Inflammatory cytokines as an underlying mechanism of the comorbidity between bipolar disorder and migraine.

abstract：:The measurement of urinary neopterin and biopterin may be an important non-specific diagnostic tool. Urinary biopterin has been found to be decreased in parkinsonian patients, and in hyperphenylalanemia as a variant of phenylketonuria. Urinary neopterin has been found to be elevated in numerous conditions. It has been...

journal_title：Medical hypotheses

authors： Rabinoff M

更新日期：1989-08-01 00:00:00

abstract：:Despite aggressive intervention, patients who survive an out-of-hospital cardiac arrest (OHCA) generally have very poor prognoses, with nationwide survival rates of approximately 10-20%. Approximately 90% of survivors will have moderate to severe neurological injury ranging from moderate cognitive impairment to brain ...

journal_title：Medical hypotheses

authors： Gul SS,Huesgen KW,Wang KK,Mark K,Tyndall JA

更新日期：2017-08-01 00:00:00

abstract：:The objective of this study was to test the hypothesis that the regular practice of mindfulness meditation is associated with increased physiological levels of melatonin. Melatonin may be related to a variety of biologic functions important in maintaining health and preventing disease, including breast and prostate ca...

journal_title：Medical hypotheses

authors： Massion AO,Teas J,Hebert JR,Wertheimer MD,Kabat-Zinn J

更新日期：1995-01-01 00:00:00

abstract：:The various neurotransmitter systems postulated to be involved in the pathogenesis of Gilles de la Tourette syndrome(GTS) are described with special reference to the endogenous opioid system(EOS). Malfunction of the opioid system is proposed as the underlying disturbance in this disease causing secondary dysfunction o...

journal_title：Medical hypotheses

authors： Gillman MA,Sandyk R

更新日期：1986-04-01 00:00:00

abstract：:The outbreak of coronavirus disease 2019 (COVID-19) has posed a severe threat to global health management system since it has been detected in the human body. This pandemic was prompted by severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2) and rapidly developed into a public emergency with an alarming incr...

journal_title：Medical hypotheses

authors： Tao H,Bai J,Zhang W,Zheng K,Guan P,Ge G,Li M,Geng D

更新日期：2020-11-01 00:00:00

abstract：:Synthetic ligands of the retinoid X receptor (RXR) have shown antidiabetic activity in mice, apparently owing to the fact that they stimulate the transcriptional activity of PPAR-gamma/RXR heterodimers, much like thiazolidinedione drugs. The chlorophyll metabolite phytanic acid has been shown to be a natural ligand fo...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Special feet connected to a prosthesis, prosthetic sports feet, enable athletes with a lower limb amputation to run. The selection of a prosthetic sports feet is usually based on body weight and preferred sports performance. The selection of a prosthetic sport feet is also based on clinicians who likely have...

journal_title：Medical hypotheses

authors： Poonsiri J,van Putten SWE,Ausma AT,Geertzen JHB,Dijkstra PU,Dekker R

更新日期：2020-10-01 00:00:00

abstract：:Our hypothesis was that testosterone therapy (TT) interacts with previously undiagnosed thrombophilia-hypofibrinolysis, leading to hospitalization for deep venous thrombosis (DVT)-pulmonary emboli (PE). We determined the prevalence of DVT-PE associated with TT 147 men hospitalized in the last 12 months for DVT-PE. Of ...

journal_title：Medical hypotheses

authors： Glueck CJ,Friedman J,Hafeez A,Hassan A,Wang P

更新日期：2015-04-01 00:00:00

abstract：:Anorexia nervosa was explored as the possible expression of an aberration of the processing of information which ordinarily has value in life protection or extension. Each of 6 areas was briefly reviewed, and noted to have the potential for failure to balance 2 or more factors. Anorexia nervosa may prove to be a psych...

journal_title：Medical hypotheses

authors： Spencer RP

更新日期：1990-09-01 00:00:00

abstract：:Although all multicellular organisms undergo structural and functional deterioration with age, senescence is not a uniform process. Rather, each organism experiences a constellation of changes that reflect the heterogeneous effects of age on molecules, cells, organs and systems, an idiosyncratic pattern that we refer ...

journal_title：Medical hypotheses

authors： Walker LC,Herndon JG

更新日期：2010-06-01 00:00:00

abstract：:Injury and organ failure after irradiation of late-responding tissues is a substantial problem in radiation oncology and a major threat after accidental or belligerent exposures. The mechanisms of injury may include death of clonogens, vascular injury, activation of cytokine networks, and/or chronic oxidative stress. ...

journal_title：Medical hypotheses

authors： Cohen SR,Cohen EP

更新日期：2013-02-01 00:00:00

abstract：:Several studies have described unusually high incidence of vascular thrombosis in coronavirus disease-2019 (COVID-19) patients. Pathogenesis of the vascular thrombosis in COVID-19 is least understood for now and presents a challenge to the treating physicians. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-...

journal_title：Medical hypotheses

authors： Kumar A,Narayan RK,Kumari C,Faiq MA,Kulandhasamy M,Kant K,Pareek V

更新日期：2020-12-01 00:00:00

abstract：:The "small-for-size" syndrome and "post-hepatectomy liver failure" refers to the development of liver failure (hyperbilirubinemia, coagulopathy, encephalopathy and refractory ascites) resulting from the reduction of liver mass beyond a certain threshold. This complication is associated with a high mortality and is a m...

journal_title：Medical hypotheses

authors： Asencio JM,Vaquero J,Olmedilla L,García Sabrido JL

更新日期：2013-05-01 00:00:00

abstract：:Reversing chronic conditions remains an elusive goal of medicine. The modern medical paradigm based on blocking overactive pathways or augmenting deficient pathways offers symptomatic benefit, but tolerance to therapy can develop and treatment cessation can produce rebound symptoms due to compensatory mechanisms. We p...

journal_title：Medical hypotheses

authors： Yun AJ,Lee PY,Bazar KA

更新日期：2005-01-01 00:00:00

abstract：:The small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis are associated with autoantibodies to neutrophil cytoplasm antigens (ANCA), principally proteinase-3 (PR3) and myeloperoxidase (MPO). There is an association between GPA and nasal carriage of Staphylococcus aureus. The re...

journal_title：Medical hypotheses

authors： Oliveira DBG

更新日期：2018-03-01 00:00:00

abstract：:Following the rate of proteoglycan synthesis as the metabolic parameter of the growth of cartilage cells, indicates that hormonal and local agents are two distinct types of extracellular regulators responsible for altering the basic metabolic rates of cells. Such changes in growth rate occur regularly at physiological...

journal_title：Medical hypotheses

authors： Nevo Z,Laron Z

更新日期：1980-04-01 00:00:00

abstract：:Dream periods during sleep have been observed in most mammals as early in history as antiquity. Sleep researchers at the University of Chicago, discovered the phase of rapid eye movement (REM) during sleep and connected it to the dream period. During this period, called the REM phase (after the American terminology), ...

journal_title：Medical hypotheses

authors： Gonfalone AA

更新日期：2019-06-01 00:00:00

abstract：:The Sudden Infant Death Syndrome (SIDS) is responsible for the death of 10,000 infants annually in the U.S.A. The cause of these deaths is not known; all SIDS infants studied died during sleep in a silent fashion and there are no specific lesions observable post mortem. It may be of significance, however, that nearly ...

journal_title：Medical hypotheses

authors： Reid GM

更新日期：1987-03-01 00:00:00

abstract：:Purpura fulminans is a life threatening complication of many septic states, most notably meningococcaemia. It can also occur due to congenital deficiency of anticoagulant proteins. The pathophysiology of purpura fulminans is complex and not fully understood, but involves abnormalities of coagulation pathways, damage t...

journal_title：Medical hypotheses

authors： Oram J,Bodenham A

更新日期：2008-01-01 00:00:00

abstract：:Many theories try to explain the existence and function of paranasal sinuses. This paper is an attempt to correlate process of paranasal sinus development in human with bone pneumatization processes in animals. It is here proposed that this mechanism starts in utero and continues after birth. During endochondral devel...

journal_title：Medical hypotheses

authors： Kurbel S,Radić R,Kristek B,Ivezić Z,Selthofer R,Kotromanović Z

更新日期：2004-01-01 00:00:00

abstract：:Ischaemic stroke ranks among the most important causes of death and disability in developed countries. Abnormal lipid metabolism is among the several factors that have a role in the pathogenesis of atherosclerosis. We hypothesize that the decreased resistance of low-density lipoproteins against oxidative stress is an ...

journal_title：Medical hypotheses

authors： Bereczki D,Balla G,Csiba L,Jeney V,Valikovics A,Magyar T,Balla J

更新日期：2001-06-01 00:00:00

abstract：:Posterior capsule opacification (PCO) is a debilitating and relatively common complication of cataract surgery despite modern medical and surgical advances. The pathophysiology of this condition has largely been attributed to peptide mediators, such as transforming growth factor-beta (TGFβ), epidermal growth factor (E...

journal_title：Medical hypotheses

authors： Lewis AC

更新日期：2013-04-01 00:00:00

abstract：:One of the most commonly alleged contraindications to the use of (ethylene diamine tetraacetic acid) chelation therapy is possible renal damage. In this experiment, 13 subjects with chronic degenerative disorders and with renal damage were treated with infusions that included EDTA, vitamins, mineral and oral supplemen...

journal_title：Medical hypotheses

authors： Sehnert KW,Clague AF,Cheraskin E

更新日期：1984-11-01 00:00:00

abstract：:Schizophrenia, if not the most difficult, is one of the most difficult mysterious puzzles for psychiatrists, psychologists, and neuroscientists to solve. In this paper, based on the previously known pathologies of schizophrenia, a new model is proposed for explanation of the formation of positive psychotic symptoms of...

journal_title：Medical hypotheses

authors： Javanbakht A

更新日期：2006-01-01 00:00:00

abstract：:Fetal death recurrence is an important problem in reproductive health that is poorly understood. Based on preliminary epidemiologic evidence, we propose an "event memory" hypothesis which posits that when fetal death occurs the event is retained (memorized) as a program that is replayed in future pregnancies. We descr...

journal_title：Medical hypotheses

authors： Salihu HM

更新日期：2008-01-01 00:00:00

abstract：:To explain why subjects vary in body fat content despite similar nutrient intake and physical activity, a hypothesis is proposed invoking individual variability in the potentially vast quantities of energy utilizable for such biomechanical functions as cellular motility processes, and for protein mobility. The collect...

journal_title：Medical hypotheses

authors： Roncari DA

更新日期：1987-05-01 00:00:00

abstract：:Essential hypertension is a heterogeneous multifactorial syndrome associated with a high cardiovascular risk. A multiple choice of antihypertensive drugs is available; however, a high individual variability to the antihypertensive therapy is still responsible for a modest reduction of the CV risk and not satisfactory ...

journal_title：Medical hypotheses

authors： Ferrari P,Ferrandi M,Valentini G,Manunta P,Bianchi G

更新日期：2007-01-01 00:00:00

abstract：:It is suggested that apart from aflatoxins, plant medicinal preparations containing active compounds imperatorin, dictamine, marmesin and heraclenin may be responsible for some human cancers in Nigeria and perhaps other parts of Africa. Therefore, in this paper, a hypothesis is put forward that these compounds or thei...

journal_title：Medical hypotheses

authors： Adekunle AA,Adekunle LV

更新日期：1983-07-01 00:00:00

abstract：:The Davson-Danielli model of the cell membrane accounted for nearly all the space within it by suggesting that it was composed of structural proteins and lipids; this would leave virtually no space for the large number of enzymes, carriers, antigens, antibodies, and receptors for hormones, transmitters, drugs and toxi...

journal_title：Medical hypotheses

authors： Hillman H

更新日期：1988-07-01 00:00:00

abstract：:Homocysteine is a sulfur-containing amino acid produced by the breakdown of methionine. Plasma homocysteine levels can be elevated due to a variety of genetic and nutritional factors. Poor nutrition from diets low in folate and vitamin B12 can lead to hyperhomocysteinemia. Mildly elevated levels of homocysteine have b...

journal_title：Medical hypotheses

authors： Ferguson SE,Smith GN,Walker MC

更新日期：2001-01-01 00:00:00