Brain "Globalopathies" cause mental disorders.

abstract：:Stress, in its many forms, is long associated with the etiology and course of schizophrenia. The mechanisms mediating the impacts of stress are not fully elucidated. Here it is proposed that stress induced cortisol alters kynurenic acid (KA) and quinolinic acid (QA) in the cortex and amygdala/striatum, respectively. T...

journal_title：Medical hypotheses

authors： Anderson G

更新日期：2011-01-01 00:00:00

abstract：:Too small size at birth (due to poor fetal growth and/or preterm delivery) has been associated with substantially elevated risks of the metabolic syndrome (dislipidemia, insulin resistance, hypertension), type 2 diabetes and cardiovascular disease in adulthood. The mechanisms of such "fetal origins" or "programming" o...

journal_title：Medical hypotheses

authors： Luo ZC,Fraser WD,Julien P,Deal CL,Audibert F,Smith GN,Xiong X,Walker M

更新日期：2006-01-01 00:00:00

abstract：:Recent articles about the roles and relationships of tissue inhibitor of metalloproteinase-1 and transforming growth factor-beta 1 in various types of normal tissues and malignancies give rise to the question: 'Is there a relationship between them with regard to malignant melanoma progression?' In the light of many re...

journal_title：Medical hypotheses

authors： Kurdoglu M,Güllü IH,Akalin I

更新日期：2001-08-01 00:00:00

abstract：:Most of the evidence of formation of amblyopia is derived traditionally from electrophysiological studies. Recently, there have been many discoveries from genetics, histopathology, biochemistry, immunology and interventional studies. On the basis of evidence gathered in the last five years, the various types of amblyo...

journal_title：Medical hypotheses

authors： Tong LM

更新日期：1997-02-01 00:00:00

abstract：:Behcet's disease (BD) is a chronic, multisystem inflammatory disorder characterized by relapsing oral aphthous and genital ulcers, ocular inflammation, erythemanodosum and folliculitis-like lesions of the skin, arthritis, and central nervous system involvement. Its pathogenesis has not been fully elucidated but the et...

journal_title：Medical hypotheses

authors： Qin H,Cai J,Xu H,Gong Y

更新日期：2009-07-01 00:00:00

abstract：:In this work a new theory of acoustic signal detection in the inner ear and an experimental explanation of the causes of bifilar cochlear structure was presented. Our innovative approach describes sound detection in a completely different way from the one currently adopted. It requires analyzing the inner ear system i...

journal_title：Medical hypotheses

authors： Dora J,Wojcieszak D,Kaczmarek D,Mazur M,Aksenczuk A

更新日期：2020-02-18 00:00:00

abstract：:Roux-en-Y gastric bypass (RYGB) surgery is one of the most effective treatments for obesity and type II diabetes. RYGB was originally believed to work by mechanically restricting caloric intake or causing macronutrient malabsorption. However, such mechanical effects play no role in the remarkable efficacy of gastric b...

journal_title：Medical hypotheses

authors： Celiker H

更新日期：2017-09-01 00:00:00

abstract：:The cancer cell appears to contain two non phosphorylating glycolytic pathways in addition to phosphorylating glycolysis and the aerobic citric acid and phosphogluconate cycles. It is hypothesised that these pathways are all interconnected and in the static adult cell non phosphorylating glycolysis is in a state of co...

journal_title：Medical hypotheses

authors： Holt JA

更新日期：1983-02-01 00:00:00

abstract：:Gastroesophageal reflux (GER) and asthma have been linked, but the true nature of this relationship is incompletely understood. Most of the literature examining this association has implicated GER as the factor contributing to asthma. GER has also been linked to conditions of the upper airway like sinusitis and obstru...

journal_title：Medical hypotheses

authors： Turbyville JC

更新日期：2010-06-01 00:00:00

abstract：:The activity of the lithium ion against DNA type viruses is explained by its competition with magnesium ions. Magnesium acts as the cofactor of the enzymes responsible for the replicative building of viral proteins and nucleosides. When lithium replaces magnesium, it appears to render the polymerase enzymes impotent. ...

journal_title：Medical hypotheses

authors： Bach RO

更新日期：1987-06-01 00:00:00

abstract：UNLABELLED:The expression of consciousness and the site of memory storage within the brain are unknown despite over a century of intense empirical scrutiny. Recent anatomical studies show that human protoplasmic astrocytes form innumerable uniform polyhedral tessellating domains that are arranged three-dimensionally. T...

journal_title：Medical hypotheses

authors： Robertson JM

更新日期：2013-12-01 00:00:00

abstract：:For a virus to survive and replicate in an organism, it must employ strategies to evade and misdirect the host's immune response. There is compelling evidence that the primary immunoevasive strategy utilized by the SARS virus, like influenza, is to inhibit its host's corticosteroid stress response. This is accomplishe...

journal_title：Medical hypotheses

authors： Wheatland R

更新日期：2004-01-01 00:00:00

abstract：:The possibility that Hematopoiesis is under CNS control has been discussed in the literature; but never been conclusively proved at the molecular level. Evidence in the form of antigenic similarity between murine brain and the Stem Cell, and the decline in the number of Stem Cells following the lesioning of the Locus ...

journal_title：Medical hypotheses

authors： Bhander MS

更新日期：1988-12-01 00:00:00

abstract：:In an effort to develop a method to ascertain whether ancient physicians used certain drugs because of their efficacy or for other reasons (random process, tradition, etc.), the authors have devised a statistical test (Efficacy Quotient-EQ) to evaluate ancient therapeutic data quantitatively. They have applied the Eff...

journal_title：Medical hypotheses

authors： Prioreschi P,Heaney RP,Brehm E

更新日期：1998-10-01 00:00:00

abstract：:The terminology of cerebellar ataxias encompasses a variety of sporadic and inherited debilitating diseases. Patients exhibit disabling deficits such as dysmetria, kinetic tremor and ataxia of stance/gait. We are currently lacking effective treatments in degenerative cerebellar ataxias. Animal models of cerebellar dis...

journal_title：Medical hypotheses

authors： Manto M,Ben Taib NO

更新日期：2008-01-01 00:00:00

abstract：:A high incidence of sudden unexplained nocturnal deaths has been reported among young Asian males. These deaths are known as Pokkuri in Japan, Bangungut in the Philippines and Sudden Unexplained Nocturnal Death in the United States. Post mortem analysis has demonstrated cardiac conduction defects in many of the victim...

journal_title：Medical hypotheses

authors： Melles RB,Katz B

更新日期：1988-06-01 00:00:00

abstract：:Endometriosis is a common gynaecological disorder causing pain, infertility, and emotional distress. Evidence presented here suggests that abnormal production of tumour necrosis factor-alpha (TNF-alpha) is required for the establishment and maintenance of endometriosis and also is responsible for the associated infert...

journal_title：Medical hypotheses

authors： Bullimore DW

更新日期：2003-01-01 00:00:00

abstract：:Benign prostatic hyperplasia (BPH) is one of the most common problems faced by aging men and can be associated with bothersome lower urinary tract symptoms that affect quality of life by interfering with normal daily activities and sleep patterns. Despite the clinical importance of BPH, its pathogenesis is still poorl...

journal_title：Medical hypotheses

authors： Cho KS,Kim J,Choi YD,Kim JH,Hong SJ

更新日期：2008-01-01 00:00:00

abstract：:It is well known that chronic hepatitis C is associated with insulin resistance and metabolic syndrome which are risk factors for atherosclerosis and coronary heart disease. As a result, chronic hepatitis C might be thought, through its association with metabolic syndrome, to increase the risk of myocardial infarction...

journal_title：Medical hypotheses

authors： Metwally AH,Elgamal MA

更新日期：2014-04-01 00:00:00

abstract：:For American medical historiography, to borrow from Dickens, these are the best of times and the worst of times. These are the times when rigorous scholarship has been brought to bear on the field (with great improvement in the quality of research) and when medicine is disappearing from its own history. These are the ...

journal_title：Medical hypotheses

authors： Prioreschi P

更新日期：1992-06-01 00:00:00

abstract：:Optic neuropathy is an invaliding pathology with diverse clinical manifestation and varying causes. Current understanding of etiopathological aspects of optical neuropathy does not provide an effective treatment protocol. In this article we discuss existing treatment methods, and their effectiveness, evaluated dependi...

journal_title：Medical hypotheses

authors： Shkarubo AN,Nikolenko VN,Velichko AY,Sinelnikov MY

更新日期：2020-10-01 00:00:00

abstract：:Ever since antimicrobial therapy was introduced, two phenomenons have been observed: drug resistance and host toxicity. Mutation(s) in microbes leads to the earlier, while off target effects of therapy cause the latter. Neither of these problems have yet to be resolved. All Microbes express specific antigens, against ...

journal_title：Medical hypotheses

authors： Singla M

更新日期：2007-01-01 00:00:00

abstract：:The etiologic basis of urinary tract anomalies and dysfunctional voiding largely remain unknown. However, the travel of urine from renal pelvis into the amniotic cavity under the pressures exerted by amniotic fluid satisfactorily explains the etiologic basis. Amniotic pressure is affected by the changes in maternal in...

journal_title：Medical hypotheses

authors： Tanyel FC

更新日期：2000-01-01 00:00:00

abstract：:Recurrent aphthous ulcer (RAU) is the most common ulcer of oral non-keratinized mucosa, but the treatment is always limited at present. Considering the multifactorial etiology of RAU, a novel therapeutic agent with multi-bioactivties should be presented. Garlic has been recognized as a favorable natural medicine again...

journal_title：Medical hypotheses

authors： Jiang XW,Hu J,Mian FI

更新日期：2008-12-01 00:00:00

abstract：:We would like to put forward the hypothesis that cancer patients may produce autoantibodies that promote uncontrolled cell growth and thereby function as oncogenes. Dying cells release proteins that stimulate the production of autoantibodies, an event also known to occur during the earliest stages of tumor growth. If ...

journal_title：Medical hypotheses

authors： Admon A,Shoshan SH

更新日期：2006-01-01 00:00:00

abstract：:The etiology of sudden-death ischemic heart disease (SDIHD) remains an enigma. Data will be presented which suggest that SDIHD may be due to hypomagnesemia in and around the coronary arterial and arteriolar vessels. We have found that blood vessels (especially arteries and arterioles) deficient with respect to Mg can ...

journal_title：Medical hypotheses

authors： Altura BM

更新日期：1979-08-01 00:00:00

abstract：:Injury and organ failure after irradiation of late-responding tissues is a substantial problem in radiation oncology and a major threat after accidental or belligerent exposures. The mechanisms of injury may include death of clonogens, vascular injury, activation of cytokine networks, and/or chronic oxidative stress. ...

journal_title：Medical hypotheses

authors： Cohen SR,Cohen EP

更新日期：2013-02-01 00:00:00

abstract：:Bacterial biofilms have been found in many human bacterial infectious processes including chronic rhinosinusitis. It was found also at the surface of nasal polyps, and both at the surface of the nasal part and the stalk of the antrochoanal polyp. However, our recent research clearly demonstrated the presence of the bi...

journal_title：Medical hypotheses

authors： Mladina R,Skitarelić N

更新日期：2010-10-01 00:00:00

abstract：:Epidemiologic literatures suggest that temporomandibular joint disorders (TMD) are more prevalent in women than in men. It is affecting approximately 7-15% of the adult population in North America, and 80% of patients treated for TMD are women. The severity of symptoms is also related to the age of the patients. The g...

journal_title：Medical hypotheses

authors： Wang J,Chao Y,Wan Q,Zhu Z

更新日期：2008-10-01 00:00:00

abstract：:Vagus nerve stimulation (VNS) and electroacupuncture (EA) at specific acupoints have both shown promising anticonvulsant effects in intractable epilepsy patients. The differences between these therapies are target selection and stimulation parameter modulation. It has been demonstrated that EA of the extremities resul...

journal_title：Medical hypotheses

authors： Chen N,Zhang H,Gao XD,Yan N,Ma Y,Yu CJ

更新日期：2013-12-01 00:00:00