Size of quadriceps femoris may contribute to thyrotoxic periodic paralysis.


:Thyrotoxic periodic paralysis (TPP) frequently occurs on male individuals at their third and forth decades. The major site of involvement is the proximal muscles of lower limbs. Increasing evidence has shown that the occurrence of TPP is determined by multiple factors. We hypothesized that apart from hormonal fluctuations, skeletal muscle itself may explain for the age and sex variance as well. Our study was established to explore whether the size of lower limb skeletal muscles were related to TPP. We conducted a clinical experiment including 43 patients diagnosed with TPP (Group 1) and 39 pure hyperthyroidism individuals (Group 2). Current age, body mass index (BMI), thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), average girth of bilateral upper arm and thigh, physical activity level (PAL) were measured. We also adopted B mode ultrasound to quantify the muscle thickness (MT) of the major muscle involved in the disease, the quadriceps femoris (QF, including rectus femoris, RF; vastus intermedius, VI; vastus medialis, VM and vastus lateralis, VL). Patients were matched in TSH, FT4 and FT3. PAL was also statistically identical between groups. Age, BMI, thigh girth, the average of bilateral MT of QF were statistically different. After adjusting for age, BMI and girth, Group 1 still presented with larger MT of QF than Group 2, regardless of their current thyroid hormone level. There indeed exists an independent relationship between muscle thickness and TPP.


Med Hypotheses


Medical hypotheses


Tang ZW,He Y,Yao Y,Qiu L,Tian HM




Has Abstract


2015-12-01 00:00:00














  • Edaravone: a new therapeutic approach for the treatment of acute stroke.

    abstract::Acute stroke, including acute ischemic stroke (AIS) and acute hemorrhagic stroke, (AHS) is a common medical problem with particular relevance to the demographic changes in industrialized societies. In recent years, treatments for AIS have emerged, including thrombolysis with tissue plasminogen activator (t-PA). Althou...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Kikuchi K,Kawahara K,Miyagi N,Uchikado H,Kuramoto T,Morimoto Y,Tancharoen S,Miura N,Takenouchi K,Oyama Y,Shrestha B,Matsuda F,Yoshida Y,Arimura S,Mera K,Tada K,Yoshinaga N,Maenosono R,Ohno Y,Hashiguchi T,Maruyama

    更新日期:2010-12-01 00:00:00

  • Hyperbaric oxygen toxicity in brain: A case of hyperoxia induced hypoglycemic brain syndrome.

    abstract::Hyperbaric oxygen exposure is a recent hazzard for higher animals that originated as humans began underwater construction, exploration, and sports. Exposure can lead to abnormal brain EEG, convulsions, and death, the time to onset of each stage of pathology decreasing with increase in oxygen pressure. We provide evide...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Wilson DF,Matschinsky FM

    更新日期:2019-11-01 00:00:00

  • Each type of cause that initiates rheumatoid arthritis or RA flares differentially affects the response to therapy.

    abstract::The autoimmune disease rheumatoid arthritis (RA) presents difficulty in diagnosis, commonly observed flare ups, polycyclical nature of RA progression, and variable response to therapies. Congruent with multiple causes, literature has documented various infectious agents, environmental factors, physical trauma, silica ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Molnar-Kimber KL,Kimber CT

    更新日期:2012-01-01 00:00:00

  • A groundless hypothesis, megaloblastic madness, and the founding of Duke University.

    abstract::In a recent issue of Medical Hypotheses, Dr H L Newbold repeats the assertion that the cause of James B Duke's death in 1925 was pernicious anemia. Dr Newbold postulates that Mr Duke was neurologically impaired as a result of vitamin B-12 deficiency and that he suffered from depression. In an attempt to relieve this d...

    journal_title:Medical hypotheses

    pub_type: 传,历史文章,杂志文章


    authors: Halperin EC

    更新日期:1991-11-01 00:00:00

  • A novel deployment design of vena cava filters might be the solution to their blockage problem.

    abstract::The blockage of a vena cava filter (VCF) by the captured blood clots presents a serious problem to the patients. Commercially available cone-shaped VCFs such as the Gunther Tulip filter has an inherent structural flaw that leads the captured blood clots to be trapped in their front spire areas where the flow-induced s...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Chen Z,Fan Y,Deng X

    更新日期:2011-12-01 00:00:00

  • Endocrine factors in haematological changes seen in dogs and ferrets given oestrogens.

    abstract::High doses of oestrogens in the dog and ferret cause myeloid hyperplasia in the bone marrow superseded by hypoplasia affecting all cell lines. In the peripheral blood after an initial leucocytosis, there is thrombocytopenia, anaemia and leucopenia. These effects, which are ultimately lethal, do not occur in cats, rats...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Hart JE

    更新日期:1985-02-01 00:00:00

  • Medical knowledge integration and "systems medicine": Needs, ambitions, limitations and options.

    abstract::Medicine today is an extremely heterogeneous field of knowledge, based on clinical observations and action knowledge and on data from the biological, behavioral and social sciences. We hypothesize at first that medicine suffers from a disciplinary hyper-diversity compared to the level of conceptual interdisciplinary i...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Tretter F,Löffler-Stastka H

    更新日期:2019-12-01 00:00:00

  • Decision making process for amputation in case of therapy resistant complex regional pain syndrome type-I in a Dutch specialist centre.

    abstract::Deciding for an amputation in case of complex regional pain syndrome type I (CRPS-I) is controversial. Evidence for favorable or adverse effects of an amputation is weak. We therefore follow a careful and well-structured decision making process. After referral of the patient with the request to amputate the affected l...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Schrier E,Dijkstra PU,Zeebregts CJ,Wolff AP,Geertzen JHB

    更新日期:2018-12-01 00:00:00

  • Therapeutic potential of lipase inhibitor orlistat in Alzheimer's disease.

    abstract::Emerging evidences indicate that elevated cholesterol and triglyceride levels precede Alzheimer's disease (AD) pathology. High caloric intake based on saturated fat raises hyperlipidaemia and also promotes AD pathology. As a result, strategy that limits the absorption of dietary fat and attenuates hyperlipidemia could...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Du J,Wang Z

    更新日期:2009-11-01 00:00:00

  • A pendular mechanism for maintenance of the immune memory.

    abstract::A possible mechanism for maintaining immune memory, based on idiotypic-anti-idiotypic interactions, is described. It is proposed that pendular dynamic swings in the levels of idiotypic antibodies (Ab1) and anti-idiotypic Ab2 may underlay immune memory. In the terms of the advanced concept, Ab dynamics in the maternal ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Seledtsov VI,Seledtsova GV

    更新日期:2001-02-01 00:00:00

  • The big bang and its universal hernias. A sire of pathologies.

    abstract::The 'Big Bang' is used to describe the origin of the Universe. While such an event could not create itself the expression is graphic. Tissue damage, traumatic, thermal, chemical; bites; insect, animal or human are all bad, but also well known factors which favor and initiate pathogenic activity. Antedating and outrank...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Baggot MG

    更新日期:1991-06-01 00:00:00

  • The excitatory:inhibitory ratio model (EIR model): An integrative explanation of acute autonomic overactivity syndromes.

    abstract::Numerous medical conditions present with acute and severe autonomic and muscular overactivity. These syndromes include Neuroleptic Malignant Syndrome, Serotonin Syndrome, Dysautonomia (or paroxysmal sympathetic storms) following acquired brain injury, Autonomic Dysreflexia, Parkinsonian-Hyperpyrexia Syndrome, Malignan...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Baguley IJ

    更新日期:2008-01-01 00:00:00

  • Calcium sulfide (CaS), a donor of hydrogen sulfide (H(2)S): a new antihypertensive drug?

    abstract::Hypertension is the leading cause of cardiovascular diseases, and an estimated 972 million people in the world are suffering from this problem. Indubitably, hypertension is an important worldwide public-health challenge. In recent years many efforts have been made to devise novel therapies involving new targets implic...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Li YF,Xiao CS,Hui RT

    更新日期:2009-09-01 00:00:00

  • Breastfeeding: A standard or an intervention? Review of systematic reviews.

    abstract::Clinical trials designed to answer treatment-related questions typically compare an intervention group that receives a drug or other intervention to a control group that serves as a standard against which results of the intervention are evaluated. An observed divergence from this trend in research papers on breastfeed...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Dimnjakovic J,Poljicanin T,Svajda M

    更新日期:2020-08-01 00:00:00

  • gamma-Glutamyltransferase is a promising biomarker for cardiovascular risk.

    abstract::Oxidative stress plays a crucial role in a variety of clinical settings of atherogenesis, and mediates many pathways linked to atherosclerosis and inflammation. gamma-Glutamyltransferase (GGT), an enzyme responsible for the extracellular catabolism of antioxidant glutathione, may directly take part in atherogenesis an...

    journal_title:Medical hypotheses

    pub_type: 杂志文章,评审


    authors: Turgut O,Yilmaz A,Yalta K,Karadas F,Birhan Yilmaz M

    更新日期:2006-01-01 00:00:00

  • Hypothesis: Role for the circadian Clock system and sleep in the pathogenesis of adhesions and chronic pelvic pain?

    abstract::Intra-peritoneal adhesions ensuing from surgery or infection may lead to chronic pelvic pain, bowel obstruction, infertility and additional invasive surgery to resolve adhesion-related complications. As a result adhesions are a major clinical, social and economic concern. The cumulative year-on-year direct costs of ad...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Sadek K,Macklon N,Bruce K,Cagampang F,Cheong Y

    更新日期:2011-03-01 00:00:00

  • A potential role of cyclin-dependent kinase inhibitor 1 (p21/WAF1) in the pathogenesis of endometriosis: Directions for future research.

    abstract::Endometriosis is a common gynecological disorder that affects approximately 6-10% of the female population impairing the quality of life of patients. Several pathophysiologic pathways have been proposed as potential regulators of its severity; however, to date, the processes that trigger the onset and that influence t...

    journal_title:Medical hypotheses

    pub_type: 杂志文章,评审


    authors: Zarkadoulas N,Pergialiotis V,Dimitroulis D,Stefanidis K,Verikokos C,Perrea DN,Kontzoglou K

    更新日期:2019-12-01 00:00:00

  • On the synergistic effects of enzymes in food with enzymes in the human body. A literature survey and analytical report.

    abstract::Recently, a theory has been postulated that suggests that vital enzymes in ingested food interact synergistically with enzymes within the human body and more specifically with enzymes in the digestive tract. Alterations in food enzymes induced by bulk processing including heating and irradiation and also the addition ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Prochaska LJ,Piekutowski WV

    更新日期:1994-06-01 00:00:00

  • The olive and central control of blood pressure.

    abstract::This evidence, then, would suggest that the olive becomes active when, with a change in the motor task, the motor performance is required to adjust to the new circumstance. From Smith's experiments on blood pressure, it is extrapolated that the olive becomes active when there is a change in the physiological state, an...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Kennedy PR

    更新日期:1978-11-01 00:00:00

  • An ezetimibe-policosanol combination has the potential to be an OTC agent that could dramatically lower LDL cholesterol without side effects.

    abstract::Although many risk factors influence atherogenesis, LDL appears to play a primary role in this process. In prospective epidemiology, coronary risk increases as LDL cholesterol increases, throughout the entire range of concentrations encountered in healthy humans. Coronary risk is minimal in individuals and populations...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: McCarty MF

    更新日期:2005-01-01 00:00:00

  • Nutraceutical strategies for ameliorating the toxic effects of alcohol.

    abstract::Rodent studies reveal that oxidative stress, much of it generated via induction/activation of NADPH oxidase, is a key mediator of a number of the pathogenic effects of chronic ethanol overconsumption. The highly reactive ethanol metabolite acetaldehyde is a key driver of this oxidative stress, and doubtless works in o...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: McCarty MF

    更新日期:2013-04-01 00:00:00

  • Vitamin D therapy and related metabolomics: is the calciferol dose and form the only requirements for successful clinical therapeutics?

    abstract::A nutraceutical that has exploded onto the prescription pad in recent years is the fat soluble vitamin, vitamin D. This is due to an increasing medical interest in the utility of the vitamin in the treatment and prevention of an array of diseases and ailments. Despite the continued debate over the correct dose, form a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Braithwaite MC,Kumar P,Tyagi C,Tomar LK,Choonara YE,Pillay V

    更新日期:2013-10-01 00:00:00

  • Loss of binocular vision as direct cause for misrouting of temporal retinal fibers in albinism.

    abstract::In humans, the nasal retina projects to the contralateral hemisphere, whereas the temporal retina projects ipsilaterally. The nasotemporal line that divides the retina into crossed and uncrossed parts coincides with the vertical meridian through the fovea. This normal projection of the retina is severely altered in al...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Banihani SM

    更新日期:2015-10-01 00:00:00

  • Can testosterone replacement decrease the memory problem of old age?

    abstract::The world is rapidly ageing. It is against this backdrop that there are increasing incidences of dementia reported worldwide, with Alzheimer's disease (AD) being the most common form of dementia in the elderly. It is estimated that AD affects almost 4 million people in the US, and costs the US economy more than 65 mil...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Lim D,Flicker L,Dharamarajan A,Martins RN

    更新日期:2003-06-01 00:00:00

  • Menstrual variation of autonomic balance may be a factor in exacerbations of certain diseases during the menstrual cycle.

    abstract::Exacerbation of certain medical conditions during specific phases of the menstrual cycle has long been recognized. Mechanisms of the cyclic variations are poorly understood, but are often attributed to fluctuations in reproductive hormones. We hypothesize that normal variations in autonomic balance during the menstrua...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Lee PY,Bazar KA,Yun AJ

    更新日期:2004-01-01 00:00:00

  • You are what you ate: the Biosetpoint hypothesis.

    abstract::The current epidemic of obesity has developed at a rate that cannot be attributed to genetic drift. Attempts to treat obesity using diet and activity have been largely disappointing. Genes are fixed at conception, but genetic expression is known to be influenced by nutriture during the stages of growth and development...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Blonz ER

    更新日期:2006-01-01 00:00:00

  • Is the EuroSCORE II best suited for reoperative risk estimation in patients with structural deterioration of aortic bioprostheses?

    abstract:BACKGROUND:Operative risk prediction systems (logistic EuroSCORE I, EuroSCORE II and STS Score) are employed together with multidisciplinary discussion to contraindicate conventional surgery in patients with valvular heart disease and propose the employment of alternative transcatheter procedures. The EuroSCORE I has b...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Anselmi A,Ruggieri VG,Harmouche M,Mascle S,Auffret V,Le Breton H,Beneux X,Verhoye JP

    更新日期:2015-05-01 00:00:00

  • An association between male homosexuality and reproductive success.

    abstract::The existence of homosexuality in humans poses a problem for evolutionary theory. Exclusive male homosexuality has a catastrophic effect on reproduction and yet inherited factors appear to contribute to it. Previous attempts to resolve this conundrum are inconsistent with aspects of evolutionary theory. Additional lim...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Dewar CS

    更新日期:2003-02-01 00:00:00

  • 5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection.

    abstract::The recent global pandemic created by the Coronavirus SARS-CoV-2, started in Wuhan, China in December 2019, has generated panic, both in term of human death (4-5% of infected patients identified through testing) and the global economy. Human sufferings seem to be continuing, and it is not clear how long this will cont...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Ahmad SI

    更新日期:2020-09-01 00:00:00

  • Enhancing central and peripheral insulin activity as a strategy for the treatment of endogenous depression--an adjuvant role for chromium picolinate?

    abstract::Depression is often associated with insulin resistance, owing to cortisol overproduction; conversely, many studies suggest that diabetics are at increased risk for depression. Recent evidence indicates that insulin is transported through the blood-brain barrier and influences brain function via widely distributed insu...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: McCarty MF

    更新日期:1994-10-01 00:00:00