Minocycline may be useful to prevent/treat postoperative cognitive decline in elderly patients.

Abstract:

:Postoperative cognitive dysfunction (POCD) is reported to occur frequently after all types especially cardiac surgery in elderly patients. It can be short-term or long-term and some cases even develop into Alzheimer's disease (AD). Although multi-risk factors associated with POCD have been identified, the etiology and pathophysiological mechanisms of this surgical complication remain elusive. Therefore, developing strategies for preventing or treating POCD is still challenging. However, increasing evidence suggests that central and systemic inflammation triggered by surgery likely plays a fundamental role in POCD developing and progression. Minocycline, a tetracycline derivative with anti-inflammatory properties, has been shown to be effective in treating neuroinflammatory related conditions or neurodegenerative diseases such as AD, Parkinson's disease, Huntington's disease. Considering that inflammation may be a potential factor of POCD and minocycline is effective in improving cognitive dysfunction induced by inflammation, we hypothesize that minocycline may be useful to treat/prevent the POCD development after surgery in elderly patients.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Fan L,Wang TL,Xu YC,Ma YH,Ye WG

doi

10.1016/j.mehy.2011.02.010

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

733-6

issue

5

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(11)00061-2

journal_volume

76

pub_type

杂志文章
  • Parkinson's disease; the hibernating spore hypothesis.

    abstract::The authors support the hypothesis that a causative agent in Parkinson's disease (PD) might be either fungus or bacteria with fungus-like properties - Actinobacteria, and that their spores may serve as 'infectious agents'. Updated research and the epidemiology of PD suggest that the disease might be induced by environ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2017.05.022

    authors: Berstad K,Berstad JER

    更新日期:2017-07-01 00:00:00

  • Water pipe smoking and human oral cancers.

    abstract::While cigarette smoking is recognized as an important risk factor in human oral cancers, the effect of water pipe smoking (WPS) on these cancers is not known. WPS is very common in the young adult population, especially in the Middle East, and has been associated with several respiratory problems. However, to date, th...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2009.10.013

    authors: Rastam S,Li FM,Fouad FM,Al Kamal HM,Akil N,Al Moustafa AE

    更新日期:2010-03-01 00:00:00

  • Does hyperglycemia downregulate glucose transporters in the brain?

    abstract::Diabetes is a metabolic condition associated with hyperglycemia manifested by the elevation of blood glucose levels occurring when the pancreas decreases or stops the production of insulin, in case of insulin resistance or both. The current literature supports that insulin resistance may be responsible for the memory ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.109614

    authors: Leão LL,Tangen G,Barca ML,Engedal K,Santos SHS,Machado FSM,de Paula AMB,Monteiro-Junior RS

    更新日期:2020-06-01 00:00:00

  • Is prolactin involved in sperm capacitation?

    abstract::Immunoreactive prolactin in high concentration was detected in the human semen. Therefore, the effect of prolactin on the various metabolic parameters of the human spermatozoa was studied. It was found that prolactin brought about many of the biochemical changes in the spermatozoa which are known to be associated with...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(79)90079-3

    authors: Shah GV,Sheth AR

    更新日期:1979-08-01 00:00:00

  • Modern menstruation: Is it abnormal and unhealthy?

    abstract::The menstrual cycle appears to have evolved in humans and some other species to improve reproductive efficiency by enabling progesterone production without the presence of the fetus. This phenomenon is termed spontaneous decidualization. Repeated menstruation is produced in modern women because of better general healt...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.109955

    authors: Goldstuck ND

    更新日期:2020-11-01 00:00:00

  • New aspects in genotoxic risk assessment of styrene exposure--a working hypothesis.

    abstract::Styrene is one of the most important plastic monomers worldwide. Styrene-7,8-oxide (SO), the major in-vivo metabolite of styrene, is classified as probably carcinogenic to humans and carcinogenic in rodents. Biological monitoring of exposure to styrene is usually carried out by determination of mandelic acid and pheny...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.1999.0907

    authors: Marczynski B,Peel M,Baur X

    更新日期:2000-04-01 00:00:00

  • The Salted Food Addiction Hypothesis may explain overeating and the obesity epidemic.

    abstract:UNLABELLED:One plausible explanation for the controversy that surrounds the causes and clinical management of obesity is the notion that overeating and obesity may only be a couple of "symptoms" associated with a yet to be discovered medical disorder. OBJECTIVES:To introduce the Salted Food Addition Hypothesis. This t...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2009.06.049

    authors: Cocores JA,Gold MS

    更新日期:2009-12-01 00:00:00

  • Smoking, lung cancer and hypothesis testing.

    abstract::It has been shown previously that the precipitator hypothesis of causation is able to account for certain key features of the epidemiological evidence that conflict with initiator and promoter hypotheses. The precipitator hypothesis states that the carcinogenic risk depends linearly in the average rate of smoking at a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(81)90145-6

    authors: Burch PR

    更新日期:1981-12-01 00:00:00

  • The role of progesterone/estradiol ratio in exploring the mechanism of late follicular progesterone elevation in low ovarian reserve women.

    abstract::Late follicular progesterone (P) elevation continues to complicate a significant part of assisted reproductive technologies (ART) cycles, despite the ardent employment of gonadotropin releasing hormone (GnRH) analogues. In women with good ovarian reserve, late follicular P elevation is believed to be the result of the...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2019.02.047

    authors: Younis JS

    更新日期:2019-04-01 00:00:00

  • Is ATP-sensitive K+ channel (K+ATP) recruitment a common mechanism for ECG-ST segment depression and elevation?

    abstract::ATP sensitive (K(+)(ATP)) potassium cardiac channels are recruited when ATP levels are low as in ischemic injury and acute trauma. Such activation results in ECG-ST elevation and cardiac arrhythmias. K(+)(ATP) channel recruitment may be blocked by the sulfonylurea glibenclamide, permitting a wide variety of animal exp...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/s0306-9877(03)00055-0

    authors: Hoffman I,Saltzman B

    更新日期:2003-04-01 00:00:00

  • Shellfish consumption: a major risk factor for colorectal cancer.

    abstract::In the last decades, relevant efforts have been made to reduce the cancer incidence in the European Union. The prevention programmes against cancer have obtained satisfactory results except for colorectal cancer (CRC). Identification of risk factors is primordial to plan preventive strategies for CRC. We hypothesize t...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2007.03.041

    authors: Manerio E,Rodas VL,Costas E,Hernandez JM

    更新日期:2008-01-01 00:00:00

  • Positive selection of type 2 diabetes genotypes - the glycaemic threshold hypothesis.

    abstract::The high prevalence of deleterious polygenic type 2 diabetes (T2D) is a paradox requiring explanation beyond food excess, inactivity and the obesity resulting from positive energy balance. Historically, hunting-foraging and later agrarian communities often manifested a converse negative energy balance due to nutrition...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2019.04.014

    authors: Wise PH

    更新日期:2019-06-01 00:00:00

  • Early-life inflammation pathways trigger a cascade leading to development of atherosclerotic plaque through the "butterfly effect" - An hypothesis.

    abstract::Atherosclerosis is a common disease whose complications, such as myocardial infarction, are a leading cause of mortality worldwide. Therefore, ideas which try to explain the circumstances of atherosclerotic plaque initiation and progression are warranted. We hypothesize that low-grade inflammation in early life (espec...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2018.10.026

    authors: Kowara M,Kasarełło K,Czarzasta K,Opolski G,Cudnoch-Jędrzejewska A

    更新日期:2019-01-01 00:00:00

  • Hv1 proton channel possibly promotes atherosclerosis by regulating reactive oxygen species production.

    abstract::Atherosclerosis and its fatal complications, such as myocardial infarction or stroke, represent the most common cause of morbidity or mortality in modern world. It was observed that an excess of reactive oxygen species (ROS) accompanies atherosclerosis. Under physiological circumstances, intracellular H+ accumulates a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.109724

    authors: Zheng Z,Zhang Z,Wang M

    更新日期:2020-08-01 00:00:00

  • Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach.

    abstract::Essential hypertension is a heterogeneous multifactorial syndrome associated with a high cardiovascular risk. A multiple choice of antihypertensive drugs is available; however, a high individual variability to the antihypertensive therapy is still responsible for a modest reduction of the CV risk and not satisfactory ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2006.07.058

    authors: Ferrari P,Ferrandi M,Valentini G,Manunta P,Bianchi G

    更新日期:2007-01-01 00:00:00

  • The binding of DNA to water soluble carbodiimide modified proteins.

    abstract::Bovine serum albumin and human serum transferrin modified by the water soluble carbodiimides N-ethyl-N'-(3-dimethyl propylamino) carbodiimide (CDI) or N-ethyl-N'-(3-trimethyl propylammonium) carbodiimide (Me+CDI) to yield N-acylurea proteins bind pBR322 DNA reversibly showing electrostatic and non-electrostatic compon...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(87)90044-2

    authors: Ariatti M,Hawtrey AO

    更新日期:1987-09-01 00:00:00

  • The effect of valsartan and nebivolol treatment on ADMA and pentraxin-3 levels in hypertensive patients.

    abstract::Long pentraxin 3 (PTX3) is a recently discovered multimeric inflammatory mediator that is structurally linked to short pentraxins, such as C-reactive protein (CRP) and serum amyloid P component. PTX3 is produced by a variety of tissues and cells, including vascular endothelial cells and macrophages. Because of its ext...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2012.05.011

    authors: Parlak A,Iyisoy A,Aydogan U,Cakir E,Saglam K

    更新日期:2012-09-01 00:00:00

  • Increased hepatic gluconeogenesis: the secret of Lance Armstrong's success.

    abstract::Enormous amounts of lactic acid are produced during endurance sport by muscle cells. This metabolite is thought responsible for the muscle pain and the fatigue during sport. Its internal removal from the body by enzymatic conversion depends mainly on the capacity of the hepatic gluconeogenesis that converts lactic aci...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2006.04.054

    authors: Bongaerts GP,Wagener DJ

    更新日期:2007-01-01 00:00:00

  • A suggested mechanism for changing tumor cell phenotype: transfection of host cells with DNA sequences of dead tumor cells.

    abstract::In observing the phenomenon of alterations of tumor cell phenotypes, one may envision a mechanism that induces the change in tumor cell characteristics and the appearance of metastasis. Schirrmacher (1) has suggested that the effect of the microenvironment on tumor cells influences the control of gene expression and t...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(81)90010-4

    authors: Klein BY

    更新日期:1981-05-01 00:00:00

  • The percussion reactions involved in brain function.

    abstract::A hypothesis is presented describing the operation of mammalian brains on the basis of rapid percussion chemical reactions and shock waves generated by such reactions. It is shown that the products of these are various chemical compounds identified as present in the brain. The manner in which the brain deals with vari...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/s0306-9877(02)00296-7

    authors: Robertson DS

    更新日期:2002-12-01 00:00:00

  • What decides the nature of extraocular muscle injury? The probable mechanism of flap tear and rupture.

    abstract::The assessment of nature and the extent of extraocular muscle injuries during initial visit in ocular emergencies is of paramount importance to avoid/minimize the subsequent need for strabismus surgery. Based on our experience in managing acute globe and orbital injuries and cases of strabismus, we propose the probabl...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2019.01.011

    authors: Pujari A,Saxena R,Sharma P,Phuljhele S

    更新日期:2019-02-01 00:00:00

  • A hypothesis for the molecular mechanism of tumor killing by porphyrins and light.

    abstract::Tumor cells have an absence or deficiency of mitochondrial superoxide dismutase. Superoxide is produced when hematoporphyrin derivative is exposed to visible light. A significant portion of the antitumor effect of porphyrin:light therapy is hypothesized to be mediated by superoxide. ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(81)90116-x

    authors: Peterson DA,McKelvey S,Edmondson PR

    更新日期:1981-02-01 00:00:00

  • Gap junctions enhancer combined with Vaughan Williams class III antiarrhythmic drugs, a promising antiarrhythmic method?

    abstract::Arrhythmias is one of the leading causes of death in the world. Current antiarrhythmic drugs are limited by unsatisfactory efficacy and adverse effects such as proarrhythmias. Reentry mechanism plays an important role in persistence of arrhythmias. Reentry can only continue when reentry path-length is longer than card...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2010.08.047

    authors: Li LD,Zhang CT,Ruan L,Ni MK,Quan XQ

    更新日期:2011-01-01 00:00:00

  • Aerosolization of cyanobacteria as a risk factor for amyotrophic lateral sclerosis.

    abstract::Sporadic amyotrophic lateral sclerosis (sALS) is a fatal neurodegenerative disease with no known cause. There are many clues to suggest an environmental trigger for the disease, including reports of conjugal couples and co-localized employees that developed sALS. On the island of Guam,a very high incidence of sALS occ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2012.11.012

    authors: Stommel EW,Field NC,Caller TA

    更新日期:2013-02-01 00:00:00

  • The role of aromatic hydrocarbons in the genesis of breast cancer.

    abstract::The incidence of breast cancer in women has increased dramatically over the last decade. Epidemiological markers of this increased incidence include: endocrine related phenomena (early menarche, age of first parity and age of menopause); exposure of the breast to X-radiation; and a group of seemingly disparate factors...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(92)90090-y

    authors: Morris JJ,Seifter E

    更新日期:1992-07-01 00:00:00

  • A new choice for the treatment of epilepsy: electrical auricula-vagus-stimulation.

    abstract::Preliminary reports have suggested that chronic, intermittent electrical stimulation of the cervical vagus nerve (VNS) is an effective treatment for patients who suffered from medically refractory epilepsy. But the traditional VNS is an invasive and implantable procedure that will bring some injury to the patient. Ana...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2011.04.021

    authors: Yang AC,Zhang JG,Rong PJ,Liu HG,Chen N,Zhu B

    更新日期:2011-08-01 00:00:00

  • Hypnosis and music interventions (HMIs) inactivate HIF-1: A potential curative efficacy for cancers and hypertension.

    abstract::Hypnosis and music interventions (HMIs) have shown positive influence on cancers for nearly 200years, but the underlying mechanisms were rarely explored systematically. The hypothesis suggests a potential curative efficacy of HMIs on cancers by inhibiting hypoxia inducible factor-1 (HIF-1), which is a key mediator of ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2015.07.008

    authors: Wang JZ,Li L,Pan LL,Chen JH

    更新日期:2015-11-01 00:00:00

  • The placebo effect on mood and behavior: the role of the endogenous opioid system.

    abstract::Evidence from clinical and experimental studies has shown that placebos influence mood and behavior, that endogenous opioids are involved in the placebo effect, and that the endogenous opioid system is related to psychological events. Recent studies have also demonstrated that the endogenous opioid system is closely c...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/s0306-9877(97)90105-5

    authors: Sher L

    更新日期:1997-04-01 00:00:00

  • Several effects of boron are induced by uncoupling steroid hormones from their transporters in blood.

    abstract::Boron is increasingly added to food supplements due to multiple effects that have been reported in mammals after boric acid administration. Among these effects are inflammatory process control, bone and muscle strength enhancement, protein expression regulation, and a decreased risk of developing some pathologies in w...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2018.06.024

    authors: Bello M,Guadarrama-García C,Velasco-Silveyra LM,Farfán-García ED,Soriano-Ursúa MA

    更新日期:2018-09-01 00:00:00

  • Progression of disease and a remedy: causative role of macrophages and microglia: remedial effect of immunomodulatory and immunosuppressive therapies "in combination".

    abstract::The possibility of a pathway, common to progression, in entities in which activated macrophages or microglia are present, amenable to particular therapies, is discussed. Immunoglobulin synthesis and activation of the complement pathway may be critical elements in progression. It is possible progression in a proportion...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2006.06.001

    authors: Milder DG

    更新日期:2006-01-01 00:00:00