Abstract:
:The possibility that Hematopoiesis is under CNS control has been discussed in the literature; but never been conclusively proved at the molecular level. Evidence in the form of antigenic similarity between murine brain and the Stem Cell, and the decline in the number of Stem Cells following the lesioning of the Locus Coeruleus Nucleus exists. The recent establishment of the CNS control of the Immune System which had been previously proposed on similar evidence is discussed. It is suggested that the advances in the study of Colony Stimulating Factors (CSFs) provide an opportunity to test the role of Neurotransmitters on the proliferation/differentiation of Stem Cells. A series of experiments using CSF-dependent and CSF-independent cell lines and the biochemical basis of CSF activity to detect neurological influences are proposed. A model of a CNS regulatory mechanism is proposed, and used to explain many unexplained features of the in vivo activity of the CSFs.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Bhander MSdoi
10.1016/0306-9877(88)90010-2subject
Has Abstractpub_date
1988-12-01 00:00:00pages
291-4issue
4eissn
0306-9877issn
1532-2777pii
0306-9877(88)90010-2journal_volume
27pub_type
杂志文章abstract::Relapse to cocaine, heroin, and alcohol is a common occurrence in ex-abusers of these substances. Although there are many potential causes for relapse, we postulate that one cause in some people may be re-exposure in an anesthesia setting to a drug similar to the formerly abused drug. We hypothesize, for example, that...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1999.0797
更新日期:1999-12-01 00:00:00
abstract::Epoxides as reactive intermediates of estrogen metabolism have been considered to be potential precursors of the 2- and 4-hydroxy, catechol estrogens and even to be mutagenic/carcinogenic agents themselves. The labile nature of the intermediates has made proof of their existence difficult in natural biological conditi...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.04.012
更新日期:2016-06-01 00:00:00
abstract::Alpha-fetoprotein (AFP) serum levels in man have long been utilized as a tumor marker and as a birth defect screening agent in the clinical laboratory. Although the physiological role of AFP has remained obscure, the stereotypic carrier/transport function of a fetal counterpart to albumin has been attributed to this o...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2001.1445
更新日期:2002-06-01 00:00:00
abstract::The few existing hypotheses for the function of the human hymen are weak. These are briefly reviewed, and a new hypothesis is proposed. We suggest that the appearance of the juvenile human hymen is based on 'premature' birth, following which infant helplessness and a subsequent advantage for vaginal protection from ex...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(97)90223-1
更新日期:1997-08-01 00:00:00
abstract::Infection of the lymphatic system by Wuchereria bancrofti microfilaria is the most common cause of elephantiasis, a disease that affects over 100 million people. The nightly release of microfilaria into the circulation coincides with the feeding activity of its mosquito vector, a synchronization that is presumably an ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.02.034
更新日期:2009-08-01 00:00:00
abstract::Recent studies suggest that blood-borne metabolites of gut microbiota, such as trimethylamine N-oxide (TMAO) are involved in the aetiology of cardiovascular diseases and may serve as markers of cardiovascular risk. To enter the bloodstream the microbiota-derived molecules need to pass the gut-blood barrier (GBB). The ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.11.012
更新日期:2017-01-01 00:00:00
abstract::Abnormal fluctuations of acetylcholine and serotonin might cause, or be correlated with, a variety of symptoms. This communication cites evidence which suggests that fluctuations of serotonin might have a causative role in migraine, mania, and depression and that fluctuations of acetylcholine might have a causative ro...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90011-e
更新日期:1993-05-01 00:00:00
abstract::Meditation is a complex mental process involving changes in cognition, sensory perception, affect, hormones, and autonomic activity. Meditation has also become widely used in psychological and medical practices for stress management as well as a variety of physical and mental disorders. However, until now, there has b...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/s0306-9877(03)00175-0
更新日期:2003-08-01 00:00:00
abstract::Bipedal locomotion and fine motility of hand and larynx of humans introduced musculoskeletal adaptations, new pyramidal, corticostriatal, corticobulbar, nigrostriatal, and cerebellar pathways and expansions of prefrontal, cingular, parieto-temporal and occipital cortices with derived new brain capabilities. All select...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.05.034
更新日期:2008-11-01 00:00:00
abstract::A primary goal in antimicrobial drug design is to find molecules which inhibit key proteins in bacteria without affecting mammalian homologues. To this aim, structural differences between eukaryotic and prokaryotic enzyme proteins involved in life processes are widely exploited. The membrane-bound enzyme complex ATP s...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.05.004
更新日期:2014-08-01 00:00:00
abstract::Roux-en-Y gastric bypass (RYGB) surgery is one of the most effective treatments for obesity and type II diabetes. RYGB was originally believed to work by mechanically restricting caloric intake or causing macronutrient malabsorption. However, such mechanical effects play no role in the remarkable efficacy of gastric b...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.08.012
更新日期:2017-09-01 00:00:00
abstract::Acute stroke, including acute ischemic stroke (AIS) and acute hemorrhagic stroke, (AHS) is a common medical problem with particular relevance to the demographic changes in industrialized societies. In recent years, treatments for AIS have emerged, including thrombolysis with tissue plasminogen activator (t-PA). Althou...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.07.038
更新日期:2010-12-01 00:00:00
abstract::Fetal death recurrence is an important problem in reproductive health that is poorly understood. Based on preliminary epidemiologic evidence, we propose an "event memory" hypothesis which posits that when fetal death occurs the event is retained (memorized) as a program that is replayed in future pregnancies. We descr...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.06.021
更新日期:2008-01-01 00:00:00
abstract::In a recent paper it was argued that all stem cells are small motile cells, the haemopoietic stem cell being no exception. Although haemopoietic stem cells arise and mature in an extravascular milieu, they are present in small numbers in the peripheral circulation, where they have a lymphocyte-like appearance, and in ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(94)90144-9
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Operative risk prediction systems (logistic EuroSCORE I, EuroSCORE II and STS Score) are employed together with multidisciplinary discussion to contraindicate conventional surgery in patients with valvular heart disease and propose the employment of alternative transcatheter procedures. The EuroSCORE I has b...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2015.01.043
更新日期:2015-05-01 00:00:00
abstract::Chronic fatigue syndrome (CFS) has gained prominence since 1988 and a substantial amount of research has been done in this domain. However, it is still regarded as a controversial condition. Moreover, most of the symptoms of CFS itself are non-specific, occurring in many illnesses; some of the symptoms are also common...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(03)00103-8
更新日期:2003-07-01 00:00:00
abstract::Many brilliant and ambitious young women lose their drive for top careers after childbirth. New maternal impulses are at odds with their original ambitions and for many mothers stress and frustration will be the result as they have to combine child care with workweeks of 60-80h to reach or remain at the top. Pregnancy...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.07.002
更新日期:2017-09-01 00:00:00
abstract::Pseudohypoaldosteronism Type I may occur due to several different causes. The authors recommend distinguishing between effector and receptor disorders with regard to the diverse mode of inheritance and prognosis. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90247-n
更新日期:1993-09-01 00:00:00
abstract::Despite the widespread use of antidepressant medication, there are no signs that the burden of depression and suicide is decreasing in the industrialised world. This is generating mounting scepticism on the effectiveness of this class of drugs as an approach for the treatment of mood disorders. These doubts are also f...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.02.037
更新日期:2005-01-01 00:00:00
abstract::Current paper aims to hypothesize that, oral surgical interventions such as tooth extractions, endosseous implant placement, subgingival curettage, etc. might result in widespread of fungal species via blood stream and can cause fungal contaminations of the cardiac valves. We hereby suggest that, an additional fungal ...
journal_title:Medical hypotheses
pub_type: 信件
doi:10.1016/j.mehy.2019.109482
更新日期:2020-02-01 00:00:00
abstract::The concept of reentry as the most important element in a hypothesis for consciousness proposed by Edelman and Tononi is reviewed. Reentry, is a process of ongoing parallel and recursive signalling between separate neuronal groups along parallel reciprocally fibers that link these groups anatomically. Reentry alters t...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.03.007
更新日期:2004-01-01 00:00:00
abstract::A hypothesis is presented concerning the origin of the action of muscles in the human and animal bodies It is advanced that muscle action originates with very rapid chemical reactions known as percussion reactions. These give rise to the temporary precipitation of solids in muscle cells. The accompanying volume change...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(02)00149-4
更新日期:2002-08-01 00:00:00
abstract::This novel, iso-osmo-resistive theory offers electro-resistivity of food components as a new dimension for digestion. Firstly, fats, carbohydrates and proteins differ markedly in their resistivity, which offers a way to monitor them, especially when digestive enzymes cause consistent and distinctive changes. Secondly ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109282
更新日期:2019-09-01 00:00:00
abstract::Narcolepsy type 1 is a lifelong sleep disorder characterized by the loss of hypocretin-producing neurons in the brain. Environmental agents, including influenza, neurotoxic metals, and combustion smoke, have been implicated in the pathogenesis, especially in carriers of the human leukocyte antigen class II DQB1*06:02 ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109294
更新日期:2019-10-01 00:00:00
abstract::Interferon-alpha (IFN) is widely used in the treatment of certain cancers and viral infections, including hepatitis C (HCV). Unfortunately, depression is a common side effect of IFN therapy, affecting approximately a third of HCV patients receiving IFN therapy. Studies have shown that selective serotonin reuptake inhi...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.01.026
更新日期:2005-01-01 00:00:00
abstract::Pellagra is a curable dietary illness that unchecked leads to dementia, diarrhoea, dermatitis and death due to lack of the precursors for NAD(H). In addition it caused a wide range of monosyndromic degenerative and functional neurological disorders as well as profound developmental, premature aging and metabolic syndr...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.01.029
更新日期:2007-01-01 00:00:00
abstract::We have previously presented a new Systemic Evolutionary Theory of Cancer (SETOC) based on the failure of proper endosymbiosis in eukaryotic cells. Here, we propose that the progressive uncoupling of two endosymbiotic subsystems (information and energy) inside the cell, as a consequence of long-term injuries, gives ri...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2018.09.033
更新日期:2018-12-01 00:00:00
abstract::In UK educational circles it has long been regarded as a platitude that a good scientific education at school and undergraduate level should aim to teach critical thinking and encourage students to challenge mainstream science, debate scientific issues and express their personal opinions. However, I believe that this ...
journal_title:Medical hypotheses
pub_type: 社论
doi:10.1016/j.mehy.2009.07.050
更新日期:2010-02-01 00:00:00
abstract::As human society is mainly cooperative, it is not clear how antisocial personality disorder (APD) persists. The current explanation is that sociopaths are cheaters who maximize their fitness by taking advantages from others. Although this argument is valid, we show here that society also benefits from APD. We propose ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.05.027
更新日期:2005-01-01 00:00:00
abstract::The nasal mucosa is very vascular, receiving more blood flow per cubic centimeter of tissue than does muscle, brain or liver (Drettner and Aust, 1974; [1]). This vascularity can present a major problem during sinus surgery. Surgeons routinely use topical vasoconstrictors in endoscopic sinus surgery however, the optima...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.03.009
更新日期:2014-06-01 00:00:00