Night terrors and sudden unexplained nocturnal death.

abstract：:We have previously presented a new Systemic Evolutionary Theory of Cancer (SETOC) based on the failure of proper endosymbiosis in eukaryotic cells. Here, we propose that the progressive uncoupling of two endosymbiotic subsystems (information and energy) inside the cell, as a consequence of long-term injuries, gives ri...

journal_title：Medical hypotheses

authors： Mazzocca A,Ferraro G,Misciagna G,Fais S

更新日期：2018-12-01 00:00:00

abstract：:In elderly, the fractures in C1-C2 are a common entity. Poor bone quality and wide range of motion hamper the natural bone fusion, thus making surgery often the only possible way to deal with the underlying pathology. The proximity to important neurovascular structures represents the stabilization in this segment a ch...

journal_title：Medical hypotheses

authors： Pavlov O,Mirchev N,Behr R

更新日期：2020-02-21 00:00:00

abstract：:On the nature of wellness, stress, netting and the radical gas nitric oxide (NO). The multi-complex role of NO resulted in its discoverers receiving a Nobel award, its presence everywhere and volatility makes it a suitable candidate to be a main signal in an instantaneous communication network. Such network, with the ...

journal_title：Medical hypotheses

authors： Ralt D

更新日期：2008-01-01 00:00:00

abstract：:Most cancer cells would not result in devastating tumours if it were not for their ability to metastasize. The process of cancer metastasis involves significant cell shape, motility, and adhesive changes of pre-cancerous cells, and the remodelling of the extracellular matrix, as well as cognate properties of neighbour...

journal_title：Medical hypotheses

authors： Haile S

更新日期：2008-01-01 00:00:00

abstract：:Previous papers of our group have reported that, in the first stages of nutritional recovery, the needs of undernourished infants, in terms of Protein Calories percentage (P%) were higher than normal, and similar to those of other mammals which double their birth weight faster than man. During this period, a high diet...

journal_title：Medical hypotheses

authors： Portela ML,Zeni S,Río ME

更新日期：1985-10-01 00:00:00

abstract：:Condylar cartilage is absolutely necessary for the normal function of temporomandibular joint (TMJ). Unfortunately, condylar cartilage defect or missing is also one of the common clinical problems. Repair or reconstruction of cartilage is always a hot topic. Cell based cartilage regeneration is suggested as novel ther...

journal_title：Medical hypotheses

authors： Dai J,Wang X,Shen G

更新日期：2011-07-01 00:00:00

abstract：:Encouraging results have been obtained with stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC). However, local control rates decrease in larger volume disease. Several studies have found a correlation between T stage or tumor volume and local progression-free survival. In man...

journal_title：Medical hypotheses

authors： Nieder C,Andratschke N

更新日期：2012-04-01 00:00:00

abstract：:Several studies have demonstrated the existence of morphological, biological, genetic and antigenic correlations between human and animal retroviruses. Furthermore, some agents of bovine and feline origin can also be considered useful comparative models for the pathogenetic study of human diseases such as leukaemia, a...

journal_title：Medical hypotheses

authors： Di Guardo G

更新日期：1989-07-01 00:00:00

abstract：:High-molecular-weight hyaluronic acid (HA) produced by the synovium may function physiologically to aid preservation of cartilage structure and prevent arthritic pain; both the size and concentration of HA in synovial fluid are diminished in osteoarthritis (OA). Glucosamine therapy for OA can be expected to increase s...

journal_title：Medical hypotheses

authors： McCarty MF,Russell AL,Seed MP

更新日期：2000-05-01 00:00:00

abstract：:In this work some aspects of carcinogenesis are given. The importance of the emergence of Z or H DNA structure in the gene, or in the flanking gene sequences for the gene deletion and unusual gene recombination, is discussed. Some considerations on the role of selective pressure (of polyamines, of Mg2+, of the various...

journal_title：Medical hypotheses

authors： Juranic Z,Kidric M,Tomin R,Juranić I,Spuzić I,Petrović J

更新日期：1991-08-01 00:00:00

abstract：:Several earlier observations by us and other investigators led us to propose a thesis that B lymphocytes, when activated by a virus, allo-antigen or bacterial protein would enter into effector arm of the immune response and cause allograft and tumor rejection or GVH-type of lesion in immunosuppressed animals. These ef...

journal_title：Medical hypotheses

authors： Krishnan G

更新日期：1990-05-01 00:00:00

abstract：:The goal in the treatment of osteonecrosis of the femoral head is to preserve, not replace, the femoral head. Although many methods have been proposed, none has proved completely satisfactory. Cellular mediators as a supplement to bone grafting and decompression is an attractive approach to this problem because it com...

journal_title：Medical hypotheses

authors： Yuan B,Liu Z

更新日期：2007-01-01 00:00:00

abstract：:Over a decade ago, I formulated the hypothesis that cumulative effects of exposure to high intracranial pressure (ICP) may contribute to the development of Alzheimer's disease (AD), though not necessarily in an exclusive way. In addition to individual ICP characteristics (high 'physiological' ICP) and diseases causing...

journal_title：Medical hypotheses

authors： Wostyn P

更新日期：2004-01-01 00:00:00

abstract：:The results of numerous investigations on the impact of obesity on renal insufficiency conducted in recent years introduce certain dilemmas about their mutual agreement. Some studies suggest that obesity is negatively correlated with the terminal phase of renal failure. On the other hand, other research has shown that...

journal_title：Medical hypotheses

authors： Stolic R

更新日期：2010-12-01 00:00:00

abstract：:Chronic stresses can induce physiological and psychological changes and result in stress-related neuropsychiatry, sometimes they may also contribute to hypersensitivity to pain known as stress-induced hyperalgesia (SIH). Recently it was found that GABAergic disinhibition is closely related to morphine and chronic infl...

journal_title：Medical hypotheses

authors： Dai S,Ma Z

更新日期：2014-12-01 00:00:00

abstract：:Arthritis is inflammation in a joint often with joint damage, usually accompanied by pain, swelling and stiffness, resulting from infection, trauma, degenerative changes, metabolic disturbances, autoimmune or other causes. It occurs in various forms, including rheumatoid arthritis, osteoarthritis, bacterial arthritis ...

journal_title：Medical hypotheses

authors： Eby G

更新日期：2005-01-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) is reported to occur frequently after all types especially cardiac surgery in elderly patients. It can be short-term or long-term and some cases even develop into Alzheimer's disease (AD). Although multi-risk factors associated with POCD have been identified, the etiology and...

journal_title：Medical hypotheses

authors： Fan L,Wang TL,Xu YC,Ma YH,Ye WG

更新日期：2011-05-01 00:00:00

abstract：:Stress, in its many forms, is long associated with the etiology and course of schizophrenia. The mechanisms mediating the impacts of stress are not fully elucidated. Here it is proposed that stress induced cortisol alters kynurenic acid (KA) and quinolinic acid (QA) in the cortex and amygdala/striatum, respectively. T...

journal_title：Medical hypotheses

authors： Anderson G

更新日期：2011-01-01 00:00:00

abstract：:Despite important advances in understanding its pathophysiology, therapy for septic shock remains largely symptomatic and supportive. Aiming to elevate the systemic arterial blood pressure by using vasoconstrictor manoeuvers are preferred without paying much attention to the ischaemia produced at the peripheral tissue...

journal_title：Medical hypotheses

authors： Iskit AB,Guc MO

更新日期：2004-01-01 00:00:00

abstract：:The apparent association of laryngeal cancer with asbestos and possibly other occupational exposures can be accounted for by the hypothesis that chronic vocal abuse peculiar to certain working conditions will act as a promoting factor for active carcinogens found mainly in tobacco smoke. ...

journal_title：Medical hypotheses

authors： Chovil A

更新日期：1981-07-01 00:00:00

abstract：:Vitamins are indispensable nutrients for metabolism. Adequate vitamin intake plays vital role in physiological processes including embryonic development, cellular and immunity proliferation and differentiation, DNA synthesis and oxidative response. In contrast, insufficient vitamin levels usually lead to a large numbe...

journal_title：Medical hypotheses

authors： Huang Y,Liu A,Liu L,Wang B,Liang G

更新日期：2020-02-01 00:00:00

abstract：:Insufficient attention has been given to reports in the literature describing patients with symptomatic migraine who, in addition to, or instead of, the well-recognized zones of hypofusion, have zones of hyperperfusion, which can be interpreted as hypermetabolism due to neuronal activation. A new neural theory of migr...

journal_title：Medical hypotheses

authors： Eggers AE

更新日期：2001-03-01 00:00:00

abstract：:Pulmonary congestion is a hallmark feature of heart failure and is a major reason for hospital admissions in this patient population. Heart failure patients often demonstrate restrictive and obstructive pulmonary function abnormalities; however, the mechanisms of these changes remain controversial. It has been suggest...

journal_title：Medical hypotheses

authors： Ceridon M,Wanner A,Johnson BD

更新日期：2009-09-01 00:00:00

abstract：:The concept of local pathology has long served neurology admirably. Relevant models include self-organizing nonlinear brain dynamics, global workspace and dynamic core theories. However such models are inconsistent with certain clinical phenomena found in Charles Bonnet syndrome, disjunctive agnosia and schizophrenia,...

journal_title：Medical hypotheses

authors： Globus GG,O'Carroll CP

更新日期：2010-11-01 00:00:00

abstract：:At the end of 2019, a new kind of pneumonia which was proven to be supported by novel coronaviruses named SARS-CoV-2 emerges and it seems to be more complicate in its clinical course and management. Related researches have demonstrated that SARS-CoV-2 serves roles in respiratory, intestinal and neuronal diseases. Give...

journal_title：Medical hypotheses

authors： Tao H,Ge G,Li W,Liang X,Wang H,Li N,Sun H,Zhang W,Geng D

更新日期：2020-12-01 00:00:00

abstract：:The author presents evidence from published papers of research done by numerous investigators that Multiple Sclerosis (MS) is an autoimmune disease, that the target tissue is the myelin sheath which covers the nerve fibers in the brain and spinal cord, that Myelin Basic Protein (MBP) is the antigen or one of the antig...

journal_title：Medical hypotheses

authors： Eidinoff H

更新日期：1988-06-01 00:00:00

abstract：:Crossed cerebellar diaschisis (CCD) refers to transneuronal degeneration of the corticopontocerebellar pathway, resulting in atrophy of cerebellum contralateral to supratentorial pathology. CCD is traditionally diagnosed on nuclear medicine studies. Our aim is to apply a biexponential diffusion model, composed of intr...

journal_title：Medical hypotheses

authors： Kohannim O,Huang JC,Hathout GM

更新日期：2018-11-01 00:00:00

abstract：:The major thesis of the proposed hypothesis is that in the absence of microbial material synovial macrophages in rheumatoid arthritis patients continue to release interleukin 1, which perpetuates the inflammation so characteristic of the disease. Its release is suggested to result from an altered synovial macrophage g...

journal_title：Medical hypotheses

authors： Rafter GW

更新日期：1982-10-01 00:00:00

abstract：:Dental implants have been widely used in clinic for the restoration of lost teeth in recent decades, but there still remains a great challenge for even a higher success rate and a shorter rehabilitation time. The osseointegration between dental implant and alveolar bone tissue is crucial for a successful implantation....

journal_title：Medical hypotheses

authors： Li L,Zhu Z,Huang C,Chen W

更新日期：2008-10-01 00:00:00

abstract：:Evidence is reviewed supporting a hypothesis of an anticarcinogenic effect of magnesium. Animal studies reported increased cancer in rodents maintained on magnesium deficient diets and a preventive effect for rodents fed excess levels of magnesium. Epidemiologic evidence is presented that magnesium levels in water, fo...

journal_title：Medical hypotheses

authors： Blondell JM

更新日期：1980-08-01 00:00:00