienta KJ,Ward WS

更新日期：1994-01-01 00:00:00

abstract：:Music is ubiquitous. Yet, its biological relevance is still an ongoing debate. Supporting the view that music had an ancestral role in courtship displays, a pilot study presented here provides preliminary evidence on the link between music and sexual selection. The underlying hypothesis is based on the fact that the s...

journal_title：Medical hypotheses

authors： Miani A

更新日期：2016-08-01 00:00:00

abstract：:In this communication I propose a technique for manipulating the idiotype anti-idiotype network with the aim of enhancing the immune response to tumors. The theoretical basis for this technique follows from Jerne's network theory of the immune system. By tolerizing the host to immunoglobulin bearing idiotypes directed...

journal_title：Medical hypotheses

authors： Sharpe RJ

更新日期：1985-11-01 00:00:00

abstract：:The essential trace element selenium is known to be capable of reducing the toxicity of heavy metals like cadmium(II), mercury(II) and silver(I). One mechanism by which this occurs is through the formation of an inert metal selenide like silver selenide. It is not clear why selenide should react in the body preferenti...

journal_title：Medical hypotheses

authors： Nuttall KL

更新日期：1987-10-01 00:00:00

abstract：:Oral administration of L-arginine in pharmacological doses induces growth hormone and insulin-like growth factor-I responses and stimulates nitric oxide synthesis. Growth hormone and insulin-like growth factor-I are important mediators of bone turnover and osteoblastic bone formation, while nitric oxide is a potent in...

journal_title：Medical hypotheses

authors： Visser JJ,Hoekman K

更新日期：1994-11-01 00:00:00

abstract：:Elevated levels of aluminium (Al), strontium (Sr), barium (Ba), iron (Fe), manganese (Mn) cations - combined with deficiencies of magnesium (Mg)/calcium (Ca) - have been observed in the foodchains that traditionally support the Chamorro populations affected by high incidence clusters of Alzheimer (AD), Parkinson-like ...

journal_title：Medical hypotheses

authors： Purdey M

更新日期：2004-01-01 00:00:00

abstract：:Nearly two million people suffer traumatic brain injury in the US each year. These injuries alter adversely the metabolism of myelin, a major lipid material in brain, both in people and in experimental injuries of animals. A newly discovered and severe human neuropathy from copper deficiency provides evidence that som...

journal_title：Medical hypotheses

authors： Klevay LM

更新日期：2013-12-01 00:00:00

abstract：:In the last decades, relevant efforts have been made to reduce the cancer incidence in the European Union. The prevention programmes against cancer have obtained satisfactory results except for colorectal cancer (CRC). Identification of risk factors is primordial to plan preventive strategies for CRC. We hypothesize t...

journal_title：Medical hypotheses

authors： Manerio E,Rodas VL,Costas E,Hernandez JM

更新日期：2008-01-01 00:00:00

abstract：:Thyrotoxic periodic paralysis (TPP) frequently occurs on male individuals at their third and forth decades. The major site of involvement is the proximal muscles of lower limbs. Increasing evidence has shown that the occurrence of TPP is determined by multiple factors. We hypothesized that apart from hormonal fluctuat...

journal_title：Medical hypotheses

authors： Tang ZW,He Y,Yao Y,Qiu L,Tian HM

更新日期：2015-12-01 00:00:00

abstract：:The epidemiologic findings of Kaposi's sarcoma (KS) among patients with the acquired immunodeficiency syndrome (AIDS) suggest that human immunodeficiency virus (HIV) infection is insufficient for the development of KS. It was speculated that another sexually transmitted infection is responsible for the markedly increa...

journal_title：Medical hypotheses

authors： Rechavi G,Katzir N,Ramot B

更新日期：1991-04-01 00:00:00

abstract：:The S-oxidation of S-carboxymethyl-l-cysteine has been reported previously to be a biomarker of disease susceptibility in Parkinson's disease and Amyotrophic lateral sclerosis. In this investigation, the original observations have been confirmed with the incidence of the poor metaboliser phenotype (no urinary recovery...

journal_title：Medical hypotheses

authors： Steventon GB,Mitchell SC

更新日期：2018-09-01 00:00:00

abstract：:A bi-directional association between mood disorders and migraine has been consistently reported. Nevertheless, the neurobiological substrate underlying the association between these disorders remains unknown. In the article herein we review evidence for the role of inflammatory cytokines in the neurobiology of bipolar...

journal_title：Medical hypotheses

authors： Brietzke E,Mansur RB,Grassi-Oliveira R,Soczynska JK,McIntyre RS

更新日期：2012-05-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) is reported to occur frequently after all types especially cardiac surgery in elderly patients. It can be short-term or long-term and some cases even develop into Alzheimer's disease (AD). Although multi-risk factors associated with POCD have been identified, the etiology and...

journal_title：Medical hypotheses

authors： Fan L,Wang TL,Xu YC,Ma YH,Ye WG

更新日期：2011-05-01 00:00:00

abstract：:Neuronal degeneration in the post-menopausal term leads to cognitive symptoms such as anxiety, difficulty in concentrating, overreacting to minor upsets, quickly becoming irritated and forgetfulness in approximately 70-80% of all women around the world. These symptoms, which result from microtubule damage in the axon ...

journal_title：Medical hypotheses

authors： Karamese M,Aksak S,Gundogdu OB,Unal B

更新日期：2013-09-01 00:00:00