Possible uses of urinary neopterin and biopterin measurement.

abstract：:Complex spinal reconstructive procedures are invariably associated with excessive intraoperative blood loss that significantly increases the risk of severe perioperative complications. In some cases, excessive hemorrhage is equivalent to estimated total blood volume. Unfortunately, widely exposed bony surfaces are not...

journal_title：Medical hypotheses

authors： Block JE

更新日期：2005-01-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) is a novel technique of non-invasive brain stimulation which has been used to treat several neuropsychiatric disorders such as major depressive disorder, chronic pain and epilepsy. Recent studies have shown that the therapeutic effects of rTMS are associated with pla...

journal_title：Medical hypotheses

authors： Brunoni AR,Boggio PS,Fregni F

更新日期：2008-08-01 00:00:00

abstract：:For some patients with radiculopathy a source of nerve root compression cannot be identified despite positive electromyography (EMG) evidence. This discrepancy hampers the effective clinical management for these individuals. Although it has been well-established that tissues in the cervical spine move in a three-dimen...

journal_title：Medical hypotheses

authors： Jaumard NV,Udupa JK,Siegler S,Schuster JM,Hilibrand AS,Hirsch BE,Borthakur A,Winkelstein BA

更新日期：2013-10-01 00:00:00

abstract：:The favourable effects of eicosapentaenoic acid (EPA)- and doco-sahexaenoic acid (DHA)-rich diets (marine fish, fish oil) on several risk factors for cardiovascular disease are well established. The present survey describes possible new indications for diets supplemented with long-chain n-3 fatty acids. During a stand...

journal_title：Medical hypotheses

authors： Singer P,Richter-Heinrich E

更新日期：1991-09-01 00:00:00

abstract：:Local-regional relapse is the main recurrence pattern of the carcinoma in gut, and leads to poor prognosis. With the development of the total mesorectal and complete mesocolic excision (TME/CME), the local relapse rate of colorectal cancer has significantly decreased. People attributed it to the improvement of lymphad...

journal_title：Medical hypotheses

authors： Shen J,Xie D,Tong Y,Gong J

更新日期：2017-06-01 00:00:00

abstract：:Dream periods during sleep have been observed in most mammals as early in history as antiquity. Sleep researchers at the University of Chicago, discovered the phase of rapid eye movement (REM) during sleep and connected it to the dream period. During this period, called the REM phase (after the American terminology), ...

journal_title：Medical hypotheses

authors： Gonfalone AA

更新日期：2019-06-01 00:00:00

abstract：:"Consciousness" "mood," "identity" and "personality" are all emergent properties from whole-brain organizations; these are typically disturbed in psychiatric disorders. This work proposes that the underlying etiopathology of mental disorders originates from disturbances to global brain dynamics, or "Globalopathies" th...

journal_title：Medical hypotheses

authors： Peled A

更新日期：2013-12-01 00:00:00

abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN), which is also called BASIGIN/CD147, is a cell surface glycoprotein that belongs to the immunoglobulin superfamily and plays a significant role in intercellular recognition in immunology, cellular differentiation and development. Apart from ACE-2, recently EMMPR...

journal_title：Medical hypotheses

authors： Varadarajan S,Balaji TM,Sarode SC,Sarode GS,Sharma NK,Gondivkar S,Gadbail A,Patil S

更新日期：2020-10-01 00:00:00

abstract：:It is increasingly admitted that Crohn's disease and ulcerative colitis, the two entities of inflammatory bowel disease, are initiated and reactivated by environmental factors in genetically susceptible hosts, and result from aberrant immune response to specific intestinal microbes, in the context of altered compositi...

journal_title：Medical hypotheses

authors： Beaugerie L,Langholz E,Nyboe-Andersen N,Pigneur B,Sokol H,ECCO Epicom.

更新日期：2018-06-01 00:00:00

abstract：:It is suggested here that a Hemoglobin S (HbS)-mediated membrane oxidant injury is responsible for both the protection from malaria infection in the heterozygous sickle cell state, and for a critical pathologic process in homozygous sickle cell disease. This suggestion is arrived at by applying to the HbS condition th...

journal_title：Medical hypotheses

authors： Anastasi J

更新日期：1984-07-01 00:00:00

abstract：:Most of the evidence of formation of amblyopia is derived traditionally from electrophysiological studies. Recently, there have been many discoveries from genetics, histopathology, biochemistry, immunology and interventional studies. On the basis of evidence gathered in the last five years, the various types of amblyo...

journal_title：Medical hypotheses

authors： Tong LM

更新日期：1997-02-01 00:00:00

abstract：:Regulation of ion transport across the airway mucosa may be involved in the mechanisms producing hyperreactivity and asthma. Atrial Natriuretic Peptide (ANP) has been proposed to participate in the pathogenesis of asthma, and it has been found to have a bronchodilatory effect on asthmatic patients. Experimental eviden...

journal_title：Medical hypotheses

authors： Almirall JJ,Hedenstierna G

更新日期：1991-09-01 00:00:00

abstract：:Normally, the transport of allergens through the intestinal epithelia to the blood is limited. It is hypothesised that if these compounds arrive in the blood circulation, they must percolate through the epithelial cell layer. Thus, food allergy (and thus atopic eczema) implies an increased intercellular leakage of the...

journal_title：Medical hypotheses

authors： Bongaerts GP,Severijnen RS

更新日期：2005-01-01 00:00:00

abstract：:The "Gamma Loop" Part I compared a model of rubber tubing to the architecture of the glomerulus with emphasis placed on the observed relationship between the position of the outflow resistance clamp and the perfusion of the loop (1, 2). Part II describes the pressures observed in the different parts of the loop, as we...

journal_title：Medical hypotheses

authors： Gatzek WJ,Wells SC

更新日期：1989-05-01 00:00:00

abstract：:The globally increasing incidences of Type 1 diabetes (T1DM) and Type 2 diabetes (T2DM) can have a common background. If challenged by the contemporary high level of nutritional glucose stimulation, the β-cells in genetically predisposed individuals are at risk for damage which can lead to the diseases. The fat to car...

journal_title：Medical hypotheses

authors： Sjöblad S

更新日期：2019-04-01 00:00:00

abstract：:Acute renal failure (ARF) is a rapid loss of kidney function. The reasons and mechanism by which this occurs has not been clarified so far thus creating obstacles to management of this disease. Presently, the experimental research using the accepted renal ischemia reperfusion injury (I/R injury) model represented for ...

journal_title：Medical hypotheses

authors： Hao JL,Li YF,Li RS

更新日期：2013-04-01 00:00:00

abstract：:Contributory risk factors to premature coronary artery disease (CAD) in premenopausal women are poorly understood and data on this subset of women is lacking. There is growing evidence that the process of inflammation is a part of the atherosclerotic process. Mechanistic insights from animal work suggest that the prof...

journal_title：Medical hypotheses

authors： Eastwood JA,Taylor DA,Johnson BD,Resende M,Sharaf BL,Ahmed B,Minissian M,Shufelt C,Merz NB

更新日期：2017-11-01 00:00:00

abstract：:This novel, iso-osmo-resistive theory offers electro-resistivity of food components as a new dimension for digestion. Firstly, fats, carbohydrates and proteins differ markedly in their resistivity, which offers a way to monitor them, especially when digestive enzymes cause consistent and distinctive changes. Secondly ...

journal_title：Medical hypotheses

authors： Sutton JA

更新日期：2019-09-01 00:00:00

abstract：:Keratoacanthomas have many characteristics of squamous cell carcinoma and in the past were interpreted as squamous cell carcinomas. It is now known that these lesions spontaneously resolve if left untreated. In man the lesions occur on sunlight damaged areas or areas exposed to tar. Many of the experimental cancers of...

journal_title：Medical hypotheses

authors： Stone OJ

更新日期：1988-06-01 00:00:00

abstract：:Carcinoma constitution originates in the hetero-duplication mitoses (4) which divide non-maturable stem cells into two different types of daughter cells: maturable and non-maturable cancerous stem cells. Throughout the progression of such mitoses, the organoid continuity of the cancer depends only on the non-maturable...

journal_title：Medical hypotheses

authors： Hirata Y

更新日期：1999-06-01 00:00:00

abstract：:Extracellular nucleotide-induced stimulation and activation of peripheral blood leukocytes and subsequent degranulation play a critical role in immediate-type hypersensitivity reaction and other inflammatory diseases. The extracellular nucleotides stimulate a P2Y receptor(s) on human PMN with the pharmacological profi...

journal_title：Medical hypotheses

authors： Kannan S

更新日期：2002-09-01 00:00:00

abstract：:Several hypotheses have been developed to interpret the progression of tubulointerstitial fibrosis (TF), including senescence, epithelial-mesenchymal transition, inflammation, chronic hypoxia, and reactive oxygen species. All of these hypotheses are based on persistent cell injury and localized cell death. Proliferati...

journal_title：Medical hypotheses

authors： Chen BC,Bai YH,Tang LL,Wang BQ,Liu B,Cai Y,Peng X,Yang YR,Zheng SL

更新日期：2014-06-01 00:00:00

abstract：:For a virus to survive and replicate in an organism, it must employ strategies to evade and misdirect the host's immune response. There is compelling evidence that the primary immunoevasive strategy utilized by the SARS virus, like influenza, is to inhibit its host's corticosteroid stress response. This is accomplishe...

journal_title：Medical hypotheses

authors： Wheatland R

更新日期：2004-01-01 00:00:00

abstract：:It is postulated that the metabolically variable fine structure of pericellular heparan glycosaminoglycans affects the ability of these molecules to influence cell proliferation-associated proteinase-catalysed reactions occurring at cell surfaces. Evidence suggesting the possibility of a wide repertoire of glycosamino...

journal_title：Medical hypotheses

authors： Long WF,Williamson FB

更新日期：1983-07-01 00:00:00

abstract：:The accumulation of fibrin/fibrinogen and other coagulation factors in and around solid tumors and metastatic foci has been recognized for a century as an aspect of cancer pathology. On this basis, anticoagulants and fibrinolytic agents have been deployed as adjuvant anticancer therapies, but they have proved clinical...

journal_title：Medical hypotheses

authors： Lu DY,Chen XL,Ding J

更新日期：2007-01-01 00:00:00

abstract：:In this work some aspects of carcinogenesis are given. The importance of the emergence of Z or H DNA structure in the gene, or in the flanking gene sequences for the gene deletion and unusual gene recombination, is discussed. Some considerations on the role of selective pressure (of polyamines, of Mg2+, of the various...

journal_title：Medical hypotheses

authors： Juranic Z,Kidric M,Tomin R,Juranić I,Spuzić I,Petrović J

更新日期：1991-08-01 00:00:00

abstract：:The per review system for the assessment of research proposals is widely respected by working scientists. Nevertheless two problems associated with the operation of this system by the US National Institutes of Health are identified. First the scientist has no control over which committee will review an application and...

journal_title：Medical hypotheses

authors： Rosenberg E

更新日期：1976-01-01 00:00:00

abstract：:Chronic, tertiary Lyme disease, a vector-borne infection most accurately designated neuroborreliosis, is often misdiagnosed. Infectors of the human brain, Lyme borrelial spirochetes are neurotropic, similar to the spirochetes of syphilis. Symptoms of either disease may be stable and persistent, transient and inconsist...

journal_title：Medical hypotheses

authors： Sherr VT

更新日期：2005-01-01 00:00:00

abstract：:Osteoarthritis (OA) is a chronic, degenerative disorder of multifactorial aetiology, characterized by loss of articular cartilage and periarticular bone remodelling. Goals of managing OA include controlling pain, maintaining and improving function and health-related quality of life, and limiting functional impairment....

journal_title：Medical hypotheses

authors： Zhang DW,Yang QS,Zhu JY,Cao XR,Li LW,Zhu QS

更新日期：2007-01-01 00:00:00

abstract：:Stress, in its many forms, is long associated with the etiology and course of schizophrenia. The mechanisms mediating the impacts of stress are not fully elucidated. Here it is proposed that stress induced cortisol alters kynurenic acid (KA) and quinolinic acid (QA) in the cortex and amygdala/striatum, respectively. T...

journal_title：Medical hypotheses

authors： Anderson G

更新日期：2011-01-01 00:00:00